Drug General Information (ID: DDIUIOD134)
Drug Name			Liothyronine		Drug Info		Sorafenib		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Hormone Replacement Agents				Antineoplastics
Structure

Mechanism of Liothyronine-Sorafenib Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Liothyronine				Sorafenib
Mechanism		Thyroid hormone				Decrease the suppression effect of exogenous thyroid hormone on differentiated thyroid carcinoma
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Liothyronine when combined with Sorafenib

Recommended Action
Management		TSH levels should be monitored monthly during sorafenib treatment for differentiated thyroid carcinoma, and the dosage of thyroid replacement medication adjusted as necessary.

References
1	Product Information. Armour thyroid (thyroid desiccated). Forest Pharmaceuticals, St. Louis, MO.
2	Product Information. Nexavar (sorafenib). Bayer Pharmaceutical Inc, West Haven, CT.
3	Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67. [PMID: 19667002]