Drug General Information (ID: DDIT0P7WGQ)
Drug Name			Calcium carbonate		Drug Info		Triethylenetetramine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antacids/Minerals And Electrolytes				Chelating Agents
Structure

Mechanism of Calcium carbonate-Triethylenetetramine Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Calcium carbonate				Triethylenetetramine
Mechanism		Polyvalent cations				Binds to polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Calcium carbonate due to formation of complexes caused by Triethylenetetramine

Recommended Action
Management		In general, mineral supplements or mineral-containing products (e.g., antacids) should not be used in patients treated with trientine.

References
1	Product Information. Syprine (trientine). Aton Pharma, Lawrenceville, NJ.