Details of Drug

Details of Drug

 Drug General Information (ID: D0229)
  Drug Name
Cabotegravir
  Drug Type Small molecule
  Drug Synonymous
Cabotegravir; 1051375-10-0; GSK1265744; UNII-HMH0132Z1Q; GSK744; GSK1265744A; GSK-1265744; HMH0132Z1Q; Cabotegravir (GSK744, GSK1265744); CAB; Oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide, N-[(2,4-difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxo-, (3S,11aR)-;Oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide, N-[(2,4-difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxo-, (3S,11aR)-; Cabotegravir [USAN:INN]; GSK744 LAP; GSK744 LA; S/GSK1265744; GSK 744; 744 LA; GSK 1265
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  Disease Class 1C60-1C62: Human immunodeficiency virus disease
  Therapeutic Class Antiviral Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C19H17F2N3O5
  InChI 1S/C19H17F2N3O5/c1-9-8-29-14-7-23-6-12(16(25)17(26)15(23)19(28)24(9)14)18(27)22-5-10-2-3-11(20)4-13(10)21/h2-4,6,9,14,26H,5,7-8H2,1H3,(H,22,27)/t9-,14+/m0/s1
  InChIKey WCWSTNLSLKSJPK-LKFCYVNXSA-N
  Canonical SMILES CC1COC2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)O
  External Link
Pubchem ID 54713659
CAS Number 1051375-10-0
TTD ID D08LDB
INTEDE ID DR1829

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM004  Affected intra/extra-hepatic metabolism
BM005  Altered gastric pH
BM023  UGT induction
BM026  Increased metabolism (Unspecific)
  Relation Graph
 Full list of drugs interacting with Cabotegravir
      Affected gastrointestinal absorption
   Altered gastric pH Drug Num:  7
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0049
 
Aluminum hydroxide
 
AlH3O3
 
10176082 
Moderate    Inter Info   
[5], [1], [3], [6]
D0236
 
Calcium carbonate
 
CCaO3
 
10112 
Moderate    Inter Info   
[1]
D0968
 
Magnesium carbonate
 
CMgO3
 
11029 
Moderate    Inter Info   
[1]
D0973
 
Magnesium hydroxide
 
H2MgO2
 
14791 
Moderate    Inter Info   
[5], [1], [3], [6]
D0974
 
Magnesium oxide
 
MgO
 
14792 
Moderate    Inter Info   
[5], [1], [3], [6]
D1480
 
Sodium bicarbonate
 
CHNaO3
 
516892 
Moderate    Inter Info   
[1]
D1483
 
Sodium citrate
 
C6H5Na3O7
 
6224 
Moderate    Inter Info   
[1]
      Affected intra/extra-hepatic metabolism
   UGT induction Drug Num:  5
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1198
 
Oxcarbazepine
 
C15H12N2O2
 
34312 
Major    Inter Info   
[1], [2], [3]
D1265
 
Phenobarbital
 
C12H12N2O3
 
4763 
Major    Inter Info   
[1], [2], [3]
D1283
 
Phenytoin
 
C15H12N2O2
 
1775 
Major    Inter Info   
[1], [2], [3]
D1400
 
Rifampicin
 
C43H58N4O12
 
135398735 
Major    Inter Info   
[1], [2], [3]
D1401
 
Rifapentine
 
C47H64N4O12
 
135403821 
Major    Inter Info   
[1], [2], [3]
   Increased metabolism (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1399
 
Rifabutin
 
C46H62N4O11
 
135398743 
Major    Inter Info   
[2], [3], [4]
References
1 Cerner Multum, Inc. "Canadian Product Information.".
2 Product Information. Cabenuva (cabotegravir-rilpivirine). ViiV Healthcare ULC, Laval, QU.
3 Product Information. Vocabria (cabotegravir). ViiV Healthcare, Research Triangle Park, NC.
4 Cerner Multum, Inc. "Canadian Product Information." O 0 (2015):
5 Cerner Multum, Inc. "Australian Product Information.".
6 US National Library of Medicine "Guidelines for the use of antiretroviral agents in adults and adolescents with HIV.".