Drug General Information (ID: DDI9LVASP6)
  Drug Name Ranitidine (bismuth citrate) Drug Info Prasugrel Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antiulcer Agents Antiplatelet Agents
  Structure

 Mechanism of Ranitidine (bismuth citrate)-Prasugrel Interaction (Severity Level: Minor)
     Altered gastric pH Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Ranitidine (bismuth citrate) Prasugrel
      Mechanism Gastric alkalinizer Gastric pH sensitive
      Key Mechanism Factor 1
Factor Name Gastric pH
Factor Description The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
      Mechanism Description
  • Decreased absorption of Prasugrel due to altered gastric pH caused by Ranitidine (bismuth citrate) 

References
1 Product Information. Effient (prasugrel). Lilly, Eli and Company, Indianapolis, IN.
2 Small DS, Farid NA, Payne CD, et al. "Effects of the proton pump inhibitor lansoprazole on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel." J Clin Pharmacol 48 (2008): 475-84. [PMID: 18303127]