Details of Drug

Details of Drug

 Drug General Information (ID: D1220)
  Drug Name
Panitumumab
  Drug Type Monoclonal antibody
  Drug Synonymous
Vectibix; Panitumumab (genetical recombination); Vectibix (TN); Panitumumab (USAN/INN); Panitumumab (genetical recombination) (JAN); Panitumumab (EGFR mAb inhibitor)
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  Disease Class 2B91: Colorectal cancer; 2D42: Head and neck cancer
  Therapeutic Class Antineoplastics
  External Link
TTD ID D0HU9H

Drug-Drug Interaction Network
  Sunburst Graph
AM006  Pharmacodynamic additive effects
BM066  Increased risk of hypomagnesemia
BM075  Increased risk of photosensitivity reactions
BM081  Increased risk of ventricular arrhythmias
BM109  Increased risk of other adverse reactions (Unspecific)
  Relation Graph
 Full list of drugs interacting with Panitumumab
      Pharmacodynamic additive effects
   Increased risk of hypomagnesemia Drug Num:  6
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0603
 
Esomeprazole
 
C17H19N3O3S
 
9568614 
Moderate    Inter Info   
[24]
D0892
 
Lansoprazole
 
C16H14F3N3O2S
 
3883 
Moderate    Inter Info   
[24]
D1179
 
Omeprazole
 
C17H19N3O3S
 
4594 
Moderate    Inter Info   
[24]
D0458
 
Dexlansoprazole
 
C16H14F3N3O2S
 
9578005 
Moderate    Inter Info   
[24]
D1222
 
Pantoprazole
 
C16H15F2N3O4S
 
4679 
Moderate    Inter Info   
[24]
D1373
 
Rabeprazole
 
C18H21N3O3S
 
5029 
Moderate    Inter Info   
[24]
   Increased risk of photosensitivity reactions Drug Num:  6
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0062
 
Aminolevulinic acid
 
C5H9NO3
 
137 
Major    Inter Info   
[1], [2]
D0063
 
Aminolevulinic acid (topical)
 
C5H9NO3
 
137 
Moderate    Inter Info   
[12], [7], [22]
D1028
 
Methoxsalen
 
C12H8O4
 
4114 
Moderate    Inter Info   
[12], [23], [1], [25], [26]
D1033
 
Methyl aminolevulinate (topical)
 
C6H11NO3
 
157922 
Moderate    Inter Info   
[12], [7], [22]
D1314
 
Porfimer sodium
 
C68H74N8O11
 
135577896 
Moderate    Inter Info   
[28], [7], [29]
D1691
 
Verteporfin
 
C82H84N8O16
 
11980904 
Moderate    Inter Info   
[7], [23], [1], [30]
   Increased risk of ventricular arrhythmias Drug Num:  9
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0066
 
Amiodarone
 
C25H29I2NO3
 
2157 
Major    Inter Info   
[3], [4]
D0107
 
Arsenic trioxide
 
As2O3
 
14888 
Major    Inter Info   
[5], [6]
D0513
 
Dofetilide
 
C19H27N3O5S2
 
71329 
Major    Inter Info   
[10]
D0535
 
Droperidol
 
C22H22FN3O2
 
3168 
Major    Inter Info   
[11], [12], [7], [13], [14], [15]
D0909
 
Levacetylmethadol
 
C23H31NO2
 
15130 
Major    Inter Info   
[16], [17], [18]
D0534
 
Dronedarone
 
C31H44N2O5S
 
208898 
Major    Inter Info   
[19]
D1292
 
Pimozide
 
C28H29F2N3O
 
16362 
Major    Inter Info   
[20]
D1726
 
Ziprasidone
 
C21H21ClN4OS
 
60854 
Major    Inter Info   
[21]
D0508
 
Disopyramide
 
C21H29N3O
 
3114 
Moderate    Inter Info   
[7], [23]
   Increased risk of other adverse reactions (Unspecific) Drug Num:  4
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0177
 
Bevacizumab
 
NA
 
NA
Major    Inter Info   
[7], [8], [9]
D0845
 
Irinotecan
 
C33H38N4O6
 
60838 
Major    Inter Info   
[12], [7], [9]
D0846
 
Irinotecan (liposomal)
 
C33H38N4O6
 
60838 
Major    Inter Info   
[12], [7], [9]
D0789
 
Idelalisib
 
C22H18FN7O
 
11625818 
Moderate    Inter Info   
[27]
References
1 Product Information. Nulibry (fosdenopterin). Origin Biosciences Inc, Boston, MA.
2 Product Information. Gleolan (aminolevulinic acid). NX Development Corp, Lexington, KY.
3 Antonelli D, Atar S, Freedberg NA, Rosenfeld T "Torsade de pointes in patients on chronic amiodarone treatment: contributing factors and drug interactions." Isr Med Assoc J 7 (2005): 163-5. [PMID: 15792261]
4 Product Information. Amiodarone Hydrochloride (amiodarone). Bedford Laboratories, Bedford, OH.
5 Ohnishi K, Yoshida H, Shigeno K, et al. "Prolongation of the QT interval and ventricular tachycardia in patients treated with arsenic trioxide for acute promyelocytic leukemia." Ann Intern Med 133 (2000): 881-5. [PMID: 11103058]
6 Product Information. Trisenox (arsenic trioxide) Cephalon Inc, West Chester, PA.
7 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
8 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports."
9 Product Information. Vectibix (panitumumab). Amgen USA, Thousand Oaks, CA.
10 Product Information. Tikosyn (dofetilide) Pfizer US Pharmaceuticals, Atlanta, GA.
11 Canadian Pharmacists Association.
12 Cerner Multum, Inc. "Australian Product Information.".
13 Glassman AH, Bigger JT Jr "Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death." Am J Psychiatry 158 (2001): 1774-82. [PMID: 11691681]
14 Product Information. Inapsine (droperidol). Janssen Pharmaceutica, Titusville, NJ.
15 EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
16 Cohen J "Long-term efficacy and safety of terazosin alone and in combination with other antihypertensive agents." Am Heart J 122 (1991): 919-25. [PMID: 1678923]
17 Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
18 Product Information. Xatral (alfuzosin). Sanofi-Synthelabo Canada Inc, Markham, ON.
19 Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
20 Product Information. Orap Tablets (pimozide). Gate Pharmaceuticals, Sellersville, PA.
21 Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.
22 Product Information. Metvixia (methyl aminolevulinate topical). Galderma Laboratories Inc, Cranbury, NJ.
23 Multum Information Services, Inc. Expert Review Panel.
24 FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Low magnesium levels can be associated with long-term use of proton pump inhibitor drugs (PPIs).".
25 Product Information. Oxsoralen (methoxsalen). ICN Pharmaceuticals Inc, Costa Mesa, CA.
26 Product Information. Uvadex (methoxsalen). Therakos Inc, Exton, PA.
27 Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
28 Blakely KM, Drucker AM, Rosen CF "Drug-induced photosensitivity-an update: Culprit drugs, prevention and management." Drug Saf 42 (2019): 827-47. [PMID: 30888626]
29 Product Information. Photofrin (porfimer). Sanofi Winthrop Pharmaceuticals, New York, NY.
30 Product Information. Visudyne (verteporfin) Valeant Pharmaceuticals, Costa Mesa, CA.