Details of Drug

Drug General Information (ID: D1457)
Drug Name	Selexipag
Drug Type	Small molecule
Drug Synonymous	Selexipag; NS-304; 475086-01-2; Uptravi; NS 304; ACT-293987; UNII-5EXC0E384L; Selexipag(NS-304); ACT 293987; 5EXC0E384L; 2-(4-((5,6-diphenylpyrazin-2-yl)(isopropyl)amino)butoxy)-N-(methylsulfonyl)acetamide; 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}-N-(methylsulfonyl)acetamide; 2-(4-((5,6-Diphenylpyrazin-2-yl)(propan-2-yl)amino)butoxy}-n-(methanesulfonyl)acetamide; Selexipag [USAN:INN]; 2-{4-[(5,6-diphenylpyrazin-2-yl)(propan-2-yl)amino]butoxy}-N-(methanesulfonyl)acetamide; Uptravi (TN) Click to Show/Hide
Disease Class	BB01: Pulmonary hypertension
Therapeutic Class	Agents For Pulmonary Hypertension
Structure
Structure	3D Structure		2D Structure
Formula	C26H32N4O4S
InChI	1S/C26H32N4O4S/c1-20(2)30(16-10-11-17-34-19-24(31)29-35(3,32)33)23-18-27-25(21-12-6-4-7-13-21)26(28-23)22-14-8-5-9-15-22/h4-9,12-15,18,20H,10-11,16-17,19H2,1-3H3,(H,29,31)
InChIKey	QXWZQTURMXZVHJ-UHFFFAOYSA-N
Canonical SMILES	CC(C)N(CCCCOCC(=O)NS(=O)(=O)C)C1=CN=C(C(=N1)C2=CC=CC=C2)C3=CC=CC=C3
External Link
	Pubchem ID	9913767
	CAS Number	475086-01-2
	CHEBI ID	90844
	TTD ID	D0N2SR
	INTEDE ID	DR1471

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM010 Transporter inhibition BM011 Transporter induction BM017 CYP450 enzyme inhibition BM019 UGT inhibition BM022 CYP450 enzyme induction BM023 UGT induction BM042 Additive hypotensive effects
Relation Graph

Full list of drugs interacting with Selexipag
Affected cellular transport
	Transporter inhibition					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[33]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[4]
D1191		Ospemifene	C24H23ClO2	3036505	Moderate		Inter Info	[4], [40], [41]
D0155		Bempedoic acid	C19H36O5	10472693	Moderate		Inter Info	[45], [46]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[4], [47], [48]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[49]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[50]
D0558		Elexacaftor	C26H34F3N7O4S	134587348	Moderate		Inter Info	[52], [53], [54]
D0568		Enasidenib	C19H17F6N7O	89683805	Moderate		Inter Info	[15], [55]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[4], [56]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[57]
D0700		Fostemsavir	C25H26N7O8P	11319217	Moderate		Inter Info	[59]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[15], [4], [60]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[4], [61]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[63]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[70]
D1539		Tedizolid	C17H15FN6O3	11234049	Moderate		Inter Info	[4], [72]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[73]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[15], [4], [75], [76]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 21
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0715		Gemfibrozil	C15H22O3	3463	Major		Inter Info	[1], [2], [3]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[3]
D0364		Clopidogrel	C16H16ClNO2S	60606	Moderate		Inter Info	[15], [4], [17], [3]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[15], [4], [17], [3]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[3]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[3]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[3]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[3]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[43]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[51]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[58]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[15], [4], [62]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[64], [65], [66]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[67]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[3]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[15], [4], [17], [3]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Moderate		Inter Info	[15], [4], [17], [3]
D1645		Trimethoprim	C14H18N4O3	5578	Moderate		Inter Info	[3]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[15], [4], [17], [3]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[3]
D0948		Lopinavir	C37H48N4O5	92727	Minor		Inter Info	[77], [78], [3]
	UGT inhibition					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[15], [4]
D1341		Probenecid	C13H19NO4S	4911	Moderate		Inter Info	[15], [4]
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[15], [4]
	CYP450 enzyme induction					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[18], [15], [4], [19]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[4], [3]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[15], [4], [3]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[4], [44]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[4], [69]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[15], [4], [71]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[15], [4], [71]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[15], [4], [74], [71]
	UGT induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[15], [4], [68]
Pharmacodynamic additive effects
	Additive hypotensive effects					Drug Num: 132
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[4], [5], [6]
D0012		Acetazolamide	C4H6N4O3S2	1986	Moderate		Inter Info	[4], [5], [6]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[4], [5], [6]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[4], [5], [6]
D0046		Alprostadil	C20H34O5	5280723	Moderate		Inter Info	[4], [5], [6]
D0055		Amifostine	C5H15N2O3PS	2141	Moderate		Inter Info	[7], [8], [9]
D0058		Amiloride	C6H8ClN7O	16231	Moderate		Inter Info	[4], [5], [6]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[4], [5], [6]
D0083		Amyl Nitrite	C5H11NO2	10026	Moderate		Inter Info	[4], [5], [6]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[7], [10], [11]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[12], [13], [14]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[4], [5], [6]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Moderate		Inter Info	[4], [5], [6]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[4], [5], [6]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[4], [5], [6]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[4], [5], [6]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[4], [5], [6]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[4], [5], [6]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[4], [5], [6]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[12], [13], [14]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[12], [13], [14]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[4], [5], [6]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[15], [4], [16]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[4], [5], [6]
D0265		Carteolol	C16H24N2O3	2583	Moderate		Inter Info	[4], [5], [6]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[4], [5], [6]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[4], [5], [6]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[4], [5], [6]
D0352		Clevidipine	C21H23Cl2NO6	153994	Moderate		Inter Info	[4], [5], [6]
D0363		Clonidine	C9H9Cl2N3	2803	Moderate		Inter Info	[4], [5], [6]
D0396		Cyclandelate	C17H24O3	2893	Moderate		Inter Info	[4], [5], [6]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[15], [4], [16]
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[4], [5], [6]
D0474		Diazoxide	C8H7ClN2O2S	3019	Moderate		Inter Info	[4], [5], [6]
D0479		Diclofenamide	C6H6Cl2N2O4S2	3038	Moderate		Inter Info	[4], [5], [6]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[4], [5], [6]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[4], [5], [6]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[15], [4], [16]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[4], [5], [6]
D0579		Ephedrine	C10H15NO	9294	Moderate		Inter Info	[20], [5], [6]
D0580		Ephedrine (nasal)	C10H15NO	9294	Moderate		Inter Info	[20], [5], [6]
D0581		Epinephrine	C9H13NO3	5816	Moderate		Inter Info	[20], [5], [6]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[4], [5], [6]
D0587		Eprosartan	C23H24N2O4S	5281037	Moderate		Inter Info	[4], [5], [6]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[4], [5], [6]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[4], [5], [6]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[4], [5], [6]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[4], [5], [6]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[4], [5], [6]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[4], [5], [6]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[4], [5], [6]
D0742		Guanabenz	C8H8Cl2N4	5702063	Moderate		Inter Info	[4], [5], [6]
D0743		Guanadrel	C10H19N3O2	38521	Moderate		Inter Info	[4], [5], [6]
D0744		Guanethidine	C10H22N4	3518	Moderate		Inter Info	[4], [5], [6]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[4], [5], [6]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[4], [5], [6]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[4], [5], [6]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[4], [5], [6]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[4], [5], [6]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[4], [5], [6]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [8], [31], [32]
D0860		Isosorbide	C6H10O4	12597	Moderate		Inter Info	[4], [5], [6]
D0861		Isosorbide dinitrate	C6H8N2O8	6883	Moderate		Inter Info	[4], [5], [6]
D0862		Isosorbide mononitrate	C6H9NO6	27661	Moderate		Inter Info	[4], [5], [6]
D0864		Isoxsuprine	C18H23NO3	3783	Moderate		Inter Info	[4], [5], [6]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[4], [5], [6]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[4], [5], [6]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[4], [5], [6]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [8], [31], [32]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[4], [5], [6]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[4], [5], [6]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[4], [5], [6]
D0978		Mannitol	C6H14O6	6251	Moderate		Inter Info	[4], [5], [6]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[34]
D0983		Mecamylamine	C11H21N	4032	Moderate		Inter Info	[4], [5], [6]
D1018		Methazolamide	C5H8N4O3S2	4100	Moderate		Inter Info	[4], [5], [6]
D1035		Methyldopa	C10H13NO4	38853	Moderate		Inter Info	[4], [5], [6]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[4], [5], [6]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[4], [5], [6]
D1072		Minoxidil	C9H15N5O	4201	Moderate		Inter Info	[4], [5], [6]
D1848		Minoxidil (topical)	C9H15N5O	4201	Moderate		Inter Info	[35], [36]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[4], [5], [6]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[4], [5], [6]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[4], [5], [6]
D1125		Nesiritide	C143H244N50O42S4	53325981	Moderate		Inter Info	[4], [5], [6]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[4], [5], [6]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[4], [5], [6]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[4], [5], [6]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[4], [5], [6]
D1146		Nitroglycerin	C3H5N3O9	4510	Moderate		Inter Info	[4], [5], [6]
D1147		Nitroprusside	C5FeN6O	11953891	Moderate		Inter Info	[4], [5], [6]
D1148		Nitrous acid	HNO2	24529	Moderate		Inter Info	[37], [38], [39]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[4], [5], [6]
D1223		Papaverine	C20H21NO4	4680	Moderate		Inter Info	[4], [5], [6]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[4], [5], [6]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[4], [5], [6]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [8], [31], [32]
D1267		Phenoxybenzamine	C18H22ClNO	4768	Moderate		Inter Info	[4], [5], [6]
D1271		Phentolamine	C17H19N3O	5775	Moderate		Inter Info	[4], [5], [6]
D1276		Phenylephrine	C9H13NO2	6041	Moderate		Inter Info	[20], [5], [6]
D1281		Phenylpropanolamine	C9H13NO	26934	Moderate		Inter Info	[20], [5], [6]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[4], [5], [6]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[4], [5], [6]
D1331		Prazosin	C19H21N5O4	4893	Moderate		Inter Info	[4], [5], [6]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [8], [31], [32]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[4], [5], [6]
D1363		Pseudoephedrine	C10H15NO	7028	Moderate		Inter Info	[20], [5], [6]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[4], [5], [6]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[4], [5], [6]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [8], [31], [32]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[4], [5], [6]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[42]
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [8], [31], [32]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [8], [31], [32]
D0213		Bromotheophylline	C7H7BrN4O2	11808	Moderate		Inter Info	[4], [5], [6]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [8], [31], [32]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[4], [5], [6]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[4], [5], [6]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[4], [5], [6]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[4], [5], [6]
D1552		Terazosin	C19H25N5O4	5401	Moderate		Inter Info	[4], [5], [6]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[4], [5], [6]
D1602		Tolazoline	C10H12N2	5504	Moderate		Inter Info	[4], [5], [6]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[4], [5], [6]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[4], [5], [6]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [8], [31], [32]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[4], [5], [6]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[4], [5], [6]
D1643		Trimethaphan	C22H25N2OS+	23576	Moderate		Inter Info	[4], [5], [6]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[4], [5], [6]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[4], [5], [6]
D1527		Tadalafil	C22H19N3O4	110635	Minor		Inter Info	[79], [80]

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