Drug General Information (ID: DDIXR483EL)
Drug Name			Rosiglitazone		Drug Info		Isosorbide dinitrate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Thiazolidinediones				Vasodilator Agents
Structure

Mechanism of Rosiglitazone-Isosorbide dinitrate Interaction (Severity Level: Moderate)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Rosiglitazone				Isosorbide dinitrate
Mechanism		Risk of myocardial ischemia				Risk of myocardial ischemia
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Rosiglitazone and Isosorbide dinitrate

Recommended Action
Management		The concomitant use of rosiglitazone and nitrates should generally be avoided.

References
1	Product Information. Avandia (rosiglitazone) SmithKline Beecham, Philadelphia, PA.
2	Product Information. Diabinese (chlorpropamide). Pfizer US Pharmaceuticals, New York, NY.
3	Canadian Pharmacists Association "e-CPS."