Drug General Information (ID: DDI9CDTWYM)
Drug Name			Oxytocin		Drug Info		Isometheptene		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Uterotonic Agents				Analgesics
Structure

Mechanism of Oxytocin-Isometheptene Interaction (Severity Level: Moderate)
Additive hypertensive effects Click to Show/Hide Mechanism Graph
Drug Name		Oxytocin				Isometheptene
Mechanism		Hypertensive effects				Hypertensive effects
Key Mechanism Factor 1
		Factor Name		Hypertensive effects
		Factor Description		Hypertension is defined as a blood pressure reading above a prescribed limit (130/90 mmHg). Most people with hypertension have no signs or symptoms; others may experience: severe headache, shortness of breath, nosebleeds, severe anxiety, and feeling a tingling sensation in the neck or head.
Mechanism Description		Additive hypertensive effects by the combination of Oxytocin and Isometheptene

Recommended Action
Management		Close monitoring of blood pressure is recommended during coadministration.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Mendelson J, Jones RT, Upton R, Jacob P 3rd "Methamphetamine and ethanol interactions in humans." Clin Pharmacol Ther 57 (1995): 559-68. [PMID: 7768079]
3	Product Information. Syntocinon (oxytocin). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.