Drug General Information (ID: DDIRWCGZKS)
Drug Name			Niacin		Drug Info		Sulfinpyrazone		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Vitamins/Antihyperlipidemic Agents				Uricosuric Agents
Structure

Mechanism of Niacin-Sulfinpyrazone Interaction (Severity Level: Minor)
Antagonize the effect of uricosuric agents Click to Show/Hide Mechanism Graph
Drug Name		Niacin				Sulfinpyrazone
Mechanism		Anti-uricosuric effects				Uricosuric
Key Mechanism Factor 1
		Factor Name		Uricosuric agents
		Factor Description		The beneficial effects of uricosuric agents may be reduced, leading to an increased risk of hyperuricemia and gout.
Mechanism Description		Antagonize the effect of Sulfinpyrazone when combined with Niacin

References
1	Gershon SL, Fox IH "Pharmacologic effects of nicotinic acid on human purine metabolism." J Lab Clin Med 84 (1974): 179-86. [PMID: 4367231]