Drug General Information (ID: DDIRJ97DN1)
Drug Name			Lipoic acid		Drug Info		Rosiglitazone		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antioxidants				Thiazolidinediones
Structure

Mechanism of Lipoic acid-Rosiglitazone Interaction (Severity Level: Minor)
Increased risk of hypoglycemia Click to Show/Hide Mechanism Graph
Drug Name		Lipoic acid				Rosiglitazone
Mechanism		Hypoglycemic effects				Hypoglycemic effects
Key Mechanism Factor 1
		Factor Name		Hypoglycemia
		Factor Description		Hypoglycemia is a condition in which your blood sugar (glucose) level is below the standard range. It causes irregular or rapid heartbeat, pale skin, numbness of the lips, tongue or cheeks, and sweating.
Mechanism Description		Increased risk of hypoglycemia by the combination of Lipoic acid and Rosiglitazone

References
1	Skillman TG, Feldman JM "The pharmacology of sulfonylureas." Am J Med 70 (1981): 361-72. [PMID: 6781341]
2	Konrad T, Bohles HJ, Vicini P, et al "alpha-Lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes." Diabetes Care 22 (1999): 280-7. [PMID: 10333946]
3	Gleiter CH, Schreeb KH, Freudenthaler S, et al "Lack of interaction between thioctic acid, glibenclamide and acarbose." Br J Clin Pharmacol 48 (1999): 819-25. [PMID: 10594485]