Details of Drug

Details of Drug

 Drug General Information (ID: D1801)
  Drug Name
Glucagon
  Drug Type Hormones
  Drug Synonymous
glucagon|Glucagonum|Glucagone|His-ser-glu(nh2)-gly-thr-phe-thr-ser-asp-tyr-ser-lys-tyr-leu-asp-ser-arg-arg-ala-glu(NH2)-asp-phe-val-glu(NH2)-trp-leu-met-asp(NH2)-thr|Glucagon-like-immunoreactivity|Glucaton|Bovine glucagon|Human glucagon|Glukagon Novo|Glucagon, pig|Glucagon (dog)|Glucagon (pig)|Glucagon (ox)|Big plasma glucagon|Glucagone [DCIT]|Glucagonum [INN-Latin]|L-histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-alpha-aspartyl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-glutaminyl-L-alpha-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-L-threonine|Glucagon (Xenopus laevis)|Glucagon (Saimiri sciureus)|Glucagon (Mesocricetus auratus)|Glucagon, porcine, for bioassay|Glucagon [USP:INN:BAN:JAN]|SCHEMBL15268863|Gut glucagon-like immunoreactants|HSDB 3337|DTXSID101016809|Glucagon, porcine, for immunoassay|HSQGTFTSDYSKYLDSRRAQDFVQWLMNT|EINECS 232-708-2|NCGC00167140-01|Glucagon, acetate salt, >=97.0% (HPLC)|Human glucagon, European Pharmacopoeia (EP) Reference Standard|His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr|L-Threonine, L-histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-.alpha.-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-.alpha.-aspartyl-L-seryl-L-arginyl-L-argin yl-L-alanyl-L-glutaminyl-L-.alpha.-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-|L-Threonine, L-histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-alpha-aspartyl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-glytaminyl-L-alpha-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-
    Click to Show/Hide
  Disease Class 5A41: Hypo-glycaemia
  Therapeutic Class Hormone Modulators/Antidiabetic Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C153H225N43O49S
  InChI InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1
  InChIKey MASNOZXLGMXCHN-ZLPAWPGGSA-N
  Canonical SMILES C[C@H]([C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC5=CNC6=CC=CC=C65)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)O)NC(=O)CNC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC7=CN=CN7)N)O
  External Link
Pubchem ID 16132283
TTD ID D06ZEC

Drug-Drug Interaction Network
  Sunburst Graph
AM004  Affected intra/extra-hepatic metabolism
AM007  Pharmacodynamic antagonistic effects
BM026  Increased metabolism (Unspecific)
BM086  Antagonize the effect of antidiabetic agents
  Relation Graph
 Full list of drugs interacting with Glucagon
      Affected intra/extra-hepatic metabolism
   Increased metabolism (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0800
 
Indomethacin
 
C19H16ClNO4
 
3715 
Moderate    Inter Info   
[1], [2]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of antidiabetic agents Drug Num:  20
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0010
 
Acebutolol
 
C18H28N2O4
 
1978 
Minor    Inter Info   
[3], [4], [5]
D0117
 
Atenolol
 
C14H22N2O3
 
2249 
Minor    Inter Info   
[3], [4], [5]
D0173
 
Betaxolol
 
C18H29NO3
 
2369 
Minor    Inter Info   
[3], [4], [5]
D0174
 
Betaxolol (ophthalmic)
 
C18H29NO3
 
2369 
Minor    Inter Info   
[3], [4], [5]
D0188
 
Bisoprolol
 
C18H31NO4
 
2405 
Minor    Inter Info   
[3], [4], [5]
D0265
 
Carteolol
 
C16H24N2O3
 
2583 
Minor    Inter Info   
[3], [4], [5]
D0266
 
Carteolol (ophthalmic)
 
C16H24N2O3
 
2583 
Minor    Inter Info   
[3], [4], [5]
D0267
 
Carvedilol
 
C24H26N2O4
 
2585 
Minor    Inter Info   
[3], [4], [5]
D0602
 
Esmolol
 
C16H25NO4
 
59768 
Minor    Inter Info   
[3], [4], [5]
D0884
 
Labetalol
 
C19H24N2O3
 
3869 
Minor    Inter Info   
[3], [4], [5]
D0914
 
Levobetaxolol (ophthalmic)
 
C18H29NO3
 
60657 
Minor    Inter Info   
[3], [4], [5]
D0915
 
Levobunolol (ophthalmic)
 
C17H25NO3
 
39468 
Minor    Inter Info   
[3], [4], [5]
D1045
 
Metipranolol (ophthalmic)
 
C17H27NO4
 
31477 
Minor    Inter Info   
[3], [4], [5]
D1049
 
Metoprolol
 
C15H25NO3
 
4171 
Minor    Inter Info   
[3], [4], [5]
D1098
 
Nadolol
 
C17H27NO4
 
39147 
Minor    Inter Info   
[3], [4], [5]
D1244
 
Penbutolol
 
C18H29NO2
 
37464 
Minor    Inter Info   
[3], [4], [5]
D1293
 
Pindolol
 
C14H20N2O2
 
4828 
Minor    Inter Info   
[3], [4], [5]
D1357
 
Propranolol
 
C16H21NO2
 
4946 
Minor    Inter Info   
[3], [4], [5]
D1585
 
Timolol
 
C13H24N4O3S
 
33624 
Minor    Inter Info   
[3], [4], [5]
D1586
 
Timolol (ophthalmic)
 
C13H24N4O3S
 
33624 
Minor    Inter Info   
[3], [4], [5]
References
1 Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
2 Product Information. Indocin (indomethacin). Merck &amp Co, Inc, West Point, PA.
3 Smith RC, Wilkinson J, Hull RL "Glucagon for propranolol overdose." JAMA 254 (1985): 2412. [PMID: 4046162]
4 Smith RC, Wilkinson DO, Hull RL "Glucagon for propranolol overdose." JAMA 254 (1985): 2412. [PMID: 4046162]
5 Mills GA, Horn JR "B-blockers and glucose control." Drug Intell Clin Pharm 19 (1985): 246-51. [PMID: 2861072]