Details of Drug-Drug Interaction
| Drug General Information (ID: DDISQM7J0R) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Morphine | Drug Info | Rifabutin | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Analgesics | Antibiotics | |||||||
| Structure | |||||||||
| Mechanism of Morphine-Rifabutin Interaction (Severity Level: Moderate) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Increased metabolism (Unspecific) Click to Show/Hide Mechanism Graph | |||||||||
| Drug Name | Morphine | Rifabutin | |||||||
| Mechanism | Morphine | Induction of morphine metabolism or elimination | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Pharmacokinetics | ||||||||
| Factor Description | Alters the metabolism of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Management | The dosage of morphine may need to be readjusted depending on changes in the patient's clinical response to pain and/or narcotic side effects, if rifampin or rifabutin is added to or removed from a patient's therapy. | ||||||||