Details of Drug

Drug General Information (ID: D1399)
Drug Name	Rifabutin
Drug Type	Small molecule
Drug Synonymous	Alfacid; Ansamycin; Ansatipin; Ansatipine; Assatipin; Mycobutin; RBT; Rifabutina; Rifabutine; Rifabutinum; Grunenthal Brand of Rifabutin; Kenfarma Brand of Rifabutin; Pfizer Brand of Rifabutin; Rifabutin Pfizer Brand; Rifabutina [Spanish]; Rifabutine [French]; Rifabutinum [Latin]; Antibiotic LM 427; LM 427; LM427; DRG-0085; LM-427; Mycobutin (TN); Rifabutin [USAN:BAN:INN]; Rifabutin (JAN/USP/INN); Mycobutin, Ansamycin, LM 427, Ansatipine, Rifabutin; (9S,12E,14S,15R,16S,17R,18R,19R,20S,21S,22E,24Z)-6,18,20-trihydroxy-1'-isobutyl-14-methoxy-7,9,15,17,19,21,25-heptamethyl-5,10,26-trioxo-3,5,9,10-tetrahydrospiro[9,4-(epoxypentadeca[1,11,13]trienoimino)furo[2',3':7,8]naphtho[1,2-d]imidazole-2,4'-piperidin; Spiro[9,4-(epoxypentadeca[1,11,13]trienimino)-2H-furo[2',3':7,8]naphth[1,2-d]imidazole-2,4'-piperidine]-5,10,26(3H,9H)-trione, 16-(acetyloxy)-6,18,20-trihydroxy-14-methoxy-7,9,15,17,19,21,25-heptameth; 1,4-Dihydro-1-deoxy-1',4-didehydro-5'-(2-methylpropyl)-1-oxorifamycin XIV; 4-Deoxo-3,4-(2-spiro(N-isobutyl-4-piperidyl)-2,5-dihydro-1H-imidazo)-rifamycin S; 4-N-isobutylspiropiperidylrifamycin S Click to Show/Hide
Disease Class	1B10-1B21: Mycobacterium infection; 1B10-1B14: HIV-infected patients with tuberculosis
Therapeutic Class	Antibiotics
Structure
Structure	3D Structure		2D Structure
Formula	C46H62N4O11
InChI	1S/C46H62N4O11/c1-22(2)21-50-18-16-46(17-19-50)48-34-31-32-39(54)28(8)42-33(31)43(56)45(10,61-42)59-20-15-30(58-11)25(5)41(60-29(9)51)27(7)38(53)26(6)37(52)23(3)13-12-14-24(4)44(57)47-36(40(32)55)35(34)49-46/h12-15,20,22-23,25-27,30,37-38,41,48,52-55H,16-19,21H2,1-11H3/b13-12+,20-15+,24-14-,47-36?/t23-,25+,26+,27+,30-,37-,38+,41+,45-/m0/s1
InChIKey	ZWBTYMGEBZUQTK-PVLSIAFMSA-N
Canonical SMILES	CC1C=CC=C(C(=O)N=C2C(=C3C(=C4C2=NC5(N4)CCN(CC5)CC(C)C)C6=C(C(=C3O)C)OC(C6=O)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)O)C
External Link
	Pubchem ID	135398743
	CAS Number	72559-06-9
	TTD ID	D05CHI
	INTEDE ID	DR1418

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM011 Transporter induction BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM023 UGT induction BM026 Increased metabolism (Unspecific) BM028 Competitive inhibition of renal tubular secretion BM044 Additive myelosuppressive effects BM055 Increased risk of hepatotoxicity BM100 Antagonize the effect of vaccine/toxoid BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Rifabutin
Affected cellular transport
	Transporter induction					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1490		Sofosbuvir	C22H29FN3O9P	45375808	Major		Inter Info	[4], [216], [217], [218]
D0026		Afatinib	C24H25ClFN5O3	10184653	Moderate		Inter Info	[346]
D0176		Betrixaban	C23H22ClN5O3	10275777	Moderate		Inter Info	[365], [366]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[14], [118], [4], [429]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[4], [460]
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1817		Indium In-111 oxyquinoline	C27H18InN3O3	16685037	Moderate		Inter Info	[425]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 21
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[104], [105]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[4], [114], [115], [116]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[124], [79], [125], [1], [126], [85]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Major		Inter Info	[187]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[198]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[104], [105]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[78], [245], [79], [246], [80], [247], [248], [1], [249], [250], [251], [252], [253], [254], [85]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[318], [319], [320]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[321], [322]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[343]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[78], [79], [14], [4], [80], [81], [351], [352], [85]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[14], [4], [114], [358]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[374], [375], [376], [318], [377], [378], [379], [380]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[78], [79], [246], [80], [81], [82], [386], [351], [352], [387], [83], [388], [389], [249], [390], [358], [87], [85]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[391], [392]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[78], [79], [14], [4], [80], [81], [351], [352], [85]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[436], [437]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[440]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[387]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[374], [375], [376], [318], [377], [378], [379], [380]
D1057		Miconazole	C18H14Cl4N2O	4189	Minor		Inter Info	[4], [1], [550]
	CYP450 enzyme induction					Drug Num: 309
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0069		Amlodipine	C20H25ClN2O5	2162	Major		Inter Info	[1], [2], [3]
D0193		Bortezomib	C19H25BN4O4	387447	Major		Inter Info	[4], [5], [6], [7], [8], [9]
D0222		Buspirone	C21H31N5O2	2477	Major		Inter Info	[10], [11], [12]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[13], [14], [4], [15], [16], [17], [1], [18], [2], [19]
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37]
D0481		Dicoumarol	C19H12O6	54676038	Major		Inter Info	[38], [39], [40]
D0497		Diltiazem	C22H26N2O4S	39186	Major		Inter Info	[1], [2], [3]
D0626		Etonogestrel	C22H28O2	6917715	Major		Inter Info	[41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [1], [63], [2], [64], [32], [65], [66], [67], [68], [69]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[70], [51], [71], [14], [4], [72], [73], [74], [75], [2], [32], [76], [77]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[78], [79], [80], [81], [82], [83], [84], [85]
D0865		Isradipine	C19H21N3O5	3784	Major		Inter Info	[1], [2], [3]
D0922		Levonorgestrel	C21H28O2	13109	Major		Inter Info	[41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [1], [63], [2], [64], [32], [65], [66], [67], [68], [69]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[78], [79], [80], [81], [86], [1], [87], [85]
D1138		Nimodipine	C21H26N2O7	4497	Major		Inter Info	[1], [2], [3]
D1141		Nisoldipine	C20H24N2O6	4499	Major		Inter Info	[1], [2], [3]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[13], [14], [4], [15], [16], [17], [1], [18], [2], [19]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[88]
D0007		Abiraterone	C24H31NO	132971	Major		Inter Info	[89]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Major		Inter Info	[90]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[91], [92], [93]
D0087		Anisindione	C16H12O3	2197	Major		Inter Info	[94], [51], [95], [96], [38], [39], [97], [98], [32], [40], [66], [99]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[4], [100]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[4], [101]
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[1], [18], [2]
D0170		Bepridil	C24H34N2O	2351	Major		Inter Info	[1], [2], [3]
D0181		Bictegravir	C21H18F3N3O5	90311989	Major		Inter Info	[4], [102], [103]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[106]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Major		Inter Info	[14], [4], [107]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[111], [112]
D0251		Capmatinib	C23H17FN6O	25145656	Major		Inter Info	[113]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Major		Inter Info	[14], [4], [117]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[14], [118], [4], [119]
D0408		Daclatasvir	C40H50N8O6	25154714	Major		Inter Info	[4], [120]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[14], [4], [121]
D0436		Deflazacort	C25H31NO6	189821	Major		Inter Info	[4]
D0485		Dienogest	C20H25NO2	68861	Major		Inter Info	[44], [63], [66]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Major		Inter Info	[127]
D0536		Drospirenone	C24H30O3	68873	Major		Inter Info	[41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [1], [63], [2], [64], [32], [65], [66], [67], [68], [69]
D0559		Eliglustat	C23H36N2O4	23652731	Major		Inter Info	[14], [128]
D0563		Elvitegravir	C23H23ClFNO5	5277135	Major		Inter Info	[14], [4], [129]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[130]
D0577		Entrectinib	C31H34F2N6O2	25141092	Major		Inter Info	[131]
D0590		Erdafitinib	C25H30N6O2	67462786	Major		Inter Info	[132]
D0619		Ethinylestradiol	C20H24O2	5991	Major		Inter Info	[44], [63], [66]
D0628		Etravirine	C20H15BrN6O	193962	Major		Inter Info	[133]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[4], [134]
D0640		Felodipine	C18H19Cl2NO4	3333	Major		Inter Info	[1], [2], [3]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[13], [14], [4], [15], [16], [17], [1], [18], [2], [19]
D0665		Flibanserin	C20H21F3N4O	6918248	Major		Inter Info	[135]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Major		Inter Info	[14], [136], [137]
D0725		Glasdegib	C21H22N6O	25166913	Major		Inter Info	[138]
D0739		Grazoprevir	C38H50N6O9S	44603531	Major		Inter Info	[139], [140]
D0745		Guanfacine	C9H9Cl2N3O	3519	Major		Inter Info	[4], [141], [142]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[13], [14], [4], [15], [16], [17], [1], [18], [2], [19]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[4], [146]
D0793		Imatinib	C29H31N7O	5291	Major		Inter Info	[147], [13], [14], [4], [148], [149]
D0845		Irinotecan	C33H38N4O6	60838	Major		Inter Info	[150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Major		Inter Info	[153], [156], [158]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Major		Inter Info	[161]
D0866		Istradefylline	C20H24N4O4	5311037	Major		Inter Info	[162]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[163], [164], [51], [165], [14], [4], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [32], [176], [66]
D0869		Ivacaftor	C24H28N2O3	16220172	Major		Inter Info	[14], [4], [177], [75], [178], [179]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[163], [164], [51], [165], [14], [4], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [32], [176], [66]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Major		Inter Info	[14], [4], [180]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[181]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[139], [182]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Major		Inter Info	[1], [2], [3]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[183]
D0953		Lorlatinib	C21H19FN6O2	71731823	Major		Inter Info	[184]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[185]
D0961		Lurasidone	C28H36N4O2S	213046	Major		Inter Info	[186]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Major		Inter Info	[188], [189]
D1124		Neratinib	C30H29ClN6O3	9915743	Major		Inter Info	[14], [190]
D1127		Netupitant	C30H32F6N4O	6451149	Major		Inter Info	[14], [136], [137]
D1130		Nicardipine	C26H29N3O6	4474	Major		Inter Info	[1], [2], [3]
D1134		Nifedipine	C17H18N2O6	4485	Major		Inter Info	[1], [2], [3]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[191]
D1154		Norethisterone	C20H26O2	6230	Major		Inter Info	[44], [63], [66]
D1156		Norgestimate	C23H31NO3	6540478	Major		Inter Info	[44], [63], [66]
D1157		Norgestrel	C21H28O2	13109	Major		Inter Info	[41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [1], [63], [2], [64], [32], [65], [66], [67], [68], [69]
D1167		Olaparib	C24H23FN4O3	23725625	Major		Inter Info	[14], [4], [192]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[13], [14], [4], [15], [16], [17], [1], [18], [2], [19]
D1189		Osilodrostat	C13H10FN3	44139752	Major		Inter Info	[4], [193]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[14], [4], [194]
D1214		Palbociclib	C24H29N7O2	5330286	Major		Inter Info	[14], [4], [195]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[196]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Major		Inter Info	[4], [197]
D1302		Pitolisant	C17H26ClNO	9948102	Major		Inter Info	[4], [199]
D1324		Pralsetinib	C27H32FN9O2	129073603	Major		Inter Info	[200]
D1330		Praziquantel	C19H24N2O2	4891	Major		Inter Info	[201], [14], [202], [203]
D1336		Pretomanid	C14H12F3N3O5	456199	Major		Inter Info	[204]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[205]
D1404		Rilpivirine	C22H18N6	6451164	Major		Inter Info	[206]
D1407		Rimegepant	C28H28F2N6O3	51049968	Major		Inter Info	[207]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Major		Inter Info	[208]
D1423		Rolapitant	C25H26F6N2O2	10311306	Major		Inter Info	[4], [209]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[4], [210]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Major		Inter Info	[211]
D1471		Simeprevir	C38H47N5O7S2	24873435	Major		Inter Info	[212], [213]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[14], [214]
D1476		Sirolimus	C51H79NO13	5284616	Major		Inter Info	[14], [4], [215]
D1496		Sonidegib	C26H26F3N3O3	24775005	Major		Inter Info	[219]
D1505		Stiripentol	C14H18O3	5311454	Major		Inter Info	[4], [148], [220], [221]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[222], [14], [4], [223], [224], [225], [226], [227], [228], [229]
D1536		Tasimelteon	C15H19NO2	10220503	Major		Inter Info	[230]
D1538		Tazemetostat	C34H44N4O4	66558664	Major		Inter Info	[231]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[4], [232], [233]
D1549		Temsirolimus	C56H87NO16	6918289	Major		Inter Info	[14], [4], [234]
D1608		Tolvaptan	C26H25ClN2O3	216237	Major		Inter Info	[4], [235]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[236]
D1673		Valbenazine	C24H38N2O4	24795069	Major		Inter Info	[239]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[14], [4], [240]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[241]
D1709		Voxelotor	C19H19N3O3	71602803	Major		Inter Info	[243]
D1711		Warfarin	C19H16O4	54678486	Major		Inter Info	[94], [51], [95], [96], [38], [39], [97], [98], [32], [40], [66], [99]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[244]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[255], [14], [4], [256], [257]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[258]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[51], [259], [1], [2], [260], [261], [32], [66]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[262], [263], [264], [265], [266], [32], [66]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[14], [4]
D0233		Calcifediol	C27H44O2	5283731	Moderate		Inter Info	[267], [268], [269], [270]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[271], [272], [273], [274], [275], [276], [277], [278]
D0268		Caspofungin	C52H88N10O15	2826718	Moderate		Inter Info	[279]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[14]
D0328		Cholecalciferol	C27H44O	5280795	Moderate		Inter Info	[267], [268], [269], [270]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[280]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[281], [14], [118], [4], [282], [283], [284]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[42], [43], [285], [45], [46], [47], [48], [50], [51], [286], [287], [288], [289], [53], [55], [56], [290], [57], [291], [292], [293], [294], [295], [296], [297], [60], [298], [299], [61], [300], [62], [301], [302], [303], [304], [64], [32], [65], [305], [306], [66], [67], [307], [68], [308], [69], [309]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[13], [14], [4], [1]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[310]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[311], [51], [312], [32]
D0530		Doxycycline	C22H24N2O8	54671203	Moderate		Inter Info	[313], [1], [2]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[73], [2], [314]
D0591		Ergocalciferol	C28H44O	5280793	Moderate		Inter Info	[267], [268], [269], [270]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[315], [316]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[317]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[315], [323]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[51], [259], [1], [2], [260], [261], [32], [66]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[324]
D0925		Levothyroxine	C15H11I4NO4	5819	Moderate		Inter Info	[14], [4], [325], [2]
D0934		Liothyronine	C15H12I3NO4	5920	Moderate		Inter Info	[14], [4], [325], [2]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[326], [327], [309]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[328]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[46], [55], [306]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[329], [330], [66]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[14], [4], [331]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[332], [333], [334], [335]
D1087		Montelukast	C35H36ClNO3S	5281040	Moderate		Inter Info	[336]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[13], [14], [4]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[329], [330], [66]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[42], [43], [285], [45], [46], [47], [48], [50], [51], [286], [287], [288], [289], [53], [55], [56], [290], [57], [291], [292], [293], [294], [295], [296], [297], [60], [298], [299], [61], [300], [62], [301], [302], [303], [304], [64], [32], [65], [305], [306], [66], [67], [307], [68], [308], [69], [309]
D1349		Progesterone (topical)	C21H30O2	5994	Moderate		Inter Info	[46], [55], [306]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[338], [339], [2], [340], [341], [342]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[344]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[345]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[347], [348], [349], [350]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[353]
D0099		Apremilast	C22H24N2O7S	11561674	Moderate		Inter Info	[354]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[355]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[356], [357]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[359], [360], [361], [362], [363]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[364]
D0130		Avatrombopag	C29H34Cl2N6O3S2	9852519	Moderate		Inter Info	[4]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[367]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[368]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[369]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[4], [370]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[371]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[372]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[373]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[51], [259], [1], [2], [260], [261], [32], [66]
D0354		Clindamycin	C18H33ClN2O5S	446598	Moderate		Inter Info	[381], [382]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[383]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[14], [4], [384]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[385]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[262], [263], [264], [265], [266], [32], [66]
D0490		Digitoxin	C41H64O13	441207	Moderate		Inter Info	[393], [51], [394], [395], [396], [2], [32], [66]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[281], [14], [4]
D0495		Dihydrotachysterol	C28H46O	5311071	Moderate		Inter Info	[267], [268], [269], [270]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[397], [398], [399], [400], [401]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[402]
D0527		Doxercalciferol	C28H44O2	5281107	Moderate		Inter Info	[267], [268], [269], [270]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[4], [403], [404], [405]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[403], [404], [405]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[406]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[407]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[14], [408]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[79], [213], [85]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[409]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[410]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[14], [4], [331]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[42], [43], [285], [45], [46], [47], [48], [50], [51], [286], [287], [288], [289], [53], [55], [56], [290], [57], [291], [292], [293], [294], [295], [296], [297], [60], [298], [299], [61], [300], [62], [301], [302], [303], [304], [64], [32], [65], [305], [306], [66], [67], [307], [68], [308], [69], [309]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[46], [55], [306]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[42], [43], [285], [45], [46], [47], [48], [50], [51], [286], [287], [288], [289], [53], [55], [56], [290], [57], [291], [292], [293], [294], [295], [296], [297], [60], [298], [299], [61], [300], [62], [301], [302], [303], [304], [64], [32], [65], [305], [306], [66], [67], [307], [68], [308], [69], [309]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[46], [55], [306]
D0621		Ethotoin	C11H12N2O2	3292	Moderate		Inter Info	[329], [330], [66]
D0630		Exemestane	C20H24O2	60198	Moderate		Inter Info	[411]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[412], [413], [414], [415], [416], [2], [417], [274]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[418]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[262], [263], [264], [265], [266], [32], [66]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[419], [420]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[329], [330], [66]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[421]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[423]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[51], [259], [1], [2], [260], [261], [32], [66]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[51], [259], [1], [2], [260], [261], [32], [66]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[262], [263], [264], [265], [266], [32], [66]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[14]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[424]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[426]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[14], [4], [427]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[428]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[430]
D0935		Liotrix	C30H21I7N2Na2O8	71371	Moderate		Inter Info	[14], [4], [325], [2]
D0965		Macimorelin	C26H30N6O3	9804938	Moderate		Inter Info	[431]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[14], [432]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[262], [263], [264], [265], [266], [32], [66]
D1051		Metronidazole	C6H9N3O3	4173	Moderate		Inter Info	[433]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[434], [435]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[4], [438]
D1104		Naloxegol	C34H53NO11	56959087	Moderate		Inter Info	[439]
D1181		Ondansetron	C18H19N3O	4595	Moderate		Inter Info	[441]
D1191		Ospemifene	C24H23ClO2	3036505	Moderate		Inter Info	[442]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[443], [444], [445], [446]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[443], [444], [445]
D1226		Paricalcitol	C27H44O3	5281104	Moderate		Inter Info	[267], [268], [269], [270]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[447]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[4], [448]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[452]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[453], [454], [455], [456], [457]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[458]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[14], [4], [459]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[262], [263], [264], [265], [266], [32], [66]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[262], [263], [264], [265], [266], [32], [66]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[14], [461], [462], [463], [464]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[42], [43], [285], [45], [46], [47], [48], [50], [51], [286], [287], [288], [289], [53], [55], [56], [290], [57], [291], [292], [293], [294], [295], [296], [297], [60], [298], [299], [61], [300], [62], [301], [302], [303], [304], [64], [32], [65], [305], [306], [66], [67], [307], [68], [308], [69], [309]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[465], [51], [394], [466], [467], [32], [341], [66]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[468]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Moderate		Inter Info	[469]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[470], [471], [472]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[63], [40]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[473]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[474]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[475]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[476]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[477]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[78], [79], [14], [4], [386], [478], [84], [85]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[479]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[14], [4], [480]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[481]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[14], [4], [482]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[14], [4], [483], [482]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[14], [4], [484]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[485]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[4], [486], [487]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[488], [256], [489], [490]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[4], [491]
D1577		Thyroid, porcine	NA	NA	Moderate		Inter Info	[14], [325], [2]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[13], [4], [492], [493], [494]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[433]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[51], [259], [1], [2], [260], [261], [32], [66]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[51], [259], [1], [2], [260], [261], [32], [66]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[4], [495], [496]
D1664		Ulipristal	C28H35NO3	13559281	Moderate		Inter Info	[4], [497]
D1666		Upadacitinib	C17H19F3N6O	58557659	Moderate		Inter Info	[498]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Moderate		Inter Info	[499], [500]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[501], [502], [51], [503], [504], [32], [3], [66]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[505]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[506]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[507], [508]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[509], [510], [511], [512], [456], [457]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[513], [514], [515], [516]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[14], [4], [482]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[517]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[518]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[518]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[518]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[518]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[78], [519], [79], [520]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[4], [521], [522], [523]
D0045		Alprazolam	C17H13ClN4	2118	Minor		Inter Info	[524], [32], [525]
D0178		Bexarotene	C24H28O2	82146	Minor		Inter Info	[490]
D0308		Cevimeline	C10H17NOS	83898	Minor		Inter Info	[526]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Minor		Inter Info	[524], [32], [525]
D0356		Clobazam	C16H13ClN2O2	2789	Minor		Inter Info	[524], [32], [525]
D0420		Dapsone (topical)	C12H12N2O2S	2955	Minor		Inter Info	[527], [177], [179]
D0513		Dofetilide	C19H27N3O5S2	71329	Minor		Inter Info	[528]
D0927		Lidocaine	C14H22N2O	3676	Minor		Inter Info	[529], [530], [531], [532]
D1017		Methadone	C21H27NO	4095	Minor		Inter Info	[533], [534]
D1128		Nevirapine	C15H14N4O	4463	Minor		Inter Info	[535], [79], [536], [85]
D0360		Clofibrate	C12H15ClO3	2796	Minor		Inter Info	[537]
D0362		Clonazepam	C15H10ClN3O3	2802	Minor		Inter Info	[524], [32], [525]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Minor		Inter Info	[524], [32]
D0473		Diazepam	C16H13ClN2O	3016	Minor		Inter Info	[524], [32], [525]
D0514		Dolasetron	C19H20N2O3	3033818	Minor		Inter Info	[538]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Minor		Inter Info	[539]
D0604		Estazolam	C16H11ClN4	3261	Minor		Inter Info	[524], [32], [525]
D0679		Flurazepam	C21H23ClFN3O	3393	Minor		Inter Info	[524], [32], [525]
D0700		Fostemsavir	C25H26N7O8P	11319217	Minor		Inter Info	[540]
D0916		Levobupivacaine	C18H28N2O	92253	Minor		Inter Info	[549]
D1060		Midazolam	C18H13ClFN3	4192	Minor		Inter Info	[524], [32], [525]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[551]
D1306		Polatuzumab vedotin	NA	NA	Minor		Inter Info	[14], [552]
D1367		Quazepam	C17H11ClF4N2S	4999	Minor		Inter Info	[524], [32], [525]
D1632		Triazolam	C17H12Cl2N4	5556	Minor		Inter Info	[524], [32], [525]
D1716		Zaleplon	C17H15N5O	5719	Minor		Inter Info	[554]
D1428		Ropivacaine	C17H26N2O	175805	Minor		Inter Info	[555]
D1726		Ziprasidone	C21H21ClN4OS	60854	Minor		Inter Info	[556], [557]
	UGT induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1377		Raltegravir	C20H21FN6O5	54671008	Minor		Inter Info	[13], [14], [4], [553]
	Increased metabolism (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0229		Cabotegravir	C19H17F2N3O5	54713659	Major		Inter Info	[108], [109], [110]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[337]
Affected excretion pathways
	Competitive inhibition of renal tubular secretion					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0706		Gadoxetic acid	C23H30GdN3O11	56841043	Moderate		Inter Info	[422]
Pharmacodynamic additive effects
	Additive myelosuppressive effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[14], [122], [123]
	Increased risk of hepatotoxicity					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0751		Halothane	C2HBrClF3	3562	Major		Inter Info	[143], [144], [145], [66]
D0858		Isoniazid	C6H7N3O	3767	Minor		Inter Info	[163], [541], [542], [13], [14], [4], [543], [544], [545], [1], [2], [546], [547], [548]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[4], [237], [238]
D1693		Vibrio cholerae CVD 103-HgR strain live antigen (live)	NA	NA	Major		Inter Info	[242]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[449], [450], [451]

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157	Product Information. Onivyde (irinotecan liposomal). Merrimack Pharmaceuticals, Cambridge, MA.
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162	Product Information. Nourianz (istradefylline). Kyowa Kirin, Inc, Bedminster, NJ.
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178	Product Information. Symdeko 4-Week (ivacaftor-tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
179	Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
180	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
181	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
182	Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
183	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
184	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
185	Product Information. Caplyta (lumateperone). Intra-Cellular Therapies, Inc., New York, NY.
186	Product Information. Latuda (lurasidone). Sunovion Pharmaceuticals Inc, Marlborough, MA.
187	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
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192	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
193	Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
194	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
195	Product Information. Ibrance (palbociclib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
196	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
197	Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
198	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
199	Product Information. Wakix (pitolisant). Harmony Biosciences, LLC, Plymouth Meeting, PA.
200	Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
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206	Product Information. Edurant (rilpivirine). Tibotec Pharmaceuticals, Titusville, NJ.
207	Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
208	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
209	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
210	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
211	Product Information. Koselugo (selumetinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
212	Product Information. Olysio (simeprevir). Janssen Pharmaceuticals, Titusville, NJ.
213	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
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217	Product Information. Harvoni (ledipasvir-sofosbuvir). Gilead Sciences, Foster City, CA.
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233	European Agency for the Evaluation of Medicinal Products. Committee for Proprietary Medicinal Products "European Public Assessment Report Ketek (telithromycin) (Rev. 2) ".
234	Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
235	Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
236	Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.
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239	Product Information. Ingrezza (valbenazine). Neurocrine Biosciences, Inc., San Diego, CA.
240	Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
241	Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
242	Product Information. Vaxchora (cholera vaccine, live). PaxVax, Miami, FL.
243	Product Information. Oxbryta (voxelotor). Global Blood Therapeutics, Inc., South San Francisco, CA.
244	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
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267	Product Information. Hectorol (doxercalciferol). Genzyme Corporation, Cambridge, MA.
268	Product Information. One-Alpha (alfacalcidol). Pharmel Inc, Montreal, IN.
269	Product Information. Rocaltrol (calcitriol). Roche Laboratories, Nutley, NJ.
270	Product Information. Zemplar (paricalcitol). Abbott Pharmaceutical, Abbott Park, IL.
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282	Product Information. Acetaminophen-Codeine Phosphate (acetaminophen-codeine). Qualitest Pharmaceuticals Inc, Huntsville, ON.
283	Product Information. Codeine Sulfate (codeine). Lannett Company Inc, Philadelphia, PA.
284	Product Information. Tuzistra XR (chlorpheniramine-codeine). Vernalis Pharmaceuticals Inc, Morristown, NJ.
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310	Product Information. Enablex (darifenacin). Novartis Pharmaceuticals, East Hanover, NJ.
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317	Product Information. Lunesta (eszopiclone). Sepracor Inc, Marlborough, MA.
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323	Product Information. Iressa (gefitinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
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327	Product Information. Provera (medroxyprogesterone). Pharmacia and Upjohn, Kalamazoo, MI.
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343	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
344	Product Information. Verzenio (abemaciclib). Lilly, Eli and Company, Indianapolis, IN.
345	Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
346	Product Information. Gilotrif (afatinib). Boehringer Ingelheim, Ridgefield, CT.
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352	Product Information. Agenerase (amprenavir). Glaxo Wellcome, Research Triangle Pk, NC.
353	Product Information. Eliquis (apixaban). Bristol-Myers Squibb Canada Inc, Montreal, IN.
354	Product Information. Otezla (apremilast). Celgene Corporation, Summit, NJ.
355	Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
356	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
357	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
358	Product Information. Reyataz (atazanavir). Bristol-Myers Squibb, Princeton, NJ.
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363	Product Information. Lipitor (atorvastatin). Parke-Davis, Morris Plains, NJ.
364	Product Information. Stendra (avanafil). Vivus Inc, Mountain View, CA.
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366	Product Information. Bevyxxa (betrixaban). Portola Pharmaceuticals, South San Francisco, CA.
367	Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
368	Product Information. Buprenex (buprenorphine). Reckitt and Colman Pharmaceutical, Richmond, VA.
369	Product Information. Jevtana (cabazitaxel). sanofi-aventis , Bridgewater, NJ.
370	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
371	Product Information. Vraylar (cariprazine). Actavis Pharma, Inc., Parsippany, NJ.
372	Product Information. Xcopri (cenobamate). SK Life Science, Inc., Paramus, NJ.
373	Product Information. Zykadia (ceritinib). Novartis Pharmaceuticals, East Hanover, NJ.
374	Apseloff G, Foulds G, LaBoy-Goral L, Willavize S, Vincent J "Comparison of azithromycin and clarithromycin in their interactions with rifabutin in healthy volunteers." J Clin Pharmacol 38 (1998): 830-5. [PMID: 9753212]
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382	Product Information. Cleocin (clindamycin). Pharmacia and Upjohn, Kalamazoo, MI.
383	Product Information. Aliqopa (copanlisib). Bayer Pharmaceutical Inc, West Haven, CT.
384	Product Information. Tafinlar (dabrafenib). GlaxoSmithKline, Research Triangle Park, NC.
385	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
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388	Product Information. Fortovase (saquinavir) Roche Laboratories, Nutley, NJ.
389	Product Information. Lexiva (fosamprenavir). GlaxoSmithKline, Research Triangle Park, NC.
390	Product Information. Prezista (darunavir). Ortho Biotech Inc, Bridgewater, NJ.
391	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
392	Skerjanec A, Wang J, Maren K, Rojkjaer L "Investigation of the pharmacokinetic interactions of deferasirox, a once-daily oral iron chelator, with midazolam, rifampin, and repaglinide in healthy volunteers." J Clin Pharmacol 50 (2010): 205-13. [PMID: 19940232]
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401	Product Information. Taxotere (docetaxel). Rhone-Poulenc Rorer, Collegeville, PA.
402	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
403	Product Information. Adriamycin PFS (doxorubicin). Pharmacia and Upjohn, Kalamazoo, MI.
404	Product Information. Doxil (doxorubicin liposomal). Sequis Pharmaceuticals Inc, Menlo Park, CA.
405	Kaytser V, Zhang P. Non-interacting, Non-opioid, and Non-barbiturate Containing Acute Medication Combinations in Headache: A Pilot Combinatorics Approach Based on DrugBank Database.?Front Neurol. 2021;12:632830. [PMID: 33679591]
406	Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
407	Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
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409	Product Information. Orilissa (elagolix). AbbVie US LLC, North Chicago, IL.
410	Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
411	Product Information. Aromasin (exemestane) Pharmacia & Upjohn, Kalamazoo, MI.
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413	Product Information. Carbatrol (carbamazepine). Athena Neurosciences Inc, South San Francisco, CA.
414	Product Information. Dilantin (phenytoin). Parke-Davis, Morris Plains, NJ.
415	Product Information. Felbatol (felbamate). Wallace Laboratories, Cranbury, NJ.
416	Product Information. Phenobarbital (phenobarbital). Lilly, Eli and Company, Indianapolis, IN.
417	Product Information. Rifamate (rifampin). Hoechst Marion-Roussel Inc, Kansas City, MO.
418	Product Information. Toviaz (fesoterodine). Pfizer U.S. Pharmaceuticals Group, New York, NY.
419	Product Information. Emend (aprepitant). Merck & Company Inc, West Point, PA.
420	Product Information. Emend for Injection (fosaprepitant). Merck & Company Inc, West Point, PA.
421	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
422	Product Information. Eovist (gadoxetate). Bayer Pharmaceutical Inc, West Haven, CT.
423	Product Information. Mavyret (glecaprevir-pibrentasvir). Abbott Pharmaceutical, Abbott Park, IL.
424	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
425	Product Information. Indium Oxyquinoline In-111 (indium oxyquinoline In-111). GE Healthcare, Princeton, NJ.
426	Product Information. Ixempra (ixabepilone). Bristol-Myers Squibb, Princeton, NJ.
427	Product Information. Tykerb (lapatinib). Novartis Pharmaceuticals, East Hanover, NJ.
428	Product Information. Dayvigo (lemborexant). Eisai Inc, Woodcliff Lake, NJ.
429	Product Information. Prevymis (letermovir). Merck & Company Inc, Whitehouse Station, NJ.
430	Product Information. Tradjenta (linagliptin). Boehringer Ingelheim, Ridgefield, CT.
431	Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
432	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
433	Product Information. Tindamax (tinidazole). Presutti Laboratories Inc, Arlington Heights, IL.
434	Dutreix C, Munarini F, Lorenzo S, Roesel J, Wang Y "Investigation into CYP3A4-mediated drug-drug interactions on midostaurin in healthy volunteers." Cancer Chemother Pharmacol 72 (2013): 1223-34. [PMID: 24085261]
435	Product Information. Rydapt (midostaurin). Novartis Pharmaceuticals, East Hanover, NJ.
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437	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
438	Product Information. Symproic (naldemedine). Shionogi USA Inc, Florham Park, NJ.
439	Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
440	Product Information. Serzone (nefazodone). Bristol-Myers Squibb, Princeton, NJ.
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442	Product Information. Osphena (ospemifene). Shionogi USA Inc, Florham Park, NJ.
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444	Product Information. Abraxane (paclitaxel protein-bound). American Pharmaceutical Partners, Schaumberg, IL.
445	Product Information. Taxol (paclitaxel). Bristol-Myers Squibb, Princeton, NJ.
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447	Product Information. Votrient (pazopanib). GlaxoSmithKline, Research Triangle Park, NC.
448	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
449	Product Information. Prepopik (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
450	MHRA. Medicines and Healthcare Regulatory Agency (general site Reference).
451	Product Information. Clenpiq (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
452	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
453	Jaakkola T, Backman JT, Neuvonen M, Laitila J, Neuvonen PJ "Effect of rifampicin on the pharmacokinetics of pioglitazone." Br J Clin Pharmacol 61 (2006): 70-8. [PMID: 16390353]
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455	Product Information. Actos (pioglitazone) Takeda Pharmaceuticals America, Lincolnshire, IL.
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458	Product Information. Pomalyst (pomalidomide). QLT Phototherapeutics Inc, Vancouver, AZ.
459	Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
460	Product Information. Noxafil (posaconazole). Schering-Plough Corporation, Kenilworth, NJ.
461	Grimm SW, Richtand NM, Winter HR, Stams KR, Reele SB "Effects of cytochrome P450 3A modulators ketoconazole and carbamazepine on quetiapine pharmacokinetics." Br J Clin Pharmacol 61 (2006): 58-69. [PMID: 16390352]
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469	Product Information. Stivarga (regorafenib). Bayer Pharmaceutical Inc, West Haven, CT.
470	Bidstrup TB, Bjornsdottir I, Sidelmann UG, Thomsen MS, Hansen KT "CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide." Br J Clin Pharmacol 56 (2003): 305-14. [PMID: 12919179]
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472	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
473	Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT.
474	Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
475	Product Information. Istodax (romidepsin). Gloucester Pharmaceuticals, Cambridge, MA.
476	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
477	Product Information. Jakafi (ruxolitinib). Incyte Corporation, Wilmington, DE.
478	Product Information. Invirase (saquinavir). Roche Laboratories, Nutley, NJ.
479	Product Information. Onglyza (saxagliptin). Bristol-Myers Squibb, Princeton, NJ.
480	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.
481	Product Information. VESIcare (solifenacin). GlaxoSmithKline, Research Triangle Park, NC.
482	Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
483	Product Information. Humatrope (somatropin). Lilly, Eli and Company, Indianapolis, IN.
484	Product Information. Sutent (sunitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
485	Product Information. Belsomra (suvorexant). Merck & Company Inc, Whitehouse Station, NJ.
486	Product Information. Adcirca (tadalafil). United Therapeutics Corporation, Silver Spring, MD.
487	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
488	Biochem Pharmacol "Variable contribution of cytochromes P450 2D6, 2C9, and 3A4 to the 4-hydroxylation of tamoxifen by human liver microsomes." Biochem Pharmacol 53 (1997): 171-8. [PMID: 9037249]
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490	Product Information. Targretin (bexarotene) Ligand Pharmaceuticals, San Diego, CA.
491	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
492	Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
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496	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
497	Product Information. ella (ulipristal). Afaxys Inc., Charleston, SC.
498	Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
499	Martin P, Oliver S, Robertson J, Kennedy SJ, Read J, Duvauchelle T "Pharmacokinetic drug interactions with vandetanib during cadministration with rifampicin or itraconazole." Drugs R D 11 (2011): 37-51. [PMID: 21410294]
500	Product Information. Vandetanib (vandetanib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
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505	Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
506	Product Information. Brintellix (vortioxetine). Takeda Pharmaceuticals America, Lincolnshire, IL.
507	Nakasa H, Nakamura H, Ono S, Tsutsui M, Kiuchi M, Ohmori S, Kitada M "Prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data." Eur J Clin Pharmacol 54 (1998): 177-83. [PMID: 9626925]
508	Product Information. Zonegran (zonisamide) Elan Pharmaceuticals, S. San Francisco, CA.
509	Baldwin SJ, Clarke SE, Chenery RJ "Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of rosiglitazone." Br J Clin Pharmacol 48 (1999): 424-32. [PMID: 10510156]
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512	Product Information. Avandia (rosiglitazone) SmithKline Beecham, Philadelphia, PA.
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514	Product Information. Revatio (sildenafil). Pfizer U.S. Pharmaceuticals Group, New York, NY.
515	Product Information. Viagra (sildenafil). Pfizer US Pharmaceuticals, New York, NY.
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517	Product Information. Nexavar (sorafenib). Bayer Pharmaceutical Inc, West Haven, CT.
518	Product Information. Marqibo (vinCRIStine liposome). Talon Therapeutics Inc, South San Francisco,, CA.
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521	Product Information. Ambien (zolpidem). sanofi-aventis, Bridgewater, NJ.
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526	Product Information. Evoxac (cevimeline) Daiichi Pharmaceuticals, Fort lee, NJ.
527	Product Information. Aczone (dapsone topical). QLT USA, Inc, Fort Collins, CO.
528	Product Information. Tikosyn (dofetilide) Pfizer US Pharmaceuticals, Atlanta, GA.
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