Drug General Information (ID: DDIBFNUEGC)
Drug Name			Methylphenidate		Drug Info		Amiloride		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Cns Stimulants				Diuretics
Structure

Mechanism of Methylphenidate-Amiloride Interaction (Severity Level: Moderate)
Antagonize the effect of antihypertensive agents Click to Show/Hide Mechanism Graph
Drug Name		Methylphenidate				Amiloride
Mechanism		Hypertensive effects				Antihypertensive agent Guanylate cyclase  Agonist
Key Mechanism Factor 1
		Factor Name		Guanylate cyclase soluble				Structure Sequence
		Protein Family		Adenylyl cyclase class-4/guanylyl cyclase family
		Protein Function		There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms. Activated by nitric oxide in the presence of magnesium or manganese ions.     Click to Show/Hide
Mechanism Description		Antagonize the effect of Methylphenidate when combined with Amiloride

Recommended Action
Management		Caution and monitoring of blood pressure is recommended if methylphenidate, dexmethylphenidate or serdexmethylphenidate are administered with antihypertensives agents such as: potassium-sparing and thiazide diuretics, calcium channel blockers, angiotensin-converting-enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), beta blockers or centrally acting alpha-2 receptor agonists. The dosage of the antihypertensive drug should be adjusted as needed.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Azstarys (dexmethylphenidate-serdexmethylphenidate). Corium, Inc., Grand Rapids, MI.