Drug General Information (ID: DDITYMCGE0)
Drug Name			Glucagon		Drug Info		Propranolol		Drug Info
Drug Type		Hormones				Small molecule
Therapeutic Class		Hormone Modulators/Antidiabetic Agents				Antianxiety Agents
Structure

Mechanism of Glucagon-Propranolol Interaction (Severity Level: Minor)
Antagonize the effect of antidiabetic agents Click to Show/Hide Mechanism Graph
Drug Name		Glucagon				Propranolol
Mechanism 1		Antidiabetic agent				Hyperglycemia
Key Mechanism Factor 1
		Factor Name		Antidiabetic agents
		Factor Description		The hypoglycemic effect of antidiabetes may be reduced, leading to higher blood glucose, increased blood glucose fluctuations, and the possibility of hyperglycemic complications
Mechanism Description		Antagonize the effect of Glucagon when combined with Propranolol
Mechanism 2		Antidiabetic agent				Hyperglycemic effects
Key Mechanism Factor 2
		Factor Name		Antidiabetic agents
		Factor Description		The hypoglycemic effect of antidiabetes may be reduced, leading to higher blood glucose, increased blood glucose fluctuations, and the possibility of hyperglycemic complications
Mechanism Description		Antagonize the effect of Glucagon when combined with Propranolol

References
1	Smith RC, Wilkinson J, Hull RL "Glucagon for propranolol overdose." JAMA 254 (1985): 2412. [PMID: 4046162]
2	Smith RC, Wilkinson DO, Hull RL "Glucagon for propranolol overdose." JAMA 254 (1985): 2412. [PMID: 4046162]
3	Mills GA, Horn JR "B-blockers and glucose control." Drug Intell Clin Pharm 19 (1985): 246-51. [PMID: 2861072]