Details of Drug

Drug General Information (ID: D1315)
Drug Name	Posaconazole
Drug Type	Small molecule
Drug Synonymous	Noxafil; Spriafil; Posaconazole SP; Posaconazole in combination with MGCD290; SCH56592; Sch 56592; X2N; Noxafil (TN); Noxafil, Posaconazole; SCH-56592; Posaconazole (USAN/INN); Posaconazole [USAN:INN:BAN]; 1-((1S,2S)-1-Ethyl-2-hydroxypropyl)-4-{4-[4-(4-{[(5S,3R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazolylmethyl)oxolan-3-yl]methoxy}phenyl)piperazinyl]phenyl}-1,2,4-triazolin-5-one; 4-(p-(4-(p-(((3R,5R)-5-(2,4-Difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)-3-furyl)methoxy)phenyl)-1-piperazinyl)phenyl)-1-((1S,2S)-1-ethyl-2-hydroxypropyl)-delta(sup 2)-1,2,4-triazolin-5-one; 4-[4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one; 4-[4-[4-[4-[[(5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one Click to Show/Hide
Disease Class	1F20: Aspergillosis
Therapeutic Class	Antifungal Agents
Structure
Structure	3D Structure		2D Structure
Formula	C37H42F2N8O4
InChI	1S/C37H42F2N8O4/c1-3-35(26(2)48)47-36(49)46(25-42-47)31-7-5-29(6-8-31)43-14-16-44(17-15-43)30-9-11-32(12-10-30)50-20-27-19-37(51-21-27,22-45-24-40-23-41-45)33-13-4-28(38)18-34(33)39/h4-13,18,23-27,35,48H,3,14-17,19-22H2,1-2H3/t26-,27+,35-,37-/m0/s1
InChIKey	RAGOYPUPXAKGKH-XAKZXMRKSA-N
Canonical SMILES	CCC(C(C)O)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OCC5CC(OC5)(CN6C=NC=N6)C7=C(C=C(C=C7)F)F
External Link
	Pubchem ID	468595
	CAS Number	171228-49-2
	CHEBI ID	64355
	TTD ID	D07ABV
	INTEDE ID	DR1316
	VARIDT ID	DR00111

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM001 Altered gastrointestinal dynamics BM005 Altered gastric pH BM010 Transporter inhibition BM011 Transporter induction BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM023 UGT induction BM038 Additive CNS depression effects BM049 Increased risk of atrioventricular block BM055 Increased risk of hepatotoxicity BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias
Relation Graph

Full list of drugs interacting with Posaconazole
Affected gastrointestinal absorption
	Altered gastrointestinal dynamics					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1046		Metoclopramide	C14H22ClN3O2	4168	Moderate		Inter Info	[20], [639]
	Altered gastric pH					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0603		Esomeprazole	C17H19N3O3S	9568614	Moderate		Inter Info	[631], [632], [633], [634], [635], [20], [636], [637], [638], [639]
D0636		Famotidine	C8H15N7O2S3	5702160	Moderate		Inter Info	[631], [25], [632], [633], [634], [635], [20], [636], [637], [638], [639]
D0892		Lansoprazole	C16H14F3N3O2S	3883	Moderate		Inter Info	[631], [632], [633], [634], [635], [20], [636], [637], [638], [639]
D1151		Nizatidine	C12H21N5O2S2	3033637	Moderate		Inter Info	[631], [25], [632], [633], [634], [635], [20], [636], [637], [638], [639]
D1179		Omeprazole	C17H19N3O3S	4594	Moderate		Inter Info	[631], [632], [633], [634], [635], [20], [636], [637], [638], [639]
D1222		Pantoprazole	C16H15F2N3O4S	4679	Moderate		Inter Info	[631], [632], [633], [634], [635], [20], [636], [637], [638], [639]
D0458		Dexlansoprazole	C16H14F3N3O2S	9578005	Moderate		Inter Info	[631], [632], [633], [634], [635], [20], [636], [637], [638], [639]
D1489		Sodium zirconium cyclosilicate	H6Na2O9Si3Zr+2	91799284	Moderate		Inter Info	[16], [753]
D1373		Rabeprazole	C18H21N3O3S	5029	Moderate		Inter Info	[631], [632], [633], [634], [635], [20], [636], [637], [638], [639]
D1381		Ranitidine	C13H22N4O3S	3001055	Moderate		Inter Info	[631], [25], [632], [633], [634], [635], [20], [636], [637], [638], [639]
D1382		Ranitidine (bismuth citrate)	C13H22N4O3S	3001055	Moderate		Inter Info	[631], [634], [636]
Affected cellular transport
	Transporter inhibition					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[271]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[617], [618], [619], [620]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[617], [619], [620]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[617], [618], [619], [620]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[16], [709], [710]
D0176		Betrixaban	C23H22ClN5O3	10275777	Moderate		Inter Info	[712]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Moderate		Inter Info	[15], [16], [714]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[734]
D0898		Ledipasvir	C49H54F2N8O6	67505836	Moderate		Inter Info	[735]
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[60]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[394]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[755]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[759]
	Transporter induction					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[16], [20]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[16], [20]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[16], [20]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[16], [20]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[16], [20]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[16], [20], [611]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[16], [20]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 286
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0035		Alfentanil	C21H32N6O3	51263	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14]
D0036		Alfuzosin	C19H27N5O4	2092	Major		Inter Info	[15], [16], [17], [18], [19]
D0045		Alprazolam	C17H13ClN4	2118	Major		Inter Info	[15], [16], [20], [21]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[22], [23], [24]
D0115		Astemizole	C28H31FN4O	2247	Major		Inter Info	[29], [30], [15], [31], [32], [33], [34], [35], [36], [37], [38], [39], [20], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51]
D0215		Budesonide	C25H34O6	5281004	Major		Inter Info	[61], [15], [16], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[75]
D0303		Cerivastatin	C26H34FNO5	446156	Major		Inter Info	[15], [16], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [20], [86]
D0336		Cilostazol	C20H27N5O2	2754	Major		Inter Info	[16], [106], [107], [108]
D0342		Cisapride	C23H29ClFN3O4	6917698	Major		Inter Info	[109], [110], [15], [111], [32], [112], [113], [114], [37], [39], [20], [115], [18], [40], [41]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[15], [120], [18], [121]
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[20]
D0424		Darifenacin	C28H30N2O2	444031	Major		Inter Info	[15], [122], [123], [18]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[15], [18], [124]
D0494		Dihydroergotamine	C33H37N5O5	10531	Major		Inter Info	[125], [126], [127], [128], [15], [32], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [20], [18], [142], [143], [144], [145], [146], [147]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[54]
D0511		Docetaxel	C43H53NO14	148124	Major		Inter Info	[148], [15], [16], [149], [150], [18], [151], [152], [153], [154]
D0557		Eletriptan	C22H26N2O2S	77993	Major		Inter Info	[159]
D0585		Eplerenone	C24H30O6	443872	Major		Inter Info	[15], [160], [18]
D0592		Ergometrine	C19H23N3O2	443884	Major		Inter Info	[127], [15], [131]
D0593		Ergotamine	C33H35N5O5	8223	Major		Inter Info	[125], [126], [127], [128], [15], [32], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [20], [18], [142], [143], [144], [145], [146], [147]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[161], [162]
D0612		Eszopiclone	C17H17ClN6O3	969472	Major		Inter Info	[166], [167], [32], [168], [169]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[15], [170], [171], [172], [18], [173], [13]
D0745		Guanfacine	C9H9Cl2N3O	3519	Major		Inter Info	[16], [199]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[200], [201], [202], [20]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[209], [210]
D0845		Irinotecan	C33H38N4O6	60838	Major		Inter Info	[25], [15], [16], [212], [213], [214], [215]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Major		Inter Info	[16], [212], [213]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Major		Inter Info	[15], [18], [216]
D0947		Loperamide	C29H33ClN2O2	3955	Major		Inter Info	[220], [221], [222], [223], [224], [225]
D0956		Lovastatin	C24H36O5	53232	Major		Inter Info	[15], [16], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [20], [86]
D1037		Methylergometrine	C20H25N3O2	8226	Major		Inter Info	[127], [15], [131]
D1041		Methylprednisolone	C22H30O5	6741	Major		Inter Info	[237], [17], [238], [239], [240], [241], [242], [243]
D1043		Methysergide	C21H27N3O2	9681	Major		Inter Info	[127], [15], [131]
D1060		Midazolam	C18H13ClFN3	4192	Major		Inter Info	[15], [16], [20], [21]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[244], [245]
D1138		Nimodipine	C21H26N2O7	4497	Major		Inter Info	[246]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[15], [16], [247]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[15], [256], [32], [257], [157], [258], [259], [260], [18]
D0006		Abemaciclib	C27H32F2N8	46220502	Major		Inter Info	[261]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[262]
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[15], [16], [264], [18]
D0108		Artemether	C16H26O5	68911	Major		Inter Info	[15], [16], [265]
D0128		Avanafil	C23H26ClN7O3	9869929	Major		Inter Info	[15], [18], [266]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[16], [267]
D0133		Axitinib	C22H18N4OS	6450551	Major		Inter Info	[15], [16], [268], [18]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[269]
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[209], [210], [270]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[15], [16], [272], [18]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Major		Inter Info	[273]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Major		Inter Info	[274]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[15], [16], [275], [18]
D0251		Capmatinib	C23H17FN6O	25145656	Major		Inter Info	[276]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Major		Inter Info	[277]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[15], [18], [278]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Major		Inter Info	[15], [279], [18]
D0380		Colchicine	C22H25NO6	6167	Major		Inter Info	[280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294], [295], [296]
D0389		Copanlisib	C23H28N8O4	135565596	Major		Inter Info	[297]
D0408		Daclatasvir	C40H50N8O6	25154714	Major		Inter Info	[16], [299]
D0436		Deflazacort	C25H31NO6	189821	Major		Inter Info	[16], [300]
D0536		Drospirenone	C24H30O3	68873	Major		Inter Info	[15], [16], [302], [303], [304], [72], [305]
D0543		Duvelisib	C22H17ClN6O	50905713	Major		Inter Info	[306]
D0555		Elagolix	C32H30F5N3O5	11250647	Major		Inter Info	[307]
D0559		Eliglustat	C23H36N2O4	23652731	Major		Inter Info	[15], [16], [308], [18]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[309]
D0571		Enfortumab vedotin	NA	NA	Major		Inter Info	[16], [310], [311], [312]
D0577		Entrectinib	C31H34F2N6O2	25141092	Major		Inter Info	[15], [16], [313]
D0590		Erdafitinib	C25H30N6O2	67462786	Major		Inter Info	[314]
D0629		Everolimus	C53H83NO14	6442177	Major		Inter Info	[15], [315], [316], [18]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[16], [317]
D0655		Fesoterodine	C26H37NO3	6918558	Major		Inter Info	[15], [18], [40], [318]
D0665		Flibanserin	C20H21F3N4O	6918248	Major		Inter Info	[320]
D0683		Fluticasone	C22H27F3O4S	5311101	Major		Inter Info	[321], [322], [323], [324], [62], [325], [326], [327], [328], [329], [330], [331], [332], [67], [333], [334], [335], [69], [336], [337], [338], [339], [340], [341], [342], [343], [344], [345], [346], [347], [348], [349], [350], [351], [352], [353], [354], [355], [356], [357]
D0684		Fluticasone (nasal)	C22H27F3O4S	5311101	Major		Inter Info	[344], [345], [357]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Major		Inter Info	[358]
D0720		Gilteritinib	C29H44N8O3	49803313	Major		Inter Info	[359]
D0725		Glasdegib	C21H22N6O	25166913	Major		Inter Info	[360]
D0739		Grazoprevir	C38H50N6O9S	44603531	Major		Inter Info	[16], [361]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[15], [16], [362]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Major		Inter Info	[364]
D0866		Istradefylline	C20H24N4O4	5311037	Major		Inter Info	[365]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[15], [16], [366], [18]
D0869		Ivacaftor	C24H28N2O3	16220172	Major		Inter Info	[15], [16], [367], [368], [369], [370]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[371]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Major		Inter Info	[15], [16], [372]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[373]
D0901		Lemborexant	C22H20F2N4O2	56944144	Major		Inter Info	[15], [374]
D0920		Levomilnacipran	C15H22N2O	6917779	Major		Inter Info	[375]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[15], [376], [18]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[377]
D0953		Lorlatinib	C21H19FN6O2	71731823	Major		Inter Info	[378]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[379]
D0961		Lurasidone	C28H36N4O2S	213046	Major		Inter Info	[15], [16], [380], [18]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Major		Inter Info	[381]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Major		Inter Info	[383]
D0980		Maraviroc	C29H41F2N5O	3002977	Major		Inter Info	[384]
D1062		Midostaurin	C35H30N4O4	9829523	Major		Inter Info	[385], [386]
D1104		Naloxegol	C34H53NO11	56959087	Major		Inter Info	[15], [16], [388], [18]
D1124		Neratinib	C30H29ClN6O3	9915743	Major		Inter Info	[389], [15], [390]
D1167		Olaparib	C24H23FN4O3	23725625	Major		Inter Info	[15], [16], [392], [18]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[393], [394]
D1189		Osilodrostat	C13H10FN3	44139752	Major		Inter Info	[16], [395]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[396]
D1214		Palbociclib	C24H29N7O2	5330286	Major		Inter Info	[398]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[400]
D1290		Pimavanserin	C25H34FN3O2	10071196	Major		Inter Info	[401]
D1306		Polatuzumab vedotin	NA	NA	Major		Inter Info	[402]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[15], [16], [403]
D1324		Pralsetinib	C27H32FN9O2	129073603	Major		Inter Info	[404]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[405]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Major		Inter Info	[15], [406]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[15], [16], [407], [18], [408]
D1434		Ruxolitinib	C17H18N6	25126798	Major		Inter Info	[409]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[16], [410]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Major		Inter Info	[411]
D1466		Silodosin	C25H32F3N3O4	5312125	Major		Inter Info	[15], [412], [18]
D1471		Simeprevir	C38H47N5O7S2	24873435	Major		Inter Info	[15], [413], [18]
D1491		Solifenacin	C23H26N2O2	154059	Major		Inter Info	[15], [16], [18], [40], [415]
D1496		Sonidegib	C26H26F3N3O3	24775005	Major		Inter Info	[416]
D1524		Suvorexant	C23H23ClN6O2	24965990	Major		Inter Info	[15], [417]
D1538		Tazemetostat	C34H44N4O4	66558664	Major		Inter Info	[418]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Major		Inter Info	[15], [16], [420], [18]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[15], [16], [421]
D1608		Tolvaptan	C26H25ClN2O3	216237	Major		Inter Info	[15], [120], [18], [121]
D1615		Trabectedin	C39H43N3O11S	108150	Major		Inter Info	[15], [16], [422], [18], [423]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Major		Inter Info	[424]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[425]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[429]
D1696		Vilazodone	C26H27N5O2	6918314	Major		Inter Info	[430]
D1705		Vorapaxar	C29H33FN2O4	10077130	Major		Inter Info	[15], [18], [431]
D1709		Voxelotor	C19H19N3O3	71602803	Major		Inter Info	[432]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[433]
D1368		Quetiapine	C21H25N3O2S	5002	Major		Inter Info	[434], [435], [436], [437], [438], [439], [440], [441]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[15], [16], [442], [443], [444], [445], [446], [447], [37], [39], [20], [56], [18], [40], [41], [448], [449], [450]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[15], [16], [451], [18]
D1473		Simvastatin	C25H38O5	54454	Major		Inter Info	[15], [16], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [20], [86]
D1476		Sirolimus	C51H79NO13	5284616	Major		Inter Info	[25], [16], [456], [20]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[463], [464], [465], [466], [467], [15], [16], [456], [468], [469], [470], [471], [472], [473], [474], [475], [20], [476], [41], [477], [478], [49], [479]
D1534		Tamsulosin	C20H28N2O5S	129211	Major		Inter Info	[15], [480], [481], [482], [18]
D1555		Terfenadine	C32H41NO2	5405	Major		Inter Info	[29], [30], [483], [15], [484], [32], [485], [35], [486], [487], [488], [489], [490], [491], [492], [493], [494], [36], [37], [39], [20], [495], [40], [41], [43], [46], [49], [51], [496], [497], [498]
D1628		Triamcinolone	C21H27FO6	31307	Major		Inter Info	[237], [503], [504], [17], [505], [506], [507], [508], [509], [510], [511], [512]
D1632		Triazolam	C17H12Cl2N4	5556	Major		Inter Info	[15], [16], [20], [21]
D1697		Vinblastine	C46H58N4O9	13342	Major		Inter Info	[513], [514], [515], [516], [517], [518], [25], [519], [15], [16], [520], [521], [522], [523], [524], [525], [526], [527], [528], [529], [530], [531], [532], [533], [534], [535], [536], [537], [538], [539], [18], [540], [541], [542], [543], [544], [545], [546], [547], [548], [549]
D1698		Vincristine	C46H56N4O10	5978	Major		Inter Info	[513], [514], [515], [516], [517], [518], [25], [519], [15], [16], [520], [521], [522], [523], [524], [525], [526], [527], [528], [529], [530], [531], [532], [533], [534], [535], [536], [537], [538], [539], [18], [540], [541], [542], [543], [544], [545], [546], [547], [548], [549]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Major		Inter Info	[516], [538], [540]
D1700		Vinorelbine	C45H54N4O8	5311497	Major		Inter Info	[513], [514], [515], [516], [517], [518], [25], [519], [15], [16], [520], [521], [522], [523], [524], [525], [526], [527], [528], [529], [530], [531], [532], [533], [534], [535], [536], [537], [538], [539], [18], [540], [541], [542], [543], [544], [545], [546], [547], [548], [549]
D0028		Albendazole	C12H15N3O2S	2082	Moderate		Inter Info	[16]
D0041		Almotriptan	C17H25N3O2S	123606	Moderate		Inter Info	[565]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[566], [567], [568], [20], [569], [570], [571], [572]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[16]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[574]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[586]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[237], [322], [61], [587], [588], [65], [17], [589], [590], [238], [329], [330], [591], [239], [240], [241], [592], [68], [593], [73], [74], [349], [594], [242], [243], [595], [596], [597], [356]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[598], [599], [600]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[601]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[16]
D0216		Budesonide (nasal)	C25H34O6	5281004	Moderate		Inter Info	[61], [15], [16]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[602]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[603], [604]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[605]
D0338		Cinacalcet	C22H22F3N	156419	Moderate		Inter Info	[606]
D0354		Clindamycin	C18H33ClN2O5S	446598	Moderate		Inter Info	[607]
D0377		Cocaine (nasal)	C17H21NO4	446220	Moderate		Inter Info	[16], [610], [611]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[612], [613], [614], [41], [615], [616]
D0388		Conjugated estrogens (topical)	C18H21NaO5S	45357473	Moderate		Inter Info	[613], [614], [616]
D0450		Desogestrel	C22H30O	40973	Moderate		Inter Info	[613], [614], [616]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[237], [322], [61], [587], [588], [65], [17], [589], [590], [238], [329], [330], [591], [239], [240], [241], [592], [68], [593], [73], [74], [349], [594], [242], [243], [595], [596], [597], [356]
D0454		Dexamethasone (nasal)	C22H29FO5	5743	Moderate		Inter Info	[65], [589], [349]
D0455		Dexamethasone (ophthalmic)	C22H29FO5	5743	Moderate		Inter Info	[65], [589], [349]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[621], [622], [364], [37], [39], [20], [18], [623], [41]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[624], [625], [626]
D0484		Dienestrol (topical)	C18H18O2	667476	Moderate		Inter Info	[613], [614], [616]
D0487		Diethylstilbestrol	C18H20O2	448537	Moderate		Inter Info	[612], [613], [614], [41], [615], [616]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[566], [567], [568], [20], [569], [570], [571], [572]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[25], [16], [627]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[16]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[16], [610], [611]
D0542		Dutasteride	C27H30F6N2O2	6918296	Moderate		Inter Info	[628]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[629], [630]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[612], [613], [614], [41], [615], [616]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[613], [614], [616]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[612], [613], [614], [41], [615], [616]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[613], [614], [616]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[16]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[612], [613], [614], [41], [615], [616]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[16]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[566], [567], [568], [20], [569], [570], [571], [572]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[237], [322], [61], [587], [588], [65], [17], [589], [590], [238], [329], [330], [591], [239], [240], [241], [592], [68], [593], [73], [74], [349], [594], [242], [243], [595], [596], [597], [356]
D0672		Flunisolide	C24H31FO6	82153	Moderate		Inter Info	[237], [322], [61], [587], [588], [65], [17], [589], [590], [238], [329], [330], [591], [239], [240], [241], [592], [68], [593], [73], [74], [349], [594], [242], [243], [595], [596], [597], [356]
D0673		Flunisolide (nasal)	C24H31FO6	82153	Moderate		Inter Info	[65], [589], [349]
D0674		Fluorometholone (ophthalmic)	C22H29FO4	9878	Moderate		Inter Info	[65], [589], [349]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[669]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[629], [670]
D0738		Granisetron	C18H24N4O	5284566	Moderate		Inter Info	[16]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[237], [322], [61], [587], [588], [65], [17], [589], [590], [238], [329], [330], [591], [239], [240], [241], [592], [68], [593], [73], [74], [349], [594], [242], [243], [595], [596], [597], [356]
D0774		Hydrocortisone (ophthalmic)	C21H30O5	5754	Moderate		Inter Info	[65], [589], [349]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[672]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[566], [567], [568], [20], [569], [570], [571], [572]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[16]
D0870		Ivermectin	C48H74O14	6321424	Moderate		Inter Info	[16], [677]
D0916		Levobupivacaine	C18H28N2O	92253	Moderate		Inter Info	[16], [681]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[612], [613], [614], [41], [615], [616]
D0927		Lidocaine	C14H22N2O	3676	Moderate		Inter Info	[16]
D0955		Loteprednol (ophthalmic)	C21H27ClO5	9865442	Moderate		Inter Info	[65], [589], [349]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[613], [614], [616]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[613], [614], [616]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[692], [693], [394], [694], [695]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[16]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[16]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[566], [567], [568], [20], [569], [570], [571], [572]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[566], [567], [568], [20], [569], [570], [571], [572]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[566], [567], [568], [20], [569], [570], [571], [572]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[25], [15], [16]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[613], [614], [616]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[698], [699], [15], [700], [701], [702], [703], [152]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[698], [699], [15]
D1226		Paricalcitol	C27H44O3	5281104	Moderate		Inter Info	[16], [704]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[25], [16], [707], [708]
D0130		Avatrombopag	C29H34Cl2N6O3S2	9852519	Moderate		Inter Info	[16]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[15], [16], [713]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[71], [72]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[41], [298], [715]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[15], [716], [18]
D0333		Ciclesonide	C32H44O7	6918155	Moderate		Inter Info	[237], [17], [717], [718]
D0334		Ciclesonide (nasal)	C32H44O7	6918155	Moderate		Inter Info	[719], [720], [717]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[721]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[15], [18], [722]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[723]
D0562		Eluxadoline	C32H35N5O5	11250029	Moderate		Inter Info	[725]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[726]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[612], [613], [614], [41], [615], [616]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[613], [614], [616]
D0611		Estrone sulfate (topical)	C18H22O5S	3001028	Moderate		Inter Info	[613], [614], [616]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[728]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[732]
D0885		Lacosamide	C13H18N2O3	219078	Moderate		Inter Info	[15], [16], [733]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[566], [567], [568], [20], [569], [570], [571], [572]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[16], [738]
D1139		Nintedanib	C31H33N5O4	135423438	Moderate		Inter Info	[739]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[612], [613], [614], [41], [615], [616]
D1191		Ospemifene	C24H23ClO2	3036505	Moderate		Inter Info	[740]
D1227		Paritaprevir	C40H43N7O7S	45110509	Moderate		Inter Info	[16], [344], [741]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[15], [16], [744]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[612], [613], [614], [41], [615], [616]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Moderate		Inter Info	[15], [18], [745]
D1407		Rimegepant	C28H28F2N6O3	51049968	Moderate		Inter Info	[750]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[15], [16], [751]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[16], [752]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[756]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[71], [72]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[15], [758], [18]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[341], [715], [354]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[237], [322], [61], [587], [588], [65], [17], [589], [590], [238], [329], [330], [591], [239], [240], [241], [592], [68], [593], [73], [74], [349], [594], [242], [243], [595], [596], [597], [356]
D1333		Prednisolone (ophthalmic)	C21H28O5	5755	Moderate		Inter Info	[65], [589], [349]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[237], [322], [61], [587], [588], [65], [17], [589], [590], [238], [329], [330], [591], [239], [240], [241], [592], [68], [593], [73], [74], [349], [594], [242], [243], [595], [596], [597], [356]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[612], [613], [614], [41], [615], [616]
D1349		Progesterone (topical)	C21H30O2	5994	Moderate		Inter Info	[613], [614], [616]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[15], [16], [770], [771], [772], [773], [774], [775], [776], [777], [778]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[779]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[780], [781], [782], [783], [784], [785], [786]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[792], [793], [173]
D1558		Testosterone	C19H28O2	6013	Moderate		Inter Info	[16]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[16]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[800], [801]
D1626		Tretinoin	C20H28O2	444795	Moderate		Inter Info	[802], [803], [804], [805], [806], [807], [808], [809], [810], [811], [812]
D1629		Triamcinolone (nasal)	C21H27FO6	31307	Moderate		Inter Info	[65], [589], [349]
D1630		Triamcinolone (ophthalmic)	C21H27FO6	31307	Moderate		Inter Info	[65], [589], [349]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[15], [16], [813]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[624], [814], [815], [625], [816], [626], [817]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[16]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[818], [819]
D0516		Donepezil	C24H29NO3	3152	Minor		Inter Info	[787], [394], [820], [821]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[15], [825], [826]
D1291		Pimecrolimus (topical)	C43H68ClNO11	6509979	Minor		Inter Info	[827]
D0053		Ambrisentan	C22H22N2O4	6918493	Minor		Inter Info	[828]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[15], [825], [826]
D0248		Cannabidiol	C21H30O2	644019	Minor		Inter Info	[16], [829]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Minor		Inter Info	[830]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Minor		Inter Info	[831]
D0589		Eravacycline	C27H31FN4O8	54726192	Minor		Inter Info	[832]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[833]
D1253		Perampanel	C23H15N3O	9924495	Minor		Inter Info	[16], [834]
D1664		Ulipristal	C28H35NO3	13559281	Minor		Inter Info	[16], [835]
D1394		Retapamulin (topical)	C30H47NO4S	6918462	Minor		Inter Info	[836]
D1428		Ropivacaine	C17H26N2O	175805	Minor		Inter Info	[837], [838], [839], [840], [841], [842], [843]
	CYP450 enzyme induction					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1549		Temsirolimus	C56H87NO16	6918289	Major		Inter Info	[15], [18], [419]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[749]
	UGT induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[20]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1673		Valbenazine	C24H38N2O4	24795069	Major		Inter Info	[426]
D0452		Deutetrabenazine	C19H27NO3	73437646	Moderate		Inter Info	[724]
	Increased risk of atrioventricular block					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[16], [689], [690]
	Increased risk of hepatotoxicity					Drug Num: 15
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[25], [217], [218]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[387]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[25], [217], [218]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[575], [576], [577], [15], [16], [578], [579], [580], [581], [582], [583], [584], [585]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[608]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[673], [674], [675], [676]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[16], [691]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[696]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[575], [576], [577], [15], [16], [578], [579], [580], [581], [582], [583], [584], [585]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[575], [576], [577], [15], [16], [578], [579], [580], [581], [582], [583], [584], [585]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[575], [576], [577], [15], [16], [578], [579], [580], [581], [582], [583], [584], [585]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[730]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[673], [674], [675], [676]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[15], [16], [746], [747], [748]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[798], [799]
	Increased risk of prolong QT interval					Drug Num: 123
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[25], [15], [16], [26]
D0170		Bepridil	C24H34N2O	2351	Major		Inter Info	[25], [15], [16], [52], [53], [23], [54], [55], [56], [57], [58], [59], [60]
D0320		Chloroquine	C18H26ClN3	2719	Major		Inter Info	[87], [16], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[25], [15], [16], [116], [117], [60], [118]
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[25], [15], [16], [119], [60]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[25], [15], [16], [155]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[25], [15], [16], [156]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[25], [15], [16], [157], [158], [60]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[25], [163], [15], [16], [164], [165], [60]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[174], [175], [176], [25], [15], [16], [177], [178], [179], [180], [161], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195]
D0740		Grepafloxacin	C19H22FN3O3	72474	Major		Inter Info	[175], [25], [15], [16], [196], [197], [198]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[25], [15], [16], [203], [204], [205], [206], [207], [208], [60]
D0787		Ibutilide	C20H36N2O3S	60753	Major		Inter Info	[25], [15], [16], [211]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[16], [219], [60]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[25], [15], [16], [226], [60]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[25], [15], [16], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [60]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[174], [175], [176], [25], [15], [16], [177], [178], [179], [180], [161], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195]
D1223		Papaverine	C20H21NO4	4680	Major		Inter Info	[248], [249], [250], [251], [252], [253], [254], [255]
D0067		Amisulpride	C17H27N3O4S	2159	Major		Inter Info	[15], [16], [263]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[298]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[25], [15], [16], [301]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Major		Inter Info	[87], [16], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[25], [15], [16], [363], [60]
D0965		Macimorelin	C26H30N6O3	9804938	Major		Inter Info	[382]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[25], [15], [16], [391]
D1230		Pasireotide	C58H66N10O9	9941444	Major		Inter Info	[25], [15], [16], [399]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Major		Inter Info	[25], [15], [16], [427]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[25], [15], [16], [428]
D1343		Procainamide	C13H21N3O	4913	Major		Inter Info	[25], [15], [16], [52], [53], [23], [54], [55], [56], [57], [58], [59], [60]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[452], [453], [25], [15], [16], [454], [455]
D1498		Sotalol	C12H20N2O3S	5253	Major		Inter Info	[25], [15], [16], [52], [53], [23], [54], [55], [56], [57], [58], [59], [60]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Major		Inter Info	[175], [25], [15], [16], [457], [458], [179], [161], [182], [459], [183], [184], [460], [186], [187], [188], [189], [461], [193], [198], [462]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[25], [15], [16], [499], [157], [500], [501], [502], [60]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[25], [15], [16], [17]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[25], [15], [16], [157], [550], [60]
D0003		Abarelix	C72H95ClN14O14	16131215	Moderate		Inter Info	[16], [551], [552], [553], [554], [555], [556], [557]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[161], [564], [60]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[25], [15], [16], [573], [60]
D0119		Atomoxetine	C17H21NO	54841	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D0139		Azithromycin	C38H72N2O12	447043	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[16], [551], [552], [553], [554], [555], [556], [557]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D0358		Clofazimine	C27H22Cl2N4	2794	Moderate		Inter Info	[609]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[161], [564], [60]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D0682		Flutamide	C11H11F3N2O3	3397	Moderate		Inter Info	[16], [551], [552], [553], [554], [555], [556], [557]
D0694		Foscarnet	CH3O5P	3415	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Moderate		Inter Info	[175], [182], [183], [188], [671]
D0737		Goserelin	C59H84N18O14	5311128	Moderate		Inter Info	[16], [551], [552], [553], [554], [555], [556], [557]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D0908		Leuprolide	C59H84N16O12	657181	Moderate		Inter Info	[16], [551], [552], [553], [554], [555], [556], [557]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[175], [25], [15], [16], [179], [180], [161], [682], [683], [183], [184], [684], [185], [685], [186], [187], [188], [189], [686], [687], [688], [193], [198]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Moderate		Inter Info	[16]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D1137		Nilutamide	C12H10F3N3O4	4493	Moderate		Inter Info	[16], [551], [552], [553], [554], [555], [556], [557]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[175], [25], [15], [16], [179], [180], [161], [682], [683], [183], [184], [684], [185], [685], [186], [187], [188], [189], [686], [687], [688], [193], [198]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[175], [25], [15], [16], [179], [180], [161], [682], [683], [183], [184], [684], [185], [685], [186], [187], [188], [189], [686], [687], [688], [193], [198]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[15], [16], [697]
D1181		Ondansetron	C18H19N3O	4595	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D1210		Oxytocin	C43H66N12O12S2	439302	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D1216		Palonosetron	C19H24N2O	6337614	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D1246		Pentamidine	C19H24N4O2	4735	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D1254		Perflutren	C3F8	6432	Moderate		Inter Info	[705], [706]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[16], [551], [552], [553], [554], [555], [556], [557]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[25], [15], [16], [711], [60]
D0437		Degarelix	C82H103ClN18O16	16136245	Moderate		Inter Info	[16], [551], [552], [553], [554], [555], [556], [557]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[25], [15], [16], [727]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D0700		Fostemsavir	C25H26N7O8P	11319217	Moderate		Inter Info	[729]
D0758		Histrelin	C66H86N18O12	25077993	Moderate		Inter Info	[16], [551], [552], [553], [554], [555], [556], [557]
D0806		Inotuzumab ozogamicin	NA	NA	Moderate		Inter Info	[16], [731]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[161], [564], [60]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[25], [15], [16], [736], [60]
D0948		Lopinavir	C37H48N4O5	92727	Moderate		Inter Info	[25], [15], [737]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D1342		Probucol	C31H48O2S2	4912	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D1388		Relugolix	C29H27F2N7O5S	10348973	Moderate		Inter Info	[16], [551], [552], [553], [554], [555], [556], [557]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[25], [15], [16], [754]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[25], [15], [16], [757], [60]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D1651		Triptorelin	C64H82N18O13	25074470	Moderate		Inter Info	[16], [551], [552], [553], [554], [555], [556], [557]
D1339		Primaquine	C15H21N3O	4908	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[760], [761], [762], [763], [764], [765], [766], [767], [768], [769]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D1463		Sevoflurane	C4H3F7O	5206	Moderate		Inter Info	[25], [15], [16], [790]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[25], [15], [16], [791]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[25], [15], [16], [794], [795], [796]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D1683		Vasopressin	C46H65N15O12S2	644077	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[25], [15], [16], [157], [161], [564], [60]
D1051		Metronidazole	C6H9N3O3	4173	Minor		Inter Info	[15], [822], [823], [824]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Minor		Inter Info	[25], [15], [16], [844], [845], [846], [847]
	Increased risk of ventricular arrhythmias					Drug Num: 35
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[27], [28]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[25], [15], [16], [319], [118]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[397]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[15], [414]
D0025		Adenosine	C10H13N5O4	60961	Moderate		Inter Info	[25], [558], [15], [16], [559], [560], [561], [114], [562], [563]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[640], [641], [642], [643], [644], [645], [646], [647], [648], [649], [650], [651], [652], [653], [341], [654], [655], [656], [657], [658], [659], [660], [661], [662], [663], [664], [665], [666], [667], [668]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[640], [641], [642], [643], [644], [645], [646], [647], [648], [649], [650], [651], [652], [653], [341], [654], [655], [656], [657], [658], [659], [660], [661], [662], [663], [664], [665], [666], [667], [668]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[653], [662], [665]
D0888		Lactulose	C12H22O11	11333	Moderate		Inter Info	[25], [15], [16], [678], [679], [680]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[653], [662], [665]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[640], [641], [642], [643], [644], [645], [646], [647], [648], [649], [650], [651], [652], [653], [341], [654], [655], [656], [657], [658], [659], [660], [661], [662], [663], [664], [665], [666], [667], [668]
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[25], [15], [16], [678], [679], [680]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[25], [15], [16], [678], [679], [680]
D0701		Frangula purshiana bark	NA	NA	Moderate		Inter Info	[15], [16], [680]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[25], [15], [16], [678], [679], [680]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[640], [641], [642], [643], [644], [645], [646], [647], [648], [649], [650], [651], [652], [653], [341], [654], [655], [656], [657], [658], [659], [660], [661], [662], [663], [664], [665], [666], [667], [668]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[25], [15], [16], [678], [679], [680]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[653], [662], [665]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[25], [15], [16], [678], [679], [680]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[25], [15], [16], [678], [679], [680]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[25], [15], [16], [678], [679], [680]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[640], [641], [642], [643], [644], [645], [646], [647], [648], [649], [650], [651], [652], [653], [341], [654], [655], [656], [657], [658], [659], [660], [661], [662], [663], [664], [665], [666], [667], [668]
D1266		Phenolphthalein	C20H14O4	4764	Moderate		Inter Info	[25], [15], [16], [678], [679], [680]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[16], [742], [743]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[640], [641], [642], [643], [644], [645], [646], [647], [648], [649], [650], [651], [652], [653], [341], [654], [655], [656], [657], [658], [659], [660], [661], [662], [663], [664], [665], [666], [667], [668]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[16], [742], [743]
D1309		Polyethylene glycol (3350)	C2H6O2	174	Moderate		Inter Info	[15], [16], [680]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[16], [742], [743]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[640], [641], [642], [643], [644], [645], [646], [647], [648], [649], [650], [651], [652], [653], [341], [654], [655], [656], [657], [658], [659], [660], [661], [662], [663], [664], [665], [666], [667], [668]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[25], [15], [16], [787], [788], [789]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[653], [662], [665]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[640], [641], [642], [643], [644], [645], [646], [647], [648], [649], [650], [651], [652], [653], [341], [654], [655], [656], [657], [658], [659], [660], [661], [662], [663], [664], [665], [666], [667], [668]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[25], [15], [16], [787], [788], [789]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[640], [641], [642], [643], [644], [645], [646], [647], [648], [649], [650], [651], [652], [653], [341], [654], [655], [656], [657], [658], [659], [660], [661], [662], [663], [664], [665], [666], [667], [668]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[15], [16], [797]

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141	Product Information. Migranal (dihydroergotamine nasal). Novartis Pharmaceuticals, East Hanover, NJ.
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159	Product Information. Relpax (eletriptan). Pfizer U.S. Pharmaceuticals, New York, NY.
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191	Product Information. Tequin (gatifloxacin) Bristol-Myers Squibb, Princeton, NJ.
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218	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
219	Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
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244	Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
245	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
246	Product Information. Nimotop (nimodipine). Bayer, West Haven, CT.
247	Product Information. OxyContin (oxycodone). Purdue Frederick Company, Norwalk, CT.
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260	Product Information. Orap Tablets (pimozide). Gate Pharmaceuticals, Sellersville, PA.
261	Product Information. Verzenio (abemaciclib). Lilly, Eli and Company, Indianapolis, IN.
262	Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
263	Product Information. Barhemsys (amisulpride). Acacia Pharma, Inc, Indianapolis, IN.
264	Product Information. Eliquis (apixaban). Bristol-Myers Squibb Canada Inc, Montreal, IN.
265	Product Information. Coartem (artemether-lumefantrine). Novartis Pharmaceuticals, East Hanover, NJ.
266	Product Information. Stendra (avanafil). Vivus Inc, Mountain View, CA.
267	Product Information. Ayvakit (avapritinib). Blueprint Medicines Corporation, Cambridge, MA.
268	Product Information. Inlyta (axitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
269	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
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271	Product Information. Orladeyo (berotralstat). BioCryst Pharmaceuticals Inc, Durham, NC.
272	Product Information. Bosulif (bosutinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
273	Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
274	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
275	Product Information. Cometriq (cabozantinib). Exelixis Inc, S San Francisco, CA.
276	Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
277	Product Information. Vraylar (cariprazine). Actavis Pharma, Inc., Parsippany, NJ.
278	Product Information. Zykadia (ceritinib). Novartis Pharmaceuticals, East Hanover, NJ.
279	Product Information. Cotellic (cobimetinib). Genentech, South San Francisco, CA.
280	Akdag I, Ersoy A, Kahvecioglu S, Gullulu M, Dilek K "Acute colchicine intoxication during clarithromycin administration in patients with chronic renal failure." J Nephrol 19 (2006): 515-7. [PMID: 17048210]
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288	Product Information. Colcrys (colchicine). AR Scientific Inc, Philadelphia, PA.
289	Product Information. Lexiva (fosamprenavir). GlaxoSmithKline, Research Triangle Park, NC.
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297	Product Information. Aliqopa (copanlisib). Bayer Pharmaceutical Inc, West Haven, CT.
298	Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
299	Product Information. Daklinza (daclatasvir). Bristol-Myers Squibb, Princeton, NJ.
300	Product Information. Emflaza (deflazacort). Marathon Pharmaceuticals, Deerfield, IL.
301	Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
302	Product Information. Prezcobix (cobicistat-darunavir). Janssen Pharmaceuticals, Titusville, NJ.
303	Product Information. Slynd (drospirenone). Exeltis USA, Inc., Chatham, NJ.
304	Product Information. Symtuza (cobicistat/darunavir/emtricitabine/tenof). Janssen Pharmaceuticals, Titusville, NJ.
305	Product Information. Yasmin (drospirenone-ethinyl estradiol) Berlex Laboratories, Richmond, CA.
306	Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
307	Product Information. Orilissa (elagolix). AbbVie US LLC, North Chicago, IL.
308	Product Information. Cerdelga (eliglustat). Genzyme Corporation, Cambridge, MA.
309	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
310	Han TH, Gopal AK, Ramchandren R, et al. "CYP3A-mediated drug-drug interaction potential and excretion of brentuximab vedotin, an antibody-drug conjugate, in patients with CD30-positive hematologic malignancies." J Clin Pharmacol 53 (2013): 866-77. [PMID: 23754575]
311	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
312	Product Information. Padcev (enfortumab vedotin). Seattle Genetics Inc, Bothell, WA.
313	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
314	Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
315	Homma S, Takahashi KI, Nihei S, Kato F, Sugihara S, Nunoda S "The successful management of respiratory complications with long-term, low-dose macrolide administration in pediatric heart transplant recipients." Int Heart J (2014):. [PMID: 25297501]
316	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
317	Product Information. Inrebic (fedratinib). Celgene Corporation, Summit, NJ.
318	Product Information. Toviaz (fesoterodine). Pfizer U.S. Pharmaceuticals Group, New York, NY.
319	Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
320	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
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341	Product Information. Breo Ellipta (fluticasone-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
342	Product Information. Flonase (fluticasone). Glaxo Wellcome, Research Triangle Park, NC.
343	Product Information. Flovent (fluticasone). Glaxo Wellcome, Research Triangle Park, NC.
344	Product Information. Norvir (ritonavir). Abbott Pharmaceutical, Abbott Park, IL.
345	Product Information. Veramyst (fluticasone nasal). GlaxoSmithKline, Research Triangle Park, NC.
346	Rouanet I, Peyriere H, Mauboussin JM, Vincent D "Cushing's syndrome in a patient treated by ritonavir/lopinavir and inhaled fluticasone." HIV Med 4 (2003): 149-50. [PMID: 12702137]
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358	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
359	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
360	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
361	Product Information. Zepatier (elbasvir-grazoprevir). Merck &amp Company Inc, Whitehouse Station, NJ.
362	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
363	Product Information. Exforge HCT (amlodipine/hydrochlorothiazide/valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
364	Product Information. Cresemba (isavuconazonium). Astellas Pharma US, Inc, Deerfield, IL.
365	Product Information. Nourianz (istradefylline). Kyowa Kirin, Inc, Bedminster, NJ.
366	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
367	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
368	Product Information. Orkambi (ivacaftor-lumacaftor). Vertex Pharmaceuticals, Cambridge, MA.
369	Product Information. Symdeko 4-Week (ivacaftor-tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
370	Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
371	Product Information. Tibsovo (ivosidenib). Agios Pharmaceuticals, Cambridge, MA.
372	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
373	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
374	Product Information. Dayvigo (lemborexant). Eisai Inc, Woodcliff Lake, NJ.
375	Product Information. Fetzima (levomilnacipran). Forest Pharmaceuticals, St. Louis, MO.
376	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
377	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
378	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
379	Product Information. Caplyta (lumateperone). Intra-Cellular Therapies, Inc., New York, NY.
380	Product Information. Latuda (lurasidone). Sunovion Pharmaceuticals Inc, Marlborough, MA.
381	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
382	Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
383	Product Information. Opsumit (macitentan). Actelion Pharmaceuticals US Inc, South San Francisco, CA.
384	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
385	Dutreix C, Munarini F, Lorenzo S, Roesel J, Wang Y "Investigation into CYP3A4-mediated drug-drug interactions on midostaurin in healthy volunteers." Cancer Chemother Pharmacol 72 (2013): 1223-34. [PMID: 24085261]
386	Product Information. Rydapt (midostaurin). Novartis Pharmaceuticals, East Hanover, NJ.
387	Product Information. Kynamro (mipomersen). Genzyme Corporation, Cambridge, MA.
388	Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
389	Abbas R, Hug BA, Leister C, Burns J, Sonnichsen D "Pharmacokinetics of oral neratinib during co-administration of ketoconazole in healthy subjects." Br J Clin Pharmacol 71 (2011): 522-7. [PMID: 21395644]
390	Product Information. Nerlynx (neratinib). Puma Biotechnology, Inc., Los Angeles, CA.
391	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
392	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
393	Product Information. Olinvyk (oliceridine). Trevena Inc, Chesterbrook, PA.
394	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
395	Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
396	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
397	Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
398	Product Information. Ibrance (palbociclib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
399	Product Information. Signifor (pasireotide). Novartis Pharmaceuticals, East Hanover, NJ.
400	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
401	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
402	Product Information. Polivy (polatuzumab vedotin). Genentech, South San Francisco, CA.
403	Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
404	Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
405	Product Information. Kisqali (ribociclib). Novartis Pharmaceuticals, East Hanover, NJ.
406	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
407	Product Information. Evotaz (atazanavir-cobicistat). Bristol-Myers Squibb, Princeton, NJ.
408	Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
409	Product Information. Jakafi (ruxolitinib). Incyte Corporation, Wilmington, DE.
410	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
411	Product Information. Koselugo (selumetinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
412	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.
413	Product Information. Olysio (simeprevir). Janssen Pharmaceuticals, Titusville, NJ.
414	Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
415	Product Information. VESIcare (solifenacin). GlaxoSmithKline, Research Triangle Park, NC.
416	Product Information. Odomzo (sonidegib). Novartis Pharmaceuticals, East Hanover, NJ.
417	Product Information. Belsomra (suvorexant). Merck & Company Inc, Whitehouse Station, NJ.
418	Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
419	Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
420	Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
421	Product Information. Xeljanz (tofacitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
422	Machiels JP, Staddon A, Herremans C, et al. "Impact of cytochrome P450 3A4 inducer and inhibitor on the pharmacokinetics of trabectedin in patients with advanced malignancies: open-label, multicenter studies." Cancer Chemother Pharmacol 74 (2014): 729-37. [PMID: 25100135]
423	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
424	Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
425	Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
426	Product Information. Ingrezza (valbenazine). Neurocrine Biosciences, Inc., San Diego, CA.
427	Product Information. Vandetanib (vandetanib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
428	Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
429	Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
430	Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
431	Product Information. Zontivity (vorapaxar). Merck & Company Inc, Whitehouse Station, NJ.
432	Product Information. Oxbryta (voxelotor). Global Blood Therapeutics, Inc., South San Francisco, CA.
433	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
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437	Product Information. Seroquel (quetiapine). Zeneca Pharmaceuticals, Wilmington, DE.
438	Spina E, de Leon J "Metabolic drug interactions with newer antipsychotics: a comparative review." Basic Clin Pharmacol Toxicol 100 (2007): 4-22. [PMID: 17214606]
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451	Product Information. Ranexa (ranolazine). Calmoseptine Inc, Huntington Beach, CA.
452	Anson BD, Weaver JG, Ackerman MJ, et al. "Blockade of HERG channels by HIV protease inhibitors." Lancet 365 (2005): 682-686. [PMID: 15721475]
453	Biondi L "Health Canada endorsed important safety information on Invirase (saquinavir mesylate)." .
454	Product Information. Invirase (saquinavir). Roche Laboratories, Nutley, NJ.
455	FDA. U.S. Food and Drug Administration "FDA drug safety communication: Ongoing safety review of Invirase (saquinavir) and possible association with abnormal heart rhythms.".
456	Dodds-Ashley E "Management of drug and food interactions with azole antifungal agents in transplant recipients." Pharmacotherapy 30 (2010): 842-54. [PMID: 20653361]
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461	Product Information. Zagam (sparfloxacin). Rhone-Poulenc Rorer, Collegeville, PA.
462	Zix JA, GeerdesFenge HF, Rau M, Vockler J, Borner K, Koeppe P, Lode H "Pharmacokinetics of sparfloxacin and interaction with cisapride and sucralfate." Antimicrob Agents Chemother 41 (1997): 1668-72. [PMID: 9257738]
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476	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
477	Soltero L, Carbajal H, Rodriguez-Montalvo C, Valdes A "Coadministration of tacrolimus and ketoconazole in renal transplant recipients: cost analysis and review of metabolic effects." Transplant Proc 35 (2003): 1319-21. [PMID: 12826147]
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539	Product Information. Oncovin (vincristine). Lilly, Eli and Company, Indianapolis, IN.
540	Product Information. Velban (vinblastine). Lilly, Eli and Company, Indianapolis, IN.
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550	Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.
551	Product Information. Eligard (leuprolide). Sanofi Winthrop Pharmaceuticals, New York, NY.
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553	Product Information. Lupron (leuprolide). TAP Pharmaceuticals Inc, Deerfield, IL.
554	Product Information. Plenaxis (abarelix). Praecis Pharmaceuticals Inc, Waltham, MA.
555	Product Information. Trelstar (triptorelin) Pharmacia and Upjohn, Kalamazoo, MI.
556	Product Information. Vantas (histrelin). Endo Pharmaceuticals (formally Indevus Pharmaceuticals Inc), Lexington, MA.
557	Product Information. Zoladex (goserelin). Zeneca Pharmaceuticals, Wilmington, DE.
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573	Product Information. Apokyn (apomorphine). Mylan Pharmaceuticals Inc, Morgantown, WV.
574	Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
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581	Product Information. Asparlas (calaspargase pegol). Servier, Boston, MA.
582	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
583	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
584	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
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599	Product Information. Velcade (bortezomib). Millennium Pharmaceuticals Inc, Cambridge, MA.
600	Uttamsingh V, Lu C, Miwa GT, Gan LS "Relative contributions of the five major human cytochromes P450, 1A2, 2C9, 2C19, 2D6, and 3A4 to the hepatic metabolism of teh protosome inhibitor bortezomib." Drug Metab Dispos 33 (2005): 1723-8. [PMID: 16103134]
601	Product Information. Tracleer (bosentan). Acetelion Pharmaceuticals US, Inc, South San Francisco, CA.
602	Product Information. Buprenex (buprenorphine). Reckitt and Colman Pharmaceutical, Richmond, VA.
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605	Product Information. Evoxac (cevimeline) Daiichi Pharmaceuticals, Fort lee, NJ.
606	Product Information. Sensipar (cinacalcet). Amgen USA, Thousand Oaks, CA.
607	Product Information. Cleocin (clindamycin). Pharmacia and Upjohn, Kalamazoo, MI.
608	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
609	Product Information. Lamprene (clofazimine). Novartis Pharmaceuticals, East Hanover, NJ.
610	Product Information. Sonata (zaleplon) Wyeth-Ayerst Laboratories, Philadelphia, PA.
611	Sansone-Parsons A, Krishna G, Calzetta A, et al. "Effect of a nutritional supplement on posaconazole pharmacokinetics following oral administration to healthy volunteers." Antimicrob Agents Chemother 50 (2006): 1881-3. [PMID: 16641468]
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618	Product Information. Cerubidine (daunorubicin). Wyeth-Ayerst Laboratories, Philadelphia, PA.
619	Product Information. Daunoxome (daunorubicin liposomal). Nexstar Pharmaceuticals Inc, Boulder, CO.
620	Product Information. Idamycin (idarubicin). Pharmacia and Upjohn, Kalamazoo, MI.
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623	Product Information. Valium (diazepam). Roche Laboratories, Nutley, NJ.
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627	Product Information. Cardura (doxazosin). Pfizer US Pharmaceuticals, New York, NY.
628	Product Information. Duagen (dutasteride). GlaxoSmithKline Healthcare, Pittsburgh, PA.
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630	Product Information. Tarceva (erlotinib). Genentech, South San Francisco, CA.
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653	Product Information. Arcapta Neohaler (indacaterol). Novartis Pharmaceuticals, East Hanover, NJ.
654	Product Information. Brovana (arformoterol). Sepracor Inc, Marlborough, MA.
655	Product Information. Foradil (formoterol) Novartis Pharmaceuticals, East Hanover, NJ.
656	Product Information. Maxair (pirbuterol). 3M Pharmaceuticals, St. Paul, MN.
657	Product Information. Proventil (albuterol). Schering Laboratories, Kenilworth, NJ.
658	Product Information. Severent (salmeterol). Glaxo Wellcome, Research Triangle Park, NC.
659	Product Information. Striverdi Respimat (olodaterol). Boehringer Ingelheim, Ridgefield, CT.
660	Product Information. Xopenex (levalbuterol). Sepracor, Marlborough, MA.
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669	Product Information. Reminyl (galantamine) Janssen Pharmaceuticals, Titusville, NJ.
670	Product Information. Iressa (gefitinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
671	Product Information. Factive (gemifloxacin). GeneSoft Inc, San Francisco, CA.
672	Product Information. Gleevec (imatinib mesylate). Novartis Pharmaceuticals, East Hanover, NJ.
673	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
674	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
675	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
676	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
677	Zeng Z, Andrew NW, Arison BH, Luffer-Atlas D, Wang RW "Identification of cytochrome P4503A4 as the major enzyme responsible for the metabolism of ivermectin by human liver microsomes." Xenobiotica 28 (1998): 313-21. [PMID: 9574819]
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681	Product Information. Chirocaine (levobupivacaine) Organon, West Orange, NJ.
682	Iannini PB, Doddamani S, Byazrova E, Curciumaru I, Kramer H "Risk of torsades de pointes with non-cardiac drugs. Prolongation of QT interval is probably a class effect of fluoroquinolones." Br Med J 322 (2001): 46-7. [PMID: 11141163]
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685	Nykamp DL, Blackmon CL, Schmidt PE, Roberson AG "QTc prolongation associated with combination therapy of levofloxacin, imipramine, and fluoxetine." Ann Pharmacother 39 (2005): 543-6. [PMID: 15687478]
686	Product Information. Floxin (ofloxacin). Ortho Pharmaceutical Corporation, Raritan, NJ.
687	Product Information. Levaquin (levofloxacin). Ortho Pharmaceutical Corporation, Raritan, NJ.
688	Samaha FF "QTC interval prolongation and polymorphic ventricular tachycardia in association with levofloxacin." Am J Med 107 (1999): 528-9. [PMID: 10569314]
689	Product Information. Lariam (mefloquine). Roche Laboratories, Nutley, NJ.
690	Canadian Pharmacists Association "e-CPS."
691	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
692	Okubo M, Murayama N, Miura J, Chiba Y, Yamazaki H "Effects of cytochrome P450 2D6 and 3A5 genotypes and possible coadministered medicines on the metabolic clearance of antidepressant mirtazapine in Japanese patients." Biochem Pharmacol 93 (2015): 104-9. [PMID: 25475885]
693	Product Information. Remeron (mirtazapine). Organon, West Orange, NJ.
694	Sitsen JM, Maris FA, Timmer CJ "Concomitant use of mirtazapine and cimetidine: a drug-drug interaction study in healthy male subjects." Eur J Clin Pharmacol 56 (2000): 389-94. [PMID: 11009047]
695	Stormer E, von Moltke LL, Shader RI, Greenblatt DJ "Metabolism of the antidepressant mirtazapine in vitro: contribution of cytochromes P-450 1A2, 2D6, and 3A4" Drug Metab Dispos 28 (2000): 1168-75. [PMID: 10997935]
696	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
697	Product Information. Zyprexa (olanzapine). Lilly, Eli and Company, Indianapolis, IN.
698	Bergmann TK, Filppula AM, Launiainen T, Nielsen F, Backman J, Brosen K "Neurotoxicity and low paclitaxel clearance associated with concomitant clopidogrel therapy in a 60 year old Caucasian woman with ovarian carcinoma." Br J Clin Pharmacol (2015):. [PMID: 26446447]
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701	Product Information. Abraxane (paclitaxel protein-bound). American Pharmaceutical Partners, Schaumberg, IL.
702	Product Information. Taxol (paclitaxel). Bristol-Myers Squibb, Princeton, NJ.
703	Spencer CM, Faulds D "Paclitaxel. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer." Drugs 48 (1994): 794-847. [PMID: 7530632]
704	Product Information. Zemplar (paricalcitol). Abbott Pharmaceutical, Abbott Park, IL.
705	Product Information. Definity (perflutren). Lantheus Medical Imaging Inc, North Billerica, MA.
706	Product Information. Optison (perflutren). Mallinckrodt Medical Inc, St. Louis, MO.
707	Product Information. Tekturna (aliskiren). Novartis Pharmaceuticals, East Hanover, NJ.
708	Tapaninen T, Backman JT, Kurkinen K, Neuvonen P, Niemi M "Itraconazole, a P-glycoprotein and CYP3A4 inhibitor, markedly raises the plasma concentrations and enhances the renin-inhibiting effect of aliskiren." J Clin Pharmacol 51 (2011): 359-67. [PMID: 20400651]
709	Product Information. Diovan (valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
710	Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
711	Product Information. Saphris (asenapine). Schering-Plough Corporation, Kenilworth, NJ.
712	Product Information. Bevyxxa (betrixaban). Portola Pharmaceuticals, South San Francisco, CA.
713	Product Information. Biktarvy (bictegravir/emtricitabine/tenofovir). Gilead Sciences, Foster City, CA.
714	Product Information. Mektovi (binimetinib). Array BioPharma Inc., Boulder, CO.
715	Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67. [PMID: 19667002]
716	Product Information. Jevtana (cabazitaxel). sanofi-aventis , Bridgewater, NJ.
717	Product Information. Alvesco (ciclesonide). Nycomed USA, Florham Park, NJ.
718	Product Information. Omnaris (ciclesonide nasal). Sepracor Inc, Marlborough, MA.
719	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
720	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
721	Product Information. Stribild (cobicistat/elvitegravir/emtricitabine/tenofov). Gilead Sciences, Foster City, CA.
722	Product Information. Tafinlar (dabrafenib). GlaxoSmithKline, Research Triangle Park, NC.
723	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
724	Product Information. Austedo (deutetrabenazine). Teva Pharmaceuticals USA, North Wales, PA.
725	Product Information. Viberzi (eluxadoline). Actavis Pharma, Inc., Parsippany, NJ.
726	Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
727	Product Information. Halaven (eribulin). Eisai Inc, Teaneck, NJ.
728	Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
729	Product Information. Rukobia (fostemsavir). ViiV Healthcare, Research Triangle Park, NC.
730	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
731	Product Information. Besponsa (inotuzumab ozogamicin). Wyeth Laboratories, Philadelphia, PA.
732	Product Information. Ixempra (ixabepilone). Bristol-Myers Squibb, Princeton, NJ.
733	Product Information. Vimpat (lacosamide). UCB Pharma Inc, Smyrna, GA.
734	Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
735	Product Information. Harvoni (ledipasvir-sofosbuvir). Gilead Sciences, Foster City, CA.
736	Product Information. Lucemyra (lofexidine). US WorldMeds LLC, Louisville , KY.
737	Product Information. Kaletra (lopinavir-ritonavir) Abbott Pharmaceutical, Abbott Park, IL.
738	Product Information. Symproic (naldemedine). Shionogi USA Inc, Florham Park, NJ.
739	Product Information. Ofev (nintedanib). Boehringer Ingelheim, Ridgefield, CT.
740	Product Information. Osphena (ospemifene). Shionogi USA Inc, Florham Park, NJ.
741	Product Information. Viekira Pak (dasabuvir/ombitasvir/paritaprevir/ritonavir). AbbVie US LLC, North Chicago, IL.
742	Product Information. Suclear (polyethylene glycol 3350 with electrolytes). Braintree Laboratories, Braintree, MA.
743	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
744	Product Information. Pomalyst (pomalidomide). QLT Phototherapeutics Inc, Vancouver, AZ.
745	Product Information. Stivarga (regorafenib). Bayer Pharmaceutical Inc, West Haven, CT.
746	European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
747	Gilead Sciences, Inc "About Remdesivir.".
748	US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
749	Product Information. Edurant (rilpivirine). Tibotec Pharmaceuticals, Titusville, NJ.
750	Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
751	Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT.
752	Product Information. Onglyza (saxagliptin). Bristol-Myers Squibb, Princeton, NJ.
753	Product Information. Lokelma (sodium zirconium cyclosilicate). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
754	Product Information. Sutent (sunitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
755	Product Information. Talzenna (talazoparib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
756	Product Information. Hetlioz (tasimelteon). Vanda Pharmaceuticals Inc, Rockville, MD.
757	Product Information. Xenazine (tetrabenazine). Prestwick Pharmaceuticals Inc, Washington DC, VA.
758	Product Information. Kadcyla (ado-trastuzumab). Genentech, South San Francisco, CA.
759	Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.
760	Hanci V, Aydin M, Yurtlu BS, et.al "Anesthesia induction with sevoflurane and propofol: evaluation of P-wave dispersion, QT and corrected QT intervals." Kaohsiung J Med Sci 26 (2010): 470-7. [PMID: 20837343]
761	Kim DH, Kweon TD, Nam SB, Han DW, Cho WY, Lee JS "Effects of target concentration infusion of propofol and tracheal intubation on QTc interval." Anaesthesia 63 (2008): 1061-4. [PMID: 18717665]
762	Kleinsasser A, Kuenszberg E, Loeckinger A, et.al "Sevoflurane, but not propofol, significantly prolongs the Q-T interval." Anesth Analg 90 (2000): 25-7. [PMID: 10624970]
763	Kleinsasser A, Loeckinger A, Lindner KH, Keller C, Boehler M, Puehringer F "Reversing sevoflurane-associated Q-Tc prolongation by changing to propofol." Anaesthesia 56 (2001): 248-50. [PMID: 11251432]
764	Paventi S, Santevecchi A, Ranieri R "Effects of sevoflurane versus propofol on QT interval." Minerva Anestesiol 67 (2001): 637-40. [PMID: 11731753]
765	Scalese MJ, Herring HR, Rathburn RC, Skrepnek GH, Ripley TL "Propofol-associated QTc prolongation." Ther Adv Drug Saf 7 (2016): 68-78. [PMID: 27298717]
766	Staikou C, Stamelos M, Stavroulakis E "Impact of anaesthetic drugs and adjuvants on ECG markers of torsadogenicity." Br J Anaesth 112 (2014): 217-30. [PMID: 24305646]
767	Toyoda T, Terao Y, Oji M, Okada M, Fukusaki M, Sumikawa K "The interaction of antiemetic dose of droperidol with propofol on QT interval during anesthetic induction." J Anesth 27 (2013): 885-9. [PMID: 23660990]
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769	Wutzler A, De Asmundis C, Matsuda H, et.al "Effects of propofol on ventricular repolarization and incidence of malignant arrhythmias in adults." J Electrocardiol 51 (2018): 170-4. [PMID: 29174097]
770	Mirghani RA, Ericsson O, Tybring G, Gustafsson LL, Bertilsson L "Quinine 3-hydroxylation as a biomarker reaction for the activity of CYP3A4 in man." Eur J Clin Pharmacol 59 (2003): 23-8. [PMID: 12743670]
771	Mirghani RA, Hellgren U, Bertilsson L, Gustafsson LL, Ericsson O "Metabolism and elimination of quinine in healthy volunteers." Eur J Clin Pharmacol (2003):. [PMID: 12920491]
772	Mirghani RA, Hellgren U, Westerberg PA, Ericsson O, Bertilsson L, Gustafsson LL "The roles of cytochrome P450 3A4 and 1A2 in the 3-hydroxylation of quinine in vivo." Clin Pharmacol Ther 66 (1999): 454-60. [PMID: 10579472]
773	Mirghani RA, Yasar U, Zheng T, et al "Enzyme kinetics for the formation of 3-hydroxyquinine and three new metabolites of quinine in vitro 3-hydroxylation by CYP3A4 is indeed the major metabolic pathway." Drug Metab Dispos 30 (2002): 1368-71. [PMID: 12433805]
774	Product Information. Qualaquin (quinine). AR Scientific Inc, Philadelphia, PA.
775	Wanwimolruk S, Paine MF, Pusek SN, Watkins PB "Is quinine a suitable probe to assess the hepatic drug-metabolizing enzyme CYP3A4?" Br J Clin Pharmacol 54 (2002): 643-51. [PMID: 12492613]
776	Zhang H, Coville PF, Walker RJ, Miners JO, Birkett DJ, Wanwimolruk S "Evidence for involvement of human CYP3A in the 3-hydroxylation of quinine." Br J Clin Pharmacol 43 (1997): 245-52. [PMID: 9088578]
777	Zhao XJ, Ishizaki T "A further interaction study of quinine with clinically important drugs by human liver microsomes: determinations of inhibition constant (K-i) and type of inhibition." Eur J Drug Metab Pharm 24 (1999): 272-8. [PMID: 10716067]
778	Zhao XJ, Ishizaki T "Metabolic interactions of selected antimalarial and non-antimalarial drugs with the major pathway (3-hydroxylation) of quinine in human liver microsomes." Br J Clin Pharmacol 44 (1997): 505-11. [PMID: 9384469]
779	Product Information. Rozerem (ramelteon). Takeda Pharmaceuticals America, Lincolnshire, IL.
780	Bidstrup TB, Bjornsdottir I, Sidelmann UG, Thomsen MS, Hansen KT "CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide." Br J Clin Pharmacol 56 (2003): 305-14. [PMID: 12919179]
781	Hatorp V, Hansen KT, Thomsen MS "Influence of drugs interacting with CYP3A4 on the pharmacokinetics, pharmacodynamics, and safety of the prandial glucose regulator repaglinide." J Clin Pharmacol 43 (2003): 649-60. [PMID: 12817528]
782	Khamaisi M, Leitersdorf E "Severe hypoglycemia from clarithromycin-repaglinide drug interaction." Pharmacotherapy 28 (2008): 682-4. [PMID: 18447665]
783	Niemi M, Neuvonen PJ, Kivisto KT "The cytochrome P4503A4 inhibitor clarithromycin increases the plasma concentrations and effects of repaglinide." Clin Pharmacol Ther 70 (2001): 58-65. [PMID: 11452245]
784	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
785	Tornio A, Niemi M, Neuvonen M, et al. "The effect of gemfibrozil on repaglinide pharmacokinetics persists for at least 12 h after the dose: evidence for mechanism-based inhibition of CYP2C8 in vivo." Clin Pharmacol Ther 84 (2008): 403-11. [PMID: 18388877]
786	Niemi M, Backman JT, Neuvonen M, Neuvonen PJ "Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics and pharmacodynamics of repaglinide: potentially hazardous interaction between gemfibrozil and repaglinide." Diabetologia 46 (2003): 347-51. [PMID: 12687332]
787	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
788	Product Information. Exelon (rivastigmine) Novartis Pharmaceuticals, East Hanover, NJ.
789	Product Information. Razadyne (galantamine). Johnson and Johnson Medical Inc, Arlington, TX.
790	Product Information. Ultane (sevoflurane). Abbott Pharmaceutical, Abbott Park, IL.
791	Product Information. Nexavar (sorafenib). Bayer Pharmaceutical Inc, West Haven, CT.
792	Bartkowski RR, Goldberg ME, Huffnagle S, Epstein RH "Sufentanil disposition. Is it affected by erythromycin administration?" Anesthesiology 78 (1993): 260-5. [PMID: 8439020]
793	Product Information. Sufenta (sufentanil). Janssen Pharmaceutica, Titusville, NJ.
794	Demolis JL, Vacheron F, Cardus S, Funck-Brentano C "Effect of single and repeated oral doses of telithromycin on cardiac QT interval in healthy subjects." Clin Pharmacol Ther 73 (2003): 242-52. [PMID: 12621389]
795	Product Information. Ketek (telithromycin). Aventis Pharmaceuticals, Bridgewater, NJ.
796	European Agency for the Evaluation of Medicinal Products. Committee for Proprietary Medicinal Products "European Public Assessment Report Ketek (telithromycin) (Rev. 2) ".
797	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
798	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
799	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
800	Brynne N, Forslund C, Hallen B, Gustafsson LL, Bertilsson L "Ketoconazole inhibits the metabolism of tolterodine in subjects with deficient CYP2D6 activity." Br J Clin Pharmacol 48 (1999): 564-72. [PMID: 10583027]
801	Product Information. Detrol (tolterodine). Pharmacia and Upjohn, Kalamazoo, MI.
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803	Cordoba R, Ramirez E, Lei SH, et al. "Hypercalcemia due to an interaction of all-trans retinoic acid (ATRA) and itraconazole therapy for acute promyelocytic leukemia successfully treated with zoledronic acid." Eur J Clin Pharmacol 64 (2008): 1031-2. [PMID: 18584165]
804	Dixon KS, Hassoun A "Pseudotumor cerebri due to the potentiation of all-trans retinoic acid by voriconazole." J Am Pharm Assoc (2003) 50 (2010): 742-4. [PMID: 21071321]
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