Drug General Information (ID: DDILOJICWR)
Drug Name			Norfloxacin		Drug Info		Bepridil		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Antiarrhythmic Agents
Structure

Mechanism of Norfloxacin-Bepridil Interaction (Severity Level: Major)
Increased risk of prolong QT interval Click to Show/Hide Mechanism Graph
Drug Name		Norfloxacin				Bepridil
Mechanism		Prolong QT interval				Prolong QT interval
Key Mechanism Factor 1
		Factor Name		QT interval
		Factor Description		Long QT syndrome is a heart signaling disorder that can cause a fast, chaotic heartbeat (arrhythmia). Many people may not exhibit symptoms, and usually the condition is detected during routine medical tests. In others, the most common symptoms include: sudden fainting, palpitations, dizziness, seizures, sudden death.
Mechanism Description		Increased risk of prolong QT interval by the combination of Norfloxacin and Bepridil

Recommended Action
Management		Product labeling for certain quinolones recommends avoiding concomitant therapy with class IA (e.g., disopyramide, quinidine, procainamide) and class III (e.g., amiodarone, dofetilide, ibutilide, sotalol) antiarrhythmic agents, as well as bepridil.

References
1	Owens RC "Risk assessment for antimicrobial agent-induced QTc interval prolongation and torsades de pointes." Pharmacotherapy 21 (2001): 301-19. [PMID: 11253855]
2	Owens RC Jr. QT prolongation with antimicrobial agents: understanding the significance.?Drugs. 2004;64(10):1091-1124. [PMID: 15139788]
3	Product Information. Zagam (sparfloxacin). Rhone-Poulenc Rorer, Collegeville, PA.