Drug General Information (ID: DDI0OZ6NIK)
Drug Name			Sorafenib		Drug Info		Neomycin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antineoplastics				Antibiotics
Structure

Mechanism of Sorafenib-Neomycin Interaction (Severity Level: Moderate)
Altered intestinal flora Click to Show/Hide Mechanism Graph
Drug Name		Sorafenib				Neomycin
Mechanism		Affected by alters GI flora				Alters GI flora
Key Mechanism Factor 1
		Factor Name		Intestinal flora
		Factor Description		The intestinal flora has multiple effects on human health, and altering the intestinal microbiota can affect the absorption of drugs and alter their pharmacological effects.
Mechanism Description		Altered absorption of Sorafenib due to GI flora changes caused by Neomycin

Recommended Action
Management		The possibility of a diminished therapeutic response to sorafenib should be considered during coadministration with oral neomycin.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
4	Product Information. Nexavar (sorafenib). Bayer Pharmaceutical Inc, West Haven, CT.