Details of Drug

Drug General Information (ID: D0170)
Drug Name	Bepridil
Drug Type	Small molecule
Drug Synonymous	Bepadin; Vascor; CERM 1978; Bepadin (TN); Bepridil (INN); Vascor (TN); N-benzyl-N-[3-(2-methylpropoxy)-2-pyrrolidin-1-ylpropyl]aniline; Beta-((2-Methylpropoxy)methyl)-N-phenyl-N-(phenylmethyl)-1-pyrrolidineethanamine; N-Benzyl-N-[3-(2-methylpropoxy)-2-pyrrolidin-1-yl-propyl]aniline hydrochloride; N-benzyl-N-[3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl]aniline; N-{3-[(2-methylpropyl)oxy]-2-pyrrolidin-1-ylpropyl}-N-(phenylmethyl)aniline Click to Show/Hide
Disease Class	BA40: Angina pectoris
Therapeutic Class	Antiarrhythmic Agents
Structure
Structure	3D Structure		2D Structure
Formula	C24H34N2O
InChI	1S/C24H34N2O/c1-21(2)19-27-20-24(25-15-9-10-16-25)18-26(23-13-7-4-8-14-23)17-22-11-5-3-6-12-22/h3-8,11-14,21,24H,9-10,15-20H2,1-2H3
InChIKey	UIEATEWHFDRYRU-UHFFFAOYSA-N
Canonical SMILES	CC(C)COCC(CN(CC1=CC=CC=C1)C2=CC=CC=C2)N3CCCC3
External Link
	Pubchem ID	2351
	CAS Number	64706-54-3
	CHEBI ID	3061
	TTD ID	D0Y4JJ
	VARIDT ID	DR00709

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM036 Additive cardiorespiratory depression effects BM042 Additive hypotensive effects BM045 Additive neuromuscular blocking effects BM049 Increased risk of atrioventricular block BM051 Increased risk of bradycardia BM052 Increased risk of cardiac depression BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias BM089 Antagonize the effect of antihypertensive agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Bepridil
Affected cellular transport
	Transporter inhibition					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0176		Betrixaban	C23H22ClN5O3	10275777	Major		Inter Info	[26], [27], [28]
D0380		Colchicine	C22H25NO6	6167	Major		Inter Info	[30], [31], [32]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[2], [37], [38], [39]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[10], [2], [61]
D0947		Loperamide	C29H33ClN2O2	3955	Major		Inter Info	[120], [121], [122], [123], [124]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[9], [2], [228], [229]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[2], [230], [231]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Moderate		Inter Info	[10], [2], [240]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[250]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[10], [2], [275]
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[20]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[2], [282]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[283]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[10], [2], [286]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[10], [287]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[291]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[9], [2], [294]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[300]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[333], [10], [2], [334], [335], [336], [337], [338], [339]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[333], [337], [338]
D0658		Fidaxomicin	C52H74Cl2O18	10034073	Minor		Inter Info	[357]
D1104		Naloxegol	C34H53NO11	56959087	Minor		Inter Info	[360]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 28
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[9], [2], [22]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[25]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[29]
D0413		Dalfopristin	C34H50N4O9S	6323289	Major		Inter Info	[33], [34], [35]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[9], [2], [43], [22]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[49], [50], [51]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[107]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[112]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[146], [147]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[216], [217]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[252]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[253], [254]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[216], [217]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[257]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[2], [258]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[271]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[276]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[280]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[288]
D1471		Simeprevir	C38H47N5O7S2	24873435	Moderate		Inter Info	[40], [292], [293]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[304], [305], [306], [307], [119], [308], [309], [310]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[40], [33], [311]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[322], [323]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[324]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[325]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[326]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[327]
D1721		Zileuton	C11H12N2O2S	60490	Minor		Inter Info	[366]
	CYP450 enzyme induction					Drug Num: 20
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[44], [45], [46]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[62], [63], [64], [65], [66]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[44], [45], [46]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[44], [45], [46]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[44], [45], [46]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[44], [45], [46]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[44], [45], [46]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[249]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[2], [251]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[10], [255]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[256]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[2], [295]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[2], [301], [302]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[303]
D0621		Ethotoin	C11H12N2O2	3292	Moderate		Inter Info	[319], [62]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[319], [62]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[10], [2], [328], [329]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[330], [331], [332]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[352], [353], [354], [355], [356]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[352], [353], [354], [355], [356]
	Competitive inhibition of metabolic enzyme					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[296], [297]
Pharmacodynamic additive effects
	Additive cardiorespiratory depression effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[10], [118], [119]
	Additive hypotensive effects					Drug Num: 93
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[208], [209], [210]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[208], [209], [210]
D0055		Amifostine	C5H15N2O3PS	2141	Moderate		Inter Info	[26], [211], [212]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[213], [214], [215]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[218], [219], [220], [221], [222], [177], [223], [224], [225], [226], [227]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[208], [209], [210]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[208], [209], [210]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[176], [238], [239]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[208], [209], [210]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[218], [219], [220], [221], [222], [177], [223], [224], [225], [226], [227]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[10], [2], [248]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[218], [219], [220], [221], [222], [177], [223], [224], [225], [226], [227]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[10], [2], [248]
D0475		Dichloralphenazone	C15H18Cl6N2O5	10188	Moderate		Inter Info	[208], [209], [210]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[208], [209], [210]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[10], [2], [248]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [211], [269], [270]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[218], [219], [220], [221], [222], [177], [223], [224], [225], [226], [227]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[218], [219], [220], [221], [222], [177], [223], [224], [225], [226], [227]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[281]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[208], [209], [210]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[218], [219], [220], [221], [222], [177], [223], [224], [225], [226], [227]
D1148		Nitrous acid	HNO2	24529	Moderate		Inter Info	[284], [109], [285]
D1183		Opium	NA	NA	Moderate		Inter Info	[208], [209], [210]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[208], [209], [210]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [211], [269], [270]
D1391		Remimazolam	C21H19BrN4O2	9867812	Moderate		Inter Info	[208], [209], [210]
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [211], [269], [270]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[2], [289], [290]
D1485		Sodium oxybate	C4H7NaO3	23663870	Moderate		Inter Info	[208], [209], [210]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[218], [219], [220], [221], [222], [177], [223], [224], [225], [226], [227]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[213], [214], [215]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[213], [214], [215]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[208], [209], [210]
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[208], [209], [210]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[208], [209], [210]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[208], [209], [210]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[208], [209], [210]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[208], [209], [210]
D0228		Cabergoline	C26H37N5O2	54746	Moderate		Inter Info	[208], [209], [210]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[208], [209], [210]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[208], [209], [210]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Moderate		Inter Info	[208], [209], [210]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[208], [209], [210]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[208], [209], [210]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[208], [209], [210]
D0445		Desflurane	C3H2F6O	42113	Moderate		Inter Info	[312], [313], [314]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[10], [52], [315]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[208], [209], [210]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[208], [209], [210]
D0570		Enflurane	C3H2ClF5O	3226	Moderate		Inter Info	[312], [313], [314]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[2], [289], [290]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[208], [209], [210]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[211], [321]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[208], [209], [210]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[208], [209], [210]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[208], [209], [210]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[208], [209], [210]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[208], [209], [210]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[2], [289], [290]
D0855		Isoflurane	C3H2ClF5O	3763	Moderate		Inter Info	[312], [313], [314]
D0923		Levorphanol	C17H23NO	5359272	Moderate		Inter Info	[208], [209], [210]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [211], [269], [270]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[208], [209], [210]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[218], [219], [220], [221], [222], [177], [223], [224], [225], [226], [227]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[208], [209], [210]
D1005		Meprobamate	C9H18N2O4	4064	Moderate		Inter Info	[208], [209], [210]
D1014		Metaxalone	C12H15NO3	15459	Moderate		Inter Info	[208], [209], [210]
D1023		Methocarbamol	C11H15NO5	4107	Moderate		Inter Info	[208], [209], [210]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[208], [209], [210]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[208], [209], [210]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[208], [209], [210]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[208], [209], [210]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[218], [219], [220], [221], [222], [177], [223], [224], [225], [226], [227]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[208], [209], [210]
D1197		Oxazepam	C15H11ClN2O2	4616	Moderate		Inter Info	[208], [209], [210]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[208], [209], [210]
D1208		Oxymorphone	C17H19NO4	5284604	Moderate		Inter Info	[208], [209], [210]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[208], [209], [210]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[208], [209], [210]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[340]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [211], [269], [270]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[208], [209], [210]
D1390		Remifentanil	C20H28N2O5	60815	Moderate		Inter Info	[208], [209], [210]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[208], [209], [210]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [211], [269], [270]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[208], [209], [210]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[265], [269], [270]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[2], [289], [290]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[208], [209], [210]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[208], [209], [210]
D0711		Garlic	NA	NA	Minor		Inter Info	[358], [359]
D1527		Tadalafil	C22H19N3O4	110635	Minor		Inter Info	[365], [291]
	Additive neuromuscular blocking effects					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0122		Atracurium	C53H72N2O12+2	47319	Moderate		Inter Info	[235], [236], [237]
D1219		Pancuronium	C35H60N2O4+2	441289	Moderate		Inter Info	[235], [236], [237]
D1684		Vecuronium	C34H57N2O4+	39765	Moderate		Inter Info	[235], [236], [237]
D0343		Cisatracurium	C53H72N2O12+2	62887	Moderate		Inter Info	[235], [236], [237]
D0522		Doxacurium	C56H78N2O16+2	60169	Moderate		Inter Info	[235], [236], [237]
D1420		Rocuronium	C32H53N2O4+	441290	Moderate		Inter Info	[235], [236], [237]
D1510		Succinylcholine	C14H30N2O4+2	5314	Moderate		Inter Info	[235], [236], [237]
	Increased risk of atrioventricular block					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0885		Lacosamide	C13H18N2O3	219078	Moderate		Inter Info	[272]
	Increased risk of bradycardia					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[244]
D0891		Lanreotide	C54H69N11O10S2	71349	Moderate		Inter Info	[273], [274]
D1600		Tofacitinib	C16H20N6O	9926791	Moderate		Inter Info	[10], [299]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[316], [317], [318]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[316], [317], [318]
D1163		Octreotide	C49H66N10O10S2	448601	Moderate		Inter Info	[273], [274]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[316], [317], [318]
	Increased risk of cardiac depression					Drug Num: 17
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204]
D0174		Betaxolol (ophthalmic)	C18H29NO3	2369	Moderate		Inter Info	[181], [190], [198]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204]
D0266		Carteolol (ophthalmic)	C16H24N2O3	2583	Moderate		Inter Info	[181], [190], [198]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204]
D0915		Levobunolol (ophthalmic)	C17H25NO3	39468	Moderate		Inter Info	[181], [190], [198]
D1045		Metipranolol (ophthalmic)	C17H27NO4	31477	Moderate		Inter Info	[181], [190], [198]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Moderate		Inter Info	[181], [190], [198]
	Increased risk of prolong QT interval					Drug Num: 152
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0036		Alfuzosin	C19H27N5O4	2092	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0068		Amitriptyline	C20H23N	2160	Major		Inter Info	[21], [17]
D0072		Amoxapine	C17H16ClN3O	2170	Major		Inter Info	[21], [17]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0097		Apomorphine	C17H17NO2	6005	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0139		Azithromycin	C38H72N2O12	447043	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0067		Amisulpride	C17H27N3O4S	2159	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0112		Asenapine	C17H16ClNO	3036780	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0437		Degarelix	C82H103ClN18O16	16136245	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0452		Deutetrabenazine	C19H27NO3	73437646	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[9], [10], [2], [36]
D0559		Eliglustat	C23H36N2O4	23652731	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0594		Eribulin	C40H59NO11	11354606	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0632		Ezogabine	C16H18FN3O2	121892	Major		Inter Info	[9], [14], [19]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[40], [41], [42]
D0700		Fostemsavir	C25H26N7O8P	11319217	Major		Inter Info	[9], [14], [19]
D0720		Gilteritinib	C29H44N8O3	49803313	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0725		Glasdegib	C21H22N6O	25166913	Major		Inter Info	[9], [14], [19]
D0758		Histrelin	C66H86N18O12	25077993	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0806		Inotuzumab ozogamicin	NA	NA	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[9], [14], [19]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0940		Lithium carbonate	CLi2O3	11125	Major		Inter Info	[9], [14], [19]
D0942		Lofexidine	C11H12Cl2N2O	30668	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Major		Inter Info	[10], [2], [52]
D0965		Macimorelin	C26H30N6O3	9804938	Major		Inter Info	[53], [54], [55]
D1062		Midostaurin	C35H30N4O4	9829523	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[9], [14], [19]
D1189		Osilodrostat	C13H10FN3	44139752	Major		Inter Info	[9], [14], [19]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1215		Paliperidone	C23H27FN4O3	115237	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1230		Pasireotide	C58H66N10O9	9941444	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1232		Pazopanib	C21H23N7O2S	10113978	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1290		Pimavanserin	C25H34FN3O2	10071196	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1302		Pitolisant	C17H26ClNO	9948102	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1404		Rilpivirine	C22H18N6	6451164	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1424		Romidepsin	C24H36N4O6S2	5352062	Major		Inter Info	[9], [14], [19]
D1432		Rucaparib	C19H18FN3O	9931954	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[9], [14], [19]
D1491		Solifenacin	C23H26N2O2	154059	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1522		Sunitinib	C22H27FN4O2	5329102	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1560		Tetrabenazine	C19H27NO3	6018	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Major		Inter Info	[9], [14], [19]
D1651		Triptorelin	C64H82N18O13	25074470	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1673		Valbenazine	C24H38N2O4	24795069	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Major		Inter Info	[9], [10], [2], [60]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0320		Chloroquine	C18H26ClN3	2719	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0324		Chlorpromazine	C17H19ClN2S	2726	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0336		Cilostazol	C20H27N5O2	2754	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[9], [10], [2], [104], [105], [20], [106]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0358		Clofazimine	C27H22Cl2N4	2794	Major		Inter Info	[9], [14], [19]
D0361		Clomipramine	C19H23ClN2	2801	Major		Inter Info	[21], [17]
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Major		Inter Info	[9], [14], [19]
D0446		Desipramine	C18H22N2	2995	Major		Inter Info	[21], [17]
D0467		Dextropropoxyphene	C22H29NO2	10100	Major		Inter Info	[9], [14], [19]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[21], [17]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[9], [10], [2], [108]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0526		Doxepin (topical)	C19H21NO	667477	Major		Inter Info	[109], [21], [17]
D0528		Doxorubicin	C27H29NO11	31703	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[9], [10], [2], [110], [111], [20]
D0584		Epirubicin	C27H29NO11	41867	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0664		Flecainide	C17H20F6N2O3	3356	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0676		Fluoxetine	C17H18F3NO	3386	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0678		Fluphenazine	C22H26F3N3OS	3372	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0682		Flutamide	C11H11F3N2O3	3397	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0694		Foscarnet	CH3O5P	3415	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[87], [113], [96]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Major		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103]
D0737		Goserelin	C59H84N18O14	5311128	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0738		Granisetron	C18H24N4O	5284566	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0751		Halothane	C2HBrClF3	3562	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0787		Ibutilide	C20H36N2O3S	60753	Major		Inter Info	[9], [10], [2], [114]
D0788		Idarubicin	C26H27NO9	42890	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0795		Imipramine	C19H24N2	3696	Major		Inter Info	[21], [17]
D0908		Leuprolide	C59H84N16O12	657181	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0919		Levofloxacin	C18H20FN3O4	149096	Major		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103]
D0979		Maprotiline	C20H23N	4011	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0992		Mefloquine	C17H16F6N2O	4046	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[10], [2], [125]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[9], [10], [2], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [20]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[9], [10], [2], [136]
D1075		Mirtazapine	C17H19N3	4205	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103]
D1137		Nilutamide	C12H10F3N3O4	4493	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1155		Norfloxacin	C16H18FN3O3	4539	Major		Inter Info	[87], [113], [96]
D1158		Nortriptyline	C19H21N	4543	Major		Inter Info	[21], [17]
D1165		Ofloxacin	C18H20FN3O4	4583	Major		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103]
D1181		Ondansetron	C18H19N3O	4595	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1210		Oxytocin	C43H66N12O12S2	439302	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1216		Palonosetron	C19H24N2O	6337614	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1246		Pentamidine	C19H24N4O2	4735	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1254		Perflutren	C3F8	6432	Major		Inter Info	[137], [138]
D1257		Perphenazine	C21H26ClN3OS	4748	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[2], [110], [139], [20]
D1339		Primaquine	C15H21N3O	4908	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1343		Procainamide	C13H21N3O	4913	Major		Inter Info	[21], [17]
D1346		Prochlorperazine	C20H24ClN3S	4917	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1352		Promethazine	C17H20N2S	4927	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1353		Propafenone	C21H27NO3	4932	Major		Inter Info	[140], [141], [142], [143], [144], [145]
D1361		Protriptyline	C19H21N	4976	Major		Inter Info	[21], [17]
D1368		Quetiapine	C21H25N3O2S	5002	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[21], [17]
D1372		Quinine	C20H24N2O2	3034034	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1413		Risperidone	C23H27FN4O2	5073	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1461		Sertraline	C17H17Cl2N	68617	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1463		Sevoflurane	C4H3F7O	5206	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1498		Sotalol	C12H20N2O3S	5253	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1533		Tamoxifen	C26H29NO	2733526	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[40], [76], [148]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[2], [173], [174]
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[9], [10], [2], [175]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1637		Trifluoperazine	C21H24F3N3S	5566	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1682		Vardenafil	C23H32N6O4S	135400189	Major		Inter Info	[176]
D1683		Vasopressin	C46H65N15O12S2	644077	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1689		Venlafaxine	C17H27NO2	5656	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[9], [10], [2], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[9], [10], [2], [110], [177], [20]
D0636		Famotidine	C8H15N7O2S3	5702160	Moderate		Inter Info	[10], [2], [320]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[341], [342], [343], [344], [345], [346], [347], [348], [349], [350]
D1051		Metronidazole	C6H9N3O3	4173	Minor		Inter Info	[10], [361], [362], [363]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Minor		Inter Info	[9], [10], [364]
	Increased risk of ventricular arrhythmias					Drug Num: 29
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0025		Adenosine	C10H13N5O4	60961	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[23], [24]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[2], [47], [48]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Major		Inter Info	[56], [57], [58]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Major		Inter Info	[56], [57], [58]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[10], [59]
D1488		Sodium sulfate	Na2O4S	24436	Major		Inter Info	[56], [57], [58]
D0859		Isoprenaline	C11H17NO3	3779	Major		Inter Info	[115], [116], [117]
D1185		Orciprenaline	C11H17NO3	4086	Major		Inter Info	[115], [116], [117]
D1554		Terbutaline	C12H19NO3	5403	Major		Inter Info	[115], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [116], [167], [168], [169], [170], [117], [171], [172]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[115], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [232], [233], [161], [162], [163], [164], [165], [234], [166], [116], [167], [168], [169], [170], [117], [171], [172]
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[9], [10], [2], [241], [242], [243]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[9], [10], [2], [241], [242], [243]
D0701		Frangula purshiana bark	NA	NA	Moderate		Inter Info	[10], [2], [243]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[9], [10], [2], [241], [242], [243]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[115], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [232], [233], [161], [162], [163], [164], [165], [234], [166], [116], [167], [168], [169], [170], [117], [171], [172]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[10], [2], [243]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[232], [167], [170]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[9], [10], [2], [241], [242], [243]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[9], [10], [2], [241], [242], [243]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[9], [10], [2], [241], [242], [243]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[232], [167], [170]
D1309		Polyethylene glycol (3350)	C2H6O2	174	Moderate		Inter Info	[10], [2], [243]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[232], [167], [170]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[115], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [232], [233], [161], [162], [163], [164], [165], [234], [166], [116], [167], [168], [169], [170], [117], [171], [172]
D0888		Lactulose	C12H22O11	11333	Moderate		Inter Info	[9], [10], [2], [241], [242], [243]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[153], [159], [164]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[115], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [232], [233], [161], [162], [163], [164], [165], [234], [166], [116], [167], [168], [169], [170], [117], [171], [172]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[10], [2], [351]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 32
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[205], [206], [207]
D0187		Bismuth subsalicylate	C7H6BiO4	16682734	Moderate		Inter Info	[205], [206], [207]
D0236		Calcium carbonate	CCaO3	10112	Moderate		Inter Info	[245], [246], [247]
D0238		Calcium citrate	C12H10Ca3O14	13136	Moderate		Inter Info	[245], [246], [247]
D0239		Calcium glubionate anhydrous	C18H32CaO19	64776	Moderate		Inter Info	[245], [246], [247]
D0241		Calcium gluconate	C12H22CaO14	9290	Moderate		Inter Info	[245], [246], [247]
D0243		Calcium lactate	C6H10CaO6	13144	Moderate		Inter Info	[245], [246], [247]
D0244		Calcium Phosphate	Ca3O8P2	24456	Moderate		Inter Info	[245], [246], [247]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[205], [206], [207]
D0549		Edetate calcium disodium anhydrous	C10H12CaN2Na2O8	6093170	Moderate		Inter Info	[245], [246], [247]
D0926		Licorice	C42H62O16Zn	163463	Moderate		Inter Info	[277], [278], [279]
D1272		Phenyl salicylate	C13H10O3	8361	Moderate		Inter Info	[205], [206], [207]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[205], [206], [207]
D0235		Calcium acetate	C4H6CaO4	6116	Moderate		Inter Info	[245], [246], [247]
D0237		Calcium chloride	CaCl2H4O2	24844	Moderate		Inter Info	[245], [246], [247]
D0240		Calcium glucoheptonate	C14H26CaO16	62859	Moderate		Inter Info	[245], [246], [247]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[205], [206], [207]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[205], [206], [207]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[205], [206], [207]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[205], [206], [207]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[205], [206], [207]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[205], [206], [207]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[205], [206], [207]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[205], [206], [207]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[205], [206], [207]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[205], [206], [207]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[205], [206], [207]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[205], [206], [207]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[205], [206], [207]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[205], [206], [207]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[205], [206], [207]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[205], [206], [207]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1905		Tetrofosmin	C18H40O4P2	4274	Moderate		Inter Info	[298]

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354	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
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362	Product Information. Flagyl (metronidazole). Searle, Skokie, IL.
363	Product Information. Pylera (bismuth subcitrate potassium/metronidazo/TCN). Aptalis Pharma, Birmingham, AL.
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365	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
366	Product Information. Zylo Filmtab (zileuton). Abbott Pharmaceutical, Abbott Park, IL.

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