Drug General Information (ID: DDIUJPXZ5A)
  Drug Name Amiloride Drug Info Amoxicillin Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Diuretics Antibiotics
  Structure

 Mechanism of Amiloride-Amoxicillin Interaction (Severity Level: Minor)
     Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph
      Drug Name Amiloride Amoxicillin
      Mechanism Decrease the absorption and the bioavailability of amoxicillin Amoxicillin
      Key Mechanism Factor 1
Factor Name Pharmacokinetic
Factor Description Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
      Mechanism Description
  • Altered absorption of Amoxicillin caused by Amiloride 

References
1 Westphal JF, Jehl F, Brogard JM, Carbon C "Amoxicillin intestinal absorption reduction by amiloride: possible role of the na+-h+ exchanger." Clin Pharmacol Ther 57 (1995): 257-64. [PMID: 7697943]