Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDI58SLCZM)
  Drug Name Glucagon Drug Info Penbutolol Drug Info
  Drug Type Hormones Small molecule
  Therapeutic Class Hormone Modulators/Antidiabetic Agents Antihypertensive Agents
  Structure

 Mechanism of Glucagon-Penbutolol Interaction (Severity Level: Minor)
     Antagonize the effect of antidiabetic agents Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Glucagon Penbutolol
      Mechanism 1 Antidiabetic agent Hyperglycemia
      Key Mechanism Factor 1
Factor Name Antidiabetic agents
Factor Description The hypoglycemic effect of antidiabetes may be reduced, leading to higher blood glucose, increased blood glucose fluctuations, and the possibility of hyperglycemic complications
      Mechanism Description
  • Antagonize the effect of Glucagon when combined with Penbutolol 
      Mechanism 2 Antidiabetic agent Hyperglycemic effects
      Key Mechanism Factor 2
Factor Name Antidiabetic agents
Factor Description The hypoglycemic effect of antidiabetes may be reduced, leading to higher blood glucose, increased blood glucose fluctuations, and the possibility of hyperglycemic complications
      Mechanism Description
  • Antagonize the effect of Glucagon when combined with Penbutolol 

References
1 Smith RC, Wilkinson J, Hull RL "Glucagon for propranolol overdose." JAMA 254 (1985): 2412. [PMID: 4046162]
2 Smith RC, Wilkinson DO, Hull RL "Glucagon for propranolol overdose." JAMA 254 (1985): 2412. [PMID: 4046162]
3 Mills GA, Horn JR "B-blockers and glucose control." Drug Intell Clin Pharm 19 (1985): 246-51. [PMID: 2861072]