Drug General Information (ID: DDIVC4RYZX)
Drug Name			Sildenafil		Drug Info		Hydrocodone		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Impotence Agents/Agents For Pulmonary Hypertension				Analgesics
Structure

Mechanism of Sildenafil-Hydrocodone Interaction (Severity Level: Moderate)
Potentiated the pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Sildenafil				Hydrocodone
Mechanism		Sildenafil				Increased sildenafil action leads to prolonged erection time
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Enhanced pharmacological effects leading to increased adverse reactions.
Mechanism Description		Potentiate the pharmacologic effects by the combination of Sildenafil and Hydrocodone

Recommended Action
Management		Patients using sildenafil should be advised of the potential for prolonged erections during acute intake of opiates, and to contact their physician if problems occur. The interaction may not occur during chronic use of opiates.

References
1	Jetter A, Kinzig-Schippers M, Walchner-Bonjean M, et al. "Effects of grapefruit juice on the pharmacokinetics of sildenafil." Clin Pharmacol Ther 71 (2002): 21-29
2	Goldmeier D, Lamba H "Prolonged erections produced by dihydrocodeine and sildenafil." BMJ 324 (2002): 1555