Details of Drug

Drug General Information (ID: D1429)
Drug Name	Rosiglitazone
Drug Type	Small molecule
Drug Synonymous	rosiglitazone; 122320-73-4; Avandia; 5-(4-(2-(Methyl(pyridin-2-yl)amino)ethoxy)benzyl)thiazolidine-2,4-dione; Rosiglizole; Brl-49653; Brl 49653; BRL49653; rosiglitazone (Avandia); Avandaryl; TDZ 01; Rezult; Avandamet; C18H19N3O3S; CHEBI:50122; MFCD00871760; Rosigilitazone; 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione; 5-((4-(2-Methyl-2-(pyridinylamino)ethoxy)phenyl)methyl)-2,4-thiazolidinedione-2-butenedioate; 2,4-Thiazolidinedione, 5-((4-(2-(methyl-2-pyridinylamino)ethoxy)phenyl)methyl)-; NSC-758698; NCGC00095124-01; BRL 49653C; 5-(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione; 2,4-thiazolidinedione, 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-; 5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione; DSSTox_CID_17131; DSSTox_RID_79303; DSSTox_GSID_37131; 5-[4-[2-[Methyl(2-pyridyl)amino]ethoxy]benzyl]thiazolidine-2,4-dione; Rosiglitazone [INN:BAN]; 5-[4-[2-(N-Methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione; 5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)methyl]-1,3-thiazolidine-2,4-dione; CAS-122320-73-4; SR-01000763023; rosiglitazona; rosiglitazonum; Gaudil; Rosvel; Rosi; DTXSID7037131; HSDB 7555; Rosiglitazone base; 5-((4-(2-(methyl-2-pyridinylamino)ethoxy)phenyl)methyl)-2,4-thiazolidinedione; 5-[4-[2-[N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione; RGZ; Gaudil (TN); Rosiglitazone (INN); Rosiglitazone- Bio-X; Spectrum_001703; 1217260-35-9; Spectrum2_001241; Spectrum3_000997; Spectrum4_001125; Spectrum5_001464; SCHEMBL5169; Dioxopromethazinehydrochloride; BSPBio_002693; KBioGR_001609; KBioSS_002183; SPECTRUM1504263; SPBio_001142; GTPL1056; TDZ-01; SCHEMBL14383595; KBio2_002183; KBio2_004751; KBio2_007319; KBio3_001913; Rosiglitazone, >=98% (HPLC); HMS1922J11; HMS2094O13; HMS3649G08; HMS3656K16; HMS3744M11; HMS3871L03; HMS3884N08; Pharmakon1600-01504263; ACT04332; BCP03047; Tox21_111434; BDBM50030474; CCG-39102; NSC758698; STL350047; AKOS015894872; Tox21_111434_1; AC-3459; BCP9000017; CS-1088; DB00412; MCULE-8293284864; NSC 758698; SB17326; NCGC00095124-02; NCGC00095124-03; NCGC00095124-04; NCGC00095124-05; NCGC00095124-06; NCGC00095124-08; BR164372; HY-17386; SY031184; BCP0726000232; FT-0602578; R0106; S2556; SW197573-6; 20R734; 6P-065; D08491; J10213; S00306; AB00698473-15; AB00698473-17; AB00698473-18; AB00698473-19; AB00698473_20; AB00698473_21; AB00698473_22; AB00698473_23; Q424771; Q-201681; SR-01000763023-5; SR-01000763023-6; BRD-A97437073-001-02-3; BRD-A97437073-001-03-1; BRD-A97437073-001-04-9; SR-01000763023-12; (RS)-5-{4-[2-(Methyl-2-pyridylamino)ethoxy]benzyl}-2,4-thiazolidinedion; 5-(4-(2-(Methyl(pyridin-2-yl)amino)ethoxy)-benzyl)thiazolidine-2,4-dione; 5-[4-[2-(N-Methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4dione; IDMB (1uM BRL49653, 1uM Dexamethasone, 0.5uM IBMX, 10ug/mL Insulin); (+/-)-5-[p-[2-(methyl-2-pyridylamino)ethoxy]benzyl]-2,4-thiazolidinedione; 2,4-Thiazolidinedione, 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]- (9CI); 5-[[4-[2-(methyl-(2-pyridyl)amino)ethoxy]phenyl]methyl] thiazolidine-2,4-dione; 5-[[4-[2-(methyl-2-pyridinylamino) ethoxy]phenyl]methyl]-2,4-thiazolidinedione; 5-[[4-[2-(Methyl-2-pyridinylamino)e thoxy]phenyl]methyl]-2,4-thiazolidinedione; 5-[[4-[2-(methyl-pyridin-2-ylamino)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione; 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl] thiazolidine-2,4-dione; 5-[4-[2-[N-methyl-N-(2-pyridyl)amino]ethoxy]phenyl methyl]thiazolidine-2,4-dione Click to Show/Hide
Therapeutic Class	Thiazolidinediones
Structure
Structure	3D Structure		2D Structure
Formula	C18H19N3O3S
InChI	InChI=1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,15H,10-12H2,1H3,(H,20,22,23)
InChIKey	YASAKCUCGLMORW-UHFFFAOYSA-N
Canonical SMILES	CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3
External Link
	Pubchem ID	77999
	INTEDE ID	DR1444
	VARIDT ID	DR01221

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM055 Increased risk of hepatotoxicity BM064 Increased risk of hypoglycemia BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Rosiglitazone
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[32], [33], [34], [35], [36], [37], [38]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[32], [33], [34], [35], [36], [37], [38]
D0715		Gemfibrozil	C15H22O3	3463	Moderate		Inter Info	[32], [34], [36], [37]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[32], [97], [98]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[32], [33], [34], [35], [36], [37], [38]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[32], [33], [34], [35], [36], [37], [38]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[102]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[32], [33], [34], [35], [36], [37], [38]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[32], [33], [34], [35], [36], [37], [38]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[32], [34], [38]
D1645		Trimethoprim	C14H18N4O3	5578	Moderate		Inter Info	[32], [33], [34], [35], [36], [37], [38]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[32], [33], [34], [35], [36], [37], [38]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[32], [33], [34], [35], [36], [37], [38]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[88], [13], [193]
	CYP450 enzyme induction					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[42], [43], [44]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[88], [13], [89]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Moderate		Inter Info	[99], [13], [100]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[32], [35], [107], [36], [37], [108]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[32], [35], [107], [36], [37], [108]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[32], [35], [107], [36], [37], [108]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[32], [36], [37]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[32], [35], [107], [36], [37], [108]
D0061		Aminoglutethimide	C13H16N2O2	2145	Minor		Inter Info	[199], [200], [27]
Pharmacodynamic additive effects
	Increased risk of hepatotoxicity					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[4], [5], [6]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[7]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[8]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[9]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[4], [5], [6]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[19], [20], [21], [22]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[19], [20], [21], [22]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[47]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[48]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[13], [49]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[87]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[90], [91]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[88], [13], [92]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[96]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[13], [101]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[103]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[19], [20], [21], [22]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[13], [189]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[194], [195]
	Increased risk of hypoglycemia					Drug Num: 32
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[13], [14], [15]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[16], [17], [18]
D1092		Moxifloxacin	C21H24FN3O4	152946	Moderate		Inter Info	[16], [17], [18]
D1862		Pegvisomant	NA	NA	Moderate		Inter Info	[26], [27], [28]
D1270		Phentermine	C10H15N	4771	Moderate		Inter Info	[29], [30], [31]
D1736		Aloe Vera Leaf	C15H10O5	10207	Moderate		Inter Info	[39], [40], [41]
D0165		Benzphetamine	C17H21N	5311017	Moderate		Inter Info	[29], [30], [31]
D1759		Chromic chloride	NA	NA	Moderate		Inter Info	[50], [51], [52]
D0332		Chromium picolinate	C18H12CrN3O6	151932	Moderate		Inter Info	[50], [51], [52]
D0340		Cinoxacin	C12H10N2O5	2762	Moderate		Inter Info	[16], [17], [18]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Moderate		Inter Info	[16], [17], [18]
D0457		Dexfenfluramine	C12H16F3N	66265	Moderate		Inter Info	[29], [30], [31]
D0486		Diethylpropion	C13H19NO	7029	Moderate		Inter Info	[29], [30], [31]
D0573		Enoxacin	C15H17FN4O3	3229	Moderate		Inter Info	[16], [17], [18]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[29], [30], [31]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Moderate		Inter Info	[16], [17], [18]
D0723		Ginseng	C42H66O17	420552	Moderate		Inter Info	[93], [94], [95]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[16], [17], [18]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Moderate		Inter Info	[16], [17], [18]
D0952		Lorcaserin	C11H14ClN	11658860	Moderate		Inter Info	[29], [30], [31]
D0981		Mazindol	C16H13ClN2O	4020	Moderate		Inter Info	[29], [30], [31]
D1012		Metamfetamine	C10H15N	10836	Moderate		Inter Info	[29], [30], [31]
D1102		Nalidixic acid	C12H12N2O3	4421	Moderate		Inter Info	[16], [17], [18]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[16], [17], [18]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[16], [17], [18]
D1187		Orlistat	C29H53NO5	3034010	Moderate		Inter Info	[29], [30], [31]
D1262		Phendimetrazine	C12H17NO	30487	Moderate		Inter Info	[29], [30], [31]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[29], [30], [31]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Moderate		Inter Info	[16], [17], [18]
D1661		Turmeric	C21H20O6	969516	Moderate		Inter Info	[190], [191], [192]
D1836		Lipoic acid	C8H14O2S2	6112	Minor		Inter Info	[27], [201], [202]
D0711		Garlic	NA	NA	Minor		Inter Info	[203], [204], [205]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0083		Amyl Nitrite	C5H11NO2	10026	Moderate		Inter Info	[36], [45], [46]
D0860		Isosorbide	C6H10O4	12597	Moderate		Inter Info	[36], [45], [46]
D0861		Isosorbide dinitrate	C6H8N2O8	6883	Moderate		Inter Info	[36], [45], [46]
D0862		Isosorbide mononitrate	C6H9NO6	27661	Moderate		Inter Info	[36], [45], [46]
D1146		Nitroglycerin	C3H5N3O9	4510	Moderate		Inter Info	[36], [45], [46]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 160
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[1], [2], [3]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[10], [11], [12]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[10], [11], [12]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[10], [11], [12]
D0388		Conjugated estrogens (topical)	C18H21NaO5S	45357473	Moderate		Inter Info	[10], [11], [12]
D0450		Desogestrel	C22H30O	40973	Moderate		Inter Info	[10], [11], [12]
D0487		Diethylstilbestrol	C18H20O2	448537	Moderate		Inter Info	[10], [11], [12]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[10], [11], [12]
D0737		Goserelin	C59H84N18O14	5311128	Moderate		Inter Info	[10], [11], [12]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[10], [11], [12]
D0908		Leuprolide	C59H84N16O12	657181	Moderate		Inter Info	[10], [11], [12]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[10], [11], [12]
D0934		Liothyronine	C15H12I3NO4	5920	Moderate		Inter Info	[10], [11], [12]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[10], [11], [12]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[10], [11], [12]
D1153		Norepinephrine	C8H11NO3	439260	Moderate		Inter Info	[10], [11], [12]
D1163		Octreotide	C49H66N10O10S2	448601	Moderate		Inter Info	[23], [24], [25]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[10], [11], [12]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[10], [11], [12]
D1276		Phenylephrine	C9H13NO2	6041	Moderate		Inter Info	[10], [11], [12]
D1281		Phenylpropanolamine	C9H13NO	26934	Moderate		Inter Info	[10], [11], [12]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[10], [11], [12]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[10], [11], [12]
D1349		Progesterone (topical)	C21H30O2	5994	Moderate		Inter Info	[10], [11], [12]
D0012		Acetazolamide	C4H6N4O3S2	1986	Moderate		Inter Info	[10], [11], [12]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[10], [11], [12]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[10], [11], [12]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[10], [11], [12]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[10], [11], [12]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[10], [11], [12]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[10], [11], [12]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[10], [11], [12]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[10], [11], [12]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[10], [11], [12]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[10], [11], [12]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[10], [11], [12]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[10], [11], [12]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[10], [11], [12]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[10], [11], [12]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[10], [11], [12]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[10], [11], [12]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[10], [11], [12]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[53], [54], [55], [56], [57], [58], [59], [60], [61], [16], [62], [1], [2], [63], [64], [17], [65], [66], [67], [68], [69], [3], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [18], [84], [85], [86]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[10], [11], [12]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[10], [11], [12]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[10], [11], [12]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[10], [11], [12]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[10], [11], [12]
D0474		Diazoxide	C8H7ClN2O2S	3019	Moderate		Inter Info	[10], [11], [12]
D0479		Diclofenamide	C6H6Cl2N2O4S2	3038	Moderate		Inter Info	[10], [11], [12]
D0484		Dienestrol (topical)	C18H18O2	667476	Moderate		Inter Info	[10], [11], [12]
D0510		Dobutamine	C18H23NO3	36811	Moderate		Inter Info	[10], [11], [12]
D0517		Dopamine	C8H11NO2	681	Moderate		Inter Info	[10], [11], [12]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[10], [11], [12]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[10], [11], [12]
D0579		Ephedrine	C10H15NO	9294	Moderate		Inter Info	[10], [11], [12]
D0581		Epinephrine	C9H13NO3	5816	Moderate		Inter Info	[10], [11], [12]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[10], [11], [12]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[10], [11], [12]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[10], [11], [12]
D0608		Estramustine	C23H31Cl2NO3	259331	Moderate		Inter Info	[10], [11], [12]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[10], [11], [12]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[10], [11], [12]
D0611		Estrone sulfate (topical)	C18H22O5S	3001028	Moderate		Inter Info	[10], [11], [12]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[10], [11], [12]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[10], [11], [12]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[10], [11], [12]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[10], [11], [12]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[10], [11], [12]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[10], [11], [12]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[10], [11], [12]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[10], [11], [12]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[10], [11], [12]
D0758		Histrelin	C66H86N18O12	25077993	Moderate		Inter Info	[10], [11], [12]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[10], [11], [12]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[10], [11], [12]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[10], [11], [12]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[10], [11], [12]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[10], [11], [12]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[10], [11], [12]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[10], [11], [12]
D0891		Lanreotide	C54H69N11O10S2	71349	Moderate		Inter Info	[23], [24], [25]
D0925		Levothyroxine	C15H11I4NO4	5819	Moderate		Inter Info	[10], [11], [12]
D0935		Liotrix	C30H21I7N2Na2O8	71371	Moderate		Inter Info	[10], [11], [12]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[10], [11], [12]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[10], [11], [12]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[10], [11], [12]
D1002		Mephentermine	C11H17N	3677	Moderate		Inter Info	[10], [11], [12]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[10], [11], [12]
D1013		Metaraminol	C9H13NO2	5906	Moderate		Inter Info	[10], [11], [12]
D1018		Methazolamide	C5H8N4O3S2	4100	Moderate		Inter Info	[10], [11], [12]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[10], [11], [12]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[10], [11], [12]
D1027		Methoxamine	C11H17NO3	6082	Moderate		Inter Info	[10], [11], [12]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[10], [11], [12]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[10], [11], [12]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[10], [11], [12]
D1129		Niacin	C6H5NO2	938	Moderate		Inter Info	[10], [11], [12]
D1132		Nicotinamide	C6H6N2O	936	Moderate		Inter Info	[10], [11], [12]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[10], [11], [12]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[10], [11], [12]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[10], [11], [12]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[10], [11], [12]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[10], [11], [12]
D1230		Pasireotide	C58H66N10O9	9941444	Moderate		Inter Info	[23], [24], [25]
D1246		Pentamidine	C19H24N4O2	4735	Moderate		Inter Info	[104], [105], [106]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[10], [11], [12]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[10], [11], [12]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[10], [11], [12]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [10], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [45], [11], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [44], [166], [167], [168], [169], [170], [171], [172], [12], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[10], [11], [12]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[10], [11], [12]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [10], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [45], [11], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [44], [166], [167], [168], [169], [170], [171], [172], [12], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[10], [11], [12]
D1363		Pseudoephedrine	C10H15NO	7028	Moderate		Inter Info	[10], [11], [12]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[10], [11], [12]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[10], [11], [12]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[10], [11], [12]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[10], [11], [12]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[10], [11], [12]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[10], [11], [12]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[10], [11], [12]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[10], [11], [12]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[10], [11], [12]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[10], [11], [12]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[10], [11], [12]
D1531		Tagraxofusp	NA	NA	Moderate		Inter Info	[10], [11], [12]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[10], [11], [12]
D1900		Teprotumumab	NA	NA	Moderate		Inter Info	[10], [11], [12]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[10], [11], [12]
D1902		Tesamorelin	C221H366N72O67S	16137828	Moderate		Inter Info	[10], [11], [12]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[10], [11], [12]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[10], [11], [12]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[10], [11], [12]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[10], [11], [12]
D1630		Triamcinolone (ophthalmic)	C21H27FO6	31307	Moderate		Inter Info	[10], [11], [12]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[10], [11], [12]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[10], [11], [12]
D1651		Triptorelin	C64H82N18O13	25074470	Moderate		Inter Info	[10], [11], [12]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[10], [11], [12]
D1707		Vorinostat	C14H20N2O3	5311	Moderate		Inter Info	[10], [11], [12]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[10], [11], [12]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[10], [11], [12]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[10], [11], [12]
D1748		Betamethasone (topical)	C22H29FO5	9782	Minor		Inter Info	[196], [197], [198]
D1762		Clobetasol (topical)	C22H28ClFO4	5311051	Minor		Inter Info	[196], [197], [198]
D1763		Clocortolone (topical)	C22H28ClFO4	5311052	Minor		Inter Info	[196], [197], [198]
D1770		Desonide (topical)	C24H32O6	5311066	Minor		Inter Info	[196], [197], [198]
D1771		Desoximetasone (topical)	C22H29FO4	5311067	Minor		Inter Info	[196], [197], [198]
D0455		Dexamethasone (ophthalmic)	C22H29FO5	5743	Minor		Inter Info	[13], [26], [27]
D1772		Dexamethasone (topical)	C22H29FO5	5743	Minor		Inter Info	[196], [197], [198]
D1786		Fluocinonide (topical)	C26H32F2O7	9642	Minor		Inter Info	[196], [197], [198]
D1788		Flurandrenolide (topical)	C24H33FO6	15209	Minor		Inter Info	[196], [197], [198]
D0685		Fluticasone (topical)	C22H27F3O4S	5311101	Minor		Inter Info	[196], [197], [198]
D1804		Halcinonide (topical)	C24H32ClFO5	443943	Minor		Inter Info	[196], [197], [198]
D1813		Hydrocortisone (topical)	C21H30O5	5754	Minor		Inter Info	[196], [197], [198]
D1844		Methylprednisolone (topical)	C22H30O5	6741	Minor		Inter Info	[196], [197], [198]
D1869		Prednicarbate (topical)	C27H36O8	6714002	Minor		Inter Info	[196], [197], [198]
D1911		Triamcinolone (topical)	C21H27FO6	31307	Minor		Inter Info	[196], [197], [198]
D1916		Ulobetasol (topical)	C22H27ClF2O4	5311167	Minor		Inter Info	[196], [197], [198]
	Antagonize the effect of antihypertensive agents					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1888		Sermorelin	C149H246N44O42S	16132413	Moderate		Inter Info	[10], [11], [12]
D1908		Thyrotropin alfa	C16H22N6O4	32281	Moderate		Inter Info	[10], [11], [12]
D1735		Alclometasone (topical)	C22H29ClO5	5311000	Minor		Inter Info	[196], [197], [198]
D1737		Amcinonide	C28H35FO7	443958	Minor		Inter Info	[196], [197], [198]
D1773		Diflorasone (topical)	C22H28F2O5	71415	Minor		Inter Info	[196], [197], [198]

References
1	Greenberg AL, Decerbo M, Fan J "Gatifloxacin therapy associated with hypoglycemia." Clin Infect Dis 40 (2005): 1210-1. [PMID: 15791528]
2	Happe MR, Mulhall BP, Maydonovitch CL, Holtzmuller KC "Gatifloxacin-induced hyperglycemia." Ann Intern Med 141 (2004): 968-9. [PMID: 15611500]
3	Park-Wyllie LY, Juurlink DN, Kopp A, et al. "Outpatient gatifloxacin therapy and dysglycemia in older adults." N Engl J Med 354 (2006): 1352-61. [PMID: 16510739]
4	Canadian Pharmacists Association.
5	EMEA "EMEA public statement on leflunomide (ARAVA) - severe and serious hepatic reactions.".
6	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
7	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
8	Product Information. Kynamro (mipomersen). Genzyme Corporation, Cambridge, MA.
9	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
10	Jori A, Carrara MC "On the mechanism of the hyperglycaemic effect of chlorpromazine." J Pharm Pharmacol 18 (1966): 623-4. [PMID: 4381950]
11	Product Information. Dymelor (acetohexamide) Lilly, Eli and Company, Indianapolis, IN.
12	Product Information. Thorazine (chlorpromazine). SmithKline Beecham, Philadelphia, PA.
13	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
14	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
15	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA."
16	Gavin JR 3rd, Kubin R, Choudhri S, et al "Moxifloxacin and glucose homeostasis: a pooled-analysis of the evidence from clinical and postmarketing studies." Drug Saf 27 (2004): 671-86. [PMID: 15230648]
17	Kelesidis T, Canseco E "Quinolone-induced hypoglycemia: a life-threatening but potentially reversible side effect." Am J Med 123 (2010): e5-6. [PMID: 20103009]
18	Yip C, Lee AJ "Gatifloxacin-induced hyperglycemia: a case report and summary of the current literature." Clin Ther 28 (2006): 1857-66. [PMID: 17213006]
19	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
20	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
21	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
22	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
23	Product Information. Sandostatin (octreotide). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
24	Product Information. Somatuline Depot (lanreotide). Ipsen Inc, Milford, MA.
25	Williams G, Fuessl HS, Burrin JM, Chilvers E, Bloom SR "Postprandial glycaemic effects of a long-acting somatostatin analogue (octreotide) in non-insulin diabetes mellitus." Horm Metab Res 20 (1988): 168-70. [PMID: 2898427]
26	Jerntorp P, Almer LO "Chlorpropamide-alcohol flushing in relation to macroangiopathy and peripheral neuropathy in non-insulin dependent diabetes." Acta Med Scand 656 (1981): 33-6. [PMID: 6953748]
27	Skillman TG, Feldman JM "The pharmacology of sulfonylureas." Am J Med 70 (1981): 361-72. [PMID: 6781341]
28	Product Information. Somavert (pegvisomant). Pharmacia and Upjohn, Kalamazoo, MI.
29	Product Information. Didrex (benzphetamine) Pharmacia and Upjohn, Kalamazoo, MI.
30	Product Information. Xenical (orlistat). Roche Laboratories, Nutley, NJ.
31	Product Information. Suprenza (phentermine). Akrimax Pharmaceuticals, Cranford, NJ.
32	Baldwin SJ, Clarke SE, Chenery RJ "Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of rosiglitazone." Br J Clin Pharmacol 48 (1999): 424-32. [PMID: 10510156]
33	Hruska MW, Amico JA, Langaee TY, Ferrell RE, Fitzgerald SM, Frye RF "The effect of trimethoprim on CYP2C8 mediated rosiglitazone metabolism in human liver microsomes and healthy subjects." Br J Clin Pharmacol 59 (2005): 70-9. [PMID: 15606443]
34	Niemi M, Backman JT, Granfors M, Laitila J, Neuvonen M, Neuvonen PJ "Gemfibrozil considerably increases the plasma concentrations of rosiglitazone." Diabetologia 46 (2003): 1319-23. [PMID: 12898007]
35	Niemi M, Backman JT, Neuvonen PJ "Effects of trimethoprim and rifampin on the pharmacokinetics of the cytochrome P450 2C8 substrate rosiglitazone." Clin Pharmacol Ther 76 (2004): 239-49. [PMID: 15371985]
36	Product Information. Avandia (rosiglitazone) SmithKline Beecham, Philadelphia, PA.
37	Scheen AJ "Pharmacokinetic interactions with thiazolidinediones." Clin Pharmacokinet 46 (2007): 1-12. [PMID: 17201456]
38	Wen X, Wang JS, Backman JT, Laitila J, Neuvonen PJ "Trimethoprim and sulfamethoxazole are selective inhibitors of CYP2C8 and CYP2C9, respectively." Drug Metab Dispos 30 (2002): 631-635. [PMID: 12019187]
39	Yeh GY, Eisenberg DM, Kaptchuk TJ, Phillips RS "Systemic review of herbs and dietary supplements for glycemic control in diabetes." Diabetes Care 26 (2003): 1277-94. [PMID: 12663610]
40	Tanaka M, Misawa E, Yousuke I, et al "Identification of five phytosterols from Aloe vera gel as anti-diabetic compounds." Biol Pharm Bull 29 (2006): 1418-22. [PMID: 16819181]
41	Vogller BK "Aloe vera: a systematic review of its clinical effectiveness." Br J Gen Pract 49 (1999): 823-8. [PMID: 10885091]
42	Fuhr U, Maier-Bruggemann A, Blume H, et al. "Grapefruit juice increases oral nimodipine bioavailability." Int J Clin Pharmacol Ther 36 (1998): 126-32. [PMID: 9562227]
43	Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41. [PMID: 10721388]
44	Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
45	Product Information. Diabinese (chlorpropamide). Pfizer US Pharmaceuticals, New York, NY.
46	Canadian Pharmacists Association "e-CPS."
47	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
48	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
49	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
50	Anderson RA, cheng N, Bryden NA, et al "Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes." Diabetes 46 (1997): 1786-91. [PMID: 9356027]
51	Martin J, Wang ZQ, Zhang XH, et al. "Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes." Diabetes Care 29 (2006): 1826-32. [PMID: 16873787]
52	Fox GN, Sabovic Z "Chromium picolinate supplementation for diabetes mellitus." J Fam Pract 46 (1998): 83-6. [PMID: 9451374]
53	Baker SE, Hangii MC "Possible gatifloxacin-induced hypoglycemia." Ann Pharmacother 36 (2002): 1722-6. [PMID: 12398567]
54	Bhasin R, Arce FC, Pasmantier R "Hypoglycemia associated with the use of gatifloxacin." Am J Med Sci 330 (2005): 250-3. [PMID: 16284487]
55	Biggs WS "Hypoglycemia and hyperglycemia associated with gatifloxacin use in elderly patients." J Am Board Fam Pract 16 (2004): 455-7. [PMID: 14645336]
56	Blommel AL, Lutes RA "Severe hyperglycemia during renally adjusted gatifloxacin therapy." Ann Pharmacother 39 (2005): 1349-52. [PMID: 15941822]
57	Brogan SE, Cahalan MK "Gatifloxacin as a possible cause of serious postoperative hypoglycemia." Anesth Analg 101 (2005): 635-6. [PMID: 16115964]
58	Donaldson AR, Vandiver JR, Finch CK "Possible gatifloxacin-induced hyperglycemia." Ann Pharmacother 38 (2004): 602-5. [PMID: 14982977]
59	Edwards DJ, Bowles SK, Svensson CK, Rybak MJ "Inhibition of drug metabolism by quinolone antibiotics." Clin Pharmacokinet 15 (1988): 194-204. [PMID: 3052987]
60	Friedrich LV, Dougherty R "Fatal hypoglycemia associated with levofloxacin." Pharmacotherapy 24 (2004): 1807-12. [PMID: 15585448]
61	Frothingham R "Glucose homeostasis abnormalities associated with use of gatifloxacin." Clin Infect Dis 41 (2005): 1269-76. [PMID: 16206101]
62	Graumlich JF, Habis S, Avelino RR, et al. "Hypoglycemia in inpatients after gatifloxacin or levofloxacin therapy: nested case-control study." Pharmacotherapy 25 (2005): 1296-302. [PMID: 16185172]
63	Hypoglycemia and hyperglycemia with fluoroquinolones. Med Lett Drugs Ther 45 (2003): 64. [PMID: 12888740]
64	Kanbay M, Aydogan T, Bozalan R, et al. "A rare but serious side effect of levofloxacin: hypoglycemia in a geriatric patient." Diabetes Care 29 (2006): 1716-7. [PMID: 16801617]
65	Khovidhunkit W, Sunthornyothin S "Hypoglycemia, hyperglycemia, and gatifloxacin." Ann Intern Med 141 (2004): 969. [PMID: 15611501]
66	LeBlanc M, Belanger C, Cossette P "Severe and resistant hypoglycemia associated with concomitant gatifloxacin and glyburide therapy." Pharmacotherapy 24 (2004): 926-31. [PMID: 15303456]
67	Haerian H, McHugh P, Brown R, Somes G, Solomon SS. Gatifloxacin produces both hypoglycemia and hyperglycemia: a retrospective study.?Am J Med Sci. 2008;335(2):95-98. [PMID: 18277115]
68	Lin G, Hays DP, Spillane L "Refractory hypoglycemia from ciprofloxacin and glyburide interaction." J Toxicol Clin Toxicol 42 (2004): 295-7. [PMID: 15362597]
69	Menzies DJ, Dorsainvil PA, Cunha BA, Johnson DH "Severe and persistent hypoglycemia due to gatifloxacin interaction with oral hypoglycemic agents." Am J Med 113 (2002): 232-4. [PMID: 12208383]
70	Product Information. Baxdela (delafloxacin). Melinta Therapeutics, Lincolnshire, IL.
71	Product Information. Cipro (ciprofloxacin). Bayer, West Haven, CT.
72	Product Information. Factive (gemifloxacin). GeneSoft Inc, San Francisco, CA.
73	Product Information. Floxin (ofloxacin). Ortho Pharmaceutical Corporation, Raritan, NJ.
74	Product Information. Levaquin (levofloxacin). Ortho Pharmaceutical Corporation, Raritan, NJ.
75	Product Information. Noroxin (norfloxacin). Merck & Co, Inc, West Point, PA.
76	Product Information. Raxar (grepafloxacin). Glaxo Wellcome, Research Triangle Park, NC.
77	Product Information. Tequin (gatifloxacin) Bristol-Myers Squibb, Princeton, NJ.
78	Product Information. Trovan (trovafloxacin). Pfizer US Pharmaceuticals, New York, NY.
79	Roberge RJ, Kaplan R, Frank R, Fore C "Glyburide-ciprofloxacin interaction with resistant hypoglycemia." Ann Emerg Med 36 (2000): 160-3. [PMID: 10918110]
80	Rubinstein E "History of quinolones and their side effects." Chemotherapy 47 Suppl 3 (2001): 3-8. [PMID: 11549783]
81	Saraya A, Yokokura M, Gonoi T, Seino S "Effects of fluoroquinolones on insulin secretion and beta-cell ATP-sensitive K(+) channels." Eur J Pharmacol 497 (2004): 111-7. [PMID: 15321742]
82	Tomita T, Onishi M, Sato E, Kimura Y, Kihira K "Gatifloxacin induces augmented insulin release and intracellular insulin." Biol Pharm Bull 30 (2007): 644-7. [PMID: 17409495]
83	Wang S, Rizvi AA "Levofloxacin-induced hypoglycemia in a nondiabetic patient." Am J Med Sci 331 (2006): 334-5. [PMID: 16775443]
84	Zhanel GG, Fontaine S, Adam H, et al. "A Review of New Fluoroquinolones : Focus on their Use in Respiratory Tract Infections." Treat Respir Med 5 (2006): 437-465. [PMID: 17154673]
85	Zvonar R "Gatifloxacin-induced dysglycemia." Am J Health Syst Pharm 63 (2006): 2087-2092. [PMID: 17057046]
86	Gajjar DA, LaCreta FP, Kollia GD, et al. "Effect of multiple-dose gatifloxacin or ciprofloxacin on glucose homeostasis and insulin production in patients with noninsulin-dependent diabetes mellitus maintained with diet and exercise." Pharmacotherapy 20 (6 Pt 2) (2000): s76-86. [PMID: 10850524]
87	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
88	Cerner Multum, Inc. "Australian Product Information.".
89	Product Information. Tafinlar (dabrafenib). GlaxoSmithKline, Research Triangle Park, NC.
90	Elsharkawy AM, Schwab U, McCarron B, et al. "Efavirenz induced acute liver failure requiring liver transplantation in a slow drug metaboliser." J Clin Virol 58 (2013): 331-3. [PMID: 23763943]
91	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
92	Product Information. Ellence (epirubicin) Pharmacia and Upjohn, Kalamazoo, MI.
93	Vuksan V, Sievenpiper JL, Koo VY, et al "American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus." Arch Intern Med 160 (2000): 1009-13. [PMID: 10761967]
94	Vuksan V, Sievenpiper JL, Koo VY, et.al "Efficacy and safety of Panax ginseng berry extract on glycemic control: A 12-wk randomized, double-blind, and placebo controlled trial." Arch Intern Med 160 (2000): 1009-13
95	Feldman AZ, Brown FM. Management of Type 1 Diabetes in Pregnancy. Curr Diab Rep. 2016 Aug;16(8):76.
96	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
97	Ong CE, Coulter S, Birkett DJ, Bhasker CR, Miners JO "The xenobiotic inhibitor profile of cytochrome P4502C8." Br J Clin Pharmacol 50 (2000): 573-80. [PMID: 11136296]
98	Park JY, Kim KA, Shin JG, Lee KY "Effect of ketoconazole on the pharmacokinetics of rosiglitazone in healthy subjects." Br J Clin Pharmacol 58 (2004): 397-402. [PMID: 15373932]
99	Cerner Multum, Inc. "Canadian Product Information.".
100	Product Information. Orkambi (ivacaftor-lumacaftor). Vertex Pharmaceuticals, Cambridge, MA.
101	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
102	Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
103	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
104	Product Information. Pentam 300 (pentamidine). Fujisawa, Deerfield, IL.
105	Coyle P, Carr AD, Depczynski BB, Chisholm DJ "Diabetes mellitus associated with pentamidine use in HIV-infected patients." Med J Aust 165 (1996): 587-8. [PMID: 8941253]
106	Shen M, Orwoll ES, Conte JE, Prince MJ "Pentamidine-induced pancreatic beta-cell dysfunction." Am J Med 86 (1989): 726-8. [PMID: 2658578]
107	Park JY, Kim KA, Kang MH, Kim SL, Shin JG "Effect of rifampin on the pharmacokinetics of rosiglitazone in healthy subjects." Clin Pharmacol Ther 75 (2004): 157-62. [PMID: 15001966]
108	Totah RA, Rettie AE "Cytochrome P450 2C8: substrates, inhibitors, pharmacogenetics, and clinical relevance." Clin Pharmacol Ther 77 (2005): 341-52. [PMID: 15900280]
109	Al-Rubeaan K, Ryan EA "Phenytoin-induced insulin insensitivity." Diabet Med 8 (1991): 968-70. [PMID: 1838051]
110	Andersen OO, Persson I "Carbohydrate metabolism during treatment with chlorthalidone and ethacrynic acid." Br Med J 2 (1968): 798-801. [PMID: 5656298]
111	Bell DS "Insulin resistance. An often unrecognized problem accompanying chronic medical disorders." Postgrad Med 93 (1993): 99-103,. [PMID: 8098525]
112	Berlin I "Prazosin, diuretics, and glucose intolerance." Ann Intern Med 119 (1993): 860. [PMID: 8257545]
113	Black DM, Filak AT "Hyperglycemia with non-insulin-dependent diabetes following intraarticular steroid injection." J Fam Pract 28 (1989): 462-3. [PMID: 2703816]
114	Blayac JP, Ribes G, Buys D, Puech R, Loubatieres-Mariani MM "Effects of a new benzothiadiazine derivative, LN 5330, on insulin secretion." Arch Int Pharmacodyn Ther 253 (1981): 154-63. [PMID: 6119962]
115	Carter BL, Small RE, Mandel MD, Starkman MT "Phenytoin-induced hyperglycemia." Am J Hosp Pharm 38 (1981): 1508-12. [PMID: 7294047]
116	Charan VD, Desai N, Singh AP, Choudhry VP "Diabetes mellitus and pancreatitis as a complication of L- asparaginase therapy." Indian Pediatr 30 (1993): 809-10. [PMID: 8132268]
117	Chaudhuri ML, Catania J "A comparison of the effects of bumetanide (Burinex) and frusemide on carbohydrate metabolism in the elderly." Br J Clin Pract 42 (1988): 427-9. [PMID: 3255422]
118	Chowdhury FR, Bleicher SJ "Chlorthalidone--induced hypokalemia and abnormal carbohydrate metabolism." Horm Metab Res 2 (1970): 13-6. [PMID: 5520746]
119	Coni NK, Gordon PW, Mukherjee AP, Read PR "The effect of frusemide and ethacrynic acid on carbohydrate metabolism." Age Ageing 3 (1974): 85-90. [PMID: 4854754]
120	Curtis J, Horrigan F, Ahearn D, Varney R, Sandler SG "Chlorthalidone-induced hyperosmolar hyperglycemic nonketotic coma." JAMA 220 (1972): 1592-3. [PMID: 4624522]
121	Diamond MT "Hyperglycemic hyperosmolar coma associated with hydrochlorothiazide and pancreatitis." N Y State J Med 72 (1972): 1741-2. [PMID: 4504065]
122	Dimitriadis G, Tegos C, Golfinopoulou L, Roboti C, Raptis S "Furosemide-induced hyperglycaemia - the implication of glycolytic kinases." Horm Metab Res 25 (1993): 557-9. [PMID: 8288156]
123	Domenet JG "Diabetogenic effect of oral diuretics." Br Med J 3 (1968): 188. [PMID: 5662559]
124	Dube MP, Johnson DL, Currier JS, Leedom JM "Protease inhibitor-associated hyperglycaemia." Lancet 350 (1997): 713-4. [PMID: 9291911]
125	Elmfeldt D, Berglund G, Wedel H, Wilhelmsen L "Incidence and importance of metabolic side-effects during antihypertensive therapy." Acta Med Scand Suppl 672 (1983): 79-83. [PMID: 6138939]
126	Erle G, Basso M, Federspil G, Sicolo N, Scandellari C "Effect of chlorpromazine on blood glucose and plasma insulin in man." Eur J Clin Pharmacol 11 (1977): 15-8. [PMID: 832653]
127	Goldman JA, Neri A, Ovadia J, Eckerling B, Vries A, de "Effect of chlorothiazide on intravenous glucose tolerance in pregnancy." Am J Obstet Gynecol 105 (1969): 556-60. [PMID: 4898816]
128	Goldman JA, Ovadia JL "The effect of estrogen on intravenous glucose tolerance in woman." Am J Obstet Gynecol 103 (1969): 172-8. [PMID: 4303772]
129	Greenstone MA, Shaw AB "Alternate day corticosteroid causes alternate day hyperglycaemia." Postgrad Med J 63 (1987): 761-4. [PMID: 3444801]
130	Gunnarsson R, Lundgren G, Magnusson G, Ost L, Groth CG "Steroid diabetes--a sign of overtreatment with steroids in the renal graft recipient?" Scand J Urol Nephrol Suppl 54 (1980): 135-8. [PMID: 7013032]
131	Haiba NA, el-Habashy MA, Said SA, Darwish EA, Abdel-Sayed WS, Nayel SE "Clinical evaluation of two monthly injectable contraceptives and their effects on some metabolic parameters." Contraception 39 (1989): 619-32. [PMID: 2666019]
132	Hannaford PC, Kay CR "Oral contraceptives and diabetes mellitus." BMJ 299 (1989): 1315-6. [PMID: 2513935]
133	Hardy H, Esch LD, Morse GD "Glucose disorders associated with HIV and its drug therapy." Ann Pharmacother 35 (2001): 343-51. [PMID: 11261533]
134	Harper R, Ennis CN, Heaney AP, Sheridan B, Gormley M, Atkinson AB, Johnston GD, Bell PM "A comparison of the effects of low- and conventional-dose thiazide diuretic on insulin action in hypertensive patients with NIDDM." Diabetologia 38 (1995): 853-9. [PMID: 7556989]
135	Javier Z, Gershberg H, Hulse M "Ovulatory suppressants, estrogens, and carbohydrate metabolism." Metabolism 17 (1968): 443-56. [PMID: 4171881]
136	Jones IG, Pickens PT "Diabetes mellitus following oral diuretics." Practitioner 199 (1967): 209-10. [PMID: 6058641]
137	Kansal PC, Buse J, Buse MG "Thiazide diuretics and control of diabetes mellitus." South Med J 62 (1969): 1372-9. [PMID: 5366432]
138	Kaufman MB, Simionatto C "A review of protease inhibitor-induced hyperglycemia." Pharmacotherapy 19 (1999): 114-7. [PMID: 9917085]
139	Leary WP, Reyes AJ "Drug interactions with diuretics." S Afr Med J 65 (1984): 455-61. [PMID: 6701709]
140	Ludvik B, Clodi M, Kautzky-Willer A, Capek M, Hartter E, Pacini G, Prager R "Effect of dexamethasone on insulin sensitivity, islet amyloid polypeptide and insulin secretion in humans." Diabetologia 36 (1993): 84-7. [PMID: 8436259]
141	Malherbe C, Burrill KC, Levin SR, Karam JH, Forsham PH "Effect of diphenylhydantoin on insulin secretion in man." N Engl J Med 286 (1972): 339-42. [PMID: 5008555]
142	Mauss S, Wolf E, Jaeger H "Impaired glucose tolerance in HIV-positive patients receiving and those not receiving protease inhibitors." Ann Intern Med 130 (1999): 162-3. [PMID: 10068370]
143	Miller NR, Moses H "Transient oculomotor nerve palsy. Association with thiazide-induced glucose intolerance." JAMA 240 (1978): 1887-8. [PMID: 691201]
144	Murphy MB, Kohner E, Lewis PJ, Schumer B, Dollery CT "Glucose intolerance in hypertensive patients treated with diuretics: a fourteen-year follow-up." Lancet 2 (1982): 1293-5. [PMID: 6128594]
145	Petri M, Cumber P, Grimes L, Treby D, Bryant R, Rawlins D, Ising H "The metabolic effects of thiazide therapy in the elderly: a population study." Age Ageing 15 (1986): 151-5. [PMID: 3739851]
146	Pickkers P, Schachter M, Hughes AD, Feher MD, Sever PS "Thiazide-induced hyperglycaemia: a role for calcium-activated potassium channels?" Diabetologia 39 (1996): 861-4. [PMID: 8817113]
147	Pollare T, Lithell H, Berne C "A comparison of the effects of hydrochlorothiazide and captopril on glucose and lipid metabolism in patients with hypertension." N Engl J Med 321 (1989): 868-73. [PMID: 2671740]
148	Product Information. Agenerase (amprenavir). Glaxo Wellcome, Research Triangle Pk, NC.
149	Product Information. Amaryl (glimepiride). Hoechst Marion-Roussel Inc, Kansas City, MO.
150	Product Information. Apidra (insulin glulisine). Aventis Pharmaceuticals, Bridgewater, NJ.
151	Product Information. Carafate (sucralfate). Hoechst Marion-Roussel Inc, Kansas City, MO.
152	Product Information. Crixivan (indinavir). Merck & Co, Inc, West Point, PA.
153	Product Information. Diabeta (glyburide). Hoechst Marion-Roussel Inc, Kansas City, MO.
154	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
155	Product Information. Elzonris (tagraxofusp). Stemline Therapeutics, New York, NY.
156	Product Information. Fortovase (saquinavir) Roche Laboratories, Nutley, NJ.
157	Product Information. Glucophage (metformin). Bristol-Myers Squibb, Princeton, NJ.
158	Product Information. Glucotrol (glipizide). Pfizer US Pharmaceuticals, New York, NY.
159	Product Information. Hyperstat I.V. (diazoxide). Schering Corp, Kenilworth, NJ.
160	Product Information. Lexiva (fosamprenavir). GlaxoSmithKline, Research Triangle Park, NC.
161	Product Information. Megace (megestrol). Bristol-Myers Squibb, Princeton, NJ.
162	Product Information. Norvir (ritonavir). Abbott Pharmaceutical, Abbott Park, IL.
163	Product Information. NovoLog Mix 70/30 (insulin aspart-insulin aspart protamine). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
164	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
165	Product Information. Orinase (tolbutamide) Pharmacia and Upjohn, Kalamazoo, MI.
166	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
167	Product Information. Precose (acarbose). Bayer, West Haven, CT.
168	Product Information. Prezista (darunavir). Ortho Biotech Inc, Bridgewater, NJ.
169	Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
170	Product Information. Reyataz (atazanavir). Bristol-Myers Squibb, Princeton, NJ.
171	Product Information. Starlix (nateglinide) Novartis Pharmaceuticals, East Hanover, NJ.
172	Product Information. Synthroid (levothyroxine). Abbott Pharmaceutical, Abbott Park, IL.
173	Product Information. Tolinase (tolazamide) Pharmacia and Upjohn, Kalamazoo, MI.
174	Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
175	Product Information. Viracept (nelfinavir). Agouron Pharma Inc, La Jolla, CA.
176	Product Information. Zolinza (vorinostat). Merck & Company Inc, West Point, PA.
177	Rowe P, Mather H "Hyperosmolar non-ketotic diabetes mellitus associated with metolazone." Br Med J 291 (1985): 25-6. [PMID: 3926049]
178	Schmitz O, Hermansen K, Nielsen OH, Christensen CK, Arnfred J, Hansen HE, Mogensen CE, Orskov H, Beck-Nielsen H "Insulin action in insulin-dependent diabetics after short-term thiazide therapy." Diabetes Care 9 (1986): 631-6. [PMID: 3542455]
179	Seifer DB, Freedman LN, Cavender JR, Baker RA "Insulin-dependent diabetes mellitus associated with danazol." Am J Obstet Gynecol 162 (1990): 474-5. [PMID: 2309833]
180	Seltzer HS, Allen EW "Hyperglycemia and inhibition of insulin secretion during administration of diazoxide and trichlormethiazide in man." Diabetes 18 (1969): 19-28. [PMID: 5761863]
181	Sotaniemi E, Kontturi M, Larmi T "Effect of diethylstilbestrol on blood glucose of prostatic cancer patients." Invest Urol 10 (1973): 438-41. [PMID: 4704169]
182	Spellacy WN, Ellingson AB, Tsibris JC "The effects of two triphasic oral contraceptives on carbohydrate metabolism in women during 1 year of use." Fertil Steril 51 (1989): 71-4. [PMID: 2642814]
183	Stambaugh JE, Tucker DC "Effect of diphenylhydantoin on glucose tolerance in patients with hypoglycemia." Diabetes 23 (1974): 679-83. [PMID: 4851631]
184	Tsiodras S, Mantzoros C, Hammer S, Samore M "Effects of protease inhibitors on hyperglycemia, hyperlipidemia, and lipodystrophy - A 5-year cohort study." Arch Intern Med 160 (2000): 2050-6. [PMID: 10888979]
185	Virutamasen P, Wongsrichanalai C, Tangkeo P, Nitichai Y, Rienprayoon D "Metabolic effects of depot-medroxyprogesterone acetate in long-term users: a cross-sectional study." Int J Gynaecol Obstet 24 (1986): 291-6. [PMID: 2878838]
186	Walli R, Demant T "Impaired glucose tolerance and protease inhibitors." Ann Intern Med 129 (1998): 837-8. [PMID: 9841594]
187	Wehring H, Alexander B, Perry PJ "Diabetes mellitus associated with clozapine therapy." Pharmacotherapy 20 (2000): 844-7. [PMID: 10907975]
188	Winchester JF, Kellett RJ, Boddy K, Boyle P, Dargie HJ, Mahaffey ME, Ward DM, Kennedy AC "Metolazone and bendroflumethiazide in hypertension: physiologic and metabolic observations." Clin Pharmacol Ther 28 (1980): 611-8. [PMID: 7438679]
189	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
190	Neerati R, Devde R, Gangi AK "Evaluation of the effects of curcumin capsules on glyburide therapy in patients with type-2 diabetes mellitus." Phytother Res 28 (2014): 1796-1800
191	Chuengsamarn S, Rattanamongkolgul s, Luechapudiporn R, Phisalaphong C, Jirawatnotai S "Curcumin extract for prevention of type 2 diabetes." Diabetes Care 35 (2012): 2121-7
192	Hodaei H, Adibian M, Nikpayam O, Hedayati M, Sohrab G "The effect of curcumin supplementation on anthropometric indices, insulin resistance and oxidative stress in patients with type 2 diabetes: a randomized, double-blind clinical trial." Diabet Metab Syndr 11 (2019): e-collection 2019
193	Product Information. VFEND (voriconazole). Pfizer U.S. Pharmaceuticals, New York, NY.
194	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
195	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
196	Seale JP, Compton MR "Side-effects of corticosteroid agents." Med J Aust 144 (1986): 139-42. [PMID: 3511355]
197	Product Information. Psorcon (diflorasone topical). Rhone-Poulenc Rorer, Collegeville, PA.
198	Pace WE "Topical corticosteroids." Can Med Assoc J 108 (1973): 11 passim. [PMID: 4682644]
199	Kvinssland S, Lonning PE, Ueland PM "Aminoglutethimide as an inducer of microsomal enzymes. Part 1: Pharmacological aspects." Breast Cancer Res Treat 7 (1986): s73-6. [PMID: 2943339]
200	Lonning PE, Lnning PE "Aminoglutethimide enzyme induction: pharmacological and endocrinological implications." Cancer Chemother Pharmacol 26 (1990): 241-4. [PMID: 2369789]
201	Konrad T, Bohles HJ, Vicini P, et al "alpha-Lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes." Diabetes Care 22 (1999): 280-7. [PMID: 10333946]
202	Gleiter CH, Schreeb KH, Freudenthaler S, et al "Lack of interaction between thioctic acid, glibenclamide and acarbose." Br J Clin Pharmacol 48 (1999): 819-25. [PMID: 10594485]
203	Izzo AA, Ernst E "Interactions between herbal medicines and prescribed drugs: a systematic review." Drugs 61 (2001): 2163-75. [PMID: 11772128]
204	Aslam M, Stockley IH "Interaction between curry ingredient (karela) and drug (chlorpropamide)." Lancet I (1979): 607
205	Semaan N "Integration of complementary disciplines into the oncology clinic - Part III. Herbal medicine - Drug interactions: The role of the pharmacist." Curr Prob Cancer 24 (2000): 213-22

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence