Details of Drug-Drug Interaction
| Drug General Information (ID: DDIX2OS35J) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Kaolin | Drug Info | Eltrombopag | Drug Info | |||||
| Drug Type | Natural product | Small molecule | |||||||
| Therapeutic Class | Herbal Products | Platelet-Stimulating Agents | |||||||
| Structure | |||||||||
| Mechanism of Kaolin-Eltrombopag Interaction (Severity Level: Moderate) | |||||||||
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| Complex formation Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Kaolin | Eltrombopag | |||||||
| Mechanism | Polyvalent cations | Binds to polyvalent cations | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Chelation | ||||||||
| Factor Description | Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Eltrombopag should be taken on an empty stomach at least 2 hours before or 4 hours after oral medications that contain antacids (e.g., didanosine buffered tablets or pediatric oral solution), aluminum, calcium, iron, magnesium, zinc or other polyvalent cations. | ||||||||
| References | |||||||||||||||||||
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| 1 | Cerner Multum, Inc. "UK Summary of Product Characteristics.". | ||||||||||||||||||
| 2 | Product Information. Promacta (eltrombopag). GlaxoSmithKline, Research Triangle Park, NC. | ||||||||||||||||||