Drug General Information (ID: DDIW1XGKPN)
  Drug Name Triethylenetetramine Drug Info Zinc gluconate Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Chelating Agents Minerals And Electrolytes
  Structure

 Mechanism of Triethylenetetramine-Zinc gluconate Interaction (Severity Level: Minor)
     Complex formation Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Triethylenetetramine Zinc gluconate
      Mechanism Binds to polyvalent cations Polyvalent cations
      Key Mechanism Factor 1
Factor Name Chelation
Factor Description Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
      Mechanism Description
  • Decreased absorption of Zinc gluconate due to formation of complexes caused by Triethylenetetramine 

References
1 Brewer GJ "Practical recommendations and new therapies for Wilson's disease." Drugs 50 (1995): 240-9. [PMID: 8521757]
2 Brewer GJ, Yuzbasiyan-Gurkan V, Johnson V, Dick RD, Wang Y "Treatment of Wilson's disease with zinc: XI. Interaction with other anticopper agents." J Am Coll Nutr 12 (1993): 26-30. [PMID: 8440814]
3 Product Information. Galzin (zinc acetate). Teva Pharmaceuticals USA, North Wales, PA.