Drug General Information (ID: DDINT8SYRO)
Drug Name			Magnesium hydroxide		Drug Info		Cabotegravir		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antacids/Laxatives				Antiviral Agents
Structure

Mechanism of Magnesium hydroxide-Cabotegravir Interaction (Severity Level: Moderate)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Magnesium hydroxide				Cabotegravir
Mechanism		Gastric alkalinizer				Gastric pH sensitive
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Cabotegravir due to altered gastric pH caused by Magnesium hydroxide

Recommended Action
Management		To minimize the risk of reduced viral susceptibility and resistance development associated with subtherapeutic levels of cabotegravir, antacids or other medications that contain antacids (e.g., didanosine buffered tablets or pediatric oral solution) should be administered at least 2 hours before or 4 hours after the oral cabotegravir dose.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "Canadian Product Information.".
3	Product Information. Vocabria (cabotegravir). ViiV Healthcare, Research Triangle Park, NC.
4	US National Library of Medicine "Guidelines for the use of antiretroviral agents in adults and adolescents with HIV.".