Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIY0LXD97)
  Drug Name Eltrombopag Drug Info Deferiprone Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Platelet-Stimulating Agents Chelating Agents
  Structure

 Mechanism of Eltrombopag-Deferiprone Interaction (Severity Level: Moderate)
     UGT inhibition Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Eltrombopag Deferiprone
      Mechanism UGT1A6 inhibitor UGT1A6 substrate
      Key Mechanism Factor 1
Factor Name UDP-glucuronosyltransferase 1A6
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Structure Sequence
MACLLRSFQRISAGVFFLALWGMVVGDKLLVVPQDGSHWLSMKDIVEVLSDRGHEIVVVVPEVNLLLKESKYYTRKIYPVPYDQEELKNRYQSFGNNHFAERSFLTAPQTEYRNNMIVIGLYFINCQSLLQDRDTLNFFKESKFDALFTDPALPCGVILAEYLGLPSVYLFRGFPCSLEHTFSRSPDPVSYIPRCYTKFSDHMTFSQRVANFLVNLLEPYLFYCLFSKYEELASAVLKRDVDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCKKRKDLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
Gene Name UGT1A6
Uniprot ID UD16_HUMAN
KEGG Pathway hsa:54578
Protein Family UDP-glycosyltransferase family
Protein Function
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 3 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity).
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      Mechanism Description
  • Decreased metabolism of Deferiprone caused by Eltrombopag mediated inhibition of UGT

Recommended Action
      Management The use of deferiprone with UGT1A6 inhibitors should be avoided.

References
1 Product Information. Ferriprox (deferiprone). ApoPharma USA Inc, Rockville, MD.