Drug General Information (ID: DDIE7TPZB9)
Drug Name			Cyclophosphamide		Drug Info		Amiodarone		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antineoplastics				Antiarrhythmic Agents
Structure

Mechanism of Cyclophosphamide-Amiodarone Interaction (Severity Level: Moderate)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Cyclophosphamide				Amiodarone
Mechanism		Pulmonary toxicity				Pulmonary toxicity
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Cyclophosphamide and Amiodarone

Recommended Action
Management		Caution is advised during coadministration of amiodarone and cyclophosphamide, particularly at high dosages. Patients should be advised to notify their physician if they experience cough, dyspnea, or any new respiratory symptoms.

References
1	Libersa CC, Brique SA, Motte KB, et al. "Dramatic inhibition of amiodarone metabolism induced by grapefruit juice." Br J Clin Pharmacol 49 (2000): 373-8. [PMID: 10759694]
2	Bhagat R, Sporn TA, Long GD, Folz RJ "Amiodarone and cyclophosphamide: potential for enhanced lung toxicity." Bone Marrow Transplant 27 (2001): 1109-11
3	Meng X, Mojaverian P, Doedee M, Lin E, Weinryb I, Chiang ST, Kowey PR "Bioavailability of Amiodarone tablets administered with and without food in healthy subjects." Am J Cardiol 87 (2001): 432-5