Details of Drug

Drug General Information (ID: D1553)
Drug Name	Terbinafine
Drug Type	Small molecule
Drug Synonymous	Bramazil; Lamasil; TerbiFoam; Terbina; Lamisil AT; Lamisil Tablet; Ternbinafine HCl; Lamasil (TN); Lamisil (TN); SF 86-327; Terbisil (TN); Zabel (TN); SF-86-327; Terbinafine (USAN/INN); Terbinafine [USAN:BAN:INN]; Lamisil, Terbinex, Corbinal, Zabel, Terbinafine; Terbinafine, SF-86-327, Lamisil, TBNF; (2E)-N,6,6-trimethyl-N-(1-naphthylmethyl)-2-hepten-4-yn-1-amine; (2E)-N,6,6-trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine; (E)-N,6,6-trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine; (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalene methanamine; (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethylamine; (E)-N-(6,6-dimethyl-2-heptenynyl)-N-methyl-1-naphthalenementhamin hydrochloride Click to Show/Hide
Disease Class	1F29-1F2F: Fungal infection; EE12: Nail/perionychium infection
Therapeutic Class	Antifungal Agents
Structure
Structure	3D Structure		2D Structure
Formula	C21H25N
InChI	1S/C21H25N/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19/h5-7,9-14H,16-17H2,1-4H3/b9-5+
InChIKey	DOMXUEMWDBAQBQ-WEVVVXLNSA-N
Canonical SMILES	CC(C)(C)C#CC=CCN(C)CC1=CC=CC2=CC=CC=C21
External Link
	Pubchem ID	1549008
	CAS Number	91161-71-6
	CHEBI ID	9448
	TTD ID	D01AYJ

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM038 Additive CNS depression effects BM055 Increased risk of hepatotoxicity BM075 Increased risk of photosensitivity reactions
Relation Graph

Full list of drugs interacting with Terbinafine
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 95
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0466		Dextromethorphan	C18H25NO	5360696	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1533		Tamoxifen	C26H29NO	2733526	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0559		Eliglustat	C23H36N2O4	23652731	Major		Inter Info	[42], [33]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[48], [33]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[43], [2], [3], [50], [51], [52]
D1302		Pitolisant	C17H26ClNO	9948102	Major		Inter Info	[3], [53]
D1708		Vortioxetine	C18H22N2S	9966051	Major		Inter Info	[55]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [33], [66], [67]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[68], [69], [70], [71]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[68], [69], [70], [71]
D0074		Amphetamine	C9H13N	3007	Moderate		Inter Info	[68], [69], [70], [71]
D0119		Atomoxetine	C17H21NO	54841	Moderate		Inter Info	[83], [84], [85]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[86]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[68], [69], [70], [71]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[68], [69], [70], [71]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[68], [69], [70], [71]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[88], [89], [90], [91], [92], [93], [33], [94], [95], [96], [97], [98], [99]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[100], [84]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[68], [69], [70], [71]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[101], [102]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[68], [69], [70], [71]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[43], [2], [3], [106]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[68], [69], [70], [71]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[68], [69], [70], [71]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[68], [69], [70], [71]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[68], [69], [70], [71]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[68], [69], [70], [71]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[68], [69], [70], [71]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[68], [69], [70], [71]
D0950		Loratadine	C22H23ClN2O2	3957	Moderate		Inter Info	[68], [69], [70], [71]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[68], [69], [70], [71]
D1054		Mexiletine	C11H17NO	4178	Moderate		Inter Info	[68], [69], [70], [71]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[112], [113], [33], [114], [115]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[68], [69], [70], [71]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[68], [69], [70], [71]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[68], [69], [70], [71]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[68], [69], [70], [71]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[68], [69], [70], [71]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[68], [69], [70], [71]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[68], [69], [70], [71]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[68], [69], [70], [71]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[68], [69], [70], [71]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[68], [69], [70], [71]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[68], [69], [70], [71]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[68], [69], [70], [71]
D1428		Ropivacaine	C17H26N2O	175805	Moderate		Inter Info	[68], [69], [70], [71]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[121], [122], [123], [33]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[124]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[68], [70], [71]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[43], [2], [3], [106]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[127]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[68], [70], [71]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[68], [69], [70], [71]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[68], [69], [70], [71]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[68], [69], [70], [71]
D0457		Dexfenfluramine	C12H16F3N	66265	Moderate		Inter Info	[68], [69], [70], [71]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[68], [70], [71]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[68], [69], [70], [71]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[68], [70], [71]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[134]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[68], [69], [70], [71]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[135]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[68], [69], [70], [71]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[43], [2], [3], [106]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[2], [3], [137]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[138], [139], [140]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[68], [69], [70], [71]
D1012		Metamfetamine	C10H15N	10836	Moderate		Inter Info	[68], [70], [71]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[68], [69], [70], [71]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[68], [69], [70], [71]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[68], [69], [70], [71]
D1181		Ondansetron	C18H19N3O	4595	Moderate		Inter Info	[68], [69], [70], [71]
D1194		Oxamniquine	C14H21N3O3	4612	Moderate		Inter Info	[68], [69], [70], [71]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[68], [69], [70], [71]
D1299		Pirfenidone	C12H11NO	40632	Moderate		Inter Info	[3], [142], [33]
D1339		Primaquine	C15H21N3O	4908	Moderate		Inter Info	[68], [69], [70], [71]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[68], [69], [70], [71]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[68], [69], [70], [71]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[146], [147], [148], [149], [150], [151], [152], [153], [154]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[68], [69], [70], [71]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[68], [69], [70], [71]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[68], [69], [70], [71]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Moderate		Inter Info	[157], [158], [159]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[68], [69], [70], [71]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[68], [69], [70], [71]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[68], [69], [70], [71]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[68], [69], [70], [71]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[68], [69], [70], [71]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[68], [69], [70], [71]
D0193		Bortezomib	C19H25BN4O4	387447	Minor		Inter Info	[162]
D0337		Cimetidine	C10H16N6S	2756	Minor		Inter Info	[163], [70]
D0516		Donepezil	C24H29NO3	3152	Minor		Inter Info	[164], [33], [165], [166]
D1383		Ranolazine	C24H33N3O4	56959	Minor		Inter Info	[167]
D1607		Tolterodine	C22H31NO	443879	Minor		Inter Info	[168], [169], [33]
D1555		Terfenadine	C32H41NO2	5405	Minor		Inter Info	[163], [70]
	CYP450 enzyme induction					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[2], [3], [120]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[125]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[3], [126]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[2], [131]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[132], [2], [3], [133]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[2], [3], [141]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[2], [3], [120]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[2], [3], [155], [120]
D1400		Rifampicin	C43H58N4O12	135398735	Minor		Inter Info	[70]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1673		Valbenazine	C24H38N2O4	24795069	Major		Inter Info	[54]
	Increased risk of hepatotoxicity					Drug Num: 24
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[43], [44], [45]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[46]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[47]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[49]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[43], [44], [45]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[72], [73], [74], [2], [3], [75], [76], [77], [78], [79], [80], [81], [82]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[87]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[103], [104]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[2], [3], [105]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[107], [108], [109], [110]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[107], [108], [109], [110]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[3], [111]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[116]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[72], [73], [74], [2], [3], [75], [76], [117], [78], [79], [80], [81], [82]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[72], [73], [74], [2], [3], [75], [76], [77], [78], [79], [80], [81], [82]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[128]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[129]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[72], [73], [74], [2], [3], [75], [76], [77], [78], [79], [80], [81], [82]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[3], [130]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[136]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[107], [108], [109], [110]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[2], [3], [143], [144], [145]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[3], [156]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[160], [161]
	Increased risk of photosensitivity reactions					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1314		Porfimer sodium	C68H74N8O11	135577896	Moderate		Inter Info	[118], [3], [119]

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