Details of Drug

Drug General Information (ID: D1635)
Drug Name	Triethylenetetramine
Drug Type	Small molecule
Drug Synonymous	Trientine HCl; 21121-06-2; triethylenetetramine HCl; SMR000058543; AC1NUQ0M; MLS000069683; SCHEMBL205201; CHEMBL1200783; CTK0I9735; DTXSID80419994; XPVOJYDIBHYVFL-UHFFFAOYSA-N; Pharmakon1600-01505675; NSC759164; NSC158271; AKOS027276425; NSC-158271; NSC-759164; 1, N,N'-bis(2-aminoethyl)-, tetrahydrochloride; 1,2-Ethanediamine, N,N'-bis(2-aminoethyl)-, hydrochloride; N'-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine hydrochloride Click to Show/Hide
Disease Class	5C50-5C59: Inborn metabolism deficiency
Therapeutic Class	Chelating Agents
Structure
Structure	3D Structure		2D Structure
Formula	C6H18N4
InChI	1S/C6H18N4/c7-1-3-9-5-6-10-4-2-8/h9-10H,1-8H2
InChIKey	VILCJCGEZXAXTO-UHFFFAOYSA-N
Canonical SMILES	C(CNCCNCCN)N
External Link
	Pubchem ID	5565
	CAS Number	112-24-3
	CHEBI ID	39501
	TTD ID	D09VAZ

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption BM003 Complex formation
Relation Graph

Full list of drugs interacting with Triethylenetetramine
Affected gastrointestinal absorption
	Complex formation					Drug Num: 27
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0235		Calcium acetate	C4H6CaO4	6116	Moderate		Inter Info	[1]
D0236		Calcium carbonate	CCaO3	10112	Moderate		Inter Info	[1]
D0847		Iron	Fe	23925	Moderate		Inter Info	[1]
D0974		Magnesium oxide	MgO	14792	Moderate		Inter Info	[1]
D0976		Manganese (chloride)	Mn	23930	Moderate		Inter Info	[1]
D0977		Manganese (sulfate)	Mn	23930	Moderate		Inter Info	[1]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[2], [3], [4]
D0238		Calcium citrate	C12H10Ca3O14	13136	Moderate		Inter Info	[1]
D0239		Calcium glubionate anhydrous	C18H32CaO19	64776	Moderate		Inter Info	[1]
D0241		Calcium gluconate	C12H22CaO14	9290	Moderate		Inter Info	[1]
D0243		Calcium lactate	C6H10CaO6	13144	Moderate		Inter Info	[1]
D0244		Calcium Phosphate	Ca3O8P2	24456	Moderate		Inter Info	[1]
D0390		Copper gluconate	C12H22CuO14	10692	Moderate		Inter Info	[1]
D0649		Ferrous fumarate	C4H2FeO4	6433164	Moderate		Inter Info	[1]
D0650		Ferrous gluconate	C12H22FeO14	23616740	Moderate		Inter Info	[1]
D0651		Ferrous sulfate anhydrous	FeO4S	24393	Moderate		Inter Info	[1]
D0849		Iron protein succinylate	NA	NA	Moderate		Inter Info	[1]
D0968		Magnesium carbonate	CMgO3	11029	Moderate		Inter Info	[1]
D0969		Magnesium chloride	Cl2H12MgO6	643991	Moderate		Inter Info	[1]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[1]
D0971		Magnesium gluconate	C12H22MgO14	11418570	Moderate		Inter Info	[1]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[1]
D1456		Selenium	Se	6326970	Moderate		Inter Info	[1]
D1566		Tetraferric tricitrate decahydrate	C18H32Fe4O31	90478690	Moderate		Inter Info	[1]
D1722		Zinc acetate	C4H6O4Zn	11192	Minor		Inter Info	[5], [6], [7]
D1724		Zinc gluconate	C12H22O14Zn	443445	Minor		Inter Info	[5], [6], [7]
D1725		Zinc sulfate	O4SZn	24424	Minor		Inter Info	[5], [6], [7]

References
1	Product Information. Syprine (trientine). Aton Pharma, Lawrenceville, NJ.
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Multum Information Services, Inc. Expert Review Panel.
4	Ray K, Dorman S, Watson R "Severe hyperkalaemia due to the concomitant use of salt substitutes and ACE inhibitors in hypertension: a potentially life threatening interaction." J Hum Hypertens 13 (1999): 717-20. [PMID: 10516744]
5	Brewer GJ "Practical recommendations and new therapies for Wilson's disease." Drugs 50 (1995): 240-9. [PMID: 8521757]
6	Brewer GJ, Yuzbasiyan-Gurkan V, Johnson V, Dick RD, Wang Y "Treatment of Wilson's disease with zinc: XI. Interaction with other anticopper agents." J Am Coll Nutr 12 (1993): 26-30. [PMID: 8440814]
7	Product Information. Galzin (zinc acetate). Teva Pharmaceuticals USA, North Wales, PA.

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