Details of Drug

Drug General Information (ID: D0828)
Drug Name	Interferon gamma-1b
Drug Type	Interferons
Disease Class	4A00: Innate/adaptive immunodeficiency
Therapeutic Class	Immunomodulatory Agents
External Link
External Link	TTD ID	D0U8US

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM017 CYP450 enzyme inhibition BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM055 Increased risk of hepatotoxicity BM069 Increased risk of lowers seizure threshold BM100 Antagonize the effect of vaccine/toxoid BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Interferon gamma-1b
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0064		Aminophylline	C16H24N10O4	9433	Moderate		Inter Info	[1], [2], [59], [60], [61], [43], [62], [63], [64]
D1201		Oxtriphylline	C12H21N5O3	656652	Moderate		Inter Info	[1], [2], [59], [60], [61], [43], [62], [63], [64]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[106], [107]
D1427		Ropinirole	C16H24N2O	5095	Moderate		Inter Info	[113], [114]
D1570		Theophylline	C7H8N4O2	2153	Moderate		Inter Info	[1], [2], [59], [60], [61], [43], [62], [63], [64]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 27
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[1], [2], [3]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[2], [20]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[25]
D1111		Natalizumab	NA	NA	Major		Inter Info	[34]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[2], [35]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[1], [38]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[39]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[42]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[56]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[1], [2]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[1], [2], [69]
D0314		Chloramphenicol (ophthalmic)	C11H12Cl2N2O5	5959	Moderate		Inter Info	[1], [2], [69]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[71]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[72]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[72]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[72]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[99]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[100]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[2], [101]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[102]
D1855		Palifermin	NA	NA	Moderate		Inter Info	[103]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[108]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[2], [112]
D1487		Sodium phosphate, monobasic (p32)	NA	NA	Moderate		Inter Info	[115]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[1], [2], [116]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[119]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[121]
	Additive myelosuppressive effects					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[2], [21], [22]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[1], [23], [24]
D1443		Samarium (153Sm) lexidronam	Sm	23951	Major		Inter Info	[37]
D1720		Zidovudine	C10H13N5O4	35370	Major		Inter Info	[2], [43], [44]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[1], [2], [79], [80]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[1], [2], [79], [80]
	Increased risk of hepatotoxicity					Drug Num: 24
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[31]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[32]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[33]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[36]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[31]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[45], [46], [47], [1], [2], [48], [49], [50], [51], [52], [53], [54], [55]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[45], [46], [47], [1], [2], [48], [49], [50], [51], [52], [53], [54], [55]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[66]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[67]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[45], [46], [47], [1], [2], [48], [49], [50], [51], [52], [53], [54], [55]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[2], [68]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[70]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[73], [74]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[1], [2], [75]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[89]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[90], [91], [92], [93]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[90], [91], [92], [93]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[2], [97]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[98]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[45], [46], [47], [1], [2], [48], [49], [50], [51], [52], [53], [54], [55]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[90], [91], [92], [93]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[1], [2], [109], [110], [111]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[117], [118]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[2], [120]
	Increased risk of lowers seizure threshold					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0220		Bupropion	C13H18ClNO	444	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[26], [27], [28], [29], [30]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[26], [27], [28], [29], [30]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[40], [18], [17], [41]
D0054		Amifampridine	C5H7N3	5918	Moderate		Inter Info	[57], [58]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[1], [2]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[81], [82], [83], [84], [85], [86], [87], [88]
D0932		Lindane	C6H6Cl6	727	Moderate		Inter Info	[94], [95], [96]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[104], [2], [105]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[104], [105], [2]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[104], [105], [2]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0178		Bexarotene	C24H28O2	82146	Major		Inter Info	[2], [4]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Minor		Inter Info	[1], [2]
D1808		Human adenovirus e serotype 4 strain cl-68578 antigen	NA	NA	Minor		Inter Info	[1], [2]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Minor		Inter Info	[1], [2]
D1839		Measles virus vaccine live attenuated	NA	NA	Minor		Inter Info	[1], [2]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Minor		Inter Info	[1], [2]
D1865		Pertussis vaccine	NA	NA	Minor		Inter Info	[1], [2]
D1881		Rotavirus vaccine	NA	NA	Minor		Inter Info	[1], [2]
D1882		Rubella virus vaccine	NA	NA	Minor		Inter Info	[1], [2]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Minor		Inter Info	[1], [2]
D1914		Typhoid vaccine (live)	NA	NA	Minor		Inter Info	[1], [2]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Minor		Inter Info	[1], [2]
D1922		Yellow Fever Vaccine	NA	NA	Minor		Inter Info	[1], [2]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0130		Avatrombopag	C29H34Cl2N6O3S2	9852519	Moderate		Inter Info	[2], [65]
D0659		Filgrastim	NA	NA	Moderate		Inter Info	[76], [77], [78]
D1235		Pegfilgrastim	C27H46N4O19	70683024	Moderate		Inter Info	[122], [123]
D1446		Sargramostim	NA	NA	Moderate		Inter Info	[76], [77], [78]

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Olumiant (baricitinib). Lilly, Eli and Company, Indianapolis, IN.
4	Product Information. Targretin (bexarotene) Ligand Pharmaceuticals, San Diego, CA.
5	Product Information. Wellbutrin XL (buPROPion). GlaxoSmithKline, Philadelphia, PA.
6	Sheehan DV, Welch JB, Fishman SM "A case of bupropion-induced seizure." J Nerv Ment Dis 174 (1986): 496-8. [PMID: 3090199]
7	Canadian Pharmacists Association.
8	Product Information. Wellbutrin (bupropion). Glaxo Wellcome, Research Triangle Park, NC.
9	Gittelman DK, Kirby MG "A seizure following bupropion overdose." J Clin Psychiatry 54 (1993): 162. [PMID: 8486598]
10	Product Information. Wellbutrin SR (bupropion). Glaxo Wellcome, Research Triangle Park, NC.
11	James WA, Lippmann S "Bupropion: overview and prescribing guidelines in depression." South Med J 84 (1991): 222-4. [PMID: 1899294]
12	Masco HL, Kiev A, Holloman LC, Batey SR, Johnston JA, Lineberry CG "Safety and efficacy of bupropion and nortriptyline in outpatients with depression." Curr Ther Res Clin Exp 55 (1994): 851-63.
13	Dufresne RL, Weber SS, Becker RE "Bupropion hydrochloride." Drug Intell Clin Pharm 18 (1984): 957-64. [PMID: 6439541]
14	Product Information. Zyban (bupropion). Glaxo Wellcome, Research Triangle Park, NC.
15	Storrow AB "Bupropion overdose and seizure." Am J Emerg Med 12 (1994): 183-4. [PMID: 8161393]
16	Johnston JA, Lineberry CG, Ascher JA, et al. "A 102-center prospective study of seizure in association with bupropion." J Clin Psychiatry 52 (1991): 450-6. [PMID: 1744061]
17	Rosenstein DL, Nelson JC, Jacobs SC "Seizures associated with antidepressants: a review." J Clin Psychiatry 54 (1993): 289-99. [PMID: 8253696]
18	Pisani F, Spina E, Oteri G "Antidepressant drugs and seizure susceptibility: from in vitro data to clinical practice." Epilepsia 40(Suppl 10) (1999): S48-56. [PMID: 10609604]
19	Product Information. Aplenzin (buPROPion). sanofi-aventis , Bridgewater, NJ.
20	Product Information. Leustatin (cladribine). Ortho Biotech Inc, Raritan, NJ.
21	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
22	Canadian Pharmacists Association "e-CPS."
23	Product Information. Ferriprox (deferiprone). ApoPharma USA Inc, Rockville, MD.
24	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports."
25	Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
26	Product Information. Isovue-M-200 (iopamidol). Bracco Diagnostics Inc, Princeton, NJ.
27	Product Information. Amipaque (metrizamide) Nycomed Inc, Princeton, NJ.
28	Hindmarsh T, Grepe A, Widen L "Metrizamide-phenothiazine interaction: report of a case with seizures following myelography." Acta Radiol Diagn (Stockh) 16 (1975): 129-35. [PMID: 810000]
29	Product Information. Omnipaque 180 (iohexol). Amersham Health, Princeton, NJ.
30	Product Information. Osmovist 240 (iotrolan). Berlex Canada Inc, Lachine, QC.
31	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
32	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
33	Product Information. Kynamro (mipomersen). Genzyme Corporation, Cambridge, MA.
34	Product Information. Tysabri (natalizumab). Elan Pharmaceutical/Athena Neurosciences Inc, South San Francisco, CA.
35	Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
36	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
37	Product Information. Quadramet (samarium sm 153 lexidronam) Berlex Laboratories, Richmond, CA.
38	Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
39	Product Information. Xeljanz (tofacitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
40	Product Information. Ultram (tramadol). McNeil Pharmaceutical, Raritan, NJ.
41	Gardiner JS, Blough D, Drinkard CR, et al. "Tramadol and seizures: a surveillance study in a managed care population." Pharmacotherapy 20 (2000): 1423-31. [PMID: 11130214]
42	Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
43	Product Information. Intron A (interferon alfa-2b). Schering Laboratories, Kenilworth, NJ.
44	Nokta M, Loh JP, Douidar SM, Ahmed AE, Pollard RB "Metabolic interaction of recombinant interferon-beta and zidovudine in AIDS patients." J Interferon Res 11 (1991): 159-64.[PMID: 1919075]
45	Al-Nawakil C, Willems L, Mauprivez C, et.al "Successful treatment of l-asparaginase-induced severe acute hepatotoxicity using mitochondrial cofactors." Leuk Lymphoma 55 (2014): 1670-4. [PMID: 24090500]
46	Bodmer M, Sulz M, Stadlmann S, Droll A, Terracciano L, Krahenbuhl S "Fatal liver failure in an adult patient with acute lymphoblastic leukemia following treatment with L-asparaginase." Digestion 74 (2006): epub. [PMID: 16988508]
47	Cerner Multum, Inc "ANVISA Bulario Eletrnico.".
48	Christ TN, Stock W, Knoebel RW "Incidence of asparaginase-related hepatotoxicity, pancreatitis, and thrombotic events in adults with acute lymphoblastic leukemia treated with a pediatric-inspired regimen." J Oncol Pharm Pract 24 (2018): 299-308. [PMID: 28355969]
49	Jenkins R, Perlin E "Severe hepatotoxicity from Escherichia coli L-asparaginase." J Natl Med Assoc 79 (1987): 775-9. [PMID: 3305969]
50	Lu G, Karur V, Herrington JD, Walker MG "Successful treatment of pegaspargase-induced acute hepatotoxicity with vitamin B complex and L-carnitine" Proc (Bayl Univ Med Cent) 29 (2016): 46-7. [PMID: 26722167]
51	Product Information. Asparlas (calaspargase pegol). Servier, Boston, MA.
52	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
53	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
54	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
55	Burke PW, Aldoss I, Lunning MA, et.al "High-grade PEGylated asparaginase-related hepatotoxicity occurrence in a pediatric-inspired adult acute lymphoblastic leukemia regimen does not necessarily predict recurrent hepatotoxicity in subsequent cycles." Blood 122 (2013): 2671. [PMID: 29407583]
56	Product Information. Campath (alemtuzumab) Berlex, Richmond, CA.
57	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
58	Product Information. Firdapse (amifampridine). Catalyst Pharmaceuticals, Inc., Coral Gables, FL.
59	Jonkman JH, Nicholson KG, Farrow PR, et al "Effects of alpha-interferon on theophylline pharmacokinetics and metabolism." Br J Clin Pharmacol 27 (1989): 795-802. [PMID: 2757895]
60	Kramer P, Tsuru M, Cook CE, et al "Effect of influenza vaccine on warfarin anticoagulation." Clin Pharmacol Ther 35 (1984): 416-8. [PMID: 6697649]
61	Okuno H, Takasu M, Kano H, Seki T, Shiozaki Y, Inoue K "Depression of drug-metabolizing activity in the human liver by interferon-beta." Hepatology 17 (1993): 65-9. [PMID: 8423043]
62	Sakai H, Okamoto T, Kikkawa Y "Suppression of hepatic drug metabolism by the interferon inducer polyriboinosinic acid:polyribocitidylic acid." J Pharmacol Exp Ther 263 (1992): 381-6. [PMID: 1403800]
63	Upton RA "Pharmacokinetic interactions between theophylline and other medication (Part II)." Clin Pharmacokinet 20 (1991): 135-50. [PMID: 1709398]
64	Williams SJ, Baird-Lambert JA, Farrell GC "Inhibition of theophylline metabolism by interferon." Lancet 10/24/87 (1987): 939-41. [PMID: 2444839]
65	Product Information. Doptelet (avatrombopag). Dova Pharmaceuticals, Durham, NC.
66	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
67	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
68	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
69	Sim SM, Back DJ, Breckenridge AM "The effect of various drugs on the glucuronidation of zidovudine (azidothymidine AZT) by human liver microsomes." Br J Clin Pharmacol 32 (1991): 17-21. [PMID: 1909542]
70	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
71	Product Information. Prolia (denosumab). Amgen USA, Thousand Oaks, CA.
72	Product Information. Vumerity (diroximel fumarate). Alkermes, Inc, Cambridge, MA.
73	Elsharkawy AM, Schwab U, McCarron B, et al. "Efavirenz induced acute liver failure requiring liver transplantation in a slow drug metaboliser." J Clin Virol 58 (2013): 331-3. [PMID: 23763943]
74	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
75	Product Information. Ellence (epirubicin) Pharmacia and Upjohn, Kalamazoo, MI.
76	Product Information. Granix (tbo-filgrastim). Teva Pharmaceuticals USA, North Wales, PA.
77	Product Information. Leukine (sargramostim). Immunex Corporation, Seattle, WA.
78	Product Information. Stemgen (ancestim) Amgen, Thousand Oaks, CA.
79	Product Information. Cytovene (ganciclovir). Genentech, South San Francisco, CA.
80	Product Information. Valcyte (valganciclovir) Roche Laboratories, Nutley, NJ.
81	Kajiyama Y, Fujii K, Takeuchi H, Manabe Y "Ginkgo seed poisoning." Pediatrics 109 (2002): 325-7. [PMID: 11826216]
82	Granger AS "Ginkgo biloba precipitating epileptic seizures." Age Ageing 30 (2001): 523-5. [PMID: 11742783]
83	Miller LG "Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions." Arch Intern Med 158 (1998): 2200-11. [PMID: 9818800]
84	Spinella M "Herbal medicines and epilepsy: the potential for benefit and adverse effects." Epilepsy Behav 2 (2001): 524-32. [PMID: 12609386]
85	Gregory PJ "Seizure associated with Ginkgo biloba?." Ann Intern Med 134 (2001): 344. [PMID: 11182853]
86	Harms SL, Garrard J, Schwinghammer P, Eberly LE, Chang Y, Leppik IE "Ginkgo biloba use in nursing home elderly with epilepsy or seizure disorder." Epilepsia 47 (2006): 323-9. [PMID: 16499756]
87	Miwa H, Iijima M, Tanaka S, Mizuno Y "Generalized convulsions after consuming a large amount of Gingko nuts." Epilepsia 42 (2001): 280-1. [PMID: 11240603]
88	Kupiec T, Raj V "Fatal seizures due to potential herb-drug interactions with Ginkgo biloba." J Anal Toxicol 29 (2005): 755-8. [PMID: 16419414]
89	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
90	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
91	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
92	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
93	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
94	Matsuoka LY "Convulsions following application of gamma benzene hexachloride." J Am Acad Dermatol 5 (1981): 98-9. [PMID: 6168673]
95	Cox R, Krupnick J, Bush N, Houpt A "Seizures caused by concomitant use of lindane and dextroamphetamine in a child with attention deficit hyperactivity disorder." J Miss State Med Assoc 41 (2000): 690-2. [PMID: 10974795]
96	Product Information. Kwell (lindane). Reed and Carnrick, Jersey City, NJ.
97	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
98	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
99	Product Information. Zejula (niraparib). Tesaro Inc., Waltham, MA.
100	Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
101	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
102	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
103	Product Information. Kepivance (palifermin). Shire US Inc, Florence, KY.
104	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
105	Salik JM, Kurtin P "Severe hyponatremia after colonoscopy preparation in a patient with the acquired immune deficiency syndrome." Am J Gastroenterol 80 (1985): 177-9. [PMID: 2983533]
106	Krahenbuhl S, Sauter B, Kupferschmidt H, Krause M, Wyss PA, Meier PJ "Case report: reversible QT prolongation with torsades de pointes in a patient with pimozide intoxication." Am J Med Sci 309 (1995): 315-6. [PMID: 7771501]
107	Product Information. Orap Tablets (pimozide). Gate Pharmaceuticals, Sellersville, PA.
108	Product Information. Xofigo (radium Ra 223 dichloride). Bayer Pharmaceutical Inc, West Haven, CT.
109	European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
110	Gilead Sciences, Inc "About Remdesivir.".
111	US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
112	Product Information. Daxas (roflumilast). Nycomed Inc, Princeton, NJ.
113	Product Information. Noroxin (norfloxacin). Merck & Co, Inc, West Point, PA.
114	Product Information. Requip (ropinirole). SmithKline Beecham, Philadelphia, PA.
115	AnazaoHealth Corporation "P32 Sodium Phosphate."
116	Multum Information Services, Inc. Expert Review Panel.
117	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
118	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
119	Product Information. Hycamtin (topotecan). SmithKline Beecham, Philadelphia, PA.
120	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
121	Product Information. Stelara (ustekinumab). Centocor Inc, Malvern, PA.
122	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
123	Product Information. Neulasta (pegfilgrastim). Amgen, Thousand Oaks, CA.

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence