Drug General Information (ID: DDIZHUQT2S)
Drug Name			Methylphenidate		Drug Info		Isometheptene		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Cns Stimulants				Analgesics
Structure

Mechanism of Methylphenidate-Isometheptene Interaction (Severity Level: Moderate)
Additive hypertensive effects Click to Show/Hide Mechanism Graph
Drug Name		Methylphenidate				Isometheptene
Mechanism		Hypertensive effects				Hypertensive effects
Key Mechanism Factor 1
		Factor Name		Hypertensive effects
		Factor Description		Hypertension is defined as a blood pressure reading above a prescribed limit (130/90 mmHg). Most people with hypertension have no signs or symptoms; others may experience: severe headache, shortness of breath, nosebleeds, severe anxiety, and feeling a tingling sensation in the neck or head.
Mechanism Description		Additive hypertensive effects by the combination of Methylphenidate and Isometheptene

Recommended Action
Management		Caution is advised if CNS stimulants are used with vasopressors or other sympathomimetic agents. Pulse and blood pressure should be closely monitored.

References
1	Product Information. Focalin (dexmethylphenidate). Mikart Inc, Atlanta, GA.
2	Product Information. Strattera (atomoxetine). Lilly, Eli and Company, Indianapolis, IN.
3	Cavanaugh JH, Griffith JD, Oates JA "Effect of amphetamine on the pressor response to tyramine: formation of p-hydroxynorephedrine from amphetamine in man." Clin Pharmacol Ther 11 (1970): 656