Details of Drug

Drug General Information (ID: D1328)
Drug Name	Prasugrel
Drug Type	Small molecule
Drug Synonymous	Effient (TN) Click to Show/Hide
Disease Class	BA41-BA43: Myocardial infarction
Therapeutic Class	Antiplatelet Agents
Structure
Structure	3D Structure		2D Structure
Formula	C20H20FNO3S
InChI	1S/C20H20FNO3S/c1-12(23)25-18-10-14-11-22(9-8-17(14)26-18)19(20(24)13-6-7-13)15-4-2-3-5-16(15)21/h2-5,10,13,19H,6-9,11H2,1H3
InChIKey	DTGLZDAWLRGWQN-UHFFFAOYSA-N
Canonical SMILES	CC(=O)OC1=CC2=C(S1)CCN(C2)C(C3=CC=CC=C3F)C(=O)C4CC4
External Link
	Pubchem ID	6918456
	CAS Number	150322-43-3
	CHEBI ID	87723
	TTD ID	D07IRF

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM001 Altered gastrointestinal dynamics BM005 Altered gastric pH BM017 CYP450 enzyme inhibition BM050 Increased risk of bleeding BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Prasugrel
Affected gastrointestinal absorption
	Altered gastrointestinal dynamics					Drug Num: 26
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[33], [14], [34], [5], [48], [49], [50], [51], [52], [53], [6], [54]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[33], [14], [34], [5], [48], [49], [50], [51], [52], [53], [6], [54]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[33], [14], [34], [5], [48], [49], [50], [51], [52], [53], [6], [54]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[33], [14], [34], [5], [48], [49], [50], [51], [52], [53], [6], [54]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[14], [5], [48]
D0470		Dezocine	C16H23NO	3033053	Moderate		Inter Info	[33], [14], [34], [5], [48], [49], [50], [51], [52], [53], [6], [54]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[14], [5], [48]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[33], [14], [34], [5], [48], [49], [50], [51], [52], [53], [6], [54]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[33], [14], [34], [5], [48], [49], [50], [51], [52], [53], [6], [54]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[33], [14], [34], [5], [48], [49], [50], [51], [52], [53], [6], [54]
D0909		Levacetylmethadol	C23H31NO2	15130	Moderate		Inter Info	[14], [5], [48]
D0923		Levorphanol	C17H23NO	5359272	Moderate		Inter Info	[33], [14], [34], [5], [48], [49], [50], [51], [52], [53], [6], [54]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[33], [14], [34], [5], [48], [49], [50], [51], [52], [53], [6], [54]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[33], [14], [34], [5], [48], [49], [50], [51], [52], [53], [6], [54]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[33], [14], [34], [5], [48], [49], [50], [51], [52], [53], [6], [54]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[33], [14], [34], [5], [48], [49], [50], [51], [52], [53], [6], [54]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[33], [14], [34], [5], [48], [49], [50], [51], [52], [53], [6], [54]
D1208		Oxymorphone	C17H19NO4	5284604	Moderate		Inter Info	[33], [14], [34], [5], [48], [49], [50], [51], [52], [53], [6], [54]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[33], [14], [34], [5], [48], [49], [50], [51], [52], [53], [6], [54]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[14], [5], [48]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[33], [14], [34], [5], [48], [49], [50], [51], [52], [53], [6], [54]
D1183		Opium	NA	NA	Moderate		Inter Info	[33], [14], [34], [5], [48], [49], [50], [51], [52], [53], [6], [54]
D1390		Remifentanil	C20H28N2O5	60815	Moderate		Inter Info	[33], [14], [34], [5], [48], [49], [50], [51], [52], [53], [6], [54]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[33], [14], [34], [5], [48], [49], [50], [51], [52], [53], [6], [54]
D1535		Tapentadol	C14H23NO	9838022	Moderate		Inter Info	[33], [14], [34], [5], [48], [49], [50], [51], [52], [53], [6], [54]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[33], [14], [34], [5], [48], [49], [50], [51], [52], [53], [6], [54]
	Altered gastric pH					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0337		Cimetidine	C10H16N6S	2756	Minor		Inter Info	[6], [177]
D0458		Dexlansoprazole	C16H14F3N3O2S	9578005	Minor		Inter Info	[6], [177]
D0603		Esomeprazole	C17H19N3O3S	9568614	Minor		Inter Info	[6], [177]
D0636		Famotidine	C8H15N7O2S3	5702160	Minor		Inter Info	[6], [177]
D0892		Lansoprazole	C16H14F3N3O2S	3883	Minor		Inter Info	[6], [177]
D1151		Nizatidine	C12H21N5O2S2	3033637	Minor		Inter Info	[6], [177]
D1179		Omeprazole	C17H19N3O3S	4594	Minor		Inter Info	[6], [177]
D1222		Pantoprazole	C16H15F2N3O4S	4679	Minor		Inter Info	[6], [177]
D1373		Rabeprazole	C18H21N3O3S	5029	Minor		Inter Info	[6], [177]
D1381		Ranitidine	C13H22N4O3S	3001055	Minor		Inter Info	[6], [177]
D1382		Ranitidine (bismuth citrate)	C13H22N4O3S	3001055	Minor		Inter Info	[6], [177]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0220		Bupropion	C13H18ClNO	444	Minor		Inter Info	[5], [6]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Minor		Inter Info	[5], [6]
D0554		Efavirenz	C14H9ClF3NO2	64139	Minor		Inter Info	[5], [6]
D0751		Halothane	C2HBrClF3	3562	Minor		Inter Info	[5], [6]
D1128		Nevirapine	C15H14N4O	4463	Minor		Inter Info	[5], [6]
D1356		Propofol	C12H18O	4943	Minor		Inter Info	[5], [6]
D1455		Selegiline	C13H17N	26757	Minor		Inter Info	[5], [6]
D1533		Tamoxifen	C26H29NO	2733526	Minor		Inter Info	[5], [6]
Pharmacodynamic additive effects
	Increased risk of bleeding					Drug Num: 143
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0005		Abciximab	NA	NA	Major		Inter Info	[1], [2], [3], [4]
D0047		Alteplase	NA	NA	Major		Inter Info	[5], [6]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[5], [6]
D0087		Anisindione	C16H12O3	2197	Major		Inter Info	[5], [6]
D0088		Anistreplase	NA	NA	Major		Inter Info	[5], [6]
D0102		Ardeparin	C26H42N2O37S5	772	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0104		Argatroban	C23H36N6O5S	92722	Major		Inter Info	[5], [6]
D0189		Bivalirudin	C98H138N24O33	16129704	Major		Inter Info	[5], [6]
D0210		Bromfenac	C15H12BrNO3	60726	Major		Inter Info	[5], [6]
D0250		Caplacizumab	NA	NA	Major		Inter Info	[14], [5], [15]
D0364		Clopidogrel	C16H16ClNO2S	60606	Major		Inter Info	[5], [6]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[16]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[17], [18]
D0435		Defibrotide	C20H21N4O6P	135565962	Major		Inter Info	[5], [19]
D0476		Diclofenac	C14H11Cl2NO2	3033	Major		Inter Info	[5], [6]
D0481		Dicoumarol	C19H12O6	54676038	Major		Inter Info	[5], [6]
D0489		Diflunisal	C13H8F2O3	3059	Major		Inter Info	[5], [6]
D0506		Dipyridamole	C24H40N8O4	3108	Major		Inter Info	[5], [6]
D0537		Drotrecogin alfa	NA	NA	Major		Inter Info	[20]
D0574		Enoxaparin	C26H42N2O37S5	772	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0588		Eptifibatide	C35H49N11O9S2	448812	Major		Inter Info	[1], [2], [3], [4]
D0624		Etodolac	C17H21NO3	3308	Major		Inter Info	[5], [6]
D0645		Fenoprofen	C15H14O3	3342	Major		Inter Info	[5], [6]
D0680		Flurbiprofen	C15H13FO2	3394	Major		Inter Info	[5], [6]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0784		Ibritumomab tiuxetan	NA	NA	Major		Inter Info	[21]
D0786		Ibuprofen	C13H18O2	3672	Major		Inter Info	[5], [6]
D0800		Indomethacin	C19H16ClNO4	3715	Major		Inter Info	[5], [6]
D0881		Ketoprofen	C16H14O3	3825	Major		Inter Info	[5], [6]
D0882		Ketorolac	C15H13NO3	3826	Major		Inter Info	[5], [6]
D0904		Lepirudin	C287H440N80O111S6	118856773	Major		Inter Info	[5], [6]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Major		Inter Info	[5], [6]
D0991		Mefenamic acid	C15H15NO2	4044	Major		Inter Info	[5], [6]
D0995		Meloxicam	C14H13N3O4S2	54677470	Major		Inter Info	[5], [6]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[22], [23]
D1097		Nabumetone	C15H16O2	4409	Major		Inter Info	[5], [6]
D1109		Naproxen	C14H14O3	156391	Major		Inter Info	[5], [6]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Major		Inter Info	[17], [24]
D1196		Oxaprozin	C18H15NO3	4614	Major		Inter Info	[5], [6]
D1274		Phenylbutazone	C19H20N2O2	4781	Major		Inter Info	[5], [6]
D1300		Piroxicam	C15H13N3O4S	54676228	Major		Inter Info	[5], [6]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[25]
D0092		Antithrombin Alfa	NA	NA	Major		Inter Info	[5], [6]
D0093		Antithrombin III human	NA	NA	Major		Inter Info	[5], [6]
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[5], [26]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[5], [27]
D0176		Betrixaban	C23H22ClN5O3	10275777	Major		Inter Info	[28]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[29]
D0414		Dalteparin	C26H42N2O37S5	772	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0415		Danaparoid	NA	NA	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0447		Desirudin	C287H440N80O110S6	16129703	Major		Inter Info	[5], [6]
D0462		Dextran (-1)	C18H32O16	4125253	Major		Inter Info	[5], [6]
D0463		Dextran (high molecular weight)	C18H32O16	4125253	Major		Inter Info	[5], [6]
D0464		Dextran (low molecular weight)	C18H32O16	4125253	Major		Inter Info	[5], [6]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[32]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[5], [6]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[33], [34], [5], [35]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[5], [17], [36]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[14], [5], [37]
D1305		Plicamycin	C52H76O24	163659	Major		Inter Info	[5], [6]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[38]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Major		Inter Info	[5], [39], [40]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[41]
D1434		Ruxolitinib	C17H18N6	25126798	Major		Inter Info	[5], [6]
D1538		Tazemetostat	C34H44N4O4	66558664	Major		Inter Info	[5], [6]
D1588		Tinzaparin	C26H42N2O37S5	772	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1705		Vorapaxar	C29H33FN2O4	10077130	Major		Inter Info	[42]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[17]
D1380		Ramucirumab	NA	NA	Major		Inter Info	[43]
D1395		Reteplase	NA	NA	Major		Inter Info	[5], [6]
D1506		Streptokinase	C11H19NO2	9815560	Major		Inter Info	[5], [6]
D1520		Sulindac	C20H17FO3S	1548887	Major		Inter Info	[5], [6]
D1550		Tenecteplase	NA	NA	Major		Inter Info	[5], [6]
D1581		Ticlopidine	C14H14ClNS	5472	Major		Inter Info	[5], [6]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Major		Inter Info	[44]
D1593		Tirofiban	C22H36N2O5S	60947	Major		Inter Info	[1], [2], [3], [4]
D1606		Tolmetin	C15H15NO3	5509	Major		Inter Info	[5], [6]
D1613		Tositumomab	NA	NA	Major		Inter Info	[45], [46]
D1614		Tositumomab (I-131)	NA	NA	Major		Inter Info	[45], [46]
D1623		Trastuzumab emtansine	NA	NA	Major		Inter Info	[14], [5], [47]
D1669		Urokinase	NA	NA	Major		Inter Info	[5], [6]
D1711		Warfarin	C19H16O4	54678486	Major		Inter Info	[5], [6]
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[6]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[55], [14], [5], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]
D0187		Bismuth subsalicylate	C7H6BiO4	16682734	Moderate		Inter Info	[6]
D0211		Bromfenac (ophthalmic)	C15H12BrNO3	60726	Moderate		Inter Info	[66], [67], [68]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[69]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[70], [71], [72]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[73], [74], [75], [76], [14], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D0384		Collagenase clostridium histolyticum	NA	NA	Moderate		Inter Info	[111]
D1769		Deoxycholic acid	C24H40O4	222528	Moderate		Inter Info	[17], [112]
D0457		Dexfenfluramine	C12H16F3N	66265	Moderate		Inter Info	[73], [74], [75], [76], [14], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D0477		Diclofenac (ophthalmic)	C14H11Cl2NO2	3033	Moderate		Inter Info	[66], [67], [68]
D0478		Diclofenac (topical)	C14H11Cl2NO2	3033	Moderate		Inter Info	[66], [67], [68]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[73], [74], [75], [76], [14], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[113], [114], [115]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[73], [74], [75], [76], [14], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[73], [74], [75], [76], [14], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[73], [74], [75], [76], [14], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D0681		Flurbiprofen (ophthalmic)	C15H13FO2	3394	Moderate		Inter Info	[66], [67], [68]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[73], [74], [75], [76], [14], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134]
D0723		Ginseng	C42H66O17	420552	Moderate		Inter Info	[135], [123], [124], [136], [125], [137], [129], [133], [138]
D0752		Hemin	C34H32FeN4O4	26945	Moderate		Inter Info	[139]
D0753		Heparin	C26H42N2O37S5	772	Moderate		Inter Info	[5], [6]
D1815		Icosapent	C20H30O2	446284	Moderate		Inter Info	[5], [140], [141]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[113], [114], [115]
D0883		Ketorolac (ophthalmic)	C15H13NO3	3826	Moderate		Inter Info	[66], [67], [68]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[73], [74], [75], [76], [14], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[73], [74], [75], [76], [14], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[55], [14], [5], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]
D1249		Pentosan polysulfate	C10H18O21S4	37720	Moderate		Inter Info	[17], [142]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[143], [144]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[55], [14], [5], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[55], [14], [5], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[6]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[73], [74], [75], [76], [14], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D0711		Garlic	NA	NA	Moderate		Inter Info	[145], [146], [120], [123], [147], [124], [125], [148], [149], [129], [150], [151], [133], [152], [153]
D0721		Ginger	C30H40O6	442138	Moderate		Inter Info	[124], [127], [154], [129], [133]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[73], [74], [75], [76], [14], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D1123		Nepafenac (ophthalmic)	C15H14N2O2	151075	Moderate		Inter Info	[66], [67], [68]
D1139		Nintedanib	C31H33N5O4	135423438	Moderate		Inter Info	[155]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[5], [156]
D1178		Omega-3 fatty acids	C60H92O6	56842239	Moderate		Inter Info	[5], [140], [141]
D1272		Phenyl salicylate	C13H10O3	8361	Moderate		Inter Info	[6]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[157], [158], [159]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[5], [53]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[73], [74], [75], [76], [14], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[73], [74], [75], [76], [14], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D1421		Rofecoxib	C17H14O4S	5090	Moderate		Inter Info	[69]
D1439		Salicylic acid (sodium)	C7H6O3	338	Moderate		Inter Info	[6]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[6]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[73], [74], [75], [76], [14], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[73], [74], [75], [76], [14], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D1523		Suprofen (ophthalmic)	C14H12O3S	5359	Moderate		Inter Info	[66], [67], [68]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[113], [114], [115]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[69]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[73], [74], [75], [76], [14], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D1703		Vitamin E	C29H50O2	14985	Moderate		Inter Info	[157], [162], [5], [163], [164], [165], [166], [124], [167], [168], [169], [170], [171], [172], [173], [158], [174], [175], [159], [176]
D0253		Capsicum	NA	NA	Minor		Inter Info	[124]
D0309		Chamomile	C15H10O5	5280443	Minor		Inter Info	[124], [178], [129]
D0368		Clove	NA	NA	Minor		Inter Info	[124], [179], [180], [181]
D1661		Turmeric	C21H20O6	969516	Minor		Inter Info	[182], [124], [183]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0247		Cangrelor	C17H25Cl2F3N5O12P3S2	9854012	Major		Inter Info	[5], [30], [31]
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[160], [161]

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