Details of Drug

Drug General Information (ID: D1465)
Drug Name	Sildenafil
Drug Type	Small molecule
Drug Synonymous	sildenafil; 139755-83-2; VIAGRA; Sildenafil [INN:BAN]; UK-92480; UNII-3M7OB98Y7H; UK-92,480-10; C22H30N6O4S; HSDB 7305; CHEMBL192; UK 92480-10; CHEBI:9139; 3M7OB98Y7H; 1-((3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine; BNRNXUUZRGQAQC-UHFFFAOYSA-N; 5-(2-Ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one; Sildenafil Click to Show/Hide
Disease Class	4A00: Innate/adaptive immunodeficiency; HA00-HA01: Sexual dysfunction
Therapeutic Class	Impotence Agents/Agents For Pulmonary Hypertension
Structure
Structure	3D Structure		2D Structure
Formula	C22H30N6O4S
InChI	1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)
InChIKey	BNRNXUUZRGQAQC-UHFFFAOYSA-N
Canonical SMILES	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C
External Link
	Pubchem ID	135398744
	CAS Number	139755-83-2
	CHEBI ID	9139
	TTD ID	D0Z7ZM
	VARIDT ID	DR00565

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM042 Additive hypotensive effects BM050 Increased risk of bleeding BM083 Potentiated the pharmacological effects (Unspecific) BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Sildenafil
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 71
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11]
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[12], [3], [4], [5], [6], [7], [13], [14], [15], [16], [17], [18], [19], [8], [20], [10], [21], [22], [11]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[12], [3], [4], [5], [6], [7], [13], [14], [15], [16], [17], [18], [19], [8], [20], [10], [21], [22], [11]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[12], [3], [4], [5], [6], [7], [13], [14], [15], [16], [17], [18], [19], [8], [20], [10], [21], [22], [11]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[3], [4], [5], [6], [7], [8], [25], [10], [11]
D0426		Darunavir	C27H37N3O7S	213039	Major		Inter Info	[12], [3], [4], [5], [6], [7], [13], [14], [15], [16], [17], [18], [19], [8], [20], [10], [21], [22], [11]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[12], [3], [4], [5], [6], [7], [13], [14], [15], [16], [17], [18], [19], [8], [20], [10], [21], [22], [11]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[12], [3], [4], [5], [6], [7], [13], [14], [15], [16], [17], [18], [19], [8], [20], [10], [21], [22], [11]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[12], [3], [4], [5], [6], [7], [13], [14], [15], [16], [17], [18], [19], [8], [20], [10], [21], [22], [11]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[12], [3], [4], [5], [6], [7], [13], [14], [15], [16], [17], [18], [19], [8], [20], [10], [21], [22], [11]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[12], [3], [4], [5], [6], [7], [13], [14], [15], [16], [17], [18], [19], [8], [20], [10], [21], [22], [11]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[12], [3], [4], [5], [6], [7], [13], [14], [15], [16], [17], [18], [19], [8], [20], [10], [21], [22], [11]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[4], [8], [10], [11]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[4], [8], [10], [11]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[28]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[4], [8], [10], [11]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[4], [8], [10], [11]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[4], [8], [10], [11]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[4], [8], [10], [11]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[4], [8], [10], [11]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[4], [10], [11], [43]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[4], [8], [10], [11]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[4], [8], [10], [11]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[3], [4], [5], [7], [44], [11]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[4], [8], [10], [11]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[8], [10], [11]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[4], [8], [10], [11]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[45], [46]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[4], [8], [10], [11]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[4], [8], [10], [11]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[4], [8], [10], [11]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[4], [8], [10], [11]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[4], [8], [10], [11]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[8], [10], [11]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[52]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[4], [8], [10], [11]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[4], [8], [10], [11]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[4], [8], [10], [11]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[4], [8], [10], [11]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[4], [8], [10], [11]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[4], [8], [10], [11]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[4], [8], [10], [11]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[65]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[8], [10], [11]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[4], [8], [10], [11]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[68]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[1], [2], [69], [70]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[8], [10], [11]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[4], [8], [10], [11]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[4], [8], [10], [11]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[4], [8], [10], [11]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[4], [8], [10], [11]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[4], [8], [10], [11]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[4], [8], [10], [11]
D1471		Simeprevir	C38H47N5O7S2	24873435	Moderate		Inter Info	[77]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[4], [8], [10], [11]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[4], [8], [10], [11]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[4], [8], [10], [11]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[4], [8], [10], [11]
	CYP450 enzyme induction					Drug Num: 50
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[29]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[4], [8], [10], [11]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[4], [8], [10], [11]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[4], [8], [10], [11]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[4], [8], [10], [11]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[8], [40]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[41]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[4], [8], [10], [11]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[4], [8], [10], [11]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[4], [8], [10], [11]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[4], [8], [10], [11]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[4], [8], [10], [11]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[4], [8], [10], [11]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[1], [49]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[4], [8], [10], [11]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[4], [8], [10], [11]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[4], [8], [10], [11]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[50]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[51]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[4], [8], [10], [11]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[4], [8], [10], [11]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[4], [8], [10], [11]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[4], [8], [10], [11]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[4], [8], [10], [11]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[4], [8], [11]
D1078		Mitotane	C14H10Cl4	4211	Moderate		Inter Info	[4], [8], [10], [11]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[4], [8], [10], [11]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[4], [8], [10], [11]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[4], [8], [10], [11]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[4], [8], [10], [11]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[4], [8], [10], [11]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[4], [8], [10], [11]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[4], [8], [10], [11]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[4], [8], [10], [11]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[4], [8], [10], [11]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[4], [8], [10], [11]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[4], [8], [11]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[4], [8], [10], [11]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[4], [8], [10], [11]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[4], [8], [11]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[4], [8], [10], [11]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[4], [8], [10], [11]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[4], [8], [10], [11]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[4], [8], [10], [11]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[2], [81]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[4], [8], [10], [11]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[4], [8], [11]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[4], [8], [10], [11]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[83], [84], [85], [86], [87]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[83], [84], [85], [86], [87]
	Competitive inhibition of metabolic enzyme					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[78], [79]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[80]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[78], [79]
Pharmacodynamic additive effects
	Additive hypotensive effects					Drug Num: 118
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0083		Amyl Nitrite	C5H11NO2	10026	Major		Inter Info	[23], [24], [10]
D0860		Isosorbide	C6H10O4	12597	Major		Inter Info	[23], [24], [10]
D0861		Isosorbide dinitrate	C6H8N2O8	6883	Major		Inter Info	[23], [24], [10]
D0862		Isosorbide mononitrate	C6H9NO6	27661	Major		Inter Info	[23], [24], [10]
D1146		Nitroglycerin	C3H5N3O9	4510	Major		Inter Info	[23], [24], [10]
D1147		Nitroprusside	C5FeN6O	11953891	Major		Inter Info	[23], [24], [10]
D1408		Riociguat	C20H19FN8O2	11304743	Major		Inter Info	[1], [2], [26]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[24], [27], [10]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[24], [27], [10]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[24], [27], [10]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[24], [27], [10]
D0012		Acetazolamide	C4H6N4O3S2	1986	Moderate		Inter Info	[24], [27], [10]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[24], [27], [10]
D0046		Alprostadil	C20H34O5	5280723	Moderate		Inter Info	[24], [27], [10]
D0053		Ambrisentan	C22H22N2O4	6918493	Moderate		Inter Info	[24], [27], [10]
D0055		Amifostine	C5H15N2O3PS	2141	Moderate		Inter Info	[30], [31], [32]
D0058		Amiloride	C6H8ClN7O	16231	Moderate		Inter Info	[24], [27], [10]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[24], [27], [10]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[30], [33], [34]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[35], [36], [37]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[24], [27], [10]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Moderate		Inter Info	[24], [27], [10]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[24], [27], [10]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[24], [27], [10]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[24], [27], [10]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[24], [27], [10]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[35], [36], [37]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[24], [27], [10]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[1], [2], [42]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[24], [27], [10]
D0265		Carteolol	C16H24N2O3	2583	Moderate		Inter Info	[24], [27], [10]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[24], [27], [10]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[24], [27], [10]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[24], [27], [10]
D0352		Clevidipine	C21H23Cl2NO6	153994	Moderate		Inter Info	[24], [27], [10]
D0363		Clonidine	C9H9Cl2N3	2803	Moderate		Inter Info	[24], [27], [10]
D0396		Cyclandelate	C17H24O3	2893	Moderate		Inter Info	[24], [27], [10]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[1], [2], [42]
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[24], [27], [10]
D0474		Diazoxide	C8H7ClN2O2S	3019	Moderate		Inter Info	[24], [27], [10]
D0479		Diclofenamide	C6H6Cl2N2O4S2	3038	Moderate		Inter Info	[24], [27], [10]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[48], [8], [10]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[1], [2], [42]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[24], [27], [10]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[24], [27], [10]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[24], [27], [10]
D0587		Eprosartan	C23H24N2O4S	5281037	Moderate		Inter Info	[24], [27], [10]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[24], [27], [10]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[2], [23], [24], [27], [10]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[24], [27], [10]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[24], [27], [10]
D0742		Guanabenz	C8H8Cl2N4	5702063	Moderate		Inter Info	[24], [27], [10]
D0743		Guanadrel	C10H19N3O2	38521	Moderate		Inter Info	[24], [27], [10]
D0744		Guanethidine	C10H22N4	3518	Moderate		Inter Info	[24], [27], [10]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[24], [27], [10]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[24], [27], [10]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[24], [27], [10]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[24], [27], [10]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[24], [27], [10]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[24], [27], [10]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [31], [63], [64]
D0864		Isoxsuprine	C18H23NO3	3783	Moderate		Inter Info	[24], [27], [10]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[24], [27], [10]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[24], [27], [10]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[24], [27], [10]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [31], [63], [64]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[24], [27], [10]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[24], [27], [10]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[67]
D0983		Mecamylamine	C11H21N	4032	Moderate		Inter Info	[24], [27], [10]
D1018		Methazolamide	C5H8N4O3S2	4100	Moderate		Inter Info	[24], [27], [10]
D1035		Methyldopa	C10H13NO4	38853	Moderate		Inter Info	[24], [27], [10]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[24], [27], [10]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[24], [27], [10]
D1072		Minoxidil	C9H15N5O	4201	Moderate		Inter Info	[24], [27], [10]
D1848		Minoxidil (topical)	C9H15N5O	4201	Moderate		Inter Info	[71], [72]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[24], [27], [10]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[24], [27], [10]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[24], [27], [10]
D1125		Nesiritide	C143H244N50O42S4	53325981	Moderate		Inter Info	[24], [27], [10]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[24], [27], [10]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[24], [27], [10]
D1148		Nitrous acid	HNO2	24529	Moderate		Inter Info	[73], [74], [75]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[24], [27], [10]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [31], [63], [64]
D1223		Papaverine	C20H21NO4	4680	Moderate		Inter Info	[24], [27], [10]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[24], [27], [10]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[76]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[24], [27], [10]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [31], [63], [64]
D1267		Phenoxybenzamine	C18H22ClNO	4768	Moderate		Inter Info	[48], [8], [10]
D1271		Phentolamine	C17H19N3O	5775	Moderate		Inter Info	[48], [8], [10]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[24], [27], [10]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[24], [27], [10]
D1331		Prazosin	C19H21N5O4	4893	Moderate		Inter Info	[48], [8], [10]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [31], [63], [64]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[24], [27], [10]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[24], [27], [10]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [31], [63], [64]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[24], [27], [10]
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [31], [63], [64]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [31], [63], [64]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[48], [8], [10]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[24], [27], [10]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[24], [27], [10]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[48], [8], [10]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[24], [27], [10]
D1552		Terazosin	C19H25N5O4	5401	Moderate		Inter Info	[48], [8], [10]
D1602		Tolazoline	C10H12N2	5504	Moderate		Inter Info	[24], [27], [10]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[24], [27], [10]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[24], [27], [10]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [31], [63], [64]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[24], [27], [10]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[24], [27], [10]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[24], [27], [10]
D1643		Trimethaphan	C22H25N2OS+	23576	Moderate		Inter Info	[24], [27], [10]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[24], [27], [10]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[24], [27], [10]
	Increased risk of bleeding					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[2], [8]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[2], [47], [8]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[2], [8]
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[38], [39]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[38], [39]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[38], [39]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[38], [39]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[38], [39]
D0470		Dezocine	C16H23NO	3033053	Moderate		Inter Info	[38], [39]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[38], [39]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[38], [39]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[38], [39]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[38], [39]
D0909		Levacetylmethadol	C23H31NO2	15130	Moderate		Inter Info	[38], [39]
D0923		Levorphanol	C17H23NO	5359272	Moderate		Inter Info	[38], [39]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[38], [39]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[38], [39]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[38], [39]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[38], [39]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[38], [39]
D1208		Oxymorphone	C17H19NO4	5284604	Moderate		Inter Info	[38], [39]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[38], [39]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0952		Lorcaserin	C11H14ClN	11658860	Moderate		Inter Info	[66]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[82], [31]

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84	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
85	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
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