Drug General Information (ID: DDIA71UDIN)
Drug Name			Rifabutin		Drug Info		Cabotegravir		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Antiviral Agents
Structure

Mechanism of Rifabutin-Cabotegravir Interaction (Severity Level: Major)
Increased metabolism (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Rifabutin				Cabotegravir
Mechanism		Decrease the plasma concentrations of cabotegravir				Cabotegravir
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the metabolism of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Increased metabolism of Cabotegravir caused by Rifabutin

Recommended Action
Management		If cabotegravir is prescribed in combination with rilpivirine, concomitant use of rifabutin is considered contraindicated by the manufacturer.

References
1	Product Information. Cabenuva (cabotegravir-rilpivirine). ViiV Healthcare ULC, Laval, QU.
2	Product Information. Vocabria (cabotegravir). ViiV Healthcare, Research Triangle Park, NC.
3	Cerner Multum, Inc. "Canadian Product Information." O 0 (2015):