Drug General Information (ID: DDIY4MCLZE)
Drug Name			Amiloride		Drug Info		Lithium carbonate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Diuretics				Antimanic Agents
Structure

Mechanism of Amiloride-Lithium carbonate Interaction (Severity Level: Major)
Decreased renal excretion (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Amiloride				Lithium carbonate
Mechanism		Decrease renal clearance of lithium				Lithium salt
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the excretion of the drug, resulting in changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Decreased renal excretion of Lithium carbonate caused by Amiloride

Recommended Action
Management		Concurrent use of diuretics and lithium should generally be avoided. Extreme caution is recommended if amiloride and lithium must be used together. Lithium levels should be monitored daily and lithium dose reductions may be required. Patients should be advised to notify their physician if they experience drowsiness, dizziness, weakness, ataxia, vomiting, diarrhea, tinnitus,tremor, thirst, blurry vision, or increased urination.

References
1	Dorevitch A, Baruch E "Lithium toxicity induced by combined amiloride HCl- hydrochlorothiazide administration." Am J Psychiatry 143 (1986): 257-8. [PMID: 3080908]
2	Product Information. Eskalith (lithium). SmithKline Beecham, Philadelphia, PA.
3	Vipond AJ, Bakewell S, Telford R, Nicholls AJ "Lithium toxicity." Anaesthesia 51 (1996): 1156-8. [PMID: 9038456]