Drug General Information (ID: DDIP10X6RG)
Drug Name			Mercaptopurine		Drug Info		Gatifloxacin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antineoplastics				Antiinfective Agents
Structure

Mechanism of Mercaptopurine-Gatifloxacin Interaction (Severity Level: Minor)
Altered intestinal mucosa Click to Show/Hide Mechanism Graph
Drug Name		Mercaptopurine				Gatifloxacin
Mechanism		Alteration of intestinal mucosa				Absorption affected by changes in intestinal mucosa
Key Mechanism Factor 1
		Factor Name		Intestinal mucosa
		Factor Description		Intestinal mucosal barrier function is the ability of the intestine to adequately contain microorganisms and molecules in the lumen while maintaining the ability to absorb nutrients. The absorption of drugs may be altered when the intestinal mucosa is disrupted.
Mechanism Description		Decreased absorption of Gatifloxacin due to intestinal mucosa variation caused by Mercaptopurine

References
1	Johnson EJ, MacGowan AP, Potter MN, et al "Reduced absorption of oral ciprofloxacin after chemotherapy for haematological malignancy." J Antimicrob Chemother 25 (1990): 837-42. [PMID: 2373666]