Details of Drug

Drug General Information (ID: D0058)
Drug Name	Amiloride
Drug Type	Small molecule
Drug Synonymous	Amiclaran; Amilorida; Amiloridum; Amipramidin; Amipramizid; Amipramizide; Amiprazidine; Amyloride; Guanamprazin; Guanamprazine; Midamor; Amiloride HCL; Amiloride hydrochloride hydrate; Amiclaran (TN); Amikal (Hydrochloride dihydrate); Amilorida [INN-Spanish]; Amiloride (INN); Amiloride [INN:BAN]; Amiloridum [INN-Latin]; Biduret (TN); Midamor (Hydrochloride dihydrate); MK-870 (Hydrochloride dihydrate); AMILORIDE (SEE ALSO: AMILORIDE HCL (2016-88-8)); N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide; N-Amidino-3,5-diamino-6-chlorpyrazincarboxamid; Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, monohydrochloride; 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide; 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide; 3,5-diamino-N-[amino(imino)methyl]-6-chloropyrazine-2-carboxamide; 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide; Amiloride (Na-Ca chanel blocker) Click to Show/Hide
Disease Class	BD10-BD1Z: Heart failure
Therapeutic Class	Diuretics
Structure
Structure	3D Structure		2D Structure
Formula	C6H8ClN7O
InChI	1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)
InChIKey	XSDQTOBWRPYKKA-UHFFFAOYSA-N
Canonical SMILES	C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N
External Link
	Pubchem ID	16231
	CAS Number	2609-46-3
	CHEBI ID	2639
	TTD ID	D0I0RJ
	VARIDT ID	DR00207

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM009 Altered absorption (Unspecific) BM028 Competitive inhibition of renal tubular secretion BM029 Altered urine pH BM032 Decreased renal excretion (Unspecific) BM038 Additive CNS depression effects BM042 Additive hypotensive effects BM058 Increased risk of hyperkalemia BM065 Increased risk of hypokalemia BM066 Increased risk of hypomagnesemia BM067 Increased risk of hyponatremia BM072 Increased risk of nephrotoxicity BM089 Antagonize the effect of antihypertensive agents BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Amiloride
Affected gastrointestinal absorption
	Altered absorption (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0073		Amoxicillin	C16H19N3O5S	33613	Minor		Inter Info	[265]
Affected excretion pathways
	Competitive inhibition of renal tubular secretion					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0513		Dofetilide	C19H27N3O5S2	71329	Moderate		Inter Info	[262]
	Altered urine pH					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1020		Methenamine	C6H12N4	4101	Moderate		Inter Info	[241], [242], [243], [244], [245]
	Decreased renal excretion (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0940		Lithium carbonate	CLi2O3	11125	Major		Inter Info	[50], [51], [52]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[263], [264]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1172		Olopatadine (nasal)	C21H23NO3	5281071	Moderate		Inter Info	[239], [251], [246]
	Additive hypotensive effects					Drug Num: 128
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[61]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[92]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[93], [94], [95]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[93], [94], [95]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[96], [97], [98]
D0067		Amisulpride	C17H27N3O4S	2159	Moderate		Inter Info	[100], [101], [102], [103], [96], [104], [97], [105], [98], [106], [107]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[93], [94], [95]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[108], [109], [110]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[111], [112], [113]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[100], [101], [102], [103], [96], [104], [97], [105], [98], [106], [107]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[100], [101], [102], [103], [96], [104], [97], [105], [98], [106], [107]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[114], [115], [116]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[93], [94], [95]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[100], [101], [102], [103], [96], [104], [97], [105], [98], [106], [107]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[93], [94], [95]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[93], [94], [95]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[143], [144], [145]
D0311		Chloral hydrate	C2H3Cl3O2	2707	Moderate		Inter Info	[93], [94], [95]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[93], [94], [95]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[93], [94], [95]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[93], [94], [95]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[143], [144], [145]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[143], [148], [149]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[93], [94], [95]
D0471		Diamorphine	C21H23NO5	5462328	Moderate		Inter Info	[93], [94], [95]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[93], [94], [95]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[93], [94], [95]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Moderate		Inter Info	[93], [94], [95]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[93], [94], [95]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[93], [94], [95]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[143], [144], [145]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[144], [161], [162]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[93], [94], [95]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[216], [217]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[93], [94], [95]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[93], [94], [95]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[143], [144], [218]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[93], [94], [95]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[100], [101], [102], [103], [96], [104], [97], [105], [98], [106], [107]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[144], [161], [162]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [216], [232], [233]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[108], [109], [234]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [216], [232], [233]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[144], [238], [239]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[100], [101], [102], [103], [96], [104], [97], [105], [98], [106], [107]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[100], [101], [102], [103], [96], [104], [97], [105], [98], [106], [107]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[93], [94], [95]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[240]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[93], [94], [95]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[100], [101], [102], [103], [96], [104], [97], [105], [98], [106], [107]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[100], [101], [102], [103], [96], [104], [97], [105], [98], [106], [107]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[100], [101], [102], [103], [96], [104], [97], [105], [98], [106], [107]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[93], [94], [95]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[100], [101], [102], [103], [96], [104], [97], [105], [98], [106], [107]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[93], [94], [95]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[246], [247], [239]
D1148		Nitrous acid	HNO2	24529	Moderate		Inter Info	[248], [249], [250]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[93], [94], [95]
D1183		Opium	NA	NA	Moderate		Inter Info	[93], [94], [95]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[93], [94], [95]
D1197		Oxazepam	C15H11ClN2O2	4616	Moderate		Inter Info	[93], [94], [95]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [216], [232], [233]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[100], [101], [102], [103], [96], [104], [97], [105], [98], [106], [107]
D1224		Paraldehyde	C6H12O3	31264	Moderate		Inter Info	[93], [94], [95]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[93], [94], [95]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[253]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[100], [101], [102], [103], [96], [104], [97], [105], [98], [106], [107]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [216], [232], [233]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[93], [94], [95]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [216], [232], [233]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[100], [101], [102], [103], [96], [104], [97], [105], [98], [106], [107]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[100], [101], [102], [103], [96], [104], [97], [105], [98], [106], [107]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[100], [101], [102], [103], [96], [104], [97], [105], [98], [106], [107]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [216], [232], [233]
D1391		Remimazolam	C21H19BrN4O2	9867812	Moderate		Inter Info	[93], [94], [95]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[256]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[100], [101], [102], [103], [96], [104], [97], [105], [98], [106], [107]
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [216], [232], [233]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [216], [232], [233]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[144], [161], [162]
D1485		Sodium oxybate	C4H7NaO3	23663870	Moderate		Inter Info	[93], [94], [95]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[93], [94], [95]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[100], [101], [102], [103], [96], [104], [97], [105], [98], [106], [107]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[100], [101], [102], [103], [96], [104], [97], [105], [98], [106], [107]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [216], [232], [233]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[93], [94], [95]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[100], [101], [102], [103], [96], [104], [97], [105], [98], [106], [107]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[114], [115], [116]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[93], [94], [95]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[93], [94], [95]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[93], [94], [95]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[93], [94], [95]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[111], [112], [113]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[111], [112], [113]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[93], [94], [95]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[93], [94], [95]
D0228		Cabergoline	C26H37N5O2	54746	Moderate		Inter Info	[93], [94], [95]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[93], [94], [95]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[100], [101], [102], [103], [96], [104], [97], [105], [98], [106], [107]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[100], [101], [102], [103], [96], [104], [97], [105], [98], [106], [107]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[93], [94], [95]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[100], [101], [102], [103], [96], [104], [97], [105], [98], [106], [107]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[93], [94], [95]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[93], [94], [95]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[93], [94], [95]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[93], [94], [95]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[100], [101], [102], [103], [96], [104], [97], [105], [98], [106], [107]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[93], [94], [95]
D1005		Meprobamate	C9H18N2O4	4064	Moderate		Inter Info	[93], [94], [95]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[93], [94], [95]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[93], [94], [95]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[93], [94], [95]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[93], [94], [95]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[93], [94], [95]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[100], [101], [102], [103], [96], [104], [97], [105], [98], [106], [107]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[93], [94], [95]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[100], [101], [102], [103], [96], [104], [97], [105], [98], [106], [107]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[100], [101], [102], [103], [96], [104], [97], [105], [98], [106], [107]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[93], [94], [95]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[114], [115], [116]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[93], [94], [95]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[100], [101], [102], [103], [96], [104], [97], [105], [98], [106], [107]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[144], [161], [162]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[100], [101], [102], [103], [96], [104], [97], [105], [98], [106], [107]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[100], [101], [102], [103], [96], [104], [97], [105], [98], [106], [107]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[93], [94], [95]
D0711		Garlic	NA	NA	Minor		Inter Info	[269], [270]
D1527		Tadalafil	C22H19N3O4	110635	Minor		Inter Info	[271], [272]
	Increased risk of hyperkalemia					Drug Num: 39
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0254		Captopril	C9H15NO3S	44093	Major		Inter Info	[23], [25], [26], [16], [27], [15], [28], [29], [10], [30], [11], [31], [13], [32], [24], [2], [3], [4], [33], [34], [5], [17], [35], [36], [37], [38], [39], [40], [7], [9], [20], [21], [22], [41], [42], [43], [44], [45], [46], [47], [48]
D0585		Eplerenone	C24H30O6	443872	Major		Inter Info	[5], [49]
D0587		Eprosartan	C23H24N2O4S	5281037	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0844		Irbesartan	C25H28N6O	3749	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0938		Lisinopril	C21H31N3O5	5362119	Major		Inter Info	[23], [25], [26], [16], [27], [15], [28], [29], [10], [30], [11], [31], [13], [32], [24], [2], [3], [4], [33], [34], [5], [17], [35], [36], [37], [38], [39], [40], [7], [9], [20], [21], [22], [41], [42], [43], [44], [45], [46], [47], [48]
D0954		Losartan	C22H23ClN6O	3961	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D1082		Moexipril	C27H34N2O7	91270	Major		Inter Info	[23], [25], [26], [16], [27], [15], [28], [29], [10], [30], [11], [31], [13], [32], [24], [2], [3], [4], [33], [34], [5], [17], [35], [36], [37], [38], [39], [40], [7], [9], [20], [21], [22], [41], [42], [43], [44], [45], [46], [47], [48]
D1086		Monopotassium phosphate	H2KO4P	516951	Major		Inter Info	[53], [3], [16]
D1256		Perindopril	C19H32N2O5	107807	Major		Inter Info	[23], [25], [26], [16], [27], [15], [28], [29], [10], [30], [11], [31], [13], [32], [24], [2], [3], [4], [33], [34], [5], [17], [35], [36], [37], [38], [39], [40], [7], [9], [20], [21], [22], [41], [42], [43], [44], [45], [46], [47], [48]
D1316		Potassium acetate	C2H3KO2	517044	Major		Inter Info	[3], [2], [5], [39], [17], [53], [54], [22], [21], [55], [56], [57], [37], [58], [23], [29], [16], [13], [20], [59], [15], [28]
D1317		Potassium bicarbonate	CHKO3	516893	Major		Inter Info	[3], [2], [5], [39], [17], [53], [54], [22], [21], [55], [56], [57], [37], [58], [23], [29], [16], [13], [20], [59], [15], [28]
D1318		Potassium chloride	ClK	4873	Major		Inter Info	[3], [2], [5], [39], [17], [53], [54], [22], [21], [55], [56], [57], [37], [58], [23], [29], [16], [13], [20], [59], [15], [28]
D1319		Potassium citrate	C6H5K3O7	13344	Major		Inter Info	[3], [2], [5], [39], [17], [53], [54], [22], [21], [55], [56], [57], [37], [58], [23], [29], [16], [13], [20], [59], [15], [28]
D1320		Potassium gluconate	C6H11KO7	16760467	Major		Inter Info	[3], [2], [5], [39], [17], [53], [54], [22], [21], [55], [56], [57], [37], [58], [23], [29], [16], [13], [20], [59], [15], [28]
D1322		Potassium perchlorate	ClKO4	516900	Major		Inter Info	[3], [2], [5], [39], [17], [53], [54], [22], [21], [55], [56], [57], [37], [58], [23], [29], [16], [13], [20], [59], [15], [28]
D1369		Quinapril	C25H30N2O5	54892	Major		Inter Info	[23], [25], [26], [16], [27], [15], [28], [29], [10], [30], [11], [31], [13], [32], [24], [2], [3], [4], [33], [34], [5], [17], [35], [36], [37], [38], [39], [40], [7], [9], [20], [21], [22], [41], [42], [43], [44], [45], [46], [47], [48]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[20], [60], [1], [5]
D1545		Telmisartan	C33H30N4O2	65999	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0156		Benazepril	C24H28N2O5	5362124	Major		Inter Info	[23], [25], [26], [16], [27], [15], [28], [29], [10], [30], [11], [31], [13], [32], [24], [2], [3], [4], [33], [34], [5], [17], [35], [36], [37], [38], [39], [40], [7], [9], [20], [21], [22], [41], [42], [43], [44], [45], [46], [47], [48]
D0567		Enalapril	C20H28N2O5	5388962	Major		Inter Info	[23], [25], [26], [16], [27], [15], [28], [29], [10], [30], [11], [31], [13], [32], [24], [2], [3], [4], [33], [34], [5], [17], [35], [36], [37], [38], [39], [40], [7], [9], [20], [21], [22], [41], [42], [43], [44], [45], [46], [47], [48]
D0695		Fosinopril	C30H46NO7P	55891	Major		Inter Info	[23], [25], [26], [16], [27], [15], [28], [29], [10], [30], [11], [31], [13], [32], [24], [2], [3], [4], [33], [34], [5], [17], [35], [36], [37], [38], [39], [40], [7], [9], [20], [21], [22], [41], [42], [43], [44], [45], [46], [47], [48]
D1170		Olmesartan	C24H26N6O3	158781	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D1379		Ramipril	C23H32N2O5	5362129	Major		Inter Info	[23], [25], [26], [16], [27], [15], [28], [29], [10], [30], [11], [31], [13], [32], [24], [2], [3], [4], [33], [34], [5], [17], [35], [36], [37], [38], [39], [40], [7], [9], [20], [21], [22], [41], [42], [43], [44], [45], [46], [47], [48]
D1501		Spironolactone	C24H32O4S	5833	Major		Inter Info	[54], [62], [1]
D1618		Trandolapril	C24H34N2O5	5484727	Major		Inter Info	[23], [25], [26], [16], [27], [15], [28], [29], [10], [30], [11], [31], [13], [32], [24], [2], [3], [4], [33], [34], [5], [17], [35], [36], [37], [38], [39], [40], [7], [9], [20], [21], [22], [41], [42], [43], [44], [45], [46], [47], [48]
D1631		Triamterene	C12H11N7	5546	Major		Inter Info	[54], [62], [1]
D1645		Trimethoprim	C14H18N4O3	5578	Major		Inter Info	[63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [21], [55], [77], [78], [79], [80], [81], [82], [83], [15], [28], [84], [20], [5], [85], [86], [87], [88], [89], [90], [91]
D1679		Valsartan	C24H29N5O3	60846	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[99]
D0414		Dalteparin	C26H42N2O37S5	772	Moderate		Inter Info	[144], [143], [147]
D0415		Danaparoid	NA	NA	Moderate		Inter Info	[144], [143], [147]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[160], [29]
D0574		Enoxaparin	C26H42N2O37S5	772	Moderate		Inter Info	[144], [143], [147]
D0753		Heparin	C26H42N2O37S5	772	Moderate		Inter Info	[144], [143], [147]
D1249		Pentosan polysulfate	C10H18O21S4	37720	Moderate		Inter Info	[252], [144], [143]
D1588		Tinzaparin	C26H42N2O37S5	772	Moderate		Inter Info	[144], [143], [147]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[257]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[5], [260], [261], [20]
	Increased risk of hypokalemia					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0490		Digitoxin	C41H64O13	441207	Moderate		Inter Info	[151], [152], [132], [153], [154], [155], [156], [157], [158], [159]
	Increased risk of hyponatremia					Drug Num: 15
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[163], [164], [93], [165], [166], [94], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[215]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[163], [164], [93], [165], [166], [94], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[163], [164], [93], [165], [166], [94], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[163], [164], [93], [165], [166], [94], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[163], [164], [93], [165], [166], [94], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[163], [164], [93], [165], [166], [94], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[163], [164], [93], [165], [166], [94], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[163], [164], [93], [165], [166], [94], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[258], [259]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[163], [164], [93], [165], [166], [94], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[163], [164], [93], [165], [166], [94], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[163], [164], [93], [165], [166], [94], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[163], [164], [93], [165], [166], [94], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[163], [164], [93], [165], [166], [94], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214]
	Increased risk of nephrotoxicity					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0831		Iodipamide	C20H14I6N2O6	3739	Moderate		Inter Info	[219], [220], [221]
D0832		Iodixanol	C35H44I6N6O15	3724	Moderate		Inter Info	[219], [220], [221]
D0833		Iohexol	C19H26I3N3O9	3730	Moderate		Inter Info	[219], [220], [221]
D0834		Iopamidol	C17H22I3N3O8	65492	Moderate		Inter Info	[219], [220], [221]
D0836		Iopromide	C18H24I3N3O8	3736	Moderate		Inter Info	[219], [220], [221]
D0837		Iothalamic acid	C11H9I3N2O4	3737	Moderate		Inter Info	[219], [220], [221]
D0838		Ioversol	C18H24I3N3O9	3741	Moderate		Inter Info	[219], [220], [221]
D0839		Ioxilan	C18H24I3N3O8	3743	Moderate		Inter Info	[219], [220], [221]
D0472		Diatrizoate	C11H9I3N2O4	2140	Moderate		Inter Info	[219], [220], [221]
D0441		Demeclocycline	C21H21ClN2O8	54680690	Minor		Inter Info	[266], [267], [268]
D1070		Minocycline	C23H27N3O7	54675783	Minor		Inter Info	[266], [267], [268]
D1209		Oxytetracycline	C22H24N2O9	54675779	Minor		Inter Info	[266], [267], [268]
D1564		Tetracycline	C22H24N2O8	54675776	Minor		Inter Info	[266], [267], [268]
D0530		Doxycycline	C22H24N2O8	54671203	Minor		Inter Info	[266], [267], [268]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[117], [118], [119]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[117], [118], [119]
D0701		Frangula purshiana bark	NA	NA	Moderate		Inter Info	[117], [118], [119]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[117], [118], [119]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[117], [118], [119]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[117], [118], [119]
D1266		Phenolphthalein	C20H14O4	4764	Moderate		Inter Info	[117], [118], [119]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[6], [254], [255]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[6], [254], [255]
D1309		Polyethylene glycol (3350)	C2H6O2	174	Moderate		Inter Info	[117], [118], [119]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[6], [254], [255]
D0888		Lactulose	C12H22O11	11333	Moderate		Inter Info	[117], [118], [119]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 35
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[120], [121], [25], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [5], [133], [134], [20], [135], [136], [137], [138], [139], [140], [141], [142]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[144], [146]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[144], [146]
D0460		Dexmethylphenidate	C14H19NO2	154101	Moderate		Inter Info	[143], [144], [150]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[120], [121], [25], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [5], [133], [134], [20], [135], [136], [137], [138], [139], [140], [141], [142]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[120], [121], [25], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [5], [133], [134], [20], [135], [136], [137], [138], [139], [140], [141], [142]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[120], [121], [25], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [5], [133], [134], [20], [135], [136], [137], [138], [139], [140], [141], [142]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[144], [146]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[120], [121], [25], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [5], [133], [134], [20], [135], [136], [137], [138], [139], [140], [141], [142]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[120], [121], [25], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [5], [133], [134], [20], [135], [136], [137], [138], [139], [140], [141], [142]
D0926		Licorice	C42H62O16Zn	163463	Moderate		Inter Info	[235], [236], [237]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[120], [121], [25]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[120], [121], [25], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [5], [133], [134], [20], [135], [136], [137], [138], [139], [140], [141], [142]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[120], [121], [25], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [5], [133], [134], [20], [135], [136], [137], [138], [139], [140], [141], [142]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[144], [146]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[120], [121], [25], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [5], [133], [134], [20], [135], [136], [137], [138], [139], [140], [141], [142]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[120], [121], [25], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [5], [133], [134], [20], [135], [136], [137], [138], [139], [140], [141], [142]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[120], [121], [25], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [5], [133], [134], [20], [135], [136], [137], [138], [139], [140], [141], [142]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[144], [146]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[144], [146]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[120], [121], [25], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [5], [133], [134], [20], [135], [136], [137], [138], [139], [140], [141], [142]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[144], [146]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[144], [146]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[144], [146]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[120], [121], [25], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [5], [133], [134], [20], [135], [136], [137], [138], [139], [140], [141], [142]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[120], [121], [25], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [5], [133], [134], [20], [135], [136], [137], [138], [139], [140], [141], [142]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[120], [121], [25], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [5], [133], [134], [20], [135], [136], [137], [138], [139], [140], [141], [142]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[120], [121], [25], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [5], [133], [134], [20], [135], [136], [137], [138], [139], [140], [141], [142]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[120], [121], [25], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [5], [133], [134], [20], [135], [136], [137], [138], [139], [140], [141], [142]
D1039		Methylphenidate	C14H19NO2	4158	Moderate		Inter Info	[143], [144], [150]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[120], [121], [25], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [5], [133], [134], [20], [135], [136], [137], [138], [139], [140], [141], [142]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[120], [121], [25], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [5], [133], [134], [20], [135], [136], [137], [138], [139], [140], [141], [142]
D1421		Rofecoxib	C17H14O4S	5090	Moderate		Inter Info	[120], [121], [25], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [5], [133], [134], [20], [135], [136], [137], [138], [139], [140], [141], [142]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[120], [121], [25], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [5], [133], [134], [20], [135], [136], [137], [138], [139], [140], [141], [142]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[120], [121], [25], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [5], [133], [134], [20], [135], [136], [137], [138], [139], [140], [141], [142]

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