Details of Drug

Drug General Information (ID: D1518)
Drug Name	Sulfinpyrazone
Drug Type	Small molecule
Drug Synonymous	Anturan; Anturane; Anturanil; Anturano; Anturen; Anturidin; Diphenylpyrazone; Enturan; Enturen; Novopyrazone; Sulfinpirazona; Sulfinpyrazine; Sulfinpyrazon; Sulfinpyrazonum; Sulfoxyphenylpyrazolidin; Sulfoxyphenylpyrazolidine; Sulphinpyrazone; Apo Sulfinpyrazone; Apotex Brand of Sulfinpyrazone; Novartis Brand of Sulfinpyrazone; Nu Pharm Brand of Sulfinpyrazone; Nu Sulfinpyrazone; G 28315; Anturane (TN); Apo-Sulfinpyrazone; G 28,315; Nu-Pharm Brand of Sulfinpyrazone; Nu-Sulfinpyrazone; Sulfinpirazona [INN-Spanish]; Sulfinpyrazone (SPZ); Sulfinpyrazonum [INN-Latin]; USAF GE-13; Sulfinpyrazone [USAN:INN:JAN]; Sulfinpyrazone (JP15/USP/INN); (+/-)-SULFINPYRAZONE; 1,2-Diphenyl-3,5-dioxo-4-(2'-phenyl-sulfinyl-aethyl)-pyrazolidin; 1,2-Diphenyl-3,5-dioxo-4-(2'-phenyl-sulfinyl-aethyl)-pyrazolidin [German]; 1,2-Diphenyl-3,5-dioxo-4-(2-phenylsulfinylethyl) pyrazolidine; 1,2-Diphenyl-3,5-dioxo-4-(2-phenylsulfinylethyl)pyrazolidine; 1,2-Diphenyl-4-(2'-phenylsulfinethyl)-3,5-pyrazolidinedione; 1,2-Diphenyl-4-(2-(phenylsulfinyl)ethyl)-3,5-pyrazolidinedione; 1,2-Diphenyl-4-(phenylsulfinylethyl)-3,5-pyrazolidinedione; 1,2-Diphenyl-4-[2-(phenylsulfinyl)ethyl-3,5-pyrazolidinedione; 1,2-diphenyl-4-[2-(phenylsulfinyl)ethyl]pyrazolidine-3,5-dione; 4-(2-Benzenesulfinylethyl)-1,2-diphenylpyrazolidine-3,5-dione; 4-(Phenylsulfoxyethyl)-1,2-diphenyl-3,5-pyrazolidinedione; 4-[2-(benzenesulfinyl)ethyl]-1,2-diphenylpyrazolidine-3,5-dione Click to Show/Hide
Disease Class	FA25: Gout
Therapeutic Class	Uricosuric Agents
Structure
Structure	3D Structure		2D Structure
Formula	C23H20N2O3S
InChI	1S/C23H20N2O3S/c26-22-21(16-17-29(28)20-14-8-3-9-15-20)23(27)25(19-12-6-2-7-13-19)24(22)18-10-4-1-5-11-18/h1-15,21H,16-17H2
InChIKey	MBGGBVCUIVRRBF-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C(C=C1)N2C(=O)C(C(=O)N2C3=CC=CC=C3)CCS(=O)C4=CC=CC=C4
External Link
	Pubchem ID	5342
	CAS Number	57-96-5
	CHEBI ID	9342
	TTD ID	D03DEI
	INTEDE ID	DR1515
	VARIDT ID	DR00513

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM013 Competitive binding of plasma proteins BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM025 Decreased metabolism (Unspecific) BM032 Decreased renal excretion (Unspecific) BM050 Increased risk of bleeding BM099 Antagonize the effect of uricosuric agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Sulfinpyrazone
Affected organization distribution
	Competitive binding of plasma proteins					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[15], [280]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[99], [15]
D1087		Montelukast	C35H36ClNO3S	5281040	Moderate		Inter Info	[277], [278]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[387], [388]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[448], [449], [450]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[453], [454]
D1112		Nateglinide	C19H27NO3	5311309	Minor		Inter Info	[493]
	CYP450 enzyme induction					Drug Num: 182
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[13]
D0011		Acetaminophen	C8H9NO2	1983	Moderate		Inter Info	[53]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[54], [55], [56], [57]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[66], [67], [68]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[69], [70]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[71], [72], [73], [74], [75], [76], [77], [38], [78], [79], [80], [81], [82], [66], [83], [67], [68]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[84], [85], [86], [87], [88]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[92]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[93], [94], [95]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[96], [97], [98], [99], [15], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[114], [115], [116], [117], [118], [119], [120], [121]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[212]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[213], [214], [215]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[99], [15], [216]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[173], [217], [218], [219], [201]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[15], [220], [221], [222]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[223], [224]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[169], [179], [204]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[225]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[169], [179], [204]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211]
D0630		Exemestane	C20H24O2	60198	Moderate		Inter Info	[226]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[96], [97], [98], [99], [15], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[223], [227]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[15], [241], [242]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[96], [97], [98], [99], [15], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[249], [74], [99], [15], [35], [250]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[71], [72], [73], [74], [75], [76], [77], [38], [78], [79], [80], [81], [82], [66], [83], [67], [68]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[251], [252], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [264], [265]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[252], [253], [258]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[266], [267], [211]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[268]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[169], [179], [204]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[96], [97], [98], [99], [15], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[99], [15], [216]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[99], [15], [216]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[269], [270]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[271], [272], [273], [274]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[275], [276]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[71], [72], [73], [74], [75], [76], [77], [38], [78], [79], [80], [81], [82], [66], [83], [67], [68]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[74], [99], [15]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[169], [179], [204]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[96], [97], [98], [99], [15], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113]
D1330		Praziquantel	C19H24N2O2	4891	Moderate		Inter Info	[281], [99], [282], [283]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211]
D1349		Progesterone (topical)	C21H30O2	5994	Moderate		Inter Info	[169], [179], [204]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[284]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[285], [286], [287]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[288], [289], [290], [291]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[99], [15], [292], [293]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[294]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[295]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[296]
D0099		Apremilast	C22H24N2O7S	11561674	Moderate		Inter Info	[297]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[298]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[275], [276]
D0108		Artemether	C16H26O5	68911	Moderate		Inter Info	[99], [15], [299]
D0133		Axitinib	C22H18N4OS	6450551	Moderate		Inter Info	[300], [301]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[302]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[15], [303], [304]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[99], [15], [305]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[306]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[307]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[15], [308]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[74], [99], [15], [35], [309], [310], [311]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[312]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[313]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[28], [15], [314]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[315]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[71], [72], [73], [74], [75], [76], [77], [38], [78], [79], [80], [81], [82], [66], [83], [67], [68]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[317], [318], [319], [320], [321]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Moderate		Inter Info	[322], [323]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[324]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[325]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[326]
D0556		Elbasvir	C49H55N9O7	71661251	Moderate		Inter Info	[327]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[328]
D0563		Elvitegravir	C23H23ClFNO5	5277135	Moderate		Inter Info	[99], [15], [329]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[330]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[15], [331]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[332]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[169], [179], [204]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[333]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[99], [15], [334]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[335]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[336]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[71], [72], [73], [74], [75], [76], [77], [38], [78], [79], [80], [81], [82], [66], [83], [67], [68]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[69], [70]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[337], [338], [215]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[354]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[372]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[373]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[374]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[375]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[15], [376]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[377], [378], [379], [380]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[381]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[382]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[99], [15], [383]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[99], [15], [384]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[385]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[99], [386]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[389]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[390]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[99], [15], [391]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[392]
D0965		Macimorelin	C26H30N6O3	9804938	Moderate		Inter Info	[393]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Moderate		Inter Info	[394], [395]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[99], [396]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[397], [398]
D1104		Naloxegol	C34H53NO11	56959087	Moderate		Inter Info	[399]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[99], [15], [402]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[97], [103], [113]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[403]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[404], [405], [406], [407]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[404], [405], [406]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[99], [15], [408]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[409]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[410]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[15], [411]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[412]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[99], [413], [414], [415], [416]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[99], [15], [417]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[99], [28], [15], [418]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[419]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[99], [420]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[421]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[422]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[71], [72], [73], [74], [75], [76], [77], [38], [78], [79], [80], [81], [82], [66], [83], [67], [68]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[423]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[99], [15], [424]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[425]
D1496		Sonidegib	C26H26F3N3O3	24775005	Moderate		Inter Info	[426]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[15], [35], [427]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[99], [15], [428]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[429]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[430]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[99], [15], [431]
D1600		Tofacitinib	C16H20N6O	9926791	Moderate		Inter Info	[99], [433]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[15], [434]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[15], [435], [436]
D1664		Ulipristal	C28H35NO3	13559281	Moderate		Inter Info	[15], [437]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[438]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[439]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[99], [15], [292], [293]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[15], [440], [441]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[442], [443], [444], [445]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[337], [446], [447]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[451], [99], [15], [443], [452]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[475]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[15], [476], [477], [478]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[479], [480]
D0117		Atenolol	C14H22N2O3	2249	Minor		Inter Info	[481]
D0173		Betaxolol	C18H29NO3	2369	Minor		Inter Info	[481]
D0178		Bexarotene	C24H28O2	82146	Minor		Inter Info	[445]
D0188		Bisoprolol	C18H31NO4	2405	Minor		Inter Info	[481]
D0193		Bortezomib	C19H25BN4O4	387447	Minor		Inter Info	[15], [482], [483], [484], [485]
D0267		Carvedilol	C24H26N2O4	2585	Minor		Inter Info	[481]
D0308		Cevimeline	C10H17NOS	83898	Minor		Inter Info	[486]
D0420		Dapsone (topical)	C12H12N2O2S	2955	Minor		Inter Info	[487], [377], [380]
D0513		Dofetilide	C19H27N3O5S2	71329	Minor		Inter Info	[488]
D0602		Esmolol	C16H25NO4	59768	Minor		Inter Info	[481]
D0884		Labetalol	C19H24N2O3	3869	Minor		Inter Info	[481]
D0927		Lidocaine	C14H22N2O	3676	Minor		Inter Info	[489], [490], [491], [492]
D1049		Metoprolol	C15H25NO3	4171	Minor		Inter Info	[481]
D1293		Pindolol	C14H20N2O2	4828	Minor		Inter Info	[481]
D1357		Propranolol	C16H21NO2	4946	Minor		Inter Info	[481]
D1498		Sotalol	C12H20N2O3S	5253	Minor		Inter Info	[481]
D0010		Acebutolol	C18H28N2O4	1978	Minor		Inter Info	[481]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Minor		Inter Info	[499]
D0700		Fostemsavir	C25H26N7O8P	11319217	Minor		Inter Info	[337], [500], [215]
D1045		Metipranolol (ophthalmic)	C17H27NO4	31477	Minor		Inter Info	[481]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[501]
D1098		Nadolol	C17H27NO4	39147	Minor		Inter Info	[481]
D1585		Timolol	C13H24N4O3S	33624	Minor		Inter Info	[481]
D1716		Zaleplon	C17H15N5O	5719	Minor		Inter Info	[504]
D1726		Ziprasidone	C21H21ClN4OS	60854	Minor		Inter Info	[505], [506]
	Decreased metabolism (Unspecific)					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[123], [124], [125]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[15], [228], [229], [230], [231], [232], [233], [123], [234], [235], [236], [124], [237], [238], [125], [239], [240]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[15], [228], [229], [230], [231], [232], [233], [123], [234], [235], [236], [124], [237], [238], [125], [239], [240]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[15], [228], [229], [230], [231], [232], [233], [123], [234], [235], [236], [124], [237], [238], [125], [239], [240]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[123], [124], [125]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[123], [124], [125]
Affected excretion pathways
Pharmacodynamic additive effects
	Increased risk of bleeding					Drug Num: 87
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0104		Argatroban	C23H36N6O5S	92722	Major		Inter Info	[1], [2], [3]
D0537		Drotrecogin alfa	NA	NA	Major		Inter Info	[4]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0784		Ibritumomab tiuxetan	NA	NA	Major		Inter Info	[12]
D0904		Lepirudin	C287H440N80O111S6	118856773	Major		Inter Info	[1], [2], [3]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[14]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[15], [16]
D0176		Betrixaban	C23H22ClN5O3	10275777	Major		Inter Info	[17], [18]
D0247		Cangrelor	C17H25Cl2F3N5O12P3S2	9854012	Major		Inter Info	[17], [15], [19]
D0414		Dalteparin	C26H42N2O37S5	772	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[20]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[21], [22]
D0435		Defibrotide	C20H21N4O6P	135565962	Major		Inter Info	[15], [23]
D0447		Desirudin	C287H440N80O110S6	16129703	Major		Inter Info	[24], [25]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[26]
D0574		Enoxaparin	C26H42N2O37S5	772	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[27], [28], [15], [29]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[15], [21], [30]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Major		Inter Info	[21], [31]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[33]
D1380		Ramucirumab	NA	NA	Major		Inter Info	[34]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Major		Inter Info	[15], [35], [36]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[37]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[21]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Major		Inter Info	[38]
D1614		Tositumomab (I-131)	NA	NA	Major		Inter Info	[39], [40]
D1711		Warfarin	C19H16O4	54678486	Major		Inter Info	[41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52]
D0047		Alteplase	NA	NA	Moderate		Inter Info	[58], [59], [60], [61], [62], [63], [64], [65]
D0189		Bivalirudin	C98H138N24O33	16129704	Moderate		Inter Info	[2]
D0211		Bromfenac (ophthalmic)	C15H12BrNO3	60726	Moderate		Inter Info	[89], [90], [91]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[122]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[126], [127], [128], [129], [99], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D0384		Collagenase clostridium histolyticum	NA	NA	Moderate		Inter Info	[164]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[89], [90], [91]
D0477		Diclofenac (ophthalmic)	C14H11Cl2NO2	3033	Moderate		Inter Info	[89], [90], [91]
D0478		Diclofenac (topical)	C14H11Cl2NO2	3033	Moderate		Inter Info	[89], [90], [91]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[126], [127], [128], [129], [99], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[89], [90], [91]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[126], [127], [128], [129], [99], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[89], [90], [91]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[126], [127], [128], [129], [99], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[89], [90], [91]
D0681		Flurbiprofen (ophthalmic)	C15H13FO2	3394	Moderate		Inter Info	[89], [90], [91]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[126], [127], [128], [129], [99], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[89], [90], [91]
D1815		Icosapent	C20H30O2	446284	Moderate		Inter Info	[15], [244], [245]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[246], [247], [248]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[89], [90], [91]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[89], [90], [91]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[89], [90], [91]
D0883		Ketorolac (ophthalmic)	C15H13NO3	3826	Moderate		Inter Info	[89], [90], [91]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[89], [90], [91]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[89], [90], [91]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[89], [90], [91]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[126], [127], [128], [129], [99], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D1249		Pentosan polysulfate	C10H18O21S4	37720	Moderate		Inter Info	[21], [279]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[89], [90], [91]
D1395		Reteplase	NA	NA	Moderate		Inter Info	[58], [59], [60], [61], [62], [63], [64], [65]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[129], [158], [159]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[126], [127], [128], [129], [99], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D1769		Deoxycholic acid	C24H40O4	222528	Moderate		Inter Info	[21], [316]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[126], [127], [128], [129], [99], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[246], [247], [248]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[126], [127], [128], [129], [99], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D0711		Garlic	NA	NA	Moderate		Inter Info	[339], [340], [341], [342], [343], [344], [345], [346], [347], [348], [349], [350], [351], [352], [353]
D0721		Ginger	C30H40O6	442138	Moderate		Inter Info	[344], [355], [356], [348], [351]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[357], [358], [359], [360], [341], [361], [362], [342], [344], [345], [363], [355], [364], [348], [365], [366], [367], [351], [368]
D0723		Ginseng	C42H66O17	420552	Moderate		Inter Info	[369], [370], [371]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[126], [127], [128], [129], [99], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[126], [127], [128], [129], [99], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D1123		Nepafenac (ophthalmic)	C15H14N2O2	151075	Moderate		Inter Info	[89], [90], [91]
D1139		Nintedanib	C31H33N5O4	135423438	Moderate		Inter Info	[400]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[15], [401]
D1178		Omega-3 fatty acids	C60H92O6	56842239	Moderate		Inter Info	[15], [244], [245]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[15], [432]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[126], [127], [128], [129], [99], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[126], [127], [128], [129], [99], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[89], [90], [91]
D1550		Tenecteplase	NA	NA	Moderate		Inter Info	[58], [59], [60], [61], [62], [63], [64], [65]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[89], [90], [91]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[246], [247], [248]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[126], [127], [128], [129], [99], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D1703		Vitamin E	C29H50O2	14985	Moderate		Inter Info	[457], [458], [15], [459], [460], [461], [462], [344], [463], [464], [465], [466], [467], [468], [469], [470], [471], [472], [473], [474]
D0253		Capsicum	NA	NA	Minor		Inter Info	[370]
D0309		Chamomile	C15H10O5	5280443	Minor		Inter Info	[370], [495], [348]
D0368		Clove	NA	NA	Minor		Inter Info	[344], [496], [497], [498]
D1661		Turmeric	C21H20O6	969516	Minor		Inter Info	[502], [344], [503]
Pharmacodynamic antagonistic effects
	Antagonize the effect of uricosuric agents					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1860		Pegloticase	NA	NA	Major		Inter Info	[32]
D0780		Hydroxyurea	CH4N2O2	3657	Moderate		Inter Info	[99], [243]
D1364		Pyrazinamide	C5H5N3O	1046	Moderate		Inter Info	[27], [15]
D1129		Niacin	C6H5NO2	938	Minor		Inter Info	[494]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[455], [456]

References
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2	Product Information. Angiomax (bivalirudin) The Medicines Compny, Cambridge, MA.
3	Product Information. Refludan (lepirudin). Hoechst Marion-Roussel Inc, Kansas City, MO.
4	Product Information. Xigris (drotrecogin alfa). Lilly, Eli and Company, Indianapolis, IN.
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8	Product Information. Innohep (tinzaparin) DuPont Pharmaceuticals, Wilmington, DE.
9	Product Information. Lovenox (enoxaparin). Rhone-Poulenc Rorer, Collegeville, PA.
10	Product Information. Normiflo (ardeparin). Wyeth-Ayerst Laboratories, Philadelphia, PA.
11	Product Information. Orgaran (danaparoid). Organon, West Orange, NJ.
12	Product Information. In-111 Zevalin (ibritumomab). IDEC Pharmaceuticals Corporation, San Diego, CA.
13	Product Information. Ranexa (ranolazine). Calmoseptine Inc, Huntington Beach, CA.
14	Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
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16	Product Information. Ayvakit (avapritinib). Blueprint Medicines Corporation, Cambridge, MA.
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18	Product Information. Bevyxxa (betrixaban). Portola Pharmaceuticals, South San Francisco, CA.
19	Product Information. Kengreal (cangrelor). The Medicines Company, Parsippany, NJ.
20	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
21	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
22	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
23	Product Information. Defitelio (defibrotide). Jazz Pharmaceuticals, Palo Alto, CA.
24	Product Information. Ipravask (desirudin). Aventis Pharmaceuticals, Swiftwater, PA.
25	Product Information. Pradaxa (dabigatran). Boehringer-Ingelheim, Ridgefield, CT.
26	Product Information. Savaysa (edoxaban). Daiichi Sankyo, Inc., Parsippany, NJ.
27	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
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29	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
30	Product Information. Tegsedi (inotersen). Akcea Therapeutics, Cambridge, MA.
31	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
32	Product Information. Krystexxa (pegloticase). Savient Pharmaceuticals, East Brunswick, NJ.
33	Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
34	Product Information. Cyramza (ramucirumab). Eli Lilly and Company, Indianapolis, IN.
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36	Product Information. Stivarga (regorafenib). Bayer Pharmaceutical Inc, West Haven, CT.
37	Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
38	Product Information. Aptivus (tipranavir). Boehringer-Ingelheim, Ridgefield, CT.
39	Product Information. Bexxar I 131 Therapeutic (iodine I 131 tositumomab). GlaxoSmithKline, Research Triangle Park, NC.
40	Product Information. BexxarTherapy (tositumomab). GlaxoSmithKline Inc, Oakville, IA.
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60	Product Information. Abbokinase (urokinase). Abbott Pharmaceutical, Abbott Park, IL.
61	Product Information. Activase (alteplase). Genentech, South San Francisco, CA.
62	Product Information. Retavase (reteplase). Boehringer Mannheim, Gaithersburg, MD.
63	Product Information. Streptase (streptokinase). Astra USA, Westborough, MA.
64	Product Information. Ticlid (ticlopidine). Syntex Laboratories Inc, Palo Alto, CA.
65	Product Information. TNKase (tenecteplase) Genentech, South San Francisco, CA.
66	Product Information. Reyataz (atazanavir). Bristol-Myers Squibb, Princeton, NJ.
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69	Product Information. Emend (aprepitant). Merck & Company Inc, West Point, PA.
70	Product Information. Emend for Injection (fosaprepitant). Merck & Company Inc, West Point, PA.
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77	Product Information. Agenerase (amprenavir). Glaxo Wellcome, Research Triangle Pk, NC.
78	Product Information. Crixivan (indinavir). Merck & Co, Inc, West Point, PA.
79	Product Information. Fortovase (saquinavir) Roche Laboratories, Nutley, NJ.
80	Product Information. Invirase (saquinavir). Roche Laboratories, Nutley, NJ.
81	Product Information. Lexiva (fosamprenavir). GlaxoSmithKline, Research Triangle Park, NC.
82	Product Information. Prezista (darunavir). Ortho Biotech Inc, Bridgewater, NJ.
83	Product Information. Viracept (nelfinavir). Agouron Pharma Inc, La Jolla, CA.
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88	Product Information. Lipitor (atorvastatin). Parke-Davis, Morris Plains, NJ.
89	Product Information. Acular (ketorolac). Allergan Inc, Irvine, CA.
90	Product Information. Nevanac (nepafenac ophthalmic). Alcon Laboratories Inc, Fort Worth, TX.
91	Product Information. Xibrom (bromfenac ophthalmic). ISTA Pharmaceuticals, Irvine, CA.
92	Product Information. Buprenex (buprenorphine). Reckitt and Colman Pharmaceutical, Richmond, VA.
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107	Product Information. Diskets (methadone). Cebert Pharmaceuticals Inc, Birmingham, AL.
108	Product Information. Duragesic Transdermal System (fentanyl). Janssen Pharmaceutica, Titusville, NJ.
109	Product Information. Ionsys (fentanyl). Ortho McNeil Pharmaceutical, Raritan, NJ.
110	Product Information. OxyContin (oxycodone). Purdue Frederick Company, Norwalk, CT.
111	Product Information. Zohydro ER (HYDROcodone). Zogenix, Inc, San Diego, CA.
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145	Product Information. Brintellix (vortioxetine). Takeda Pharmaceuticals America, Lincolnshire, IL.
146	Product Information. Celexa (citalopram). Forest Pharmaceuticals, St. Louis, MO.
147	Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
148	Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
149	Product Information. Fetzima (levomilnacipran). Forest Pharmaceuticals, St. Louis, MO.
150	Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
151	Product Information. Luvox (fluvoxamine). Solvay Pharmaceuticals Inc, Marietta, GA.
152	Product Information. Paxil (paroxetine). GlaxoSmithKline, Research Triangle Park, NC.
153	Product Information. Pristiq (desvenlafaxine). Wyeth Laboratories, Philadelphia, PA.
154	Product Information. Prozac (fluoxetine). Dista Products Company, Indianapolis, IN.
155	Product Information. Savella (milnacipran). Forest Pharmaceuticals, St. Louis, MO.
156	Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
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293	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
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295	Product Information. Verzenio (abemaciclib). Lilly, Eli and Company, Indianapolis, IN.
296	Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
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328	Product Information. Cerdelga (eliglustat). Genzyme Corporation, Cambridge, MA.
329	Product Information. Vitekta (elvitegravir). Gilead Sciences, Foster City, CA.
330	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
331	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
332	Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
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336	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
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376	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
377	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
378	Product Information. Orkambi (ivacaftor-lumacaftor). Vertex Pharmaceuticals, Cambridge, MA.
379	Product Information. Symdeko 4-Week (ivacaftor-tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
380	Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
381	Product Information. Ixempra (ixabepilone). Bristol-Myers Squibb, Princeton, NJ.
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384	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
385	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
386	Product Information. Dayvigo (lemborexant). Eisai Inc, Woodcliff Lake, NJ.
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499	Product Information. Tivicay (dolutegravir). ViiV Healthcare, Research Triangle Park, NC.
500	Product Information. Rukobia (fostemsavir). ViiV Healthcare, Research Triangle Park, NC.
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