Drug General Information (ID: DDIVI47WPL)
Drug Name			Protriptyline		Drug Info		Bepridil		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antidepressants				Antiarrhythmic Agents
Structure

Mechanism of Protriptyline-Bepridil Interaction (Severity Level: Major)
Increased risk of prolong QT interval Click to Show/Hide Mechanism Graph
Drug Name		Protriptyline				Bepridil
Mechanism		Prolong QT interval				Prolong QT interval
Key Mechanism Factor 1
		Factor Name		QT interval
		Factor Description		Long QT syndrome is a heart signaling disorder that can cause a fast, chaotic heartbeat (arrhythmia). Many people may not exhibit symptoms, and usually the condition is detected during routine medical tests. In others, the most common symptoms include: sudden fainting, palpitations, dizziness, seizures, sudden death.
Mechanism Description		Increased risk of prolong QT interval by the combination of Protriptyline and Bepridil

Recommended Action
Management		The manufacturer considers the concurrent use of other QT interval-prolonging drugs contraindicated with bepridil.

References
1	Hollingshead LM, Faulds D, Fitton A "Bepridil. A review of its pharmacological properties and therapeutic use in stable angina pectoris." Drugs 44 (1992): 835-57. [PMID: 1280569]
2	Product Information. Vascor (bepridil). McNeil Pharmaceutical, Raritan, NJ.