Drug General Information (ID: DDI8FTDGC6)
Drug Name			Gatifloxacin		Drug Info		Potassium citrate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiinfective Agents				Minerals And Electrolytes
Structure

Mechanism of Gatifloxacin-Potassium citrate Interaction (Severity Level: Moderate)
Altered urine pH Click to Show/Hide Mechanism Graph
Drug Name		Gatifloxacin				Potassium citrate
Mechanism		Urine pH sensitive				Urine alkalinizer Increase the risk of crystalluria
Key Mechanism Factor 1
		Factor Name		Urine pH
		Factor Description		The normal range of urine pH is between 4.5 and 8, depending mainly on the hydrogen ion concentration. Changes in urine pH may significantly affect drug reabsorption and excretion.
Mechanism Description		Altered elimination of Gatifloxacin caused by Potassium citrate mediated altered urine pH

Recommended Action
Management		Concomitant use should generally be avoided. Patients receiving this combination should be monitored for signs of renal toxicity and crystalluria.

References
1	Multum Information Services, Inc. Expert Review Panel.
2	Product Information. Cipro (ciprofloxacin). Bayer, West Haven, CT.