Drug General Information (ID: DDIV1MQH6P)
Drug Name			Rifabutin		Drug Info		Gadoxetic acid		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Mri Contrast Media
Structure

Mechanism of Rifabutin-Gadoxetic acid Interaction (Severity Level: Moderate)
Competitive inhibition of renal tubular secretion Click to Show/Hide Mechanism Graph
Drug Name		Rifabutin				Gadoxetic acid
Mechanism		Competitive inhibition of bile excretion of gadoxetate				Gadoxetate
Key Mechanism Factor 1
		Factor Name		Renal tubular secretion
		Factor Description		Renal tubular secretion allows selective transfer of substances from the blood around the capillaries into the renal tubules via filtrate. Drug excretion may be reduced when two drugs compete for renal tubular secretion.
Mechanism Description		Decreased elimination of Gadoxetic acid caused by Rifabutin mediated competitive inhibition of renal tubular secretion

Recommended Action
Management		Clinicians should be aware of possible interference with gadoxetate imaging in patients receiving rifamycin therapy.

References
1	Product Information. Eovist (gadoxetate). Bayer Pharmaceutical Inc, West Haven, CT.