Details of Drug

Drug General Information (ID: D0400)
Drug Name	Cyclophosphamide
Drug Type	Small molecule
Drug Synonymous	ASTA; Ciclofosfamida; Ciclophosphamide; Clafen; Claphene; Cycloblastin; Cyclophosphamid; Cyclophosphamides; Cyclophosphamidum; Cyclophosphan; Cyclophosphane; Cyclophosphanum; Cyclophosphoramide; Cyclostin; Cyklofosfamid; Cytophosphan; Cytophosphane; Cytoxan; Endoxan; Endoxana; Endoxanal; Endoxane; Enduxan; Genoxal; Mitoxan; Neosar; Procytox; Revimmune; Semdoxan; Sendoxan; Senduxan; Zyklophosphamid; Ciclophosphamide [INN]; Cyclophosphamide Sterile; Cyclophosphamide anhydrous; Cyklofosfamid [Czech]; Cytoxan Lyoph; Endoxan R; Lyophilized Cytoxan; Zyklophosphamid [German]; ASTA B518; Asta B 518; B 518; C 0768; CB 4564; SK 20501; B-518; CB-4564; Ciclofosfamida [INN-Spanish]; Cyclophosphamide (INN); Cyclophosphamide (TN); Cyclophosphamide (anhydrous form); Cyclophosphamide (anhydrous); Cyclophosphamidum [INN-Latin]; Cytoxan (TN); Endoxan (TN); Endoxan-Asta; Neosar (TN); Occupation, cyclophosphamide exposure; Procytox (TN); Revimmune (TN); Bis(2-Chloroethyl)phosphami de cyclic propanolamide; Bis(2-Chloroethyl)phosphamide cyclic propanolamide ester; Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester; D,L-Cyclophosphamide; Cyclophosphamide, (+-)-Isomer; N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide; (+-)-Cyclophosphamide; (-)-Cyclophosphamide; (RS)-Cyclophosphamide; 1-(bis(2-chloroethyl)amino)-1-oxo-2-aza-5-oxaphosphoridine; 1-Bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridin; 4-Hydroxy-cyclophosphan-mamophosphatide Click to Show/Hide
Disease Class	2A00-2F9Z: Solid tumour/cancer
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C7H15Cl2N2O2P
InChI	1S/C7H15Cl2N2O2P/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14/h1-7H2,(H,10,12)
InChIKey	CMSMOCZEIVJLDB-UHFFFAOYSA-N
Canonical SMILES	C1CNP(=O)(OC1)N(CCCl)CCCl
External Link
	Pubchem ID	2907
	CAS Number	50-18-0
	CHEBI ID	4027
	TTD ID	D0CT9C
	INTEDE ID	DR0391
	VARIDT ID	DR00425

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM006 Altered intestinal mucosa BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM027 Decreased renal excretion due to nephrotoxicity BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM045 Additive neuromuscular blocking effects BM047 Additive thrombogenic effects BM054 Increased risk of GI mucosal injury/bleeding risk BM055 Increased risk of hepatotoxicity BM064 Increased risk of hypoglycemia BM067 Increased risk of hyponatremia BM072 Increased risk of nephrotoxicity BM091 Antagonize the effect of cholinergic agents BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Cyclophosphamide
Affected gastrointestinal absorption
	Altered intestinal mucosa					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[444], [445], [446], [447], [448]
D0340		Cinoxacin	C12H10N2O5	2762	Minor		Inter Info	[483]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Minor		Inter Info	[483]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Minor		Inter Info	[483]
D0712		Gatifloxacin	C19H22FN3O4	5379	Minor		Inter Info	[483]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Minor		Inter Info	[483]
D0919		Levofloxacin	C18H20FN3O4	149096	Minor		Inter Info	[483]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Minor		Inter Info	[483]
D1155		Norfloxacin	C16H18FN3O3	4539	Minor		Inter Info	[483]
D1165		Ofloxacin	C18H20FN3O4	4583	Minor		Inter Info	[483]
D1657		Trovafloxacin	C20H15F3N4O3	62959	Minor		Inter Info	[483]
D0573		Enoxacin	C15H17FN4O3	3229	Minor		Inter Info	[483]
D0740		Grepafloxacin	C19H22FN3O3	72474	Minor		Inter Info	[483]
D1092		Moxifloxacin	C21H24FN3O4	152946	Minor		Inter Info	[483]
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0708		Gallium chloride Ga-67	Cl3Ga	73415785	Moderate		Inter Info	[215]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 28
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0264		Carmustine	C5H9Cl2N3O2	2578	Moderate		Inter Info	[158], [159]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[160]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[165], [166], [167]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[171], [172], [173], [174], [175], [176]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[180]
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[185], [15], [8], [186], [187], [188], [189], [190], [191], [192], [193], [194]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[15], [8], [191]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[203]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[204]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[207]
D0642		Fenofibrate	C20H21ClO4	3339	Moderate		Inter Info	[15], [8], [211]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[165], [166], [167]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[171], [172], [173], [174], [175], [176]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[214]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[218]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[220], [221], [222]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[224]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[226]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[246], [247], [248], [249], [250], [251], [252], [253], [176]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[255]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[262]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[449], [450], [451], [452], [453]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[458], [459]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[461]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[438], [15], [464]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Minor		Inter Info	[480], [481], [482]
D1328		Prasugrel	C20H20FNO3S	6918456	Minor		Inter Info	[8], [488]
D1383		Ranolazine	C24H33N3O4	56959	Minor		Inter Info	[8]
	CYP450 enzyme induction					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[161]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[8], [170]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[184]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[198], [199], [200]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[201]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[15], [208]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[209], [15], [8], [210]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[8], [219]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[15], [223]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[225]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[231], [232], [233]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[8], [241]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[8], [256]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[260], [261]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[15], [8], [462], [463]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[468]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[472], [473], [474], [475], [476], [477], [478]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[484], [485]
D1265		Phenobarbital	C12H12N2O3	4763	Minor		Inter Info	[486], [487]
	Competitive inhibition of metabolic enzyme					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[15], [212], [213]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[15], [212], [213]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[257], [258]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[257], [258]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[257], [258]
Affected excretion pathways
	Decreased renal excretion due to nephrotoxicity					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[15], [8], [243], [244], [245]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 67
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[8], [9]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[15], [8], [16]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [5], [6]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[19]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[21], [22]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[8], [24]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[15], [26]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[21], [22]
D1575		Thiotepa	C6H12N3PS	5453	Major		Inter Info	[46]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[47]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[48]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0802		Infliximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[8], [150], [151]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[27], [152], [153]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[154]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[155], [156], [157]
D0190		Bleomycin	C55H84N17O21S3+	5360373	Moderate		Inter Info	[8], [150], [151]
D0312		Chlorambucil	C14H19Cl2NO2	2708	Moderate		Inter Info	[8], [150], [151]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[8], [150], [151]
D0157		Bendamustine	C16H21Cl2N3O2	65628	Moderate		Inter Info	[8], [150], [151]
D0223		Busulfan	C6H14O6S2	2478	Moderate		Inter Info	[8], [150], [151]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[155], [156], [157]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[8], [150], [151]
D0404		Cytarabine	C9H13N3O5	6253	Moderate		Inter Info	[8], [150], [151]
D0405		Cytarabine (liposomal)	C9H13N3O5	6253	Moderate		Inter Info	[8], [150], [151]
D0407		Dacarbazine	C6H10N6O	135398738	Moderate		Inter Info	[8], [150], [151]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[8], [150], [151]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[205]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[206]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[206]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[8], [150], [151]
D0675		Fluorouracil	C4H3FN2O2	3385	Moderate		Inter Info	[8], [150], [151]
D0780		Hydroxyurea	CH4N2O2	3657	Moderate		Inter Info	[8], [150], [151]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[8], [150], [151]
D0851		Isatuximab	NA	NA	Moderate		Inter Info	[8], [150], [151]
D0945		Lomustine	C9H16ClN3O2	3950	Moderate		Inter Info	[8], [150], [151]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[8], [150], [151]
D0996		Melphalan	C13H18Cl2N2O2	460612	Moderate		Inter Info	[8], [150], [151]
D1007		Mercaptopurine	C5H4N4S	667490	Moderate		Inter Info	[8], [150], [151]
D1079		Mitoxantrone	C22H28N4O6	4212	Moderate		Inter Info	[8], [150], [151]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[206]
D1113		Naxitamab	NA	NA	Moderate		Inter Info	[8], [150], [151]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[227]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[228]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[8], [229]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[230]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[242]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[155], [156], [157]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[8], [254]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[8], [150], [151]
D1487		Sodium phosphate, monobasic (p32)	NA	NA	Moderate		Inter Info	[259]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[15], [8], [177]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[263]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[264]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[8], [150], [151]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[454]
D0666		Floxuridine	C9H11FN2O5	5790	Moderate		Inter Info	[8], [150], [151]
D0714		Gemcitabine	C9H11F2N3O4	60750	Moderate		Inter Info	[8], [150], [151]
D1077		Mitomycin	C15H18N4O5	5746	Moderate		Inter Info	[8], [150], [151]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[8], [150], [151]
D1855		Palifermin	NA	NA	Moderate		Inter Info	[465]
D1508		Streptozocin	C8H15N3O7	29327	Moderate		Inter Info	[8], [150], [151]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[8], [150], [151]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[15], [8], [479]
	Additive myelosuppressive effects					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[8], [10], [11]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[15], [17], [18]
D1443		Samarium (153Sm) lexidronam	Sm	23951	Major		Inter Info	[25]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[15], [8], [216], [217]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[15], [8], [216], [217]
	Additive neuromuscular blocking effects					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0122		Atracurium	C53H72N2O12+2	47319	Moderate		Inter Info	[177], [178]
D0343		Cisatracurium	C53H72N2O12+2	62887	Moderate		Inter Info	[177], [178]
D1080		Mivacurium	C58H80N2O14+2	5281042	Moderate		Inter Info	[177], [178]
D1219		Pancuronium	C35H60N2O4+2	441289	Moderate		Inter Info	[177], [178]
D1420		Rocuronium	C32H53N2O4+	441290	Moderate		Inter Info	[177], [178]
D1684		Vecuronium	C34H57N2O4+	39765	Moderate		Inter Info	[177], [178]
	Additive thrombogenic effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1569		Thalidomide	C13H10N2O4	5426	Major		Inter Info	[30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45]
	Increased risk of GI mucosal injury/bleeding risk					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1102		Nalidixic acid	C12H12N2O3	4421	Major		Inter Info	[23]
	Increased risk of hepatotoxicity					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[179]
	Increased risk of hypoglycemia					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149]
	Increased risk of hyponatremia					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0449		Desmopressin	C46H64N14O12S2	5311065	Moderate		Inter Info	[15], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294], [295], [296], [297], [298], [299], [300], [301], [302], [303], [304], [305], [306], [307], [308], [309], [310], [311], [312], [313], [314], [315], [316], [317], [318], [319], [320], [321], [322], [323], [324], [325], [326], [327], [328], [329], [330], [331], [332], [333], [334], [335], [336], [337], [338], [339], [340], [341], [342], [343], [344], [345], [346], [347], [348], [349], [350], [351], [352], [353], [354], [355], [356], [357], [358], [359], [360], [361], [362], [363], [364], [365], [366], [367], [368], [369], [370], [371], [372], [373], [374], [375], [376], [377], [378], [379], [380], [381], [382], [383], [384], [385], [386], [387], [388], [389], [390], [391], [392], [393], [394], [395], [396], [397], [398], [399], [400], [8], [401], [402], [403], [404], [405], [406], [407], [408], [409], [410], [411], [412], [413], [414], [415], [416], [417], [418], [419], [420], [421], [422], [423], [424], [425], [426], [427], [428], [429], [430], [431], [432], [433], [434], [435], [436], [437], [438], [439], [440], [441], [442], [443]
D1683		Vasopressin	C46H65N15O12S2	644077	Moderate		Inter Info	[15], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294], [295], [296], [297], [298], [299], [300], [301], [302], [303], [304], [305], [306], [307], [308], [309], [310], [311], [312], [313], [314], [315], [316], [317], [318], [319], [320], [321], [322], [323], [324], [325], [326], [327], [328], [329], [330], [331], [332], [333], [334], [335], [336], [337], [338], [339], [340], [341], [342], [343], [344], [345], [346], [347], [348], [349], [350], [351], [352], [353], [354], [355], [356], [357], [358], [359], [360], [361], [362], [363], [364], [365], [366], [367], [368], [369], [370], [371], [372], [373], [374], [375], [376], [377], [378], [379], [380], [381], [382], [383], [384], [385], [386], [387], [388], [389], [390], [391], [392], [393], [394], [395], [396], [397], [398], [399], [400], [8], [401], [402], [403], [404], [405], [406], [407], [408], [409], [410], [411], [412], [413], [414], [415], [416], [417], [418], [419], [420], [421], [422], [423], [424], [425], [426], [427], [428], [429], [430], [431], [432], [433], [434], [435], [436], [437], [438], [439], [440], [441], [442], [443]
D0800		Indomethacin	C19H16ClNO4	3715	Minor		Inter Info	[314]
	Increased risk of nephrotoxicity					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0335		Cidofovir	C8H14N3O6P	60613	Major		Inter Info	[7]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[8], [20]
D0292		Ceftazidime	C22H22N6O7S2	5481173	Moderate		Inter Info	[15], [8]
D0075		Amphotericin B	C47H73NO17	5280965	Moderate		Inter Info	[15], [8]
D0076		Amphotericin B (cholesteryl sulfate)	C47H73NO17	5280965	Moderate		Inter Info	[15], [8]
D0077		Amphotericin B (lipid complex)	C47H73NO17	5280965	Moderate		Inter Info	[15], [8]
D0078		Amphotericin B (liposomal)	C47H73NO17	5280965	Moderate		Inter Info	[15], [8]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[202]
D0724		Givosiran	C78H139N11O30	119058042	Moderate		Inter Info	[15], [8]
D1304		Plazomicin	C25H48N6O10	42613186	Moderate		Inter Info	[15], [8]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[162], [163], [164]
Pharmacodynamic antagonistic effects
	Antagonize the effect of cholinergic agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1510		Succinylcholine	C14H30N2O4+2	5314	Moderate		Inter Info	[469], [178], [470], [471]
	Antagonize the effect of vaccine/toxoid					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[12], [13], [14]
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[12], [13], [14]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[12], [13], [14]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[12], [13], [14]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[12], [13], [14]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[27], [15], [28]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[29]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[12], [13], [14]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[12], [13], [14]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[12], [13], [14]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[27], [168], [169]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[27], [168], [169]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[27], [168], [169]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[27], [168], [169]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[27], [168], [169]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[27], [168], [169]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[27], [168], [169]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[27], [168], [169]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[234], [27], [15], [235], [236], [237], [168], [238], [239], [240], [169]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[27], [168], [169]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[27], [168], [169]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[27], [168], [169]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[460]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[181], [182], [183]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[181], [182], [183]
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[195], [196], [197]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[195], [196], [197]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[195], [196], [197]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[195], [196], [197]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0659		Filgrastim	NA	NA	Moderate		Inter Info	[455], [456], [457]
D1235		Pegfilgrastim	C27H46N4O19	70683024	Moderate		Inter Info	[466], [467]
D1446		Sargramostim	NA	NA	Moderate		Inter Info	[455], [456], [457]

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115	Product Information. Diabinese (chlorpropamide). Pfizer US Pharmaceuticals, New York, NY.
116	Product Information. Dymelor (acetohexamide) Lilly, Eli and Company, Indianapolis, IN.
117	Product Information. Glucotrol (glipizide). Pfizer US Pharmaceuticals, New York, NY.
118	Product Information. Increlex (mecasermin). Tercica Inc, Brisbane, CA.
119	Product Information. Micronase (glyburide). Pharmacia and Upjohn, Kalamazoo, MI.
120	Product Information. Orinase (tolbutamide) Pharmacia and Upjohn, Kalamazoo, MI.
121	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
122	Product Information. Starlix (nateglinide) Novartis Pharmaceuticals, East Hanover, NJ.
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186	Product Information. Aplenzin (buPROPion). sanofi-aventis , Bridgewater, NJ.
187	Product Information. Contrave (buPROPion-naltrexone). Orexigen Therapeutics Inc, La Jolla, CA.
188	Product Information. Forfivo XL (buPROPion (bupropion)). Almatica Pharma Inc, Parsippany, NJ.
189	Product Information. Wellbutrin (bupropion). Glaxo Wellcome, Research Triangle Park, NC.
190	Product Information. Wellbutrin SR (bupropion). Glaxo Wellcome, Research Triangle Park, NC.
191	Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
192	Product Information. Zyban (bupropion). Glaxo Wellcome, Research Triangle Park, NC.
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196	Product Information. Candin (candida albicans extract). Nielsen Biosciences Inc, San Diego, CA.
197	Product Information. Spherulin (coccidioidin skin test). ALK Laboratories Inc, Wallingford, CT.
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202	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
203	Product Information. Synercid (dalfopristin-quinupristin) Rhone-Poulenc Rorer, Collegeville, PA.
204	Product Information. Prezista (darunavir). Ortho Biotech Inc, Bridgewater, NJ.
205	Product Information. Prolia (denosumab). Amgen USA, Thousand Oaks, CA.
206	Product Information. Vumerity (diroximel fumarate). Alkermes, Inc, Cambridge, MA.
207	Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
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211	Product Information. Antara (fenofibrate). Lupin Pharmaceuticals Inc, Baltimore, MD.
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214	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
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216	Product Information. Cytovene (ganciclovir). Genentech, South San Francisco, CA.
217	Product Information. Valcyte (valganciclovir) Roche Laboratories, Nutley, NJ.
218	Product Information. Gleevec (imatinib mesylate). Novartis Pharmaceuticals, East Hanover, NJ.
219	Product Information. Cresemba (isavuconazonium). Astellas Pharma US, Inc, Deerfield, IL.
220	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
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226	Product Information. Serzone (nefazodone). Bristol-Myers Squibb, Princeton, NJ.
227	Product Information. Zejula (niraparib). Tesaro Inc., Waltham, MA.
228	Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
229	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
230	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
231	Product Information. Trileptal (oxcarbazepine) Novartis Pharmaceuticals, East Hanover, NJ.
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237	Product Information. Havrix (hepatitis A vaccine). SmithKline Beecham, Philadelphia, PA.
238	Product Information. Influenza Virus Vaccine, H5N1, Inactivated (influenza virus vaccine, H5N1, inactivated). GlaxoSmithKline, Research Triangle Park, NC.
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240	CDC Centers for Disease Control and Prevention "Interim Clinical Considerations for Use of COVID-19 Vaccines Currently Approved or Authorized in the United States.".
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257	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
258	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
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455	Product Information. Granix (tbo-filgrastim). Teva Pharmaceuticals USA, North Wales, PA.
456	Product Information. Leukine (sargramostim). Immunex Corporation, Seattle, WA.
457	Product Information. Stemgen (ancestim) Amgen, Thousand Oaks, CA.
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465	Product Information. Kepivance (palifermin). Shire US Inc, Florence, KY.
466	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
467	Product Information. Neulasta (pegfilgrastim). Amgen, Thousand Oaks, CA.
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