Details of Drug

Drug General Information (ID: D0561)
Drug Name	Eltrombopag
Drug Type	Small molecule
Drug Synonymous	Eltrombopag [INN]; SB 497115; SB497115; SB-497115; [1,1'-Biphenyl]-3-carboxylic acid, 3'-[(2Z)-[1-(3,4-dime; Thylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-(9CI); (E)-3\'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2\'-hydroxybiphenyl-3-carboxylic acid Click to Show/Hide
Disease Class	3B64: Thrombocytopenia
Therapeutic Class	Platelet-Stimulating Agents
Structure
Structure	3D Structure		2D Structure
Formula	C25H22N4O4
InChI	1S/C25H22N4O4/c1-14-10-11-19(12-15(14)2)29-24(31)22(16(3)28-29)27-26-21-9-5-8-20(23(21)30)17-6-4-7-18(13-17)25(32)33/h4-13,28,30H,1-3H3,(H,32,33)
InChIKey	SVOQIEJWJCQGDQ-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C=C(C=C1)N2C(=O)C(=C(N2)C)N=NC3=CC=CC(=C3O)C4=CC(=CC=C4)C(=O)O)C
External Link
	Pubchem ID	135449332
	CAS Number	496775-61-2
	CHEBI ID	85010
	TTD ID	D00PEH
	VARIDT ID	DR00908

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM003 Complex formation BM010 Transporter inhibition BM011 Transporter induction BM017 CYP450 enzyme inhibition BM019 UGT inhibition BM023 UGT induction BM047 Additive thrombogenic effects BM055 Increased risk of hepatotoxicity
Relation Graph

Full list of drugs interacting with Eltrombopag
Affected gastrointestinal absorption
	Complex formation					Drug Num: 31
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0125		Attapulgite	Al2H29Mg2O15Si4-	56842194	Moderate		Inter Info	[4], [15]
D0235		Calcium acetate	C4H6CaO4	6116	Moderate		Inter Info	[4], [15]
D0483		Didanosine	C10H12N4O3	135398739	Moderate		Inter Info	[4], [15]
D0049		Aluminum hydroxide	AlH3O3	10176082	Moderate		Inter Info	[4], [15]
D0236		Calcium carbonate	CCaO3	10112	Moderate		Inter Info	[4], [15]
D0238		Calcium citrate	C12H10Ca3O14	13136	Moderate		Inter Info	[4], [15]
D0239		Calcium glubionate anhydrous	C18H32CaO19	64776	Moderate		Inter Info	[4], [15]
D0241		Calcium gluconate	C12H22CaO14	9290	Moderate		Inter Info	[4], [15]
D0242		Calcium glycerophosphate	C3H7CaO6P	120096	Moderate		Inter Info	[4], [15]
D0243		Calcium lactate	C6H10CaO6	13144	Moderate		Inter Info	[4], [15]
D0244		Calcium Phosphate	Ca3O8P2	24456	Moderate		Inter Info	[4], [15]
D0332		Chromium picolinate	C18H12CrN3O6	151932	Moderate		Inter Info	[4], [15]
D0390		Copper gluconate	C12H22CuO14	10692	Moderate		Inter Info	[4], [15]
D0649		Ferrous fumarate	C4H2FeO4	6433164	Moderate		Inter Info	[4], [15]
D0650		Ferrous gluconate	C12H22FeO14	23616740	Moderate		Inter Info	[4], [15]
D0651		Ferrous sulfate anhydrous	FeO4S	24393	Moderate		Inter Info	[4], [15]
D0849		Iron protein succinylate	NA	NA	Moderate		Inter Info	[4], [15]
D0967		Magaldrate	AlHMgO5S+2	3086011	Moderate		Inter Info	[4], [15]
D0968		Magnesium carbonate	CMgO3	11029	Moderate		Inter Info	[4], [15]
D0969		Magnesium chloride	Cl2H12MgO6	643991	Moderate		Inter Info	[4], [15]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[4], [15]
D0972		Magnesium glycinate	C4H8MgN2O4	84645	Moderate		Inter Info	[4], [15]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[4], [15]
D1456		Selenium	Se	6326970	Moderate		Inter Info	[4], [15]
D1566		Tetraferric tricitrate decahydrate	C18H32Fe4O31	90478690	Moderate		Inter Info	[4], [15]
D1724		Zinc gluconate	C12H22O14Zn	443445	Moderate		Inter Info	[4], [15]
D1725		Zinc sulfate	O4SZn	24424	Moderate		Inter Info	[4], [15]
D0847		Iron	Fe	23925	Moderate		Inter Info	[4], [15]
D0877		Kaolin	Al2H4O9Si2	56841936	Moderate		Inter Info	[4], [15]
D0974		Magnesium oxide	MgO	14792	Moderate		Inter Info	[4], [15]
D0975		Magnesium sulfate	MgO4S	24083	Moderate		Inter Info	[4], [15]
Affected cellular transport
	Transporter inhibition					Drug Num: 49
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[1]
D0562		Eluxadoline	C32H35N5O5	11250029	Major		Inter Info	[4], [5], [6]
D0739		Grazoprevir	C38H50N6O9S	44603531	Major		Inter Info	[4], [7], [8]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[2], [10]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[28], [2], [29]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[28], [12], [2], [30], [15]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[28], [2], [29]
D0348		Cladribine	C10H12ClN5O3	20279	Moderate		Inter Info	[2], [4], [31]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[2], [4], [15], [33]
D0109		Artesunate	C19H28O8	6917864	Moderate		Inter Info	[28], [12], [2], [30], [15]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[28], [12], [30]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Moderate		Inter Info	[2], [4], [38]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[4], [40], [41]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[43]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[44]
D0568		Enasidenib	C19H17F6N7O	89683805	Moderate		Inter Info	[2], [47]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[4], [48]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[2], [4], [49]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[4], [50]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[28], [12], [2], [30], [15]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[52]
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[28], [12], [2], [30], [15]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[4]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[28], [12], [2], [30], [15]
D1301		Pitavastatin	C25H24FNO4	5282452	Moderate		Inter Info	[28], [2], [29]
D1396		Revefenacin	C35H43N5O4	11753673	Moderate		Inter Info	[61], [7], [62]
D1407		Rimegepant	C28H28F2N6O3	51049968	Moderate		Inter Info	[63]
D1471		Simeprevir	C38H47N5O7S2	24873435	Moderate		Inter Info	[28], [12], [2], [30], [15]
D1539		Tedizolid	C17H15FN6O3	11234049	Moderate		Inter Info	[4], [66]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[68]
D1710		Voxilaprevir	C40H52F4N6O9S	89921642	Moderate		Inter Info	[69]
D0656		Fexofenadine	C32H39NO4	3348	Moderate		Inter Info	[28], [12], [2], [30], [15]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[28], [2], [29]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[28], [12], [2], [30], [15]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[28], [12], [2], [30], [15]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[28], [12], [2], [30], [15]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[28], [12], [30]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[28], [12], [2], [30], [15]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[28], [2], [29]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[28], [12], [2], [30], [15]
D1079		Mitoxantrone	C22H28N4O6	4212	Moderate		Inter Info	[28], [12], [2], [30], [15]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[28], [12], [2], [30], [15]
D1329		Pravastatin	C23H36O7	54687	Moderate		Inter Info	[28], [2], [29]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[28], [12], [2], [30], [15]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[28], [12], [30]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[28], [2], [29]
D1517		Sulfasalazine	C18H14N4O5S	5339	Moderate		Inter Info	[28], [12], [2], [30], [15]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[28], [12], [2], [30], [15]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[28], [12], [2], [30], [15]
	Transporter induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[4], [36]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0821		Interferon alfa-2a, Recombinant	NA	NA	Major		Inter Info	[2], [4], [15]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Major		Inter Info	[2], [4], [15]
D0824		Interferon alfa-n1	NA	NA	Major		Inter Info	[2], [4], [15]
D0823		Interferon alfacon-1	NA	NA	Major		Inter Info	[2], [4], [15]
D1237		Peginterferon alfa-2a	NA	NA	Major		Inter Info	[2], [4], [15]
D1238		Peginterferon alfa-2b	NA	NA	Major		Inter Info	[2], [4], [15]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[46]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[67]
	UGT inhibition					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0433		Deferiprone	C7H9NO2	2972	Moderate		Inter Info	[45]
D1528		Tafamidis	C14H7Cl2NO3	11001318	Moderate		Inter Info	[4], [64], [65]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[71]
D1191		Ospemifene	C24H23ClO2	3036505	Moderate		Inter Info	[4], [73], [74]
	UGT induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[2], [4], [53]
Pharmacodynamic additive effects
	Additive thrombogenic effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0261		Carfilzomib	C40H57N5O7	11556711	Major		Inter Info	[2], [3], [4]
	Increased risk of hepatotoxicity					Drug Num: 21
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[9]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[11]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[12], [13], [14]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[12], [13], [14]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[16]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[17], [18], [19], [2], [4], [20], [21], [22], [23], [24], [25], [26], [27]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[32]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[34], [35]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[17], [18], [19], [2], [4], [20], [21], [22], [23], [24], [25], [26], [27]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[37]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[39]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[4], [42]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[51]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[54], [55], [56], [57]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[2], [4], [58], [59], [60]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[2], [4], [70]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[54], [55], [56], [57]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[54], [55], [56], [57]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[72]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[17], [18], [19], [2], [4], [20], [21], [22], [23], [24], [25], [26], [27]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[75], [76]

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73	Product Information. Nexavar (sorafenib). Bayer Pharmaceutical Inc, West Haven, CT.
74	Product Information. Osphena (ospemifene). Shionogi USA Inc, Florham Park, NJ.
75	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
76	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.

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Details of Drug

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