Details of Drug

Drug General Information (ID: D1474)
Drug Name	Siponimod
Drug Type	Small molecule
Drug Synonymous	BAF312 Click to Show/Hide
Disease Class	2C12: Liver cancer; FA20: Rheumatoid arthritis; 8A40: Multiple sclerosis
Therapeutic Class	Selective Immunosuppressants
Structure
Structure	3D Structure		2D Structure
Formula	C29H35F3N2O3
InChI	1S/C29H35F3N2O3/c1-3-21-14-23(10-11-24(21)15-34-16-25(17-34)28(35)36)19(2)33-37-18-20-9-12-26(22-7-5-4-6-8-22)27(13-20)29(30,31)32/h9-14,22,25H,3-8,15-18H2,1-2H3,(H,35,36)/b33-19+
InChIKey	KIHYPELVXPAIDH-HNSNBQBZSA-N
Canonical SMILES	CCC1=C(C=CC(=C1)C(=NOCC2=CC(=C(C=C2)C3CCCCC3)C(F)(F)F)C)CN4CC(C4)C(=O)O
External Link
	Pubchem ID	44599207
	CAS Number	1230487-00-9
	TTD ID	D07FKQ
	INTEDE ID	DR1487

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM043 Additive immunosuppressive effects BM049 Increased risk of atrioventricular block BM051 Increased risk of bradycardia BM055 Increased risk of hepatotoxicity BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens
Relation Graph

Full list of drugs interacting with Siponimod
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 36
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[1], [2]
D0100		Aprepitant	C23H21F7N4O3	135413536	Major		Inter Info	[1], [2]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[1], [2]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Major		Inter Info	[1], [2]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[1], [2]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[1], [2]
D0413		Dalfopristin	C34H50N4O9S	6323289	Major		Inter Info	[1], [3], [2]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[1], [2]
D0543		Duvelisib	C22H17ClN6O	50905713	Major		Inter Info	[1], [2]
D0642		Fenofibrate	C20H21ClO4	3339	Major		Inter Info	[1], [2]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Major		Inter Info	[1], [2]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[1], [2]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Major		Inter Info	[1], [2]
D0715		Gemfibrozil	C15H22O3	3463	Major		Inter Info	[1], [2]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[1], [2]
D0793		Imatinib	C29H31N7O	5291	Major		Inter Info	[1], [2]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[1], [2]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Major		Inter Info	[1], [2]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[1], [2]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[1], [2]
D0906		Letermovir	C29H28F4N4O4	45138674	Major		Inter Info	[1], [2]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[1], [2]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[1], [2]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[1], [2]
D1143		Nitisinone	C14H10F3NO5	115355	Major		Inter Info	[1], [2]
D1195		Oxandrolone	C19H30O3	5878	Major		Inter Info	[1], [2]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[1], [2]
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[1], [2]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[1], [2]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[1], [2]
D1709		Voxelotor	C19H19N3O3	71602803	Major		Inter Info	[1], [2]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[1], [2]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[1], [2]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[9]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[61], [62], [63], [64]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[1], [41], [86]
	CYP450 enzyme induction					Drug Num: 25
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0194		Bosentan	C27H29N5O6S	104865	Major		Inter Info	[1], [2]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[1], [2]
D0300		Cenobamate	C10H10ClN5O2	11962412	Major		Inter Info	[1], [2]
D0453		Dexamethasone	C22H29FO5	5743	Major		Inter Info	[1], [2]
D0628		Etravirine	C20H15BrN6O	193962	Major		Inter Info	[1], [2]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[1], [2]
D0953		Lorlatinib	C21H19FN6O2	71731823	Major		Inter Info	[1], [2]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[1], [6], [2]
D1081		Modafinil	C15H15NO2S	4236	Major		Inter Info	[1], [2]
D1099		Nafcillin	C21H22N2O5S	8982	Major		Inter Info	[1], [2]
D1128		Nevirapine	C15H14N4O	4463	Major		Inter Info	[1], [2]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[1], [2]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[1], [2]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[1], [2]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[1], [2]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[1], [6], [2]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[1], [2]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Major		Inter Info	[1], [2]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[1], [2]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[1], [2]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[10]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[1], [85]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[1], [41], [90]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[1], [41], [90]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[1], [41], [91], [90]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 186
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0004		Abatacept	NA	NA	Major		Inter Info	[1], [2]
D0006		Abemaciclib	C27H32F2N8	46220502	Major		Inter Info	[1], [2]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[1], [2]
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2]
D0027		Aflibercept	NA	NA	Major		Inter Info	[1], [2]
D0030		Aldesleukin	NA	NA	Major		Inter Info	[1], [2]
D0032		Alefacept	NA	NA	Major		Inter Info	[1], [2]
D0033		Alemtuzumab	NA	NA	Major		Inter Info	[1], [2]
D0048		Altretamine	C9H18N6	2123	Major		Inter Info	[1], [2]
D0085		Anakinra	C20H23N5O7S2	146171046	Major		Inter Info	[1], [2]
D0091		Antilymphocyte immunoglobulin (horse)	NA	NA	Major		Inter Info	[1], [2]
D0094		Antithymocyte immunoglobulin (rabbit)	NA	NA	Major		Inter Info	[1], [2]
D0114		Asparaginase Escherichia coli	NA	NA	Major		Inter Info	[1], [2]
D0118		Atezolizumab	NA	NA	Major		Inter Info	[1], [2]
D0134		Azacitidine	C8H12N4O5	9444	Major		Inter Info	[1], [2]
D0136		Azathioprine	C9H7N7O2S	2265	Major		Inter Info	[1], [2]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[1], [2]
D0147		Basiliximab	NA	NA	Major		Inter Info	[1], [2]
D0151		Belatacept	NA	NA	Major		Inter Info	[1], [2]
D0152		Belimumab	NA	NA	Major		Inter Info	[1], [2]
D0153		Belinostat	C15H14N2O4S	6918638	Major		Inter Info	[1], [2]
D0157		Bendamustine	C16H21Cl2N3O2	65628	Major		Inter Info	[1], [2]
D0172		Betamethasone	C22H29FO5	9782	Major		Inter Info	[1], [2]
D0178		Bexarotene	C24H28O2	82146	Major		Inter Info	[1], [2]
D0190		Bleomycin	C55H84N17O21S3+	5360373	Major		Inter Info	[1], [2]
D0191		Blinatumomab	NA	NA	Major		Inter Info	[1], [2]
D0193		Bortezomib	C19H25BN4O4	387447	Major		Inter Info	[1], [2]
D0199		Brentuximab vedotin	NA	NA	Major		Inter Info	[1], [2]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Major		Inter Info	[1], [2]
D0209		Brodalumab	NA	NA	Major		Inter Info	[1], [2]
D0215		Budesonide	C25H34O6	5281004	Major		Inter Info	[1], [2]
D0223		Busulfan	C6H14O6S2	2478	Major		Inter Info	[1], [2]
D0227		Cabazitaxel	C45H57NO14	9854073	Major		Inter Info	[1], [2]
D0246		Canakinumab	NA	NA	Major		Inter Info	[1], [2]
D0260		Carboplatin	C6H12N2O4Pt	426756	Major		Inter Info	[1], [2]
D0261		Carfilzomib	C40H57N5O7	11556711	Major		Inter Info	[1], [2]
D0264		Carmustine	C5H9Cl2N3O2	2578	Major		Inter Info	[1], [2]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [2]
D0312		Chlorambucil	C14H19Cl2NO2	2708	Major		Inter Info	[1], [2]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Major		Inter Info	[1], [2]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[1], [2]
D0357		Clofarabine	C10H11ClFN5O3	119182	Major		Inter Info	[1], [2]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Major		Inter Info	[1], [2]
D0392		Corticotropin	C207H308N56O58S	16132265	Major		Inter Info	[1], [2]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Major		Inter Info	[1], [2]
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[1], [2]
D0404		Cytarabine	C9H13N3O5	6253	Major		Inter Info	[1], [2]
D0407		Dacarbazine	C6H10N6O	135398738	Major		Inter Info	[1], [2]
D0410		Dactinomycin	C62H86N12O16	457193	Major		Inter Info	[1], [2]
D0422		Daratumumab	NA	NA	Major		Inter Info	[1], [2]
D0431		Decitabine	C8H12N4O4	451668	Major		Inter Info	[1], [2]
D0436		Deflazacort	C25H31NO6	189821	Major		Inter Info	[1], [2]
D0442		Denileukin diftitox	NA	NA	Major		Inter Info	[1], [2]
D0499		Dimethyl fumarate	C6H8O4	637568	Major		Inter Info	[1], [2]
D0501		Dinutuximab	NA	NA	Major		Inter Info	[1], [2]
D0511		Docetaxel	C43H53NO14	148124	Major		Inter Info	[1], [2]
D0540		Dupilumab	NA	NA	Major		Inter Info	[1], [2]
D0541		Durvalumab	NA	NA	Major		Inter Info	[1], [2]
D0553		Efalizumab	NA	NA	Major		Inter Info	[1], [2]
D0560		Elotuzumab	NA	NA	Major		Inter Info	[1], [2]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2]
D0627		Etoposide	C29H32O13	36462	Major		Inter Info	[1], [2]
D0666		Floxuridine	C9H11FN2O5	5790	Major		Inter Info	[1], [2]
D0669		Fludarabine	C10H12FN5O4	657237	Major		Inter Info	[1], [2]
D0675		Fluorouracil	C4H3FN2O2	3385	Major		Inter Info	[1], [2]
D0714		Gemcitabine	C9H11F2N3O4	60750	Major		Inter Info	[1], [2]
D0717		Gemtuzumab ozogamicin	NA	NA	Major		Inter Info	[1], [2]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2]
D0747		Guselkumab	NA	NA	Major		Inter Info	[1], [2]
D0773		Hydrocortisone	C21H30O5	5754	Major		Inter Info	[1], [2]
D0780		Hydroxyurea	CH4N2O2	3657	Major		Inter Info	[1], [2]
D0784		Ibritumomab tiuxetan	NA	NA	Major		Inter Info	[1], [2]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[1], [2]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Major		Inter Info	[1], [2]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Major		Inter Info	[1], [2]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Major		Inter Info	[1], [2]
D0824		Interferon alfa-n1	NA	NA	Major		Inter Info	[1], [2]
D0823		Interferon alfacon-1	NA	NA	Major		Inter Info	[1], [2]
D0828		Interferon gamma-1b	NA	NA	Major		Inter Info	[1], [2]
D0829		Iobenguane (I-131)	C8H10IN3	60860	Major		Inter Info	[1], [2]
D0845		Irinotecan	C33H38N4O6	60838	Major		Inter Info	[1], [2]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Major		Inter Info	[1], [2]
D0873		Ixabepilone	C27H42N2O5S	6445540	Major		Inter Info	[1], [2]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Major		Inter Info	[1], [2]
D0875		Ixekizumab	NA	NA	Major		Inter Info	[1], [2]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[1], [2]
D0902		Lenalidomide	C13H13N3O3	216326	Major		Inter Info	[1], [2]
D0910		Levamisole	C11H12N2S	26879	Major		Inter Info	[1], [2]
D0945		Lomustine	C9H16ClN3O2	3950	Major		Inter Info	[1], [2]
D0986		Mechlorethamine	C5H11Cl2N	4033	Major		Inter Info	[1], [2]
D0996		Melphalan	C13H18Cl2N2O2	460612	Major		Inter Info	[1], [2]
D1007		Mercaptopurine	C5H4N4S	667490	Major		Inter Info	[1], [2]
D1025		Methotrexate	C20H22N8O5	126941	Major		Inter Info	[1], [2]
D1041		Methylprednisolone	C22H30O5	6741	Major		Inter Info	[1], [2]
D1077		Mitomycin	C15H18N4O5	5746	Major		Inter Info	[1], [2]
D1079		Mitoxantrone	C22H28N4O6	4212	Major		Inter Info	[1], [2]
D1093		Muromonab	NA	NA	Major		Inter Info	[1], [2]
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Major		Inter Info	[1], [2]
D1095		Mycophenolic acid	C17H20O6	446541	Major		Inter Info	[1], [2]
D1111		Natalizumab	NA	NA	Major		Inter Info	[1], [2]
D1118		Nelarabine	C11H15N5O5	3011155	Major		Inter Info	[1], [2]
D1140		Niraparib	C19H20N4O	24958200	Major		Inter Info	[1], [2]
D1161		Obinutuzumab	NA	NA	Major		Inter Info	[1], [2]
D1162		Ocrelizumab	NA	NA	Major		Inter Info	[1], [2]
D1164		Ofatumumab	NA	NA	Major		Inter Info	[1], [2]
D1167		Olaparib	C24H23FN4O3	23725625	Major		Inter Info	[1], [2]
D1168		Olaratumab	NA	NA	Major		Inter Info	[1], [2]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Major		Inter Info	[1], [2]
D1212		Paclitaxel	C47H51NO14	36314	Major		Inter Info	[1], [2]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Major		Inter Info	[1], [2]
D1214		Palbociclib	C24H29N7O2	5330286	Major		Inter Info	[1], [2]
D1234		Pegaspargase	C14H19NO	436058	Major		Inter Info	[1], [2]
D1237		Peginterferon alfa-2a	NA	NA	Major		Inter Info	[1], [2]
D1238		Peginterferon alfa-2b	NA	NA	Major		Inter Info	[1], [2]
D1241		Pemetrexed	C20H21N5O6	135410875	Major		Inter Info	[1], [2]
D1250		Pentostatin	C11H16N4O4	439693	Major		Inter Info	[1], [2]
D1305		Plicamycin	C52H76O24	163659	Major		Inter Info	[1], [2]
D1306		Polatuzumab vedotin	NA	NA	Major		Inter Info	[1], [2]
D1312		Pomalidomide	C13H11N3O4	134780	Major		Inter Info	[1], [2]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[1], [2]
D1323		Pralatrexate	C23H23N7O5	148121	Major		Inter Info	[1], [2]
D1332		Prednisolone	C21H28O5	5755	Major		Inter Info	[1], [2]
D1334		Prednisone	C21H26O5	5865	Major		Inter Info	[1], [2]
D1345		Procarbazine	C12H19N3O	4915	Major		Inter Info	[1], [2]
D1403		Rilonacept	NA	NA	Major		Inter Info	[1], [2]
D1416		Rituximab	NA	NA	Major		Inter Info	[1], [2]
D1434		Ruxolitinib	C17H18N6	25126798	Major		Inter Info	[1], [2]
D1447		Sarilumab	NA	NA	Major		Inter Info	[1], [2]
D1454		Secukinumab	NA	NA	Major		Inter Info	[1], [2]
D1458		Selinexor	C17H11F6N7O	71481097	Major		Inter Info	[1], [2]
D1467		Siltuximab	NA	NA	Major		Inter Info	[1], [2]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[1], [2]
D0132		Axicabtagene ciloleucel	NA	NA	Major		Inter Info	[1], [2]
D0150		Belantamab mafodotin	NA	NA	Major		Inter Info	[1], [2]
D0203		Brexucabtagene autoleucel	NA	NA	Major		Inter Info	[1], [2]
D0389		Copanlisib	C23H28N8O4	135565596	Major		Inter Info	[1], [2]
D0507		Diroximel fumarate	C11H13NO6	73330464	Major		Inter Info	[1], [2]
D0571		Enfortumab vedotin	NA	NA	Major		Inter Info	[1], [2]
D0801		Inebilizumab	NA	NA	Major		Inter Info	[1], [2]
D0851		Isatuximab	NA	NA	Major		Inter Info	[1], [2]
D0939		Lisocabtagene maraleucel	NA	NA	Major		Inter Info	[1], [2]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Major		Inter Info	[1], [2]
D0964		Lutetium Lu 177 dotatate	C65H87LuN14O19S2	76966897	Major		Inter Info	[1], [2]
D1083		Mogamulizumab	NA	NA	Major		Inter Info	[1], [2]
D1085		Monomethyl fumarate	C5H6O4	5369209	Major		Inter Info	[1], [2]
D1113		Naxitamab	NA	NA	Major		Inter Info	[1], [2]
D1410		Risankizumab	NA	NA	Major		Inter Info	[1], [2]
D1435		Sacituzumab govitecan	C76H104N12O24S	91668186	Major		Inter Info	[1], [2]
D1448		Satralizumab	NA	NA	Major		Inter Info	[1], [2]
D1529		Tafasitamab	NA	NA	Major		Inter Info	[1], [2]
D1583		Tildrakizumab	NA	NA	Major		Inter Info	[1], [2]
D1594		Tisagenlecleucel	NA	NA	Major		Inter Info	[1], [2]
D1622		Trastuzumab deruxtecan	NA	NA	Major		Inter Info	[1], [2]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[1], [2]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[1], [2]
D1476		Sirolimus	C51H79NO13	5284616	Major		Inter Info	[1], [2]
D1508		Streptozocin	C8H15N3O7	29327	Major		Inter Info	[1], [2]
D1532		Talazoparib	C19H14F2N6O	135565082	Major		Inter Info	[1], [2]
D1548		Temozolomide	C6H6N6O2	5394	Major		Inter Info	[1], [2]
D1549		Temsirolimus	C56H87NO16	6918289	Major		Inter Info	[1], [2]
D1551		Teniposide	C32H32O13S	452548	Major		Inter Info	[1], [2]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[1], [2]
D1563		Tetracosactide	C136H210N40O31S	16133802	Major		Inter Info	[1], [2]
D1575		Thiotepa	C6H12N3PS	5453	Major		Inter Info	[1], [2]
D1589		Tioguanine	C5H5N5S	2723601	Major		Inter Info	[1], [2]
D1599		Tocilizumab	NA	NA	Major		Inter Info	[1], [2]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[1], [2]
D1610		Topotecan	C23H23N3O5	60700	Major		Inter Info	[1], [2]
D1613		Tositumomab	NA	NA	Major		Inter Info	[1], [2]
D1615		Trabectedin	C39H43N3O11S	108150	Major		Inter Info	[1], [2]
D1621		Trastuzumab	NA	NA	Major		Inter Info	[1], [2]
D1628		Triamcinolone	C21H27FO6	31307	Major		Inter Info	[1], [2]
D1630		Triamcinolone (ophthalmic)	C21H27FO6	31307	Major		Inter Info	[1], [2]
D1639		Trifluridine	C10H11F3N2O5	6256	Major		Inter Info	[1], [2]
D1646		Trimetrexate	C19H23N5O3	5583	Major		Inter Info	[1], [2]
D1667		Uracil mustard	C8H11Cl2N3O2	6194	Major		Inter Info	[1], [2]
D1671		Ustekinumab	NA	NA	Major		Inter Info	[1], [2]
D1685		Vedolizumab	NA	NA	Major		Inter Info	[1], [2]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[1], [2]
D1697		Vinblastine	C46H58N4O9	13342	Major		Inter Info	[1], [2]
D1698		Vincristine	C46H56N4O10	5978	Major		Inter Info	[1], [2]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Major		Inter Info	[1], [2]
D1700		Vinorelbine	C45H54N4O8	5311497	Major		Inter Info	[1], [2]
D1720		Zidovudine	C10H13N5O4	35370	Major		Inter Info	[1], [2]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[56]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[41], [81]
	Increased risk of atrioventricular block					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Minor		Inter Info	[41], [99]
	Increased risk of bradycardia					Drug Num: 60
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0010		Acebutolol	C18H28N2O4	1978	Major		Inter Info	[1], [2]
D0031		Alectinib	C30H34N4O2	49806720	Major		Inter Info	[1], [2]
D0052		Ambenonium	C28H42Cl2N4O2+2	2131	Major		Inter Info	[1], [2]
D0069		Amlodipine	C20H25ClN2O5	2162	Major		Inter Info	[1], [2]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[1], [2]
D0117		Atenolol	C14H22N2O3	2249	Major		Inter Info	[1], [2]
D0173		Betaxolol	C18H29NO3	2369	Major		Inter Info	[1], [2]
D0174		Betaxolol (ophthalmic)	C18H29NO3	2369	Major		Inter Info	[1], [2]
D0188		Bisoprolol	C18H31NO4	2405	Major		Inter Info	[1], [2]
D0265		Carteolol	C16H24N2O3	2583	Major		Inter Info	[1], [2]
D0266		Carteolol (ophthalmic)	C16H24N2O3	2583	Major		Inter Info	[1], [2]
D0267		Carvedilol	C24H26N2O4	2585	Major		Inter Info	[1], [2]
D0308		Cevimeline	C10H17NOS	83898	Major		Inter Info	[1], [2]
D0337		Cimetidine	C10H16N6S	2756	Major		Inter Info	[1], [2]
D0352		Clevidipine	C21H23Cl2NO6	153994	Major		Inter Info	[1], [2]
D0440		Demecarium (ophthalmic)	C32H52N4O4+2	5966	Major		Inter Info	[1], [2]
D0490		Digitoxin	C41H64O13	441207	Major		Inter Info	[1], [2]
D0491		Digoxin	C41H64O14	2724385	Major		Inter Info	[1], [2]
D0497		Diltiazem	C22H26N2O4S	39186	Major		Inter Info	[1], [2]
D0516		Donepezil	C24H29NO3	3152	Major		Inter Info	[1], [2]
D0546		Echothiophate (ophthalmic)	C9H23NO3PS+	10548	Major		Inter Info	[1], [2]
D0552		Edrophonium	C10H16NO+	3202	Major		Inter Info	[1], [2]
D0602		Esmolol	C16H25NO4	59768	Major		Inter Info	[1], [2]
D0636		Famotidine	C8H15N7O2S3	5702160	Major		Inter Info	[1], [2]
D0640		Felodipine	C18H19Cl2NO4	3333	Major		Inter Info	[1], [2]
D0707		Galantamine	C17H21NO3	9651	Major		Inter Info	[1], [2]
D0856		Isoflurophate (ophthalmic)	C6H14FO3P	5936	Major		Inter Info	[1], [2]
D0865		Isradipine	C19H21N3O5	3784	Major		Inter Info	[1], [2]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[1], [2]
D0884		Labetalol	C19H24N2O3	3869	Major		Inter Info	[1], [2]
D0885		Lacosamide	C13H18N2O3	219078	Major		Inter Info	[1], [2]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Major		Inter Info	[1], [2]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Major		Inter Info	[1], [2]
D0914		Levobetaxolol (ophthalmic)	C18H29NO3	60657	Major		Inter Info	[1], [2]
D0915		Levobunolol (ophthalmic)	C17H25NO3	39468	Major		Inter Info	[1], [2]
D1045		Metipranolol (ophthalmic)	C17H27NO4	31477	Major		Inter Info	[1], [2]
D1049		Metoprolol	C15H25NO3	4171	Major		Inter Info	[1], [2]
D1088		Moricizine	C22H25N3O4S	34633	Major		Inter Info	[1], [2]
D1098		Nadolol	C17H27NO4	39147	Major		Inter Info	[1], [2]
D1114		Nebivolol	C22H25F2NO4	71301	Major		Inter Info	[1], [2]
D1122		Neostigmine	C12H19N2O2+	4456	Major		Inter Info	[1], [2]
D1130		Nicardipine	C26H29N3O6	4474	Major		Inter Info	[1], [2]
D1134		Nifedipine	C17H18N2O6	4485	Major		Inter Info	[1], [2]
D1138		Nimodipine	C21H26N2O7	4497	Major		Inter Info	[1], [2]
D1141		Nisoldipine	C20H24N2O6	4499	Major		Inter Info	[1], [2]
D1151		Nizatidine	C12H21N5O2S2	3033637	Major		Inter Info	[1], [2]
D1244		Penbutolol	C18H29NO2	37464	Major		Inter Info	[1], [2]
D1285		Physostigmine	C15H21N3O2	5983	Major		Inter Info	[1], [2]
D1286		Physostigmine (ophthalmic)	C15H21N3O2	5983	Major		Inter Info	[1], [2]
D1288		Pilocarpine	C11H16N2O2	5910	Major		Inter Info	[1], [2]
D1293		Pindolol	C14H20N2O2	4828	Major		Inter Info	[1], [2]
D1357		Propranolol	C16H21NO2	4946	Major		Inter Info	[1], [2]
D1381		Ranitidine	C13H22N4O3S	3001055	Major		Inter Info	[1], [2]
D1382		Ranitidine (bismuth citrate)	C13H22N4O3S	3001055	Major		Inter Info	[1], [2]
D1418		Rivastigmine	C14H22N2O2	77991	Major		Inter Info	[1], [2]
D1510		Succinylcholine	C14H30N2O4+2	5314	Major		Inter Info	[1], [2]
D1525		Tacrine	C13H14N2	1935	Major		Inter Info	[1], [2]
D1585		Timolol	C13H24N4O3S	33624	Major		Inter Info	[1], [2]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Major		Inter Info	[1], [2]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[1], [2]
	Increased risk of hepatotoxicity					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[5]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[7]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[41], [55]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[57], [58], [59], [60]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[57], [58], [59], [60]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[67]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[57], [58], [59], [60]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[1], [41], [87], [88], [89]
	Increased risk of prolong QT interval					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[1], [41], [42], [43], [44], [45], [46], [47]
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[65], [66]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[1], [41], [68]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[71], [72], [73], [74], [75], [76], [77], [78], [79], [80]
D1051		Metronidazole	C6H9N3O3	4173	Minor		Inter Info	[1], [92], [93], [94]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Minor		Inter Info	[48], [1], [41], [95], [96], [97], [98]
	Increased risk of ventricular arrhythmias					Drug Num: 192
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0003		Abarelix	C72H95ClN14O14	16131215	Major		Inter Info	[1], [2]
D0025		Adenosine	C10H13N5O4	60961	Major		Inter Info	[1], [2]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[1], [2]
D0067		Amisulpride	C17H27N3O4S	2159	Major		Inter Info	[1], [2]
D0068		Amitriptyline	C20H23N	2160	Major		Inter Info	[1], [2]
D0072		Amoxapine	C17H16ClN3O	2170	Major		Inter Info	[1], [2]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[1], [2]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[1], [2]
D0097		Apomorphine	C17H17NO2	6005	Major		Inter Info	[1], [2]
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[1], [2]
D0112		Asenapine	C17H16ClNO	3036780	Major		Inter Info	[1], [2]
D0115		Astemizole	C28H31FN4O	2247	Major		Inter Info	[1], [2]
D0119		Atomoxetine	C17H21NO	54841	Major		Inter Info	[1], [2]
D0139		Azithromycin	C38H72N2O12	447043	Major		Inter Info	[1], [2]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[1], [2]
D0170		Bepridil	C24H34N2O	2351	Major		Inter Info	[1], [2]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Major		Inter Info	[1], [2]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[1], [2]
D0219		Buprenorphine	C29H41NO4	644073	Major		Inter Info	[1], [2]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[1], [2]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[1], [2]
D0320		Chloroquine	C18H26ClN3	2719	Major		Inter Info	[1], [2]
D0324		Chlorpromazine	C17H19ClN2S	2726	Major		Inter Info	[1], [2]
D0336		Cilostazol	C20H27N5O2	2754	Major		Inter Info	[1], [2]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[1], [2]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[1], [2]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[1], [2]
D0358		Clofazimine	C27H22Cl2N4	2794	Major		Inter Info	[1], [2]
D0361		Clomipramine	C19H23ClN2	2801	Major		Inter Info	[1], [2]
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[1], [2]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[1], [2]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[1], [2]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Major		Inter Info	[1], [2], [4]
D0437		Degarelix	C82H103ClN18O16	16136245	Major		Inter Info	[1], [2]
D0446		Desipramine	C18H22N2	2995	Major		Inter Info	[1], [2]
D0452		Deutetrabenazine	C19H27NO3	73437646	Major		Inter Info	[1], [2]
D0467		Dextropropoxyphene	C22H29NO2	10100	Major		Inter Info	[1], [2], [4]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[1], [2]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[1], [2]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[1], [2]
D0526		Doxepin (topical)	C19H21NO	667477	Major		Inter Info	[1], [2], [4]
D0528		Doxorubicin	C27H29NO11	31703	Major		Inter Info	[1], [2]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Major		Inter Info	[1], [2], [4]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[1], [2]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[1], [2]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[1], [2]
D0577		Entrectinib	C31H34F2N6O2	25141092	Major		Inter Info	[1], [2]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[1], [2]
D0584		Epirubicin	C27H29NO11	41867	Major		Inter Info	[1], [2]
D0594		Eribulin	C40H59NO11	11354606	Major		Inter Info	[1], [2]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[1], [2]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[1], [2]
D0664		Flecainide	C17H20F6N2O3	3356	Major		Inter Info	[1], [2]
D0676		Fluoxetine	C17H18F3NO	3386	Major		Inter Info	[1], [2]
D0678		Fluphenazine	C22H26F3N3OS	3372	Major		Inter Info	[1], [2]
D0682		Flutamide	C11H11F3N2O3	3397	Major		Inter Info	[1], [2]
D0694		Foscarnet	CH3O5P	3415	Major		Inter Info	[1], [2]
D0700		Fostemsavir	C25H26N7O8P	11319217	Major		Inter Info	[1], [2]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[1], [2]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Major		Inter Info	[1], [2]
D0720		Gilteritinib	C29H44N8O3	49803313	Major		Inter Info	[1], [2]
D0725		Glasdegib	C21H22N6O	25166913	Major		Inter Info	[1], [2]
D0737		Goserelin	C59H84N18O14	5311128	Major		Inter Info	[1], [2]
D0740		Grepafloxacin	C19H22FN3O3	72474	Major		Inter Info	[1], [2]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[1], [2]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[1], [2]
D0751		Halothane	C2HBrClF3	3562	Major		Inter Info	[1], [2]
D0758		Histrelin	C66H86N18O12	25077993	Major		Inter Info	[1], [2]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Major		Inter Info	[1], [2]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Major		Inter Info	[1], [2]
D0787		Ibutilide	C20H36N2O3S	60753	Major		Inter Info	[1], [2]
D0788		Idarubicin	C26H27NO9	42890	Major		Inter Info	[1], [2]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[1], [2]
D0795		Imipramine	C19H24N2	3696	Major		Inter Info	[1], [2]
D0806		Inotuzumab ozogamicin	NA	NA	Major		Inter Info	[1], [2]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Major		Inter Info	[1], [2]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Major		Inter Info	[1], [2]
D0908		Leuprolide	C59H84N16O12	657181	Major		Inter Info	[1], [2]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[1], [2], [4]
D0919		Levofloxacin	C18H20FN3O4	149096	Major		Inter Info	[1], [2]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Major		Inter Info	[1], [2]
D0942		Lofexidine	C11H12Cl2N2O	30668	Major		Inter Info	[1], [2]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Major		Inter Info	[1], [2]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Major		Inter Info	[1], [2], [4]
D0979		Maprotiline	C20H23N	4011	Major		Inter Info	[1], [2]
D0992		Mefloquine	C17H16F6N2O	4046	Major		Inter Info	[1], [2]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[1], [2]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[1], [2]
D1026		Methotrimeprazine	C19H24N2OS	72287	Major		Inter Info	[1], [2]
D1062		Midostaurin	C35H30N4O4	9829523	Major		Inter Info	[1], [2]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[1], [2]
D1075		Mirtazapine	C17H19N3	4205	Major		Inter Info	[1], [2]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[1], [2]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[1], [2]
D1137		Nilutamide	C12H10F3N3O4	4493	Major		Inter Info	[1], [2]
D1155		Norfloxacin	C16H18FN3O3	4539	Major		Inter Info	[1], [2]
D1158		Nortriptyline	C19H21N	4543	Major		Inter Info	[1], [2]
D1165		Ofloxacin	C18H20FN3O4	4583	Major		Inter Info	[1], [2]
D1181		Ondansetron	C18H19N3O	4595	Major		Inter Info	[1], [2]
D1189		Osilodrostat	C13H10FN3	44139752	Major		Inter Info	[1], [2]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[1], [2]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Major		Inter Info	[1], [2]
D1210		Oxytocin	C43H66N12O12S2	439302	Major		Inter Info	[1], [2]
D1215		Paliperidone	C23H27FN4O3	115237	Major		Inter Info	[1], [2]
D1216		Palonosetron	C19H24N2O	6337614	Major		Inter Info	[1], [2]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[1], [2]
D1223		Papaverine	C20H21NO4	4680	Major		Inter Info	[1], [2]
D1230		Pasireotide	C58H66N10O9	9941444	Major		Inter Info	[1], [2]
D1232		Pazopanib	C21H23N7O2S	10113978	Major		Inter Info	[1], [2]
D1246		Pentamidine	C19H24N4O2	4735	Major		Inter Info	[1], [2]
D1254		Perflutren	C3F8	6432	Major		Inter Info	[1], [2]
D1257		Perphenazine	C21H26ClN3OS	4748	Major		Inter Info	[1], [2]
D1290		Pimavanserin	C25H34FN3O2	10071196	Major		Inter Info	[1], [2]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[1], [2]
D1339		Primaquine	C15H21N3O	4908	Major		Inter Info	[1], [2]
D1342		Probucol	C31H48O2S2	4912	Major		Inter Info	[1], [2]
D1343		Procainamide	C13H21N3O	4913	Major		Inter Info	[1], [2]
D1351		Promazine	C17H20N2S	4926	Major		Inter Info	[1], [2]
D1352		Promethazine	C17H20N2S	4927	Major		Inter Info	[1], [2]
D1353		Propafenone	C21H27NO3	4932	Major		Inter Info	[1], [2]
D1368		Quetiapine	C21H25N3O2S	5002	Major		Inter Info	[1], [2]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[1], [2]
D1372		Quinine	C20H24N2O2	3034034	Major		Inter Info	[1], [2]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[1], [2]
D1388		Relugolix	C29H27F2N7O5S	10348973	Major		Inter Info	[1], [2]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[1], [2]
D1404		Rilpivirine	C22H18N6	6451164	Major		Inter Info	[1], [2]
D1413		Risperidone	C23H27FN4O2	5073	Major		Inter Info	[1], [2]
D1424		Romidepsin	C24H36N4O6S2	5352062	Major		Inter Info	[1], [2]
D1432		Rucaparib	C19H18FN3O	9931954	Major		Inter Info	[1], [2]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[1], [2]
D1461		Sertraline	C17H17Cl2N	68617	Major		Inter Info	[1], [2]
D1463		Sevoflurane	C4H3F7O	5206	Major		Inter Info	[1], [2]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[1], [2]
D0940		Lithium carbonate	CLi2O3	11125	Major		Inter Info	[1], [2], [4]
D0965		Macimorelin	C26H30N6O3	9804938	Major		Inter Info	[1], [2]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[1], [2]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[1], [2]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[1], [2]
D1491		Solifenacin	C23H26N2O2	154059	Major		Inter Info	[1], [2]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Major		Inter Info	[1], [2]
D1522		Sunitinib	C22H27FN4O2	5329102	Major		Inter Info	[1], [2]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[1], [2]
D1533		Tamoxifen	C26H29NO	2733526	Major		Inter Info	[1], [2]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Major		Inter Info	[1], [2]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[1], [2]
D1555		Terfenadine	C32H41NO2	5405	Major		Inter Info	[1], [2]
D1560		Tetrabenazine	C19H27NO3	6018	Major		Inter Info	[1], [2]
D1569		Thalidomide	C13H10N2O4	5426	Major		Inter Info	[1], [2]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[1], [2]
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[1], [2]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[1], [2]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[1], [2]
D1624		Trazodone	C19H22ClN5O	5533	Major		Inter Info	[1], [2]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Major		Inter Info	[1], [2]
D1637		Trifluoperazine	C21H24F3N3S	5566	Major		Inter Info	[1], [2]
D1638		Triflupromazine	C18H19F3N2S	5568	Major		Inter Info	[1], [2]
D1647		Trimipramine	C20H26N2	5584	Major		Inter Info	[1], [2]
D1651		Triptorelin	C64H82N18O13	25074470	Major		Inter Info	[1], [2]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Major		Inter Info	[1], [2]
D1682		Vardenafil	C23H32N6O4S	135400189	Major		Inter Info	[1], [2]
D1683		Vasopressin	C46H65N15O12S2	644077	Major		Inter Info	[1], [2]
D1689		Venlafaxine	C17H27NO2	5656	Major		Inter Info	[1], [2]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[1], [2]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[1], [2]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[48], [1], [41], [49], [50], [51]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[48], [1], [41], [49], [50], [51]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[48], [1], [41], [49], [50], [51]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[24], [34], [37]
D0888		Lactulose	C12H22O11	11333	Moderate		Inter Info	[48], [1], [41], [49], [50], [51]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[48], [1], [41], [49], [50], [51]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[48], [1], [41], [49], [50], [51]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[48], [1], [41], [49], [50], [51]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[24], [34], [37]
D1266		Phenolphthalein	C20H14O4	4764	Moderate		Inter Info	[48], [1], [41], [49], [50], [51]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[41], [69], [70]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[41], [69], [70]
D1309		Polyethylene glycol (3350)	C2H6O2	174	Moderate		Inter Info	[1], [41], [51]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[24], [34], [37]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D0701		Frangula purshiana bark	NA	NA	Moderate		Inter Info	[1], [41], [51]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[48], [1], [41], [49], [50], [51]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[24], [34], [37]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[41], [69], [70]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[24], [34], [37]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[1], [2]
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[1], [2]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[1], [2]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[1], [2]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[1], [2]
D1808		Human adenovirus e serotype 4 strain cl-68578 antigen	NA	NA	Major		Inter Info	[1], [2]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[1], [2]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[8]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[1], [2]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[1], [2]
D1693		Vibrio cholerae CVD 103-HgR strain live antigen (live)	NA	NA	Major		Inter Info	[1], [2]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[1], [2]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[82], [83], [84]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[82], [83], [84]
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[52], [53], [54]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[52], [53], [54]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[52], [53], [54]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[52], [53], [54]

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