Drug General Information (ID: DDIPJMRAQD)
Drug Name			Telithromycin		Drug Info		Bepridil		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Antiarrhythmic Agents
Structure

Mechanism of Telithromycin-Bepridil Interaction (Severity Level: Major)
Increased risk of prolong QT interval Click to Show/Hide Mechanism Graph
Drug Name		Telithromycin				Bepridil
Mechanism		Prolong QT interval				Prolong QT interval
Key Mechanism Factor 1
		Factor Name		QT interval
		Factor Description		Long QT syndrome is a heart signaling disorder that can cause a fast, chaotic heartbeat (arrhythmia). Many people may not exhibit symptoms, and usually the condition is detected during routine medical tests. In others, the most common symptoms include: sudden fainting, palpitations, dizziness, seizures, sudden death.
Mechanism Description		Increased risk of prolong QT interval by the combination of Telithromycin and Bepridil

Recommended Action
Management		Telithromycin should be avoided in patients treated with class IA (e.g., disopyramide, quinidine, procainamide) or class III (e.g., amiodarone, dofetilide, sotalol) antiarrhythmic agents.

References
1	Ace LN, Jaffe JM, Kunka RL "Effect of food and an antacid on quinidine bioavailability." Biopharm Drug Dispos 4 (1983): 183-90. [PMID: 6882885]
2	Iannini PB "Cardiotoxicity of macrolides, ketolides and fluoroquinolones that prolong the QTc interval." Expert Opin Drug Saf 1 (2002): 121-8. [PMID: 12904146]
3	Product Information. Ketek (telithromycin). Aventis Pharmaceuticals, Bridgewater, NJ.