Details of Drug

Details of Drug

 Drug General Information (ID: D0712)
  Drug Name
Gatifloxacin
  Drug Type Small molecule
  Drug Synonymous
Bonoq; GTFX; Gaity; Gatiflo; Gatilox; Gatiquin; Gatispan; Tequin; Zymar; Zymaxid; Zymer; AM 1155; CG 5501;PD 135432; PD135432; AM-1155; BMS 206584-01; BMS-206584; CG-5501; Gatiflo (TN); Gatifloxacin & Gamma Interferon; Gatifloxacin (INN); Gatifloxacin (TN); Gatifloxacin [USAN:INN]; PD-135432; Tequin (TN); Tequin in dextrose 5% in plastic container; Zymar (TN); Zymer (TN); BMS-206584-01; Gatiflo,Tequin and Zymar, Gatifloxacin; AM-1155 (*Sesquihydrate*); (+-)-1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 1-Cyclopropyl-1,4-dihydro-6-fluoro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
    Click to Show/Hide
  Disease Class CA07-CA4Z: Respiratory infection
  Therapeutic Class Antiinfective Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C19H22FN3O4
  InChI 1S/C19H22FN3O4/c1-10-8-22(6-5-21-10)16-14(20)7-12-15(18(16)27-2)23(11-3-4-11)9-13(17(12)24)19(25)26/h7,9-11,21H,3-6,8H2,1-2H3,(H,25,26)
  InChIKey XUBOMFCQGDBHNK-UHFFFAOYSA-N
  Canonical SMILES CC1CN(CCN1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F
  External Link
Pubchem ID 5379
CAS Number 112811-59-3
CHEBI ID 5280
TTD ID D03CQE
VARIDT ID DR01165

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM003  Affected organization distribution
AM004  Affected intra/extra-hepatic metabolism
AM005  Affected excretion pathways
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM002  Altered intestinal flora
BM003  Complex formation
BM006  Altered intestinal mucosa
BM014  Interference of cell/tissue uptake
BM017  CYP450 enzyme inhibition
BM028  Competitive inhibition of renal tubular secretion
BM029  Altered urine pH
BM038  Additive CNS depression effects
BM039  Additive CNS stimulant effects
BM050  Increased risk of bleeding
BM064  Increased risk of hypoglycemia
BM069  Increased risk of lowers seizure threshold
BM074  Increased risk of peripheral neuropathy
BM075  Increased risk of photosensitivity reactions
BM076  Increased risk of prolong QT interval
BM080  Increased risk of tendinitis/tendon rupture
BM081  Increased risk of ventricular arrhythmias
BM086  Antagonize the effect of antidiabetic agents
BM089  Antagonize the effect of antihypertensive agents
BM100  Antagonize the effect of vaccine/toxoid
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Gatifloxacin
      Affected gastrointestinal absorption
   Altered intestinal flora Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1094
 
Mycophenolate mofetil
 
C23H31NO7
 
5281078 
Moderate    Inter Info   
[292], [293]
D1095
 
Mycophenolic acid
 
C17H20O6
 
446541 
Moderate    Inter Info   
[292], [293]
   Complex formation Drug Num:  39
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0235
 
Calcium acetate
 
C4H6CaO4
 
6116 
Moderate    Inter Info   
[208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [64], [81], [66], [225], [226], [227], [85], [228], [229], [230], [231], [232], [233], [234], [235]
D0483
 
Didanosine
 
C10H12N4O3
 
135398739 
Moderate    Inter Info   
[242], [243], [219], [244], [245], [30], [246], [247], [248]
D0619
 
Ethinylestradiol
 
C20H24O2
 
5991 
Moderate    Inter Info   
[253], [254], [255]
D0049
 
Aluminum hydroxide
 
AlH3O3
 
10176082 
Moderate    Inter Info   
[208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [64], [81], [66], [225], [226], [227], [85], [228], [229], [230], [231], [232], [233], [234], [235]
D0125
 
Attapulgite
 
Al2H29Mg2O15Si4-
 
56842194 
Moderate    Inter Info   
[221], [222], [231]
D0236
 
Calcium carbonate
 
CCaO3
 
10112 
Moderate    Inter Info   
[221], [222], [231]
D0238
 
Calcium citrate
 
C12H10Ca3O14
 
13136 
Moderate    Inter Info   
[208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [64], [81], [66], [225], [226], [227], [85], [228], [229], [230], [231], [232], [233], [234], [235]
D0239
 
Calcium glubionate anhydrous
 
C18H32CaO19
 
64776 
Moderate    Inter Info   
[221], [222], [231]
D0241
 
Calcium gluconate
 
C12H22CaO14
 
9290 
Moderate    Inter Info   
[208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [64], [81], [66], [225], [226], [227], [85], [228], [229], [230], [231], [232], [233], [234], [235]
D0242
 
Calcium glycerophosphate
 
C3H7CaO6P
 
120096 
Moderate    Inter Info   
[221], [222], [231]
D0243
 
Calcium lactate
 
C6H10CaO6
 
13144 
Moderate    Inter Info   
[208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [64], [81], [66], [225], [226], [227], [85], [228], [229], [230], [231], [232], [233], [234], [235]
D0244
 
Calcium Phosphate
 
Ca3O8P2
 
24456 
Moderate    Inter Info   
[221], [222], [231]
D0332
 
Chromium picolinate
 
C18H12CrN3O6
 
151932 
Moderate    Inter Info   
[208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [64], [81], [66], [225], [226], [227], [85], [228], [229], [230], [231], [232], [233], [234], [235]
D0390
 
Copper gluconate
 
C12H22CuO14
 
10692 
Moderate    Inter Info   
[221], [222], [231]
D0649
 
Ferrous fumarate
 
C4H2FeO4
 
6433164 
Moderate    Inter Info   
[208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [64], [81], [66], [225], [226], [227], [85], [228], [229], [230], [231], [232], [233], [234], [235]
D0650
 
Ferrous gluconate
 
C12H22FeO14
 
23616740 
Moderate    Inter Info   
[208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [64], [81], [66], [225], [226], [227], [85], [228], [229], [230], [231], [232], [233], [234], [235]
D0651
 
Ferrous sulfate anhydrous
 
FeO4S
 
24393 
Moderate    Inter Info   
[221], [222], [231]
D0847
 
Iron
 
Fe
 
23925 
Moderate    Inter Info   
[221], [222], [231]
D0849
 
Iron protein succinylate
 
NA
 
NA
Moderate    Inter Info   
[208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [64], [81], [66], [225], [226], [227], [85], [228], [229], [230], [231], [232], [233], [234], [235]
D0877
 
Kaolin
 
Al2H4O9Si2
 
56841936 
Moderate    Inter Info   
[221], [222], [231]
D0893
 
Lanthanum carbonate
 
C3La2O9
 
168924 
Moderate    Inter Info   
[2], [41], [32], [281], [282], [283]
D0967
 
Magaldrate
 
AlHMgO5S+2
 
3086011 
Moderate    Inter Info   
[221], [222], [231]
D0968
 
Magnesium carbonate
 
CMgO3
 
11029 
Moderate    Inter Info   
[221], [222], [231]
D0969
 
Magnesium chloride
 
Cl2H12MgO6
 
643991 
Moderate    Inter Info   
[208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [64], [81], [66], [225], [226], [227], [85], [228], [229], [230], [231], [232], [233], [234], [235]
D0970
 
Magnesium citrate
 
C12H10Mg3O14
 
6099959 
Moderate    Inter Info   
[208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [64], [81], [66], [225], [226], [227], [85], [228], [229], [230], [231], [232], [233], [234], [235]
D0971
 
Magnesium gluconate
 
C12H22MgO14
 
11418570 
Moderate    Inter Info   
[208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [64], [81], [66], [225], [226], [227], [85], [228], [229], [230], [231], [232], [233], [234], [235]
D0972
 
Magnesium glycinate
 
C4H8MgN2O4
 
84645 
Moderate    Inter Info   
[221], [222], [231]
D0973
 
Magnesium hydroxide
 
H2MgO2
 
14791 
Moderate    Inter Info   
[208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [64], [81], [66], [225], [226], [227], [85], [228], [229], [230], [231], [232], [233], [234], [235]
D0974
 
Magnesium oxide
 
MgO
 
14792 
Moderate    Inter Info   
[208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [64], [81], [66], [225], [226], [227], [85], [228], [229], [230], [231], [232], [233], [234], [235]
D1011
 
Mestranol
 
C21H26O2
 
6291 
Moderate    Inter Info   
[253], [254], [255]
D1456
 
Selenium
 
Se
 
6326970 
Moderate    Inter Info   
[208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [64], [81], [66], [225], [226], [227], [85], [228], [229], [230], [231], [232], [233], [234], [235]
D1566
 
Tetraferric tricitrate decahydrate
 
C18H32Fe4O31
 
90478690 
Moderate    Inter Info   
[221], [222], [231]
D1722
 
Zinc acetate
 
C4H6O4Zn
 
11192 
Moderate    Inter Info   
[208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [64], [81], [66], [225], [226], [227], [85], [228], [229], [230], [231], [232], [233], [234], [235]
D1724
 
Zinc gluconate
 
C12H22O14Zn
 
443445 
Moderate    Inter Info   
[208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [64], [81], [66], [225], [226], [227], [85], [228], [229], [230], [231], [232], [233], [234], [235]
D1725
 
Zinc sulfate
 
O4SZn
 
24424 
Moderate    Inter Info   
[208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [64], [81], [66], [225], [226], [227], [85], [228], [229], [230], [231], [232], [233], [234], [235]
D0975
 
Magnesium sulfate
 
MgO4S
 
24083 
Moderate    Inter Info   
[208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [64], [81], [66], [225], [226], [227], [85], [228], [229], [230], [231], [232], [233], [234], [235]
D1369
 
Quinapril
 
C25H30N2O5
 
54892 
Moderate    Inter Info   
[32], [271]
D1462
 
Sevelamer
 
C6H12ClNO
 
3085017 
Moderate    Inter Info   
[306]
D1511
 
Sucralfate
 
C12H54Al9O55S8
 
121494085 
Moderate    Inter Info   
[208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [64], [81], [66], [225], [226], [227], [85], [228], [229], [230], [231], [232], [233], [234], [235]
   Altered intestinal mucosa Drug Num:  50
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0030
 
Aldesleukin
 
NA
 
NA
Minor    Inter Info   
[309]
D0048
 
Altretamine
 
C9H18N6
 
2123 
Minor    Inter Info   
[309]
D0190
 
Bleomycin
 
C55H84N17O21S3+
 
5360373 
Minor    Inter Info   
[309]
D0223
 
Busulfan
 
C6H14O6S2
 
2478 
Minor    Inter Info   
[309]
D0260
 
Carboplatin
 
C6H12N2O4Pt
 
426756 
Minor    Inter Info   
[309]
D0264
 
Carmustine
 
C5H9Cl2N3O2
 
2578 
Minor    Inter Info   
[309]
D0312
 
Chlorambucil
 
C14H19Cl2NO2
 
2708 
Minor    Inter Info   
[309]
D0344
 
Cisplatin
 
Cl2H6N2Pt
 
5702198 
Minor    Inter Info   
[309]
D0357
 
Clofarabine
 
C10H11ClFN5O3
 
119182 
Minor    Inter Info   
[309]
D0400
 
Cyclophosphamide
 
C7H15Cl2N2O2P
 
2907 
Minor    Inter Info   
[309]
D0404
 
Cytarabine
 
C9H13N3O5
 
6253 
Minor    Inter Info   
[309]
D0407
 
Dacarbazine
 
C6H10N6O
 
135398738 
Minor    Inter Info   
[309]
D0410
 
Dactinomycin
 
C62H86N12O16
 
457193 
Minor    Inter Info   
[309]
D0442
 
Denileukin diftitox
 
NA
 
NA
Minor    Inter Info   
[309]
D0627
 
Etoposide
 
C29H32O13
 
36462 
Minor    Inter Info   
[309]
D0666
 
Floxuridine
 
C9H11FN2O5
 
5790 
Minor    Inter Info   
[309]
D0675
 
Fluorouracil
 
C4H3FN2O2
 
3385 
Minor    Inter Info   
[309]
D0249
 
Capecitabine
 
C15H22FN3O6
 
60953 
Minor    Inter Info   
[309]
D0511
 
Docetaxel
 
C43H53NO14
 
148124 
Minor    Inter Info   
[309]
D0669
 
Fludarabine
 
C10H12FN5O4
 
657237 
Minor    Inter Info   
[309]
D0790
 
Ifosfamide
 
C7H15Cl2N2O2P
 
3690 
Minor    Inter Info   
[309]
D0945
 
Lomustine
 
C9H16ClN3O2
 
3950 
Minor    Inter Info   
[309]
D0962
 
Lurbinectedin
 
C41H44N4O10S
 
57327016 
Minor    Inter Info   
[309]
D0997
 
Melphalan flufenamide
 
C24H30Cl2FN3O3
 
9935639 
Minor    Inter Info   
[309]
D1079
 
Mitoxantrone
 
C22H28N4O6
 
4212 
Minor    Inter Info   
[309]
D1212
 
Paclitaxel
 
C47H51NO14
 
36314 
Minor    Inter Info   
[309]
D1213
 
Paclitaxel (protein-bound)
 
C47H51NO14
 
36314 
Minor    Inter Info   
[309]
D1305
 
Plicamycin
 
C52H76O24
 
163659 
Minor    Inter Info   
[309]
D1345
 
Procarbazine
 
C12H19N3O
 
4915 
Minor    Inter Info   
[309]
D1575
 
Thiotepa
 
C6H12N3PS
 
5453 
Minor    Inter Info   
[309]
D0714
 
Gemcitabine
 
C9H11F2N3O4
 
60750 
Minor    Inter Info   
[309]
D0717
 
Gemtuzumab ozogamicin
 
NA
 
NA
Minor    Inter Info   
[309]
D0780
 
Hydroxyurea
 
CH4N2O2
 
3657 
Minor    Inter Info   
[309]
D0845
 
Irinotecan
 
C33H38N4O6
 
60838 
Minor    Inter Info   
[309]
D0986
 
Mechlorethamine
 
C5H11Cl2N
 
4033 
Minor    Inter Info   
[309]
D0996
 
Melphalan
 
C13H18Cl2N2O2
 
460612 
Minor    Inter Info   
[309]
D1007
 
Mercaptopurine
 
C5H4N4S
 
667490 
Minor    Inter Info   
[309]
D1077
 
Mitomycin
 
C15H18N4O5
 
5746 
Minor    Inter Info   
[309]
D1250
 
Pentostatin
 
C11H16N4O4
 
439693 
Minor    Inter Info   
[309]
D1508
 
Streptozocin
 
C8H15N3O7
 
29327 
Minor    Inter Info   
[309]
D1548
 
Temozolomide
 
C6H6N6O2
 
5394 
Minor    Inter Info   
[309]
D1551
 
Teniposide
 
C32H32O13S
 
452548 
Minor    Inter Info   
[309]
D1589
 
Tioguanine
 
C5H5N5S
 
2723601 
Minor    Inter Info   
[309]
D1610
 
Topotecan
 
C23H23N3O5
 
60700 
Minor    Inter Info   
[309]
D1626
 
Tretinoin
 
C20H28O2
 
444795 
Minor    Inter Info   
[309]
D1667
 
Uracil mustard
 
C8H11Cl2N3O2
 
6194 
Minor    Inter Info   
[309]
D1697
 
Vinblastine
 
C46H58N4O9
 
13342 
Minor    Inter Info   
[309]
D1698
 
Vincristine
 
C46H56N4O10
 
5978 
Minor    Inter Info   
[309]
D1699
 
Vincristine (liposome)
 
C46H56N4O10
 
5978 
Minor    Inter Info   
[309]
D1700
 
Vinorelbine
 
C45H54N4O8
 
5311497 
Minor    Inter Info   
[309]
      Affected organization distribution
   Interference of cell/tissue uptake Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1817
 
Indium In-111 oxyquinoline
 
C27H18InN3O3
 
16685037 
Moderate    Inter Info   
[280]
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0994
 
Melatonin
 
C13H16N2O2
 
896 
Minor    Inter Info   
[41]
      Affected excretion pathways
   Competitive inhibition of renal tubular secretion Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0576
 
Entecavir
 
C12H15N5O3
 
135398508 
Moderate    Inter Info   
[252]
D1241
 
Pemetrexed
 
C20H21N5O6
 
135410875 
Moderate    Inter Info   
[295]
D1341
 
Probenecid
 
C13H19NO4S
 
4911 
Minor    Inter Info   
[81], [313], [314]
   Altered urine pH Drug Num:  4
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1760
 
Citric acid
 
C6H8O7
 
311 
Moderate    Inter Info   
[271], [65]
D1319
 
Potassium citrate
 
C6H5K3O7
 
13344 
Moderate    Inter Info   
[271], [65]
D1480
 
Sodium bicarbonate
 
CHNaO3
 
516892 
Moderate    Inter Info   
[271], [65]
D1483
 
Sodium citrate
 
C6H5Na3O7
 
6224 
Moderate    Inter Info   
[271], [65]
      Pharmacodynamic additive effects
   Additive CNS depression effects Drug Num:  9
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0298
 
Celecoxib
 
C17H14F3N3O2S
 
2662 
Moderate    Inter Info   
[81], [225], [65], [56], [82], [236], [205], [30], [237], [238], [239], [240], [241], [66]
D0489
 
Diflunisal
 
C13H8F2O3
 
3059 
Moderate    Inter Info   
[81], [225], [65], [56], [82], [236], [205], [30], [237], [238], [239], [240], [241], [66]
D0624
 
Etodolac
 
C17H21NO3
 
3308 
Moderate    Inter Info   
[81], [225], [65], [56], [82], [236], [205], [30], [237], [238], [239], [240], [241], [66]
D0645
 
Fenoprofen
 
C15H14O3
 
3342 
Moderate    Inter Info   
[81], [225], [65], [56], [82], [236], [205], [30], [237], [238], [239], [240], [241], [66]
D0680
 
Flurbiprofen
 
C15H13FO2
 
3394 
Moderate    Inter Info   
[81], [225], [65], [56], [82], [236], [205], [30], [237], [238], [239], [240], [241], [66]
D0786
 
Ibuprofen
 
C13H18O2
 
3672 
Moderate    Inter Info   
[81], [225], [65], [56], [82], [236], [205], [30], [237], [238], [239], [240], [241], [66]
D0800
 
Indomethacin
 
C19H16ClNO4
 
3715 
Moderate    Inter Info   
[81], [225], [65], [56], [82], [236], [205], [30], [237], [238], [239], [240], [241], [66]
D0881
 
Ketoprofen
 
C16H14O3
 
3825 
Moderate    Inter Info   
[81], [225], [65], [56], [82], [236], [205], [30], [237], [238], [239], [240], [241], [66]
D0882
 
Ketorolac
 
C15H13NO3
 
3826 
Moderate    Inter Info   
[81], [225], [65], [56], [82], [236], [205], [30], [237], [238], [239], [240], [241], [66]
   Additive CNS stimulant effects Drug Num:  17
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0017
 
Acetylsalicylic acid
 
C9H8O4
 
2244 
Moderate    Inter Info   
[205], [56], [81]
D0210
 
Bromfenac
 
C15H12BrNO3
 
60726 
Moderate    Inter Info   
[205], [56], [81]
D0331
 
Choline salicylate
 
C12H19NO4
 
54686350 
Moderate    Inter Info   
[205], [56], [81]
D1272
 
Phenyl salicylate
 
C13H10O3
 
8361 
Moderate    Inter Info   
[205], [56], [81]
D1442
 
Salsalate
 
C14H10O5
 
5161 
Moderate    Inter Info   
[81], [225], [65], [56], [82], [236], [205], [30], [237], [238], [239], [240], [241], [66]
D0988
 
Meclofenamic acid
 
C14H11Cl2NO2
 
4037 
Moderate    Inter Info   
[205], [56], [81]
D0995
 
Meloxicam
 
C14H13N3O4S2
 
54677470 
Moderate    Inter Info   
[81], [225], [65], [56], [82], [236], [205], [30], [237], [238], [239], [240], [241], [66]
D1097
 
Nabumetone
 
C15H16O2
 
4409 
Moderate    Inter Info   
[81], [225], [65], [56], [82], [236], [205], [30], [237], [238], [239], [240], [241], [66]
D1109
 
Naproxen
 
C14H14O3
 
156391 
Moderate    Inter Info   
[81], [225], [65], [56], [82], [236], [205], [30], [237], [238], [239], [240], [241], [66]
D1196
 
Oxaprozin
 
C18H15NO3
 
4614 
Moderate    Inter Info   
[81], [225], [65], [56], [82], [236], [205], [30], [237], [238], [239], [240], [241], [66]
D1274
 
Phenylbutazone
 
C19H20N2O2
 
4781 
Moderate    Inter Info   
[205], [56], [81]
D1300
 
Piroxicam
 
C15H13N3O4S
 
54676228 
Moderate    Inter Info   
[81], [225], [65], [56], [82], [236], [205], [30], [237], [238], [239], [240], [241], [66]
D1421
 
Rofecoxib
 
C17H14O4S
 
5090 
Moderate    Inter Info   
[205], [56], [81]
D1439
 
Salicylic acid (sodium)
 
C7H6O3
 
338 
Moderate    Inter Info   
[205], [56], [81]
D1520
 
Sulindac
 
C20H17FO3S
 
1548887 
Moderate    Inter Info   
[81], [225], [65], [56], [82], [236], [205], [30], [237], [238], [239], [240], [241], [66]
D1606
 
Tolmetin
 
C15H15NO3
 
5509 
Moderate    Inter Info   
[81], [225], [65], [56], [82], [236], [205], [30], [237], [238], [239], [240], [241], [66]
D1674
 
Valdecoxib
 
C16H14N2O3S
 
119607 
Moderate    Inter Info   
[205], [56], [81]
   Increased risk of bleeding Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0481
 
Dicoumarol
 
C19H12O6
 
54676038 
Major    Inter Info   
[73], [74], [75]
D0087
 
Anisindione
 
C16H12O3
 
2197 
Major    Inter Info   
[73], [74], [75]
D1711
 
Warfarin
 
C19H16O4
 
54678486 
Major    Inter Info   
[73], [74], [75]
   Increased risk of lowers seizure threshold Drug Num:  6
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0220
 
Bupropion
 
C13H18ClNO
 
444 
Major    Inter Info   
[97], [98], [2], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D0833
 
Iohexol
 
C19H26I3N3O9
 
3730 
Major    Inter Info   
[121], [122], [123], [124], [125]
D0834
 
Iopamidol
 
C17H22I3N3O8
 
65492 
Major    Inter Info   
[121], [122], [123], [124], [125]
D0054
 
Amifampridine
 
C5H7N3
 
5918 
Moderate    Inter Info   
[32], [260], [261]
D0722
 
Ginkgo biloba
 
NA
 
NA
Moderate    Inter Info   
[272], [273], [274], [275], [276], [277], [278], [279]
D0932
 
Lindane
 
C6H6Cl6
 
727 
Moderate    Inter Info   
[285], [286], [287]
   Increased risk of photosensitivity reactions Drug Num:  5
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0062
 
Aminolevulinic acid
 
C5H9NO3
 
137 
Major    Inter Info   
[60], [61]
D0063
 
Aminolevulinic acid (topical)
 
C5H9NO3
 
137 
Moderate    Inter Info   
[41], [32], [206]
D1028
 
Methoxsalen
 
C12H8O4
 
4114 
Moderate    Inter Info   
[41], [271], [60], [290], [291]
D1033
 
Methyl aminolevulinate (topical)
 
C6H11NO3
 
157922 
Moderate    Inter Info   
[41], [32], [206]
D1691
 
Verteporfin
 
C82H84N8O16
 
11980904 
Moderate    Inter Info   
[32], [271], [60], [308]
   Increased risk of prolong QT interval Drug Num:  175
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0003
 
Abarelix
 
C72H95ClN14O14
 
16131215 
Major    Inter Info   
[1], [2], [3]
D0036
 
Alfuzosin
 
C19H27N5O4
 
2092 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0068
 
Amitriptyline
 
C20H23N
 
2160 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0072
 
Amoxapine
 
C17H16ClN3O
 
2170 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0084
 
Anagrelide
 
C10H7Cl2N3O
 
135409400 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0097
 
Apomorphine
 
C17H17NO2
 
6005 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0115
 
Astemizole
 
C28H31FN4O
 
2247 
Major    Inter Info   
[1], [2], [3]
D0119
 
Atomoxetine
 
C17H21NO
 
54841 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0139
 
Azithromycin
 
C38H72N2O12
 
447043 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0219
 
Buprenorphine
 
C29H41NO4
 
644073 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0320
 
Chloroquine
 
C18H26ClN3
 
2719 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0324
 
Chlorpromazine
 
C17H19ClN2S
 
2726 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0342
 
Cisapride
 
C23H29ClFN3O4
 
6917698 
Major    Inter Info   
[2], [41], [68]
D0345
 
Citalopram
 
C20H21FN2O
 
2771 
Major    Inter Info   
[2], [41], [32], [69], [70], [71], [72]
D0358
 
Clofazimine
 
C27H22Cl2N4
 
2794 
Major    Inter Info   
[1], [2], [3]
D0370
 
Clozapine
 
C18H19ClN4
 
135398737 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0429
 
Daunorubicin
 
C27H29NO10
 
30323 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0430
 
Daunorubicin (liposomal)
 
C27H29NO10
 
30323 
Major    Inter Info   
[1], [2], [3]
D0467
 
Dextropropoxyphene
 
C22H29NO2
 
10100 
Major    Inter Info   
[1], [2], [3]
D0508
 
Disopyramide
 
C21H29N3O
 
3114 
Major    Inter Info   
[1], [39], [40], [42], [76], [43], [77], [44], [45], [46], [47], [48], [78], [49], [50], [79], [80], [51], [52], [53], [54], [55], [56], [81], [82], [66], [83], [84], [30], [85], [86], [3], [57], [87], [58], [59], [88]
D0513
 
Dofetilide
 
C19H27N3O5S2
 
71329 
Major    Inter Info   
[2], [41], [32], [89]
D0514
 
Dolasetron
 
C19H20N2O3
 
3033818 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0528
 
Doxorubicin
 
C27H29NO11
 
31703 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0529
 
Doxorubicin (liposomal)
 
C27H29NO11
 
31703 
Major    Inter Info   
[1], [2], [3]
D0535
 
Droperidol
 
C22H22FN3O2
 
3168 
Major    Inter Info   
[2], [41], [32], [90], [91], [71]
D0554
 
Efavirenz
 
C14H9ClF3NO2
 
64139 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0584
 
Epirubicin
 
C27H29NO11
 
41867 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0597
 
Erythromycin
 
C37H67NO13
 
12560 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0667
 
Fluconazole
 
C13H12F2N6O
 
3365 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0676
 
Fluoxetine
 
C17H18F3NO
 
3386 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0678
 
Fluphenazine
 
C22H26F3N3OS
 
3372 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0682
 
Flutamide
 
C11H11F3N2O3
 
3397 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0007
 
Abiraterone
 
C24H31NO
 
132971 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0037
 
Alimemazine
 
C18H22N2S
 
5574 
Major    Inter Info   
[1], [2], [3]
D0066
 
Amiodarone
 
C25H29I2NO3
 
2157 
Major    Inter Info   
[1], [39], [40], [42], [76], [43], [77], [44], [45], [46], [47], [48], [78], [49], [50], [79], [80], [51], [52], [53], [54], [55], [56], [81], [82], [66], [83], [84], [30], [85], [86], [3], [57], [87], [58], [59], [88]
D0067
 
Amisulpride
 
C17H27N3O4S
 
2159 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0095
 
Apalutamide
 
C21H15F4N5O2S
 
24872560 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0112
 
Asenapine
 
C17H16ClNO
 
3036780 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0149
 
Bedaquiline
 
C32H31BrN2O2
 
5388906 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0170
 
Bepridil
 
C24H34N2O
 
2351 
Major    Inter Info   
[54], [96], [85]
D0180
 
Bicalutamide
 
C18H14F4N2O4S
 
2375 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0195
 
Bosutinib
 
C26H29Cl2N5O3
 
5328940 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0230
 
Cabozantinib
 
C28H24FN3O5
 
25102847 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0302
 
Ceritinib
 
C28H36ClN5O3S
 
57379345 
Major    Inter Info   
[2], [41], [32], [111]
D0336
 
Cilostazol
 
C20H27N5O2
 
2754 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0349
 
Clarithromycin
 
C38H69NO13
 
84029 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0361
 
Clomipramine
 
C19H23ClN2
 
2801 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0393
 
Crizotinib
 
C21H22Cl2FN5O
 
11626560 
Major    Inter Info   
[112]
D0428
 
Dasatinib
 
C22H26ClN7O2S
 
3062316 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0437
 
Degarelix
 
C82H103ClN18O16
 
16136245 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0446
 
Desipramine
 
C18H22N2
 
2995 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0452
 
Deutetrabenazine
 
C19H27NO3
 
73437646 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0525
 
Doxepin
 
C19H21NO
 
667477 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0526
 
Doxepin (topical)
 
C19H21NO
 
667477 
Major    Inter Info   
[1], [2], [3]
D0534
 
Dronedarone
 
C31H44N2O5S
 
208898 
Major    Inter Info   
[2], [41], [32], [113]
D0577
 
Entrectinib
 
C31H34F2N6O2
 
25141092 
Major    Inter Info   
[1], [2], [3]
D0578
 
Enzalutamide
 
C21H16F4N4O2S
 
15951529 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0594
 
Eribulin
 
C40H59NO11
 
11354606 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0599
 
Escitalopram
 
C20H21FN2O
 
146570 
Major    Inter Info   
[2], [114], [41], [32], [115], [116], [71]
D0632
 
Ezogabine
 
C16H18FN3O2
 
121892 
Major    Inter Info   
[1], [2], [3]
D0664
 
Flecainide
 
C17H20F6N2O3
 
3356 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0700
 
Fostemsavir
 
C25H26N7O8P
 
11319217 
Major    Inter Info   
[1], [2], [3]
D0720
 
Gilteritinib
 
C29H44N8O3
 
49803313 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0725
 
Glasdegib
 
C21H22N6O
 
25166913 
Major    Inter Info   
[1], [2], [3]
D0749
 
Halofantrine
 
C26H30Cl2F3NO
 
37393 
Major    Inter Info   
[41], [118], [119]
D0751
 
Halothane
 
C2HBrClF3
 
3562 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0758
 
Histrelin
 
C66H86N18O12
 
25077993 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0779
 
Hydroxychloroquine
 
C18H26ClN3O
 
3652 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0788
 
Idarubicin
 
C26H27NO9
 
42890 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0791
 
Iloperidone
 
C24H27FN2O4
 
71360 
Major    Inter Info   
[2], [41], [32], [120], [71]
D0806
 
Inotuzumab ozogamicin
 
NA
 
NA
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0872
 
Ivosidenib
 
C28H22ClF3N6O3
 
71657455 
Major    Inter Info   
[1], [2], [3]
D0894
 
Lapatinib
 
C29H26ClFN4O4S
 
208908 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0899
 
Lefamulin
 
C28H45NO5S
 
25185057 
Major    Inter Info   
[131], [132], [133]
D0903
 
Lenvatinib
 
C21H19ClN4O4
 
9823820 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0909
 
Levacetylmethadol
 
C23H31NO2
 
15130 
Major    Inter Info   
[32], [134], [71]
D0937
 
Lisdexamfetamine
 
C15H25N3O
 
11597698 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0940
 
Lithium carbonate
 
CLi2O3
 
11125 
Major    Inter Info   
[1], [2], [3]
D0942
 
Lofexidine
 
C11H12Cl2N2O
 
30668 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0948
 
Lopinavir
 
C37H48N4O5
 
92727 
Major    Inter Info   
[1], [2], [3]
D0965
 
Macimorelin
 
C26H30N6O3
 
9804938 
Major    Inter Info   
[131], [135], [133]
D1026
 
Methotrimeprazine
 
C19H24N2OS
 
72287 
Major    Inter Info   
[1], [2], [3]
D1062
 
Midostaurin
 
C35H30N4O4
 
9829523 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1136
 
Nilotinib
 
C28H22F3N7O
 
644241 
Major    Inter Info   
[2], [41], [32], [136]
D1169
 
Oliceridine
 
C22H30N2O2S
 
66553195 
Major    Inter Info   
[1], [2], [3]
D1189
 
Osilodrostat
 
C13H10FN3
 
44139752 
Major    Inter Info   
[1], [2], [3]
D1190
 
Osimertinib
 
C28H33N7O2
 
71496458 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1211
 
Ozanimod
 
C23H24N4O3
 
52938427 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1215
 
Paliperidone
 
C23H27FN4O3
 
115237 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1221
 
Panobinostat
 
C21H23N3O2
 
6918837 
Major    Inter Info   
[137]
D1223
 
Papaverine
 
C20H21NO4
 
4680 
Major    Inter Info   
[138], [139], [140], [141], [142], [143], [144], [145]
D1230
 
Pasireotide
 
C58H66N10O9
 
9941444 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1232
 
Pazopanib
 
C21H23N7O2S
 
10113978 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1290
 
Pimavanserin
 
C25H34FN3O2
 
10071196 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1292
 
Pimozide
 
C28H29F2N3O
 
16362 
Major    Inter Info   
[32], [90], [146], [71]
D1302
 
Pitolisant
 
C17H26ClNO
 
9948102 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1315
 
Posaconazole
 
C37H42F2N8O4
 
468595 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1339
 
Primaquine
 
C15H21N3O
 
4908 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1342
 
Probucol
 
C31H48O2S2
 
4912 
Major    Inter Info   
[1], [2], [3]
D1352
 
Promethazine
 
C17H20N2S
 
4927 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1353
 
Propafenone
 
C21H27NO3
 
4932 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1368
 
Quetiapine
 
C21H25N3O2S
 
5002 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1388
 
Relugolix
 
C29H27F2N7O5S
 
10348973 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1398
 
Ribociclib
 
C23H30N8O
 
44631912 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1404
 
Rilpivirine
 
C22H18N6
 
6451164 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1432
 
Rucaparib
 
C19H18FN3O
 
9931954 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1444
 
Saquinavir
 
C38H50N6O5
 
441243 
Major    Inter Info   
[147], [148], [2], [41], [32], [149], [150]
D1459
 
Selpercatinib
 
C29H31N7O3
 
134436906 
Major    Inter Info   
[1], [2], [3]
D1461
 
Sertraline
 
C17H17Cl2N
 
68617 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1463
 
Sevoflurane
 
C4H3F7O
 
5206 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1491
 
Solifenacin
 
C23H26N2O2
 
154059 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1522
 
Sunitinib
 
C22H27FN4O2
 
5329102 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1542
 
Telavancin
 
C80H106Cl2N11O27P
 
3081362 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1560
 
Tetrabenazine
 
C19H27NO3
 
6018 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1634
 
Triclabendazole
 
C14H9Cl3N2OS
 
50248 
Major    Inter Info   
[1], [2], [3]
D1651
 
Triptorelin
 
C64H82N18O13
 
25074470 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1673
 
Valbenazine
 
C24H38N2O4
 
24795069 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1681
 
Vandetanib
 
C22H24BrFN4O2
 
3081361 
Major    Inter Info   
[2], [41], [32], [154]
D1687
 
Vemurafenib
 
C23H18ClF2N3O3S
 
42611257 
Major    Inter Info   
[2], [41], [32], [155]
D0737
 
Goserelin
 
C59H84N18O14
 
5311128 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0738
 
Granisetron
 
C18H24N4O
 
5284566 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0750
 
Haloperidol
 
C21H23ClFNO2
 
3559 
Major    Inter Info   
[2], [41], [32], [157], [158], [159], [160], [161], [162], [71]
D0781
 
Hydroxyzine
 
C21H27ClN2O2
 
3658 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0787
 
Ibutilide
 
C20H36N2O3S
 
60753 
Major    Inter Info   
[2], [41], [32], [163]
D0795
 
Imipramine
 
C19H24N2
 
3696 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0880
 
Ketoconazole
 
C26H28Cl2N4O4
 
456201 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0908
 
Leuprolide
 
C59H84N16O12
 
657181 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0979
 
Maprotiline
 
C20H23N
 
4011 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0992
 
Mefloquine
 
C17H16F6N2O
 
4046 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1010
 
Mesoridazine
 
C21H26N2OS2
 
4078 
Major    Inter Info   
[41], [32], [164]
D1017
 
Methadone
 
C21H27NO
 
4095 
Major    Inter Info   
[2], [41], [32], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [71]
D1063
 
Mifepristone
 
C29H35NO2
 
55245 
Major    Inter Info   
[2], [41], [32], [175]
D1075
 
Mirtazapine
 
C17H19N3
 
4205 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1137
 
Nilutamide
 
C12H10F3N3O4
 
4493 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1158
 
Nortriptyline
 
C19H21N
 
4543 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1181
 
Ondansetron
 
C18H19N3O
 
4595 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1193
 
Oxaliplatin
 
C8H14N2O4Pt
 
9887053 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1210
 
Oxytocin
 
C43H66N12O12S2
 
439302 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1216
 
Palonosetron
 
C19H24N2O
 
6337614 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1246
 
Pentamidine
 
C19H24N4O2
 
4735 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1254
 
Perflutren
 
C3F8
 
6432 
Major    Inter Info   
[176], [177]
D1257
 
Perphenazine
 
C21H26ClN3OS
 
4748 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1343
 
Procainamide
 
C13H21N3O
 
4913 
Major    Inter Info   
[1], [39], [40], [42], [76], [43], [77], [44], [45], [46], [47], [48], [78], [49], [50], [79], [80], [51], [52], [53], [54], [55], [56], [81], [82], [66], [83], [84], [30], [85], [86], [3], [57], [87], [58], [59], [88]
D1346
 
Prochlorperazine
 
C20H24ClN3S
 
4917 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1351
 
Promazine
 
C17H20N2S
 
4926 
Major    Inter Info   
[1], [2], [3]
D1361
 
Protriptyline
 
C19H21N
 
4976 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1371
 
Quinidine
 
C20H24N2O2
 
441074 
Major    Inter Info   
[1], [39], [40], [42], [76], [43], [77], [44], [45], [46], [47], [48], [78], [49], [50], [79], [80], [51], [52], [53], [54], [55], [56], [81], [82], [66], [83], [84], [30], [85], [86], [3], [57], [87], [58], [59], [88]
D1372
 
Quinine
 
C20H24N2O2
 
3034034 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1383
 
Ranolazine
 
C24H33N3O4
 
56959 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1413
 
Risperidone
 
C23H27FN4O2
 
5073 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1497
 
Sorafenib
 
C21H16ClF3N4O3
 
216239 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1498
 
Sotalol
 
C12H20N2O3S
 
5253 
Major    Inter Info   
[1], [39], [40], [42], [76], [43], [77], [44], [45], [46], [47], [48], [78], [49], [50], [79], [80], [51], [52], [53], [54], [55], [56], [81], [82], [66], [83], [84], [30], [85], [86], [3], [57], [87], [58], [59], [88]
D1526
 
Tacrolimus
 
C44H69NO12
 
445643 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1533
 
Tamoxifen
 
C26H29NO
 
2733526 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1544
 
Telithromycin
 
C43H65N5O10
 
3002190 
Major    Inter Info   
[1], [2], [3]
D1555
 
Terfenadine
 
C32H41NO2
 
5405 
Major    Inter Info   
[1], [2], [3]
D1574
 
Thioridazine
 
C21H26N2S2
 
5452 
Major    Inter Info   
[32], [202], [203]
D1596
 
Tizanidine
 
C9H8ClN5S
 
5487 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1612
 
Toremifene
 
C26H28ClNO
 
3005573 
Major    Inter Info   
[2], [41], [32], [204]
D1616
 
Tramadol
 
C16H25NO2
 
33741 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1624
 
Trazodone
 
C19H22ClN5O
 
5533 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1637
 
Trifluoperazine
 
C21H24F3N3S
 
5566 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1638
 
Triflupromazine
 
C18H19F3N2S
 
5568 
Major    Inter Info   
[1], [2], [3]
D1647
 
Trimipramine
 
C20H26N2
 
5584 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1682
 
Vardenafil
 
C23H32N6O4S
 
135400189 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1683
 
Vasopressin
 
C46H65N15O12S2
 
644077 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1689
 
Venlafaxine
 
C17H27NO2
 
5656 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D1706
 
Voriconazole
 
C16H14F3N5O
 
71616 
Major    Inter Info   
[1], [39], [40], [2], [41], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [30], [3], [57], [58], [59]
D0636
 
Famotidine
 
C8H15N7O2S3
 
5702160 
Moderate    Inter Info   
[41], [32], [256]
D0105
 
Aripiprazole
 
C23H27Cl2N3O2
 
60795 
Moderate    Inter Info   
[41], [32], [262], [263], [264], [265], [266], [267]
D0947
 
Loperamide
 
C29H33ClN2O2
 
3955 
Moderate    Inter Info   
[288], [289]
D1166
 
Olanzapine
 
C17H20N4S
 
135398745 
Moderate    Inter Info   
[41], [32], [294]
D1356
 
Propofol
 
C12H18O
 
4943 
Moderate    Inter Info   
[296], [297], [298], [299], [300], [301], [302], [303], [304], [305]
D1051
 
Metronidazole
 
C6H9N3O3
 
4173 
Minor    Inter Info   
[41], [310], [311], [312]
D1516
 
Sulfamethoxazole
 
C10H11N3O3S
 
5329 
Minor    Inter Info   
[2], [41], [315]
   Increased risk of tendinitis/tendon rupture Drug Num:  10
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0172
 
Betamethasone
 
C22H29FO5
 
9782 
Major    Inter Info   
[62], [63], [56], [64], [65], [66], [67]
D0671
 
Fludrocortisone
 
C21H29FO5
 
31378 
Major    Inter Info   
[62], [63], [56], [64], [65], [66], [67]
D0155
 
Bempedoic acid
 
C19H36O5
 
10472693 
Major    Inter Info   
[94], [95]
D0436
 
Deflazacort
 
C25H31NO6
 
189821 
Major    Inter Info   
[62], [63], [56], [64], [65], [66], [67]
D0453
 
Dexamethasone
 
C22H29FO5
 
5743 
Major    Inter Info   
[62], [63], [56], [64], [65], [66], [67]
D0773
 
Hydrocortisone
 
C21H30O5
 
5754 
Major    Inter Info   
[62], [63], [56], [64], [65], [66], [67]
D1041
 
Methylprednisolone
 
C22H30O5
 
6741 
Major    Inter Info   
[62], [63], [56], [64], [65], [66], [67]
D1332
 
Prednisolone
 
C21H28O5
 
5755 
Major    Inter Info   
[62], [63], [56], [64], [65], [66], [67]
D1334
 
Prednisone
 
C21H26O5
 
5865 
Major    Inter Info   
[62], [63], [56], [64], [65], [66], [67]
D1628
 
Triamcinolone
 
C21H27FO6
 
31307 
Major    Inter Info   
[62], [63], [56], [64], [65], [66], [67]
   Increased risk of ventricular arrhythmias Drug Num:  34
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0025
 
Adenosine
 
C10H13N5O4
 
60961 
Major    Inter Info   
[31], [32], [33], [34], [35], [36], [37], [38]
D0107
 
Arsenic trioxide
 
As2O3
 
14888 
Major    Inter Info   
[92], [93]
D0661
 
Fingolimod
 
C19H33NO2
 
107970 
Major    Inter Info   
[2], [41], [32], [117], [72]
D0859
 
Isoprenaline
 
C11H17NO3
 
3779 
Major    Inter Info   
[126], [127], [128]
D0868
 
Ivabradine
 
C27H36N2O5
 
132999 
Major    Inter Info   
[32], [129], [130]
D1474
 
Siponimod
 
C29H35F3N2O3
 
44599207 
Major    Inter Info   
[41], [151]
D1185
 
Orciprenaline
 
C11H17NO3
 
4086 
Major    Inter Info   
[126], [127], [128]
D1414
 
Ritodrine
 
C17H21NO3
 
33572 
Major    Inter Info   
[126], [127], [128]
D1554
 
Terbutaline
 
C12H19NO3
 
5403 
Major    Inter Info   
[126], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [127], [196], [197], [198], [199], [128], [200], [201]
D0516
 
Donepezil
 
C24H29NO3
 
3152 
Moderate    Inter Info   
[2], [41], [32], [249], [250], [251]
D0691
 
Formoterol
 
C19H24N2O4
 
3410 
Moderate    Inter Info   
[126], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [257], [258], [190], [191], [192], [193], [194], [259], [195], [127], [196], [197], [198], [199], [128], [200], [201]
D0707
 
Galantamine
 
C17H21NO3
 
9651 
Moderate    Inter Info   
[2], [41], [32], [249], [250], [251]
D0103
 
Arformoterol
 
C19H24N2O4
 
3083544 
Moderate    Inter Info   
[126], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [257], [258], [190], [191], [192], [193], [194], [259], [195], [127], [196], [197], [198], [199], [128], [200], [201]
D0184
 
Bisacodyl
 
C22H19NO4
 
2391 
Moderate    Inter Info   
[2], [41], [32], [268], [269], [270]
D0269
 
Castor oil
 
C57H104O9
 
14030006 
Moderate    Inter Info   
[2], [41], [32], [268], [269], [270]
D0701
 
Frangula purshiana bark
 
NA
 
NA
Moderate    Inter Info   
[41], [32], [270]
D0731
 
Glycerin
 
C3H8O3
 
753 
Moderate    Inter Info   
[2], [41], [32], [268], [269], [270]
D0797
 
Indacaterol
 
C24H28N2O3
 
6918554 
Moderate    Inter Info   
[126], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [257], [258], [190], [191], [192], [193], [194], [259], [195], [127], [196], [197], [198], [199], [128], [200], [201]
D0887
 
Lactitol
 
C12H24O11
 
157355 
Moderate    Inter Info   
[41], [32], [270]
D0924
 
Levosalbutamol
 
C13H21NO3
 
123600 
Moderate    Inter Info   
[257], [196], [199]
D1069
 
Mineral oil
 
NA
 
NA
Moderate    Inter Info   
[2], [41], [32], [268], [269], [270]
D1171
 
Olodaterol
 
C21H26N2O5
 
11504295 
Moderate    Inter Info   
[126], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [257], [258], [190], [191], [192], [193], [194], [259], [195], [127], [196], [197], [198], [199], [128], [200], [201]
D1266
 
Phenolphthalein
 
C20H14O4
 
4764 
Moderate    Inter Info   
[41], [32], [270]
D1298
 
Pirbuterol
 
C12H20N2O3
 
4845 
Moderate    Inter Info   
[257], [196], [199]
D1308
 
Polyethylene glycol (3350 with electrolytes)
 
C2H6O2
 
174 
Moderate    Inter Info   
[2], [226], [284]
D1309
 
Polyethylene glycol (3350)
 
C2H6O2
 
174 
Moderate    Inter Info   
[41], [32], [270]
D1695
 
Vilanterol
 
C24H33Cl2NO5
 
10184665 
Moderate    Inter Info   
[257], [196], [199]
D0854
 
Isoetharine
 
C13H21NO3
 
3762 
Moderate    Inter Info   
[257], [196], [199]
D0888
 
Lactulose
 
C12H22O11
 
11333 
Moderate    Inter Info   
[2], [41], [32], [268], [269], [270]
D1418
 
Rivastigmine
 
C14H22N2O2
 
77991 
Moderate    Inter Info   
[2], [41], [32], [249], [250], [251]
D1438
 
Salbutamol
 
C13H21NO3
 
2083 
Moderate    Inter Info   
[182], [188], [193]
D1440
 
Salmeterol
 
C25H37NO4
 
5152 
Moderate    Inter Info   
[126], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [257], [258], [190], [191], [192], [193], [194], [259], [195], [127], [196], [197], [198], [199], [128], [200], [201]
D1525
 
Tacrine
 
C13H14N2
 
1935 
Moderate    Inter Info   
[41], [250], [251]
D1569
 
Thalidomide
 
C13H10N2O4
 
5426 
Moderate    Inter Info   
[41], [32], [307]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of antidiabetic agents Drug Num:  40
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0009
 
Acarbose
 
C25H43NO18
 
41774 
Major    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D0013
 
Acetohexamide
 
C15H20N2O4S
 
1989 
Major    Inter Info   
[4], [5], [6]
D0325
 
Chlorpropamide
 
C10H13ClN2O3S
 
2727 
Major    Inter Info   
[4], [5], [6]
D0029
 
Albiglutide
 
C148H224N40O45
 
145994868 
Major    Inter Info   
[4], [5], [6]
D0042
 
Alogliptin
 
C18H21N5O2
 
11450633 
Major    Inter Info   
[4], [5], [6]
D0245
 
Canagliflozin
 
C24H25FO5S
 
24812758 
Major    Inter Info   
[4], [5], [6]
D0418
 
Dapagliflozin
 
C21H25ClO6
 
9887712 
Major    Inter Info   
[4], [5], [6]
D0565
 
Empagliflozin
 
C23H27ClO7
 
11949646 
Major    Inter Info   
[4], [5], [6]
D0728
 
Glipizide
 
C21H27N5O4S
 
3478 
Major    Inter Info   
[4], [5], [6]
D0807
 
Insulin aspart (aspart protamine)
 
C256H381N65O79S6
 
118984445 
Major    Inter Info   
[4], [5], [6]
D0808
 
Insulin aspart (aspart)
 
C256H381N65O79S6
 
118984445 
Major    Inter Info   
[4], [5], [6]
D0809
 
Insulin degludec
 
C274H411N65O81S6
 
118984462 
Major    Inter Info   
[4], [5], [6]
D0810
 
Insulin detemir
 
C267H402N64O76S6
 
16137271 
Major    Inter Info   
[4], [5], [6]
D0812
 
Insulin glulisine
 
C258H384N64O78S6
 
16136701 
Major    Inter Info   
[4], [5], [6]
D0930
 
Linagliptin
 
C25H28N8O2
 
10096344 
Major    Inter Info   
[4], [5], [6]
D0936
 
Liraglutide
 
C172H265N43O51
 
16134956 
Major    Inter Info   
[4], [5], [6]
D0941
 
Lixisenatide
 
C215H347N61O65S
 
90472060 
Major    Inter Info   
[4], [5], [6]
D1294
 
Pioglitazone
 
C19H20N2O3S
 
4829 
Major    Inter Info   
[4], [5], [6]
D1326
 
Pramlintide
 
C171H267N51O53S2
 
70691388 
Major    Inter Info   
[4], [5], [6]
D1449
 
Saxagliptin
 
C18H25N3O2
 
11243969 
Major    Inter Info   
[4], [5], [6]
D1477
 
Sitagliptin
 
C16H15F6N5O
 
4369359 
Major    Inter Info   
[4], [5], [6]
D1603
 
Tolbutamide
 
C12H18N2O3S
 
5505 
Major    Inter Info   
[4], [5], [6]
D0727
 
Glimepiride
 
C24H34N4O5S
 
3476 
Major    Inter Info   
[4], [5], [6]
D0730
 
Glyburide
 
C23H28ClN3O5S
 
3488 
Major    Inter Info   
[4], [5], [6]
D0811
 
Insulin glargine
 
C267H404N72O78S6
 
118984454 
Major    Inter Info   
[4], [5], [6]
D0813
 
Insulin human
 
C257H383N65O77S6
 
118984375 
Major    Inter Info   
[4], [5], [6]
D0814
 
Insulin human (inhalation, rapid acting)
 
C257H383N65O77S6
 
118984375 
Major    Inter Info   
[4], [5], [6]
D0815
 
Insulin human (isophane)
 
C257H383N65O77S6
 
118984375 
Major    Inter Info   
[4], [5], [6]
D0816
 
Insulin human (regular)
 
C257H383N65O77S6
 
118984375 
Major    Inter Info   
[4], [5], [6]
D0817
 
Insulin human (zinc extended)
 
C257H383N65O77S6
 
118984375 
Major    Inter Info   
[4], [5], [6]
D0818
 
Insulin human (zinc)
 
C257H383N65O77S6
 
118984375 
Major    Inter Info   
[4], [5], [6]
D0819
 
Insulin lispro
 
C257H389N65O77S6
 
16132438 
Major    Inter Info   
[4], [5], [6]
D0820
 
Insulin lispro (protamine)
 
C257H389N65O77S6
 
16132438 
Major    Inter Info   
[4], [5], [6]
D1015
 
Metformin
 
C4H11N5
 
4091 
Major    Inter Info   
[4], [5], [6]
D1064
 
Miglitol
 
C8H17NO5
 
441314 
Major    Inter Info   
[4], [5], [6]
D1112
 
Nateglinide
 
C19H27NO3
 
5311309 
Major    Inter Info   
[4], [5], [6]
D1392
 
Repaglinide
 
C27H36N2O4
 
65981 
Major    Inter Info   
[4], [5], [6]
D1429
 
Rosiglitazone
 
C18H19N3O3S
 
77999 
Major    Inter Info   
[4], [5], [6]
D1601
 
Tolazamide
 
C14H21N3O3S
 
5503 
Major    Inter Info   
[4], [5], [6]
D1652
 
Troglitazone
 
C24H27NO5S
 
5591 
Major    Inter Info   
[4], [5], [6]
   Antagonize the effect of antihypertensive agents Drug Num:  4
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1779
 
Dulaglutide
 
NA
 
NA
Major    Inter Info   
[4], [5], [6]
D1782
 
Ertugliflozin
 
C22H25ClO7
 
44814423 
Major    Inter Info   
[4], [5], [6]
D1784
 
Exenatide
 
C184H282N50O60S
 
45588096 
Major    Inter Info   
[4], [5], [6]
D1887
 
Semaglutide
 
C187H291N45O59
 
56843331 
Major    Inter Info   
[4], [5], [6]
   Antagonize the effect of vaccine/toxoid Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1914
 
Typhoid vaccine (live)
 
NA
 
NA
Major    Inter Info   
[32], [152], [153]
D1693
 
Vibrio cholerae CVD 103-HgR strain live antigen (live)
 
NA
 
NA
Major    Inter Info   
[156]
   Attenuated pharmacological effects (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0145
 
Balsalazide
 
C17H15N3O6
 
54585 
Moderate    Inter Info   
[207]
References
1 Ansari SR, Chopra N "Gatifloxacin and Prolonged QT Interval." Am J Med Sci 327 (2004): 55-6. [PMID: 14722399]
2 Canadian Pharmacists Association.
3 Siepmann M, Kirch W "Drug points - Tachycardia associated with moxifloxacin." Br Med J 322 (2001): 23. [PMID: 11141146]
4 Greenberg AL, Decerbo M, Fan J "Gatifloxacin therapy associated with hypoglycemia." Clin Infect Dis 40 (2005): 1210-1. [PMID: 15791528]
5 Happe MR, Mulhall BP, Maydonovitch CL, Holtzmuller KC "Gatifloxacin-induced hyperglycemia." Ann Intern Med 141 (2004): 968-9. [PMID: 15611500]
6 Park-Wyllie LY, Juurlink DN, Kopp A, et al. "Outpatient gatifloxacin therapy and dysglycemia in older adults." N Engl J Med 354 (2006): 1352-61. [PMID: 16510739]
7 Hypoglycemia and hyperglycemia with fluoroquinolones. Med Lett Drugs Ther 45 (2003): 64. [PMID: 12888740]
8 Blommel AL, Lutes RA "Severe hyperglycemia during renally adjusted gatifloxacin therapy." Ann Pharmacother 39 (2005): 1349-52. [PMID: 15941822]
9 Gajjar DA, LaCreta FP, Kollia GD, et al. "Effect of multiple-dose gatifloxacin or ciprofloxacin on glucose homeostasis and insulin production in patients with noninsulin-dependent diabetes mellitus maintained with diet and exercise." Pharmacotherapy 20 (6 Pt 2) (2000): s76-86. [PMID: 10850524]
10 Tomita T, Onishi M, Sato E, Kimura Y, Kihira K "Gatifloxacin induces augmented insulin release and intracellular insulin." Biol Pharm Bull 30 (2007): 644-7. [PMID: 17409495]
11 Donaldson AR, Vandiver JR, Finch CK "Possible gatifloxacin-induced hyperglycemia." Ann Pharmacother 38 (2004): 602-5. [PMID: 14982977]
12 Gavin JR 3rd, Kubin R, Choudhri S, et al "Moxifloxacin and glucose homeostasis: a pooled-analysis of the evidence from clinical and postmarketing studies." Drug Saf 27 (2004): 671-86. [PMID: 15230648]
13 Zhanel GG, Fontaine S, Adam H, et al. "A Review of New Fluoroquinolones : Focus on their Use in Respiratory Tract Infections." Treat Respir Med 5 (2006): 437-465. [PMID: 17154673]
14 Roberge RJ, Kaplan R, Frank R, Fore C "Glyburide-ciprofloxacin interaction with resistant hypoglycemia." Ann Emerg Med 36 (2000): 160-3. [PMID: 10918110]
15 Rubinstein E "History of quinolones and their side effects." Chemotherapy 47 Suppl 3 (2001): 3-8. [PMID: 11549783]
16 Brogan SE, Cahalan MK "Gatifloxacin as a possible cause of serious postoperative hypoglycemia." Anesth Analg 101 (2005): 635-6. [PMID: 16115964]
17 Khovidhunkit W, Sunthornyothin S "Hypoglycemia, hyperglycemia, and gatifloxacin." Ann Intern Med 141 (2004): 969. [PMID: 15611501]
18 Bhasin R, Arce FC, Pasmantier R "Hypoglycemia associated with the use of gatifloxacin." Am J Med Sci 330 (2005): 250-3. [PMID: 16284487]
19 Saraya A, Yokokura M, Gonoi T, Seino S "Effects of fluoroquinolones on insulin secretion and beta-cell ATP-sensitive K(+) channels." Eur J Pharmacol 497 (2004): 111-7. [PMID: 15321742]
20 Baker SE, Hangii MC "Possible gatifloxacin-induced hypoglycemia." Ann Pharmacother 36 (2002): 1722-6. [PMID: 12398567]
21 Menzies DJ, Dorsainvil PA, Cunha BA, Johnson DH "Severe and persistent hypoglycemia due to gatifloxacin interaction with oral hypoglycemic agents." Am J Med 113 (2002): 232-4. [PMID: 12208383]
22 Graumlich JF, Habis S, Avelino RR, et al. "Hypoglycemia in inpatients after gatifloxacin or levofloxacin therapy: nested case-control study." Pharmacotherapy 25 (2005): 1296-302. [PMID: 16185172]
23 Haerian H, McHugh P, Brown R, Somes G, Solomon SS. Gatifloxacin produces both hypoglycemia and hyperglycemia: a retrospective study.?Am J Med Sci. 2008;335(2):95-98. [PMID: 18277115]
24 Lin G, Hays DP, Spillane L "Refractory hypoglycemia from ciprofloxacin and glyburide interaction." J Toxicol Clin Toxicol 42 (2004): 295-7. [PMID: 15362597]
25 Frothingham R "Glucose homeostasis abnormalities associated with use of gatifloxacin." Clin Infect Dis 41 (2005): 1269-76. [PMID: 16206101]
26 LeBlanc M, Belanger C, Cossette P "Severe and resistant hypoglycemia associated with concomitant gatifloxacin and glyburide therapy." Pharmacotherapy 24 (2004): 926-31. [PMID: 15303456]
27 Biggs WS "Hypoglycemia and hyperglycemia associated with gatifloxacin use in elderly patients." J Am Board Fam Pract 16 (2004): 455-7. [PMID: 14645336]
28 Yip C, Lee AJ "Gatifloxacin-induced hyperglycemia: a case report and summary of the current literature." Clin Ther 28 (2006): 1857-66. [PMID: 17213006]
29 Zvonar R "Gatifloxacin-induced dysglycemia." Am J Health Syst Pharm 63 (2006): 2087-2092. [PMID: 17057046]
30 Product Information. Tequin (gatifloxacin) Bristol-Myers Squibb, Princeton, NJ.
31 Celiker A, Tokel K, Cil E, Ozkutlu S, Ozme S "Adenosine induced torsades de pointes in a child with congenital long QT syndrome." Pacing Clin Electrophysiol 17 (1994): 1814-7. [PMID: 7838793]
32 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
33 Teodorovich N, Margolin E, Kogan Y, Paz O, Swissa M. Torsades de pointes after adenosine administration. J Electrocardiol. 2016;49(2):171-173. [PMID: 26850499]
34 Harrington GR, Froelich EG "Adenosine-induced torsades de pointes." Chest 103 (1993): 1299-1301. [PMID: 8131497]
35 Mallet ML "Proarrhythmic effects of adenosine: a review of the literature." Emerg Med J 21 (2004): 408-10. [PMID: 15208219]
36 Michalets EL, Williams CR "Drug interactions with cisapride: clinical implications." Clin Pharmacokinet 39 (2000): 49-75. [PMID: 10926350]
37 Tachakra SS, Robinson S "Adenosine and cardiac arrhythmias." BMJ 305 (1992): 422. [PMID: 1392935]
38 Wesley RC Jr, Turnquest P "Torsades de pointe after intravenous adenosine in the presence of prolonged QT syndrome." Am Heart J 123 (1992): 794-6. [PMID: 1539535]
39 Ball P "Quinolone-induced QT interval prolongation: a not-so-unexpected class effect." J Antimicrob Chemother 45 (2000): 557-9. [PMID: 10797074]
40 Bertino JS Jr, Owens RC Jr, Carnes TD, Iannini PB "Gatifloxacin-associated corrected QT interval prolongation, torsades de pointes, and ventricular fibrillation in patients with known risk factors." Clin Infect Dis 34 (2002): 861-3. [PMID: 11830802]
41 Cerner Multum, Inc. "Australian Product Information.".
42 Dale KM, Lertsburapa K, Kluger J, White CM "Moxifloxacin and torsade de pointes." Ann Pharmacother 41 (2007): 336-40. [PMID: 17284508]
43 Demolis JL, Kubitza D, Tenneze L, Funck-Bretano C "Effect of a single oral dose of moxifloxacin (400 mg and 800 mg) on ventricular repolarization in healthy subjects." Clin Pharmacol Ther 68 (2000): 658-66. [PMID: 11180026]
44 Falagas ME, Rafailidis PI, Rosmarakis ES "Arrhythmias associated with fluoroquinolone therapy." Int J Antimicrob Agents 29 (2007): 374-9. [PMID: 17241772]
45 Frothingham R "Rates of torsades de pointes associated with ciprofloxacin, ofloxacin, levofloxacin, gatifloxacin, and moxifloxacin." Pharmacotherapy 21 (2001): 1468-72. [PMID: 11765299]
46 Iannini PB "Cardiotoxicity of macrolides, ketolides and fluoroquinolones that prolong the QTc interval." Expert Opin Drug Saf 1 (2002): 121-8. [PMID: 12904146]
47 Iannini PB, Circiumaru I "Gatifloxacin-induced QTc prolongation and ventricular tachycardia." Pharmacotherapy 21 (2001): 361-2. [PMID: 11253862]
48 Iannini PB, Doddamani S, Byazrova E, Curciumaru I, Kramer H "Risk of torsades de pointes with non-cardiac drugs." BMJ 322 (2001): 46-7. [PMID: 11141163]
49 Kang J, Wang L, Chen XL, Triggle DJ, Rampe D "Interactions of a series of fluoroquinolone antibacterial drugs with the human cardiac K+ channel HERG." Mol Pharmacol 59 (2001): 122-6. [PMID: 11125032]
50 Katritsis D, Camm AJ "Quinolones: cardioprotective or cardiotoxic." Pacing Clin Electrophysiol 26 (2003): 2317-20. [PMID: 14675020]
51 Noel GJ, Natarajan J, Chien S, Hunt TL, Goodman DB, Abels R "Effects of three fluoroquinolones on QT interval in healthy adults after single doses." Clin Pharmacol Ther 73 (2003): 292-303. [PMID: 12709719]
52 Oliphant CM, Green GM "Quinolones: a comprehensive review." Am Fam Physician 65 (2002): 455-64. [PMID: 11858629]
53 Owens RC "QT Prolongation with Antimicrobial Agents : Understanding the Significance." Drugs 64 (2004): 1091-124. [PMID: 15139788]
54 Owens RC "Risk assessment for antimicrobial agent-induced QTc interval prolongation and torsades de pointes." Pharmacotherapy 21 (2001): 301-19. [PMID: 11253855]
55 Owens RC Jr, Ambrose PG "Torsades de pointes associated with fluoroquinolones." Pharmacotherapy 22 (2002): 663-8 discussion 668-72. [PMID: 12013370]
56 Product Information. Avelox (moxifloxacin) Bayer, West Haven, CT.
57 Stahlmann R "Clinical toxicological aspects of fluoroquinolones." Toxicol Lett 127 (2002): 269-77. [PMID: 12052667]
58 Tsikouris JP, Peeters MJ, Cox CD, Meyerrose GE, Seifert CF "Effects of three fluoroquinolones on QT analysis after standard treatment courses." Ann Noninvasive Electrocardiol 11 (2006): 52-6. [PMID: 16472283]
59 White CM, Grant EM, Quintiliani R "Moxifloxacin does increase the corrected QT interval." Clin Infect Dis 33 (2001): 1441-2. [PMID: 11565091]
60 Product Information. Nulibry (fosdenopterin). Origin Biosciences Inc, Boston, MA.
61 Product Information. Gleolan (aminolevulinic acid). NX Development Corp, Lexington, KY.
62 FDA. U.S. Food and Drug Administration "Information for Healthcare Professionals. Fluoroquinolone Antimicrobial Drugs. FDA Alert [7/8/2008].".
63 Khaliq Y, Zhanel GG "Fluoroquinolone-Associated Tendinopathy: A Critical Review of the Literature." Clin Infect Dis 36 (2003): 1404-1410. [PMID: 12766835]
64 Product Information. Baxdela (delafloxacin). Melinta Therapeutics, Lincolnshire, IL.
65 Product Information. Cipro (ciprofloxacin). Bayer, West Haven, CT.
66 Product Information. Levaquin (levofloxacin). Ortho Pharmaceutical Corporation, Raritan, NJ.
67 van der Linden PD, Sturkenboom MC, Herings RM, Leufkens HM, Rowlands S, Stricker BH "Increased risk of achilles tendon rupture with quinolone antibacterial use, especially in elderly patients taking oral corticosteroids." Arch Intern Med 163 (2003): 1801-7. [PMID: 12912715]
68 Product Information. Propulsid (cisapride). Janssen Pharmaceutica, Titusville, NJ.
69 FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Abnormal heart rhythms associated with high doses of Celexa (citalopram hydrobromide).".
70 Product Information. Celexa (citalopram). Forest Pharmaceuticals, St. Louis, MO.
71 EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
72 FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Revised recommendations for cardiovascular monitoring and use of multiple sclerosis drug Gilenya (fingolimod).".
73 Arnold LM, Nissen LR, Ng TM "Moxifloxacin and warfarin: additional evidence for a clinically relevant interaction." Pharmacotherapy 25 (2005): 904-7.[PMID: 15927911]
74 Glasheen JJ, Fugit RV, Prochazka AV "Effect of levofloxacin coadministration on the international normalized ratios during warfarin therapy--a comment." Pharmacotherapy 23 (2003): 1079-80 discussion 1080.[PMID: 12921255]
75 Bianco TM, Bussey HI, Farnett LE, Linn WD, Roush MK, Wong YW "Potential warfarin-ciprofloxacin interaction in patients receiving long-term anticoagulation." Pharmacotherapy 12 (1992): 435-9.[PMID: 1492006]
76 Demolis JL, Charransol A, Funck-Brentano C, Jaillon P "Effects of a single oral dose of sparfloxacin on ventricular repolarization in healthy volunteers." Br J Clin Pharmacol 41 (1996): 499-503. [PMID: 8799513]
77 Dupont H, Timsit JF, Souweine B, Gachot B, Wolff M, Regnier B "Torsades de pointe probably related to sparfloxacin." Eur J Clin Microbiol Infect Dis 15 (1996): 350-1. [PMID: 8781892]
78 Jaillon P, Morganroth J, Brumpt I, Talbot G "Overview of electrocardiographic and cardiovascular safety data for sparfloxacin. Sparfloxacin Safety Group." J Antimicrob Chemother 37(suppl a) (1996): 161-7. [PMID: 8737135]
79 Lipsky BA, Dorr MB, Magner DJ, Talbot GH "Safety profile of sparfloxacin, a new fluoroquinolone antibiotic." Clin Ther 21 (1999): 148-59. [PMID: 10090432]
80 Makaryus AN, Byrns K, Makaryus MN, Natarajan U, Singer C, Goldner B "Effect of ciprofloxacin and levofloxacin on the QT interval: is this a significant "clinical" event?" South Med J 99 (2006): 52-6. [PMID: 16466123]
81 Product Information. Factive (gemifloxacin). GeneSoft Inc, San Francisco, CA.
82 Product Information. Floxin (ofloxacin). Ortho Pharmaceutical Corporation, Raritan, NJ.
83 Product Information. Maxaquin (lomefloxacin). Searle, Skokie, IL.
84 Product Information. Noroxin (norfloxacin). Merck & Co, Inc, West Point, PA.
85 Product Information. Zagam (sparfloxacin). Rhone-Poulenc Rorer, Collegeville, PA.
86 Samaha FF "QTC interval prolongation and polymorphic ventricular tachycardia in association with levofloxacin." Am J Med 107 (1999): 528-9. [PMID: 10569314]
87 Thomas M, Maconochie JG, Fletcher E "The dilemma of the prolonged QT interval in early drug studies." Br J Clin Pharmacol 41 (1996): 77-81. [PMID: 8838432]
88 Zix JA, GeerdesFenge HF, Rau M, Vockler J, Borner K, Koeppe P, Lode H "Pharmacokinetics of sparfloxacin and interaction with cisapride and sucralfate." Antimicrob Agents Chemother 41 (1997): 1668-72. [PMID: 9257738]
89 Product Information. Tikosyn (dofetilide) Pfizer US Pharmaceuticals, Atlanta, GA.
90 Glassman AH, Bigger JT Jr "Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death." Am J Psychiatry 158 (2001): 1774-82. [PMID: 11691681]
91 Product Information. Inapsine (droperidol). Janssen Pharmaceutica, Titusville, NJ.
92 Ohnishi K, Yoshida H, Shigeno K, et al. "Prolongation of the QT interval and ventricular tachycardia in patients treated with arsenic trioxide for acute promyelocytic leukemia." Ann Intern Med 133 (2000): 881-5. [PMID: 11103058]
93 Product Information. Trisenox (arsenic trioxide) Cephalon Inc, West Chester, PA.
94 Product Information. Nexletol (bempedoic acid). Esperion Therapeutics, Ann Arbor, MI.
95 Product Information. Nexlizet (bempedoic acid-ezetimibe). Esperion Therapeutics, Ann Arbor, MI.
96 Owens RC Jr. QT prolongation with antimicrobial agents: understanding the significance.?Drugs. 2004;64(10):1091-1124. [PMID: 15139788]
97 Product Information. Wellbutrin XL (buPROPion). GlaxoSmithKline, Philadelphia, PA.
98 Sheehan DV, Welch JB, Fishman SM "A case of bupropion-induced seizure." J Nerv Ment Dis 174 (1986): 496-8. [PMID: 3090199]
99 Product Information. Wellbutrin (bupropion). Glaxo Wellcome, Research Triangle Park, NC.
100 Gittelman DK, Kirby MG "A seizure following bupropion overdose." J Clin Psychiatry 54 (1993): 162. [PMID: 8486598]
101 Product Information. Wellbutrin SR (bupropion). Glaxo Wellcome, Research Triangle Park, NC.
102 James WA, Lippmann S "Bupropion: overview and prescribing guidelines in depression." South Med J 84 (1991): 222-4. [PMID: 1899294]
103 Masco HL, Kiev A, Holloman LC, Batey SR, Johnston JA, Lineberry CG "Safety and efficacy of bupropion and nortriptyline in outpatients with depression." Curr Ther Res Clin Exp 55 (1994): 851-63.
104 Dufresne RL, Weber SS, Becker RE "Bupropion hydrochloride." Drug Intell Clin Pharm 18 (1984): 957-64. [PMID: 6439541]
105 Product Information. Zyban (bupropion). Glaxo Wellcome, Research Triangle Park, NC.
106 Storrow AB "Bupropion overdose and seizure." Am J Emerg Med 12 (1994): 183-4. [PMID: 8161393]
107 Johnston JA, Lineberry CG, Ascher JA, et al. "A 102-center prospective study of seizure in association with bupropion." J Clin Psychiatry 52 (1991): 450-6. [PMID: 1744061]
108 Rosenstein DL, Nelson JC, Jacobs SC "Seizures associated with antidepressants: a review." J Clin Psychiatry 54 (1993): 289-99. [PMID: 8253696]
109 Pisani F, Spina E, Oteri G "Antidepressant drugs and seizure susceptibility: from in vitro data to clinical practice." Epilepsia 40(Suppl 10) (1999): S48-56. [PMID: 10609604]
110 Product Information. Aplenzin (buPROPion). sanofi-aventis , Bridgewater, NJ.
111 Product Information. Zykadia (ceritinib). Novartis Pharmaceuticals, East Hanover, NJ.
112 Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
113 Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
114 Castro VM, Clements CC, Murphy SN, et al. "QT interval and antidepressant use: a cross sectional study of electronic health records." BMJ 346 (2013): f288. [PMID: 23360890]
115 Do A, Noohi S, Elie D, et al. Health Canada Warning on Citalopram and Escitalopram--Its Effects on Prescribing in Consultation-Liaison Psychiatry.?Psychosomatics. 2016;57(1):57-63. [PMID: 26633294]
116 Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
117 Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
118 Product Information. Halfan (halofantrine). GlaxoSmithKline, Philadelphia, PA.
119 Product Information. Lariam (mefloquine). Roche Laboratories, Nutley, NJ.
120 Product Information. Exforge HCT (amlodipine/hydrochlorothiazide/valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
121 Product Information. Isovue-M-200 (iopamidol). Bracco Diagnostics Inc, Princeton, NJ.
122 Product Information. Amipaque (metrizamide) Nycomed Inc, Princeton, NJ.
123 Hindmarsh T, Grepe A, Widen L "Metrizamide-phenothiazine interaction: report of a case with seizures following myelography." Acta Radiol Diagn (Stockh) 16 (1975): 129-35. [PMID: 810000]
124 Product Information. Omnipaque 180 (iohexol). Amersham Health, Princeton, NJ.
125 Product Information. Osmovist 240 (iotrolan). Berlex Canada Inc, Lachine, QC.
126 Bengtsson B, Fagerstrom PO "Extrapulmonary effects of terbutaline during prolonged administration." Clin Pharmacol Ther 31 (1982): 726-32. [PMID: 7042176]
127 Rakhmanina NY, Kearns GL, Farrar HC "Hypokalemia in an asthmatic child from abuse of albuterol metered dose inhaler." Pediatr Emerg Care 14 (1998): 145-7. [PMID: 9583400]
128 Windom H, Grainger J, Burgess C, Crane J, Pearce N, Beasley R "A comparison of the haemodynamic and hypokalaemic effects of inhaled pirbuterol and salbutamol." N Z Med J 103 (1990): 259-61. [PMID: 1972557]
129 Mittal SR "Slow junctional rhythm, QTc prolongation and transient torsades de-pointes following combined use of Ivabradine, Diltiazem and Ranolazine." J Assoc Physicians India 62 (2014): 426-7. [PMID: 25438492]
130 Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
131 Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
132 Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
133 Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
134 Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
135 Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
136 Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
137 Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
138 Goto M, Sato M, Kitzazawa H, et.al "Papaverine-induced QT interval prolongation and ventricular fibrillation in a patient with a history of drug-induced QT prolongation." Intern Med 53 (2014): 1629-31. [PMID: 25088875]
139 Inoue T, Asahi S, Takayanagi K, Morooka S, Takabatake Y "QT prolongation and possibility of ventricular arrhythmias after intracoronary papaverine." Cardiology 84 (1994): 9-13. [PMID: 7511988]
140 Jain A, Jenkins MG "Intracoronary electrocardiogram during torsade des pointes secondary to intracoronary papaverine." Cathet Cardiovasc Diagn 18 (1989): 255-7. [PMID: 2605630]
141 Kern MJ, Deligonul U, Serota H, Gudipati C, Buckingham T "Ventricular arrhythmia due to intracoronary papaverine: analysis of QT intervals and coronary vasodilatory reserve." Cathet Cardiovasc Diagn 19 (1990): 229-36. [PMID: 2334953]
142 Nakayama M, Saito A, Kitazawa H, et.al "Papaverine-induced polymorphic ventricular tachycardia in relation to QTU and giant T-U waves in four cases." Intern Med 51 (2012): 351-6. [PMID: 22333368]
143 Nakayama M, Tanaka N, Sakoda K, et.al "Papaverine-induced polymorphic ventricular tachycardia during coronary flow reserve study of patients with moderate coronary artery disease." Circ J 79 (2015): 530-6. [PMID: 25746536]
144 Talman CL, Winniford MD, Rossen JD, Simonetti I, Kienzle MG, Marcus ML "Polymorphous ventricular tachycardia: a side effect of intracoronary papaverine." J Am Coll Cardiol 15 (1990): 275-8. [PMID: 2299067]
145 Vrolix M, Piessens J, De Geest H "Torsades de pointes after intracoronary papaverine." Eur Heart J 12 (1991): 273-6. [PMID: 2044564]
146 Product Information. Orap Tablets (pimozide). Gate Pharmaceuticals, Sellersville, PA.
147 Anson BD, Weaver JG, Ackerman MJ, et al. "Blockade of HERG channels by HIV protease inhibitors." Lancet 365 (2005): 682-686. [PMID: 15721475]
148 Biondi L "Health Canada endorsed important safety information on Invirase (saquinavir mesylate)." .
149 Product Information. Invirase (saquinavir). Roche Laboratories, Nutley, NJ.
150 FDA. U.S. Food and Drug Administration "FDA drug safety communication: Ongoing safety review of Invirase (saquinavir) and possible association with abnormal heart rhythms.".
151 Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
152 UK government "Typhoid.".
153 American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association (1994).
154 Product Information. Vandetanib (vandetanib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
155 Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
156 Product Information. Vaxchora (cholera vaccine, live). PaxVax, Miami, FL.
157 Hatta K, Takahashi T, Nakamura H, Yamashiro H, Asukai N, Matsuzaki I, Yonezawa Y "The association between intravenous haloperidol and prolonged QT interval." J Clin Psychopharmacol 21 (2001): 257-61. [PMID: 11386487]
158 Huyse F, van Schijndel RS "Haloperidol and cardiac arrest." Lancet 2 (1988): 568-9. [PMID: 2900948]
159 Metzger E, Friedman R "Prolongation of the corrected QT and torsades de pointes cardiac arrhythmia associated with intravenous haloperidol in the medically ill." J Clin Psychopharmacol 13 (1993): 128-32. [PMID: 8463445]
160 O'Brien JM, Rockwood RP, Suh KI "Haloperidol-induced torsade de pointes." Ann Pharmacother 33 (1999): 1046-9. [PMID: 10534216]
161 Product Information. Haldol (haloperidol). McNeil Pharmaceutical, Raritan, NJ.
162 Wilt JL, Minnema AM, Johnson RF, Rosenblum AM "Torsade de pointes associated with the use of intravenous haloperidol." Ann Intern Med 119 (1993): 391-4. [PMID: 8338292]
163 Product Information. Corvert (ibutilide). Pharmacia and Upjohn, Kalamazoo, MI.
164 Product Information. Serentil (mesoridazine) Boehringer-Ingelheim, Ridgefield, CT.
165 De Bels D, Staroukine M, Devriendt J "Torsades de pointes due to methadone." Ann Intern Med 139 (2003): E156. [PMID: 12859181]
166 Ehret GB, Desmeules JA, Broers B "Methadone-associated long QT syndrome: improving pharmacotherapy for dependence on illegal opioids and lessons learned for pharmacology." Expert Opin Drug Saf 6 (2007): 289-303. [PMID: 17480178]
167 Gil M, Sala M, Anguera I, et al. "QT prolongation and Torsades de Pointes in patients infected with human immunodeficiency virus and treated with methadone." Am J Cardiol 92 (2003): 995-7. [PMID: 14556883]
168 Krantz MJ, Kutinsky IB, Robertson AD, Mehler PS "Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes." Pharmacotherapy 23 (2003): 802-5. [PMID: 12820821]
169 Krantz MJ, Lewkowiez L, Hays H, et al "Torsade de pointes associated with very-high-dose methadone." Ann Intern Med 137 (2002): 501-4. [PMID: 12230351]
170 Krantz MJ, Mehler PS "Synthetic opioids and QT prolongation." Arch Intern Med 163 (2003): 1615 author reply 1615. [PMID: 12860589]
171 Martell BA, Arnsten JH, Krantz MJ, Gourevitch MN "Impact of methadone treatment on cardiac repolarization and conduction in opioid users." Am J Cardiol 95 (2005): 915-8. [PMID: 15781034]
172 Mokwe EO, Ositadinma O "Torsade de pointes due to methadone." Ann Intern Med 139 (2003): W64. [PMID: 12966000]
173 Sala M, Anguera I, Cervantes M "Torsade de pointes due to methadone." Ann Intern Med 139 (2003): W64. [PMID: 12966001]
174 Walker PW, Klein D, Kasza L "High dose methadone and ventricular arrhythmias: a report of three cases." Pain 103 (2003): 321-4. [PMID: 12791438]
175 Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
176 Product Information. Definity (perflutren). Lantheus Medical Imaging Inc, North Billerica, MA.
177 Product Information. Optison (perflutren). Mallinckrodt Medical Inc, St. Louis, MO.
178 Braden GL, vonOeyen PT, Germain MJ, Watson DJ, Haag BL "Ritodrine- and terbutaline-induced hypokalemia in preterm labor: Mechanisms and consequences." Kidney Int 51 (1997): 1867-75. [PMID: 9186877]
179 Clifton GD, Hunt BA, Patel RC, Burki NK "Effects of sequential doses of parenteral terbutaline on plasma levels of potassium and related cardiopulmonary responses." Am Rev Respir Dis 141 (1990): 575-9. [PMID: 2178522]
180 Dickens GR, Mccoy RA, West R, Stapczynski JS, Clifton GD "Effect of nebulized albuterol on serum potassium and cardiac rhythm in patients with asthma or chronic obstructive pulmonary disease." Pharmacotherapy 14 (1994): 729-33. [PMID: 7885977]
181 Ferguson GT, Funck-Brentano C, Fischer T, Darken P, Reisner C "Cardiovascular Safety of Salmeterol in COPD." Chest 123 (2003): 1817-24. [PMID: 12796155]
182 Gelmont DM, Balmes JR, Yee A "Hypokalemia induced by inhaled bronchodilators." Chest 94 (1988): 763-6. [PMID: 3168573]
183 Gross TL, Sokol RJ "Severe hypokalemia and acidosis: a potential complication of beta- adrenergic treatment." Am J Obstet Gynecol 138 (1980): 1225-6. [PMID: 7446635]
184 Hastwell G, Lambert BE "The effect of oral salbutamol on serum potassium and blood sugar." Br J Obstet Gynaecol 85 (1978): 767-9. [PMID: 708661]
185 Hurlbert BJ, Edelman JD, David K "Serum potassium levels during and after terbutaline." Anesth Analg 60 (1981): 723-5. [PMID: 7197475]
186 Hypokalaemia due to salbutamol overdosage. Br Med J (Clin Res Ed) 283 (1981): 500-1. [PMID: 6114774]
187 Kantola I, Tarssanen L "Hypokalemia from usual salbutamol dosage ." Chest 89 (1986): 619-20. [PMID: 3956296]
188 Lowe MD, Rowland E, Brown MJ, Grace AA "Beta(2) adrenergic receptors mediate important electrophysiological effects in human ventricular myocardium." Heart 86 (2001): 45-51. [PMID: 11410561]
189 Milic M, Bao X, Rizos D, Liu F, Ziegler MG "Literature review and pilot studies of the effect of qt correction formulas on reported beta(2)-agonist-induced QTc prolongation." Clin Ther 28 (2006): 582-90. [PMID: 16750469]
190 Product Information. Brovana (arformoterol). Sepracor Inc, Marlborough, MA.
191 Product Information. Foradil (formoterol) Novartis Pharmaceuticals, East Hanover, NJ.
192 Product Information. Maxair (pirbuterol). 3M Pharmaceuticals, St. Paul, MN.
193 Product Information. Proventil (albuterol). Schering Laboratories, Kenilworth, NJ.
194 Product Information. Severent (salmeterol). Glaxo Wellcome, Research Triangle Park, NC.
195 Product Information. Xopenex (levalbuterol). Sepracor, Marlborough, MA.
196 Sanders JP, Potter DE, Ellis S, Bee DE, Grant JA "Metabolic and cardiovascular effects of carbuterol and metaproterenol." J Allergy Clin Immunol 60 (1977): 174-9. [PMID: 19514]
197 Sun ZH, Swan H, Vitasalo M, Toivonen L "Effects of epinephrine and phenylephrine on QT interval dispersion in congenital long QT syndrome." J Am Coll Cardiol 31 (1998): 1400-5. [PMID: 9581741]
198 Tveskov C, Djurhuus MS, Klitgaard NAH, Egstrup K "Potassium and magnesium distribution, ECG changes, and ventricular ectopic beats during beta(2)-adrenergic stimulation with terbutaline in healthy subjects." Chest 106 (1994): 1654-9. [PMID: 7988180]
199 Whyte KF, Addis GJ, Whitesmith R, Reid JL "The mechanism of salbutamol-induced hypokalaemia." Br J Clin Pharmacol 23 (1987): 65-71. [PMID: 3545273]
200 Wong CS, Pavord ID, Williams J, Britton JR, Tattersfield AE "Bronchodilator, cardiovascular, and hypokalaemic effects of fenoterol, salbutamol, and terbutaline in asthma." Lancet 336 (1990): 1396-9. [PMID: 1978872]
201 Larsson S, Svedmyr N "Bronchodilating effect and side effects of beta2- adrenoceptor stimulants by different modes of administration (tablets, metered aerosol, and combinations thereof). A study with salbutamol inasthmatics." Am Rev Respir Dis 116 (1977): 861-9. [PMID: 921062]
202 Liberatore MA, Robinson DS "Torsade de pointes: a mechanism for sudden death associated with neuroleptic drug therapy?" J Clin Psychopharmacol 4 (1984): 143-6. [PMID: 6145728]
203 Product Information. Mellaril (thioridazine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
204 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
205 Davey PG "Overview of drug interactions with the quinolones." J Antimicrob Chemother 22(suppl c) (1988): 97-107. [PMID: 3053579]
206 Product Information. Metvixia (methyl aminolevulinate topical). Galderma Laboratories Inc, Cranbury, NJ.
207 Product Information. Colazal (balsalazide) Salix Pharmaceuticals, Palo Alto, CA.
208 Akerele JO, Okhamafe AO "Influence of oral co-administered metallic drugs on ofloxacin pharmacokinetics." J Antimicrob Chemother 28 (1991): 87-94. [PMID: 1663108]
209 Allen A, Vousden M, Porter A, Lewis A "Effect of Maalox((R)) on the bioavailability of oral gemifloxacin in healthy volunteers." Chemotherapy 45 (1999): 504-11. [PMID: 10567782]
210 Campbell NR, Kara M, Hasinoff BB, Haddara WM, McKay DW "Norfloxacin interaction with antacids and minerals." Br J Clin Pharmacol 33 (1992): 115-6. [PMID: 1540482]
211 Frost RW, Lasseter KC, Noe AJ, Shamblen EC, Lettieri JT "Effects of aluminum hydroxide and calcium carbonate antacids on the bioavailability of ciprofloxacin." Antimicrob Agents Chemother 36 (1992): 830-2. [PMID: 1503446]
212 Garrelts JC, Godley PJ, Peterie JD, Gerlach EH, Yakshe CC "Sucralfate significantly reduces ciprofloxacin concentrations in serum." Antimicrob Agents Chemother 34 (1990): 931-3. [PMID: 2360833]
213 Grasela TH Jr, Schentag JJ, Sedman AJ, et al "Inhibition of enoxacin absorption by antacids or ranitidine." Antimicrob Agents Chemother 33 (1989): 615-7. [PMID: 2751276]
214 Honig PK, Gillespie BK "Clinical significance of pharmacokinetic drug interactions with over-the-counter (OTC) drugs." Clin Pharmacokinet 35 (1998): 167-71. [PMID: 9784931]
215 Johnson RD, Dorr MB, Talbot GH, Caille G "Effect of Maalox on the oral absorption of sparfloxacin." Clin Ther 20 (1998): 1149-58. [PMID: 9916608]
216 Kamberi M, Nakashima H, Ogawa K, Oda N, Nakano S "The effect of staggered dosing of sucralfate on oral bioavailability of sparfloxacin." Br J Clin Pharmacol 49 (2000): 98-103. [PMID: 10671902]
217 Lehto P, Kivisto KT "Different effects of products containing metal ions on the absorption of lomefloxacin." Clin Pharmacol Ther 56 (1994): 477-82. [PMID: 7955811]
218 Lehto P, Kivisto KT "Effect of sucralfate on absorption of norfloxacin and ofloxacin." Antimicrob Agents Chemother 38 (1994): 248-51. [PMID: 8192452]
219 Lober S, Ziege S, Rau M, Schreiber G, Mignot A, Koeppe P, Lode H "Pharmacokinetics of gatifloxacin and interaction with an antacid containing aluminum and magnesium." Antimicrob Agents Chemother 43 (1999): 1067-71. [PMID: 10223915]
220 Nix DE, Watson WA, Lener ME, et al "Effects of aluminum and magnesium antacids and ranitidine on the absorption of ciprofloxacin." Clin Pharmacol Ther 46 (1989): 700-5. [PMID: 2598571]
221 Nix DE, Wilton JH, Ronald B, Distlerath L, Williams VC, Norman A "Inhibition of norfloxacin absorption by antacids." Antimicrob Agents Chemother 34 (1990): 432-5. [PMID: 2334155]
222 Noyes M, Polk RE "Norfloxacin and absorption of magnesium-aluminum." Ann Intern Med 109 (1988): 168-9. [PMID: 3382110]
223 Parpia SH, Nix DE, Hejmanowski LG, Goldstein HR, Wilton JH, Schentag JJ "Sucralfate reduces the gastrointestinal absorption of norfloxacin." Antimicrob Agents Chemother 33 (1989): 99-102. [PMID: 2712548]
224 Polk RE, Helay DP, Sahai J, Drwal L, Racht E "Effect of ferrous sulfate and multivitamins with zinc on absorption of ciprofloxacin in normal volunteers." Antimicrob Agents Chemother 33 (1989): 1841-4. [PMID: 2610494]
225 Product Information. Raxar (grepafloxacin). Glaxo Wellcome, Research Triangle Park, NC.
226 Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
227 Product Information. Trovan (trovafloxacin). Pfizer US Pharmaceuticals, New York, NY.
228 Sahai J, Healy DP, Stotka J, Polk RE "The influence of chronic administration of calcium carbonate on the bioavailability of oral ciprofloxacin." Br J Clin Pharmacol 35 (1993): 302-4. [PMID: 8471407]
229 Shimada J, Shiba K, Oguma T, et al "Effect of antacid on absorption of the quinolone lomefloxacin." Antimicrob Agents Chemother 36 (1992): 1219-24. [PMID: 1329615]
230 Spivey JM, Cummings DM, Pierson NR "Failure of prostatitis treatment secondary to probable ciprofloxacin-sucralfate drug interaction." Pharmacotherapy 16 (1996): 314-6. [PMID: 8820479]
231 Teng R, Dogolo LC, Willavize SA, Friedman HL, Vincent J "Effect of Maalox and omeprazole on the bioavailability of trovafloxacin." J Antimicrob Chemother 39 Suppl B (1997): 93-7. [PMID: 9222077]
232 Wadworth AN, Goa KL "Lomefloxacin: a review of its antibacterial activity, pharmacokinetic properties and therapeutic use." Drugs 42 (1991): 1018-60. [PMID: 1724637]
233 Yuk JH "Ciprofloxacin levels when receiving sucralfate." J Am Geriatr Soc 262 (1989): 901. [PMID: 2754785]
234 Zix JA, Geerdes-Fenge HF, Rau M, Vockler J, Borner K, Koeppe P, Lode H "Pharmacokinetics of sparfloxacin and interaction with cisapride and sucralfate." Antimicrob Agents Chemother 41 (1997): 1668-72. [PMID: 9257738]
235 Deppermann KM, Lode H, Hoffken G, Tschink G, Kalz C, Koeppe P "Influence of ranitidine, pirenzepine, and aluminum magnesium hydroxide on the bioavailability of various antibiotics, including amoxicillin, cephalexin, doxycycline, and amoxicillin-clavulanic acid." Antimicrob Agents Chemother 33 (1989): 1901-7. [PMID: 2610502]
236 Product Information. Penetrex (enoxacin). Rhone-Poulenc Rorer, Collegeville, PA.
237 Ball P, Tillotson G "Tolerability of fluoroquinolone antibiotics: past, present and future." Drug Saf 13 (1996): 343-8. [PMID: 8652079]
238 Segev S. Rehavi M, Rubinstein E "Quinolones, theophylline, and diclofenac interactions with the gamma-aminobutyric acid receptor." Antimicrob Agents Chemother 32 (1988): 1624-6. [PMID: 2855295]
239 Domagala JM "Structure-activity and structure-side-effect relationships for the quinolone antibacterials." J Antimicrob Chemother 33 (1994): 685-706. [PMID: 8056688]
240 Hooper DC, Wolfson JS "The fluoroquinolones: pharmacology, clinical uses, and toxicities in humans." Antimicrob Agents Chemother 28 (1985): 716-21. [PMID: 2936302]
241 Ball P "Ciprofloxacin: an overview of adverse experiences." J Antimicrob Chemother 18 (1986): 187-93. [PMID: 3542945]
242 Deppermann KM, Lode H "Fluoroquinolones: interaction profile during enteral absorption." Drugs 45 Suppl 3 (1993): 65-72. [PMID: 7689454]
243 Knupp CA, Barbhaiya RH "A multiple-dose pharmacokinetic interaction study between didanosine (videx(r)) and ciprofloxacin (cipro(r)) in male subjects seropositive for HIV but asymptomatic." Biopharm Drug Dispos 18 (1997): 65-77. [PMID: 9008270]
244 Marchbanks CR "Drug-drug interactions with fluoroquinolones." Pharmacotherapy 13 (1993): s23-8. [PMID: 8474934]
245 Polk RE "Drug-drug interactions with ciprofloxacin and other fluoroquinolones." Am J Med 87 (1989): s76-81. [PMID: 2686430]
246 Product Information. Videx (didanosine). Bristol-Myers Squibb, Princeton, NJ.
247 Sahai J, Gallicano K, Oliveras L, Khaliq S, Hawley-Foss N, Garber G "Cations in the didanosine tablet reduce ciprofloxacin bioavailability." Clin Pharmacol Ther 53 (1993): 292-7. [PMID: 8453847]
248 Damle BD, Mummaneni V, Kaul S, Knupp C "Lack of Effect of Simultaneously Administered Didanosine Encapsulated Enteric Bead Formulation (Videx EC) on Oral Absorption of Indinavir, Ketoconazole, or Ciprofloxacin." Antimicrob Agents Chemother 46 (2002): 385-91. [PMID: 11796346]
249 Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
250 Product Information. Exelon (rivastigmine) Novartis Pharmaceuticals, East Hanover, NJ.
251 Product Information. Razadyne (galantamine). Johnson and Johnson Medical Inc, Arlington, TX.
252 Product Information. Baraclude (entecavir). Bristol-Myers Squibb, Princeton, NJ.
253 Friedman CI, Huneke AL, Kim MH, Powell J "The effect of ampicillin on oral contraceptive effectiveness." Obstet Gynecol 55 (1980): 33-7. [PMID: 7188714]
254 Kleier DJ, Tucker JE "Oral contraceptive failure secondary to dentally prescribed drugs: fact or fiction?" J Colo Dent Assoc 66 (1987): 5-6. [PMID: 3478352]
255 Silber TJ "Apparent oral contraceptive failure associated with antibiotic administration." J Adolesc Health Care 4 (1983): 287-9. [PMID: 6643209]
256 Product Information. Pepcid (famotidine). Merck & Co, Inc, West Point, PA.
257 Product Information. Arcapta Neohaler (indacaterol). Novartis Pharmaceuticals, East Hanover, NJ.
258 Product Information. Breo Ellipta (fluticasone-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
259 Product Information. Striverdi Respimat (olodaterol). Boehringer Ingelheim, Ridgefield, CT.
260 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
261 Product Information. Firdapse (amifampridine). Catalyst Pharmaceuticals, Inc., Coral Gables, FL.
262 Goodnick PJ, Jerry J, Parra F "Psychotropic drugs and the ECG: focus on the QTc interval." Expert Opin Pharmacother 3 (2002): 479-98. [PMID: 11996627]
263 Kane JM, Carson WH, Saha AR, et al. "Efficacy and safety of aripiprazole and haloperidol versus placebo in patients with schizophrenia and schizoaffective disorder." J Clin Psychiatry 63 (2002): 763-71. [PMID: 12363115]
264 Keck PE Jr, Marcus R, Tourkodimitris S, et al. "A placebo-controlled, double-blind study of the efficacy and safety of aripiprazole in patients with acute bipolar mania." Am J Psychiatry 160 (2003): 1651-8. [PMID: 12944341]
265 Nelson S, Leung JG "Torsades de Pointes After Administration of Low-Dose Aripiprazole (February)." Ann Pharmacother (2013):. [PMID: 23362038]
266 Pigott TA, Carson WH, Saha AR, Torbeyns AF, Stock EG, Ingenito GG "Aripiprazole for the prevention of relapse in stabilized patients with chronic schizophrenia: a placebo-controlled 26-week study." J Clin Psychiatry 64 (2003): 1048-56. [PMID: 14628980]
267 Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
268 Chin RL "Laxative-induced hypokalemia." Ann Emerg Med 32 (1998): 517-8. [PMID: 9774942]
269 Muller-Lissner SA "Adverse effects of laxatives: fact and fiction." Pharmacology 47 (1993): 138-45. [PMID: 8234421]
270 Schaefer DC, Cheskin LJ "Constipation in the elderly." Am Fam Physician 58 (1998): 907-14. [PMID: 9767726]
271 Multum Information Services, Inc. Expert Review Panel.
272 Kajiyama Y, Fujii K, Takeuchi H, Manabe Y "Ginkgo seed poisoning." Pediatrics 109 (2002): 325-7. [PMID: 11826216]
273 Granger AS "Ginkgo biloba precipitating epileptic seizures." Age Ageing 30 (2001): 523-5. [PMID: 11742783]
274 Miller LG "Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions." Arch Intern Med 158 (1998): 2200-11. [PMID: 9818800]
275 Spinella M "Herbal medicines and epilepsy: the potential for benefit and adverse effects." Epilepsy Behav 2 (2001): 524-32. [PMID: 12609386]
276 Gregory PJ "Seizure associated with Ginkgo biloba?." Ann Intern Med 134 (2001): 344. [PMID: 11182853]
277 Harms SL, Garrard J, Schwinghammer P, Eberly LE, Chang Y, Leppik IE "Ginkgo biloba use in nursing home elderly with epilepsy or seizure disorder." Epilepsia 47 (2006): 323-9. [PMID: 16499756]
278 Miwa H, Iijima M, Tanaka S, Mizuno Y "Generalized convulsions after consuming a large amount of Gingko nuts." Epilepsia 42 (2001): 280-1. [PMID: 11240603]
279 Kupiec T, Raj V "Fatal seizures due to potential herb-drug interactions with Ginkgo biloba." J Anal Toxicol 29 (2005): 755-8. [PMID: 16419414]
280 Product Information. Indium Oxyquinoline In-111 (indium oxyquinoline In-111). GE Healthcare, Princeton, NJ.
281 Product Information. Fosrenol (lanthanum carbonate). Shire US Inc, Florence, KY.
282 Product Information. Nuzyra (omadacycline). Paratek Pharmaceuticals, Inc., Boston, MA.
283 Product Information. Seysara (sarecycline). Allergan Inc, Irvine, CA.
284 Salik JM, Kurtin P "Severe hyponatremia after colonoscopy preparation in a patient with the acquired immune deficiency syndrome." Am J Gastroenterol 80 (1985): 177-9. [PMID: 2983533]
285 Matsuoka LY "Convulsions following application of gamma benzene hexachloride." J Am Acad Dermatol 5 (1981): 98-9. [PMID: 6168673]
286 Cox R, Krupnick J, Bush N, Houpt A "Seizures caused by concomitant use of lindane and dextroamphetamine in a child with attention deficit hyperactivity disorder." J Miss State Med Assoc 41 (2000): 690-2. [PMID: 10974795]
287 Product Information. Kwell (lindane). Reed and Carnrick, Jersey City, NJ.
288 Eggleston W, Clark KH, Marraffa JM "Loperamide abuse associated with cardiac dysrhythmia and death." Ann Emerg Med 69 (2017): 83-6. [PMID: 27140747]
289 US Food and Drug Administration "FDA warns about serious heart problems with high doses of the antidiarrheal medicine loperamide (Imodium), including from abuse and misuse.".
290 Product Information. Oxsoralen (methoxsalen). ICN Pharmaceuticals Inc, Costa Mesa, CA.
291 Product Information. Uvadex (methoxsalen). Therakos Inc, Exton, PA.
292 Product Information. CellCept (mycophenolate mofetil). Roche Laboratories, Nutley, NJ.
293 Product Information. Myfortic (mycophenolic acid). Novartis Pharmaceuticals, East Hanover, NJ.
294 Product Information. Zyprexa (olanzapine). Lilly, Eli and Company, Indianapolis, IN.
295 Product Information. Alimta (pemetrexed). Lilly, Eli and Company, Indianapolis, IN.
296 Hanci V, Aydin M, Yurtlu BS, et.al "Anesthesia induction with sevoflurane and propofol: evaluation of P-wave dispersion, QT and corrected QT intervals." Kaohsiung J Med Sci 26 (2010): 470-7. [PMID: 20837343]
297 Kim DH, Kweon TD, Nam SB, Han DW, Cho WY, Lee JS "Effects of target concentration infusion of propofol and tracheal intubation on QTc interval." Anaesthesia 63 (2008): 1061-4. [PMID: 18717665]
298 Kleinsasser A, Kuenszberg E, Loeckinger A, et.al "Sevoflurane, but not propofol, significantly prolongs the Q-T interval." Anesth Analg 90 (2000): 25-7. [PMID: 10624970]
299 Kleinsasser A, Loeckinger A, Lindner KH, Keller C, Boehler M, Puehringer F "Reversing sevoflurane-associated Q-Tc prolongation by changing to propofol." Anaesthesia 56 (2001): 248-50. [PMID: 11251432]
300 Paventi S, Santevecchi A, Ranieri R "Effects of sevoflurane versus propofol on QT interval." Minerva Anestesiol 67 (2001): 637-40. [PMID: 11731753]
301 Scalese MJ, Herring HR, Rathburn RC, Skrepnek GH, Ripley TL "Propofol-associated QTc prolongation." Ther Adv Drug Saf 7 (2016): 68-78. [PMID: 27298717]
302 Staikou C, Stamelos M, Stavroulakis E "Impact of anaesthetic drugs and adjuvants on ECG markers of torsadogenicity." Br J Anaesth 112 (2014): 217-30. [PMID: 24305646]
303 Toyoda T, Terao Y, Oji M, Okada M, Fukusaki M, Sumikawa K "The interaction of antiemetic dose of droperidol with propofol on QT interval during anesthetic induction." J Anesth 27 (2013): 885-9. [PMID: 23660990]
304 Whyte SD, Booker PD, Buckley DG "The Effects of Propofol and Sevoflurane on the QT Interval and Transmural Dispersion of Repolarization in Children." Anesth Analg 100 (2005): 71-77. [PMID: 15616054]
305 Wutzler A, De Asmundis C, Matsuda H, et.al "Effects of propofol on ventricular repolarization and incidence of malignant arrhythmias in adults." J Electrocardiol 51 (2018): 170-4. [PMID: 29174097]
306 Kays MB, Overholser BR, Mueller BA, Moe SM, Sowinski KM "Effects of sevelamer hydrochloride and calcium acetate on the oral bioavailability of ciprofloxacin." Am J Kidney Dis 42 (2003): 1253-9. [PMID: 14655198]
307 Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
308 Product Information. Visudyne (verteporfin) Valeant Pharmaceuticals, Costa Mesa, CA.
309 Johnson EJ, MacGowan AP, Potter MN, et al "Reduced absorption of oral ciprofloxacin after chemotherapy for haematological malignancy." J Antimicrob Chemother 25 (1990): 837-42. [PMID: 2373666]
310 Kounas SP, Letsas KP, Sideris A, Efraimidis M, Kardaras F "QT interval prolongation and torsades de pointes due to a coadministration of metronidazole and amiodarone." Pacing Clin Electrophysiol 28 (2005): 472-3. [PMID: 15869686]
311 Product Information. Flagyl (metronidazole). Searle, Skokie, IL.
312 Product Information. Pylera (bismuth subcitrate potassium/metronidazo/TCN). Aptalis Pharma, Birmingham, AL.
313 Weidekamm E, Portmann R, Suter K, et al "Single- and multiple-dose pharmacokinetics of fleroxacin, a trifluorinated quinolone, in humans." Antimicrob Agents Chemother 31 (1987): 1909-14
314 Shimada J, Yamaji T, Ueda Y, Uchida H, Kusajma H, Irikura T "Mechanism of renal excretion of AM-715, a new quinolonecarboxylic acid derivative, in rabbits, dogs, and humans." Antimicrob Agents Chemother 23 (1983): 1-7
315 Crouch MA, Limon L, Cassano AT "Clinical relevance and management of drug-related QT interval prolongation." Pharmacotherapy 23 (2003): 881-908. [PMID: 12885102]