Drug General Information (ID: DDIS8K3JOH)
Drug Name			Metoclopramide		Drug Info		Posaconazole		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiemetics				Antifungal Agents
Structure

Mechanism of Metoclopramide-Posaconazole Interaction (Severity Level: Moderate)
Altered gastrointestinal dynamics Click to Show/Hide Mechanism Graph
Drug Name		Metoclopramide				Posaconazole
Mechanism		Increase gastrointestinal motility				Absorption is influenced by gastrointestinal motility
Key Mechanism Factor 1
		Factor Name		Gastrointestinal Motility
		Factor Description		Gastrointestinal motility is an important factor in determining the absorption of orally administered drugs, and it controls the residence time of the drug in the digestive tract.
Mechanism Description		Altered absorption of Posaconazole due to GI dynamics variation caused by Metoclopramide

Recommended Action
Management		Caution is advised if posaconazole is prescribed in combination with metoclopramide. Patients should be monitored for the development of breakthrough fungal infections.

References
1	Product Information. Noxafil (posaconazole). Schering-Plough Corporation, Kenilworth, NJ.
2	Krishna G, Moton A, Ma L, Malavade D, Medlock M, McLeod J "Effect of gastric pH, dosing regimen and prandial state, food and meal timing relative to dose, and gastro-intestinal motility on absorption and pharmacokinetics of the antifungal posaconazole." 18th European Congress of Clinical Microbiology and Infectious Diseases April (2008): 20.