Details of Drug

Drug General Information (ID: D1497)
Drug Name	Sorafenib
Drug Type	Small molecule
Drug Synonymous	Nexavar; Sorafenibum; Sorafenib [INN]; Nexavar (TN); Sorafenib (INN); N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea; N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea; N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcar bamoyl)-4-pyridyloxy)phenyl)urea; 4(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide; 4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide; 4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic acid methyamide-4-methylbenzenesulfonate; 4-(4-{3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide; 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide; 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide; 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide; 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide; 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE; Sorafenib (Pan-TK inhibitor) Click to Show/Hide
Disease Class	2C90: Renal cell carcinoma; 2A37: Myelodysplastic syndrome; 2C12: Liver cancer
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C21H16ClF3N4O3
InChI	1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
InChIKey	MLDQJTXFUGDVEO-UHFFFAOYSA-N
Canonical SMILES	CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F
External Link
	Pubchem ID	216239
	CAS Number	284461-73-0
	CHEBI ID	50924
	TTD ID	D0W5HK
	INTEDE ID	DR1500
	VARIDT ID	DR00304

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM002 Altered intestinal flora BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM019 UGT inhibition BM022 CYP450 enzyme induction BM038 Additive CNS depression effects BM044 Additive myelosuppressive effects BM050 Increased risk of bleeding BM055 Increased risk of hepatotoxicity BM074 Increased risk of peripheral neuropathy BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Sorafenib
Affected gastrointestinal absorption
	Altered intestinal flora					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1120		Neomycin	C23H46N6O13	8378	Moderate		Inter Info	[2], [3], [155], [137]
Affected cellular transport
	Transporter inhibition					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[60]
D0380		Colchicine	C22H25NO6	6167	Major		Inter Info	[88], [89], [90]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[2], [3], [157]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Moderate		Inter Info	[2], [3], [236]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[245], [246], [247], [248]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[245], [247], [248]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[3], [253], [137], [254]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[3], [137], [254]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[245], [246], [247], [248]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[2], [298]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[301]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[304]
D0658		Fidaxomicin	C52H74Cl2O18	10034073	Minor		Inter Info	[2], [3], [313]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[132]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[177], [178], [137]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[1], [3], [225], [226]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[2], [3], [235]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[240], [91], [214]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[257]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[137], [262]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[137], [262]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[270]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[3], [62], [275], [137]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[62], [275], [137]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[306]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[310]
D1104		Naloxegol	C34H53NO11	56959087	Minor		Inter Info	[317]
	UGT inhibition					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1435		Sacituzumab govitecan	C76H104N12O24S	91668186	Major		Inter Info	[137], [138]
D0153		Belinostat	C15H14N2O4S	6918638	Moderate		Inter Info	[234]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[269]
D1191		Ospemifene	C24H23ClO2	3036505	Moderate		Inter Info	[3], [137], [274]
D0418		Dapagliflozin	C21H25ClO6	9887712	Minor		Inter Info	[311]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Minor		Inter Info	[312]
D1377		Raltegravir	C20H21FN6O5	54671008	Minor		Inter Info	[318]
	CYP450 enzyme induction					Drug Num: 49
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[137]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[137]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[137]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[137]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[137]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[217], [137], [218]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[137]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[137]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[137]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[137]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[137]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[137]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[137]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[3], [244]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[137]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[137]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[2], [255]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[137]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[137]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[137]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[137]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[137]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[137]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[137]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[2], [263]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[137]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[137]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Moderate		Inter Info	[268], [137]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[217], [137], [218]
D1050		Metreleptin	NA	NA	Moderate		Inter Info	[137]
D1078		Mitotane	C14H10Cl4	4211	Moderate		Inter Info	[137]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[137]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[137]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[2], [3], [7]
D1186		Oritavancin	C86H97Cl3N10O26	16136912	Moderate		Inter Info	[137]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[137]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[137]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[137]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[137]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[268], [137]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[137]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[137]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[217], [137], [218]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[137]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[137]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[137]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[137]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[217], [137], [218]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[137]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0452		Deutetrabenazine	C19H27NO3	73437646	Moderate		Inter Info	[249]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[307]
	Additive myelosuppressive effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[9], [10]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[273]
	Increased risk of bleeding					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[177], [178], [137]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[177], [178], [137]
	Increased risk of hepatotoxicity					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[1], [113], [114]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[116]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[120]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[1], [113], [114]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[166], [167], [168], [2], [3], [169], [170], [171], [172], [173], [174], [175], [176]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[179], [180], [181], [182]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[179], [180], [181], [182]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[166], [167], [168], [2], [3], [169], [170], [171], [172], [173], [174], [175], [176]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[166], [167], [168], [2], [3], [169], [170], [171], [172], [173], [174], [175], [176]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[166], [167], [168], [2], [3], [169], [170], [171], [172], [173], [174], [175], [176]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[3], [241]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[242]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[260]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[3], [271]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[272]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[179], [180], [181], [182]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[2], [3], [295], [296], [297]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[3], [305]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[308], [309]
	Increased risk of prolong QT interval					Drug Num: 161
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[1], [2], [3], [4]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[1], [2], [3], [5], [6], [7], [8]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[1], [2], [3], [11], [12], [13], [14], [15], [16], [17], [18], [19], [7]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[1], [2], [3], [20]
D0740		Grepafloxacin	C19H22FN3O3	72474	Major		Inter Info	[21], [1], [2], [3], [22], [23], [24]
D0787		Ibutilide	C20H36N2O3S	60753	Major		Inter Info	[1], [2], [3], [25]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[1], [2], [3], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [7]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[36], [21], [37], [1], [2], [3], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[1], [2], [3], [11], [12], [13], [14], [15], [16], [17], [18], [19], [7]
D0067		Amisulpride	C17H27N3O4S	2159	Major		Inter Info	[58]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[59]
D0170		Bepridil	C24H34N2O	2351	Major		Inter Info	[1], [2], [3], [11], [12], [13], [14], [15], [16], [17], [18], [19], [7]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[3], [61]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[1], [2], [3], [65]
D0320		Chloroquine	C18H26ClN3	2719	Major		Inter Info	[66], [3], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84]
D0342		Cisapride	C23H29ClFN3O4	6917698	Major		Inter Info	[1], [2], [3], [85], [86], [87]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[91]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[1], [2], [3], [92]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[1], [2], [3], [93]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[94]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[36], [21], [37], [1], [2], [3], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[96], [1], [2], [3], [97], [98], [99], [100], [101]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[1], [2], [3], [102], [103], [104], [105], [106], [107], [7]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Major		Inter Info	[66], [3], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[1], [2], [3], [108], [7]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[111]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[112]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[3], [115], [7]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Major		Inter Info	[2], [3], [117]
D0965		Macimorelin	C26H30N6O3	9804938	Major		Inter Info	[118]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[1], [2], [3], [119], [7]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[1], [2], [3], [10]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[121]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[122]
D1223		Papaverine	C20H21NO4	4680	Major		Inter Info	[123], [124], [125], [126], [127], [128], [129], [130]
D1230		Pasireotide	C58H66N10O9	9941444	Major		Inter Info	[1], [2], [3], [131]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[3], [133], [134], [7]
D1343		Procainamide	C13H21N3O	4913	Major		Inter Info	[1], [2], [3], [11], [12], [13], [14], [15], [16], [17], [18], [19], [7]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[1], [2], [3], [11], [12], [13], [14], [15], [16], [17], [18], [19], [7]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[1], [2], [3], [133], [42], [135], [136], [7]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[139], [140], [1], [2], [3], [141], [142]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[3], [143]
D1498		Sotalol	C12H20N2O3S	5253	Major		Inter Info	[1], [2], [3], [11], [12], [13], [14], [15], [16], [17], [18], [19], [7]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Major		Inter Info	[21], [1], [2], [3], [145], [146], [40], [42], [44], [147], [45], [46], [148], [48], [49], [50], [51], [149], [55], [24], [150]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[1], [2], [3], [151], [133], [152], [153], [154], [7]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[1], [2], [3], [155]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[1], [2], [3], [156]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[1], [2], [3], [133], [158], [7]
D0003		Abarelix	C72H95ClN14O14	16131215	Moderate		Inter Info	[3], [159], [160], [161], [162], [163], [164], [165]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[1], [2], [3], [137]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[1], [2], [3], [137]
D0119		Atomoxetine	C17H21NO	54841	Moderate		Inter Info	[1], [2], [3], [137]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[1], [2], [3], [137]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[1], [2], [3], [137]
D0737		Goserelin	C59H84N18O14	5311128	Moderate		Inter Info	[3], [159], [160], [161], [162], [163], [164], [165]
D0908		Leuprolide	C59H84N16O12	657181	Moderate		Inter Info	[3], [159], [160], [161], [162], [163], [164], [165]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[1], [2], [3], [137]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[215]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[2], [3], [216]
D1210		Oxytocin	C43H66N12O12S2	439302	Moderate		Inter Info	[1], [2], [3], [137]
D1216		Palonosetron	C19H24N2O	6337614	Moderate		Inter Info	[1], [2], [3], [137]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[1], [2], [3], [137]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[1], [2], [3], [137]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[1], [2], [3]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[1], [2], [3], [137]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[2], [3], [227], [228], [229], [230], [231], [232]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[1], [2], [3], [233], [7]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[1], [2], [3], [137]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[3], [159], [160], [161], [162], [163], [164], [165]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[1], [2], [3], [137]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[1], [2], [3], [137]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[1], [2], [3], [137]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[1], [2], [3], [137]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[1], [2], [3], [137]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[1], [2], [3], [137]
D0358		Clofazimine	C27H22Cl2N4	2794	Moderate		Inter Info	[243]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[1], [2], [3], [137]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[1], [2], [3], [137]
D0437		Degarelix	C82H103ClN18O16	16136245	Moderate		Inter Info	[3], [159], [160], [161], [162], [163], [164], [165]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[1], [2], [3]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[1], [2], [3], [137]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[1], [2], [3]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[1], [2], [3], [137]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[1], [2], [3], [137]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[1], [2], [3], [137]
D0636		Famotidine	C8H15N7O2S3	5702160	Moderate		Inter Info	[2], [3], [256]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[1], [2], [3], [137]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[1], [2], [3], [137]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[1], [2], [3], [137]
D0682		Flutamide	C11H11F3N2O3	3397	Moderate		Inter Info	[3], [159], [160], [161], [162], [163], [164], [165]
D0694		Foscarnet	CH3O5P	3415	Moderate		Inter Info	[1], [2], [3], [137]
D0700		Fostemsavir	C25H26N7O8P	11319217	Moderate		Inter Info	[1], [2], [3], [137]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Moderate		Inter Info	[1], [2], [3], [137]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[258]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[259]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[1], [2], [3], [137]
D0758		Histrelin	C66H86N18O12	25077993	Moderate		Inter Info	[3], [159], [160], [161], [162], [163], [164], [165]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[1], [2], [3], [137]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[1], [2], [3], [137]
D0806		Inotuzumab ozogamicin	NA	NA	Moderate		Inter Info	[3], [261]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[1], [2], [3], [137]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[1], [2], [3], [137]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Moderate		Inter Info	[1], [2], [3], [137]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[1], [2], [3], [137]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Moderate		Inter Info	[3]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[1], [2], [3]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[1], [2], [3], [264], [7]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Moderate		Inter Info	[1], [2], [3], [137]
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[265], [266]
D0948		Lopinavir	C37H48N4O5	92727	Moderate		Inter Info	[1], [2], [267]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[1], [2], [3], [137]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[1], [2], [3], [137]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[1], [2], [3], [137]
D1137		Nilutamide	C12H10F3N3O4	4493	Moderate		Inter Info	[3], [159], [160], [161], [162], [163], [164], [165]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[1], [2], [3], [137]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[1], [2], [3], [137]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[1], [2], [3], [137]
D1181		Ondansetron	C18H19N3O	4595	Moderate		Inter Info	[1], [2], [3], [137]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[1], [2], [3], [137]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[1], [2], [3], [137]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[1], [2], [3], [137]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[1], [2], [3], [137]
D1246		Pentamidine	C19H24N4O2	4735	Moderate		Inter Info	[1], [2], [3], [137]
D1254		Perflutren	C3F8	6432	Moderate		Inter Info	[276], [277]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[1], [2], [3], [137]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[280]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[1], [2], [3], [137]
D1339		Primaquine	C15H21N3O	4908	Moderate		Inter Info	[1], [2], [3], [137]
D1342		Probucol	C31H48O2S2	4912	Moderate		Inter Info	[1], [2], [3], [137]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[1], [2], [3], [137]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[1], [2], [3], [137]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[1], [2], [3], [137]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[281], [282], [283], [284], [285], [286], [287], [288], [289], [290]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[1], [2], [3], [133], [291], [292], [293], [294], [7]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[1], [2], [3], [137]
D1388		Relugolix	C29H27F2N7O5S	10348973	Moderate		Inter Info	[3], [159], [160], [161], [162], [163], [164], [165]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[1], [2], [3], [137]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[1], [2], [3], [137]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[1], [2], [3], [137]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[1], [2], [3], [137]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[1], [2], [3], [137]
D1463		Sevoflurane	C4H3F7O	5206	Moderate		Inter Info	[1], [2], [3], [300]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[1], [2], [3], [137]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[1], [2], [3], [137]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[1], [2], [3], [137]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Moderate		Inter Info	[1], [2], [3], [137]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[1], [2], [3], [137]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[1], [2], [3], [302], [7]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Moderate		Inter Info	[1], [2], [3], [137]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[1], [2], [3], [137]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[1], [2], [3], [137]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[1], [2], [3], [137]
D1651		Triptorelin	C64H82N18O13	25074470	Moderate		Inter Info	[3], [159], [160], [161], [162], [163], [164], [165]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[1], [2], [3], [137]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[1], [2], [3], [137]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[1], [2], [3], [137]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[1], [2], [3], [137]
D1683		Vasopressin	C46H65N15O12S2	644077	Moderate		Inter Info	[1], [2], [3], [137]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[1], [2], [3], [137]
D1051		Metronidazole	C6H9N3O3	4173	Minor		Inter Info	[2], [314], [315], [316]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Minor		Inter Info	[1], [2], [3], [319], [320], [321], [322]
	Increased risk of ventricular arrhythmias					Drug Num: 35
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[1], [2], [3], [95], [8]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[3], [109], [110]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[2], [144]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212]
D0025		Adenosine	C10H13N5O4	60961	Moderate		Inter Info	[1], [219], [2], [3], [220], [221], [222], [85], [223], [224]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212]
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[1], [2], [3], [237], [238], [239]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[1], [2], [3], [237], [238], [239]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[1], [2], [3], [250], [251], [252]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212]
D0701		Frangula purshiana bark	NA	NA	Moderate		Inter Info	[2], [3], [239]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[1], [2], [3], [250], [251], [252]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[1], [2], [3], [237], [238], [239]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[196], [206], [209]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[1], [2], [3], [237], [238], [239]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[196], [206], [209]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[1], [2], [3], [237], [238], [239]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[1], [2], [3], [237], [238], [239]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[1], [2], [3], [237], [238], [239]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[196], [206], [209]
D1266		Phenolphthalein	C20H14O4	4764	Moderate		Inter Info	[1], [2], [3], [237], [238], [239]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[3], [278], [279]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[3], [278], [279]
D1309		Polyethylene glycol (3350)	C2H6O2	174	Moderate		Inter Info	[2], [3], [239]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[1], [2], [3], [250], [251], [252]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[196], [206], [209]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[3], [278], [279]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[2], [3], [303]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[1], [2], [3], [250], [251], [252]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1426		Romosozumab	NA	NA	Moderate		Inter Info	[299]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0260		Carboplatin	C6H12N2O4Pt	426756	Major		Inter Info	[62], [63], [64]
D0934		Liothyronine	C15H12I3NO4	5920	Moderate		Inter Info	[213], [137], [214]
D0925		Levothyroxine	C15H11I4NO4	5819	Moderate		Inter Info	[213], [137], [214]
D0935		Liotrix	C30H21I7N2Na2O8	71371	Moderate		Inter Info	[213], [137], [214]
D1577		Thyroid, porcine	NA	NA	Moderate		Inter Info	[213], [137], [214]

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156	Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
157	Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
158	Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.
159	Product Information. Eligard (leuprolide). Sanofi Winthrop Pharmaceuticals, New York, NY.
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161	Product Information. Lupron (leuprolide). TAP Pharmaceuticals Inc, Deerfield, IL.
162	Product Information. Plenaxis (abarelix). Praecis Pharmaceuticals Inc, Waltham, MA.
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173	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
174	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
175	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
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180	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
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279	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
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