Details of Drug-Drug Interaction
| Drug General Information (ID: DDI0QZTGFK) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Ranitidine (bismuth citrate) | Drug Info | Posaconazole | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antiulcer Agents | Antifungal Agents | |||||||
| Structure | |||||||||
| Mechanism of Ranitidine (bismuth citrate)-Posaconazole Interaction (Severity Level: Moderate) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Altered gastric pH Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Ranitidine (bismuth citrate) | Posaconazole | |||||||
| Mechanism | Gastric alkalinizer | Gastric pH sensitive | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Gastric pH | ||||||||
| Factor Description | The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Concomitant use of posaconazole oral suspension with cimetidine should generally be avoided. Until more information is available, this precaution should also be considered for other H2-receptor antagonists, although the manufacturer suggests otherwise. If possible, prescribers may consider suspending the H2 antagonist until completion of posaconazole therapy, or substituting an antifungal agent like fluconazole or voriconazole whose absorption is not affected by stomach pH. Delayed-release tablets of posaconazole may be used with H2 antagonists, as no pharmacokinetic interaction has been demonstrated with ranitidine or other agents affecting gastric pH such as proton pump inhibitors or antacids. | ||||||||